GOLGA8R

Summary

GOLGA8R (golgin A8 family member R, HGNC:44407) is a protein-coding gene on chromosome 15q13.2, encoding Golgin subfamily A member 8R (I6L899). It is a selective cancer dependency (DepMap: 19.9% of cell lines).

Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network.

Source: NCBI Gene 101059918 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 2 total
• Cancer dependency (DepMap): dependent in 19.9% of screened cell lines
• MANE Select transcript: NM_001282484

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44407
Approved symbol	GOLGA8R
Name	golgin A8 family member R
Location	15q13.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000186399
Ensembl biotype	protein_coding
Entrez	101059918

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 TEC

ENST00000327271, ENST00000624918

RefSeq mRNA: 1 — MANE Select: NM_001282484 NM_001282484

CCDS: CCDS61575

Canonical transcript exons

ENST00000327271 — 19 exons

Exon	Start	End
ENSE00001603774	30409541	30409650
ENSE00001607629	30404252	30404349
ENSE00001610354	30408402	30408488
ENSE00001615457	30404432	30404532
ENSE00001617059	30406951	30407019
ENSE00001621316	30411119	30411199
ENSE00001651360	30411381	30411440
ENSE00001689025	30407908	30407992
ENSE00001695658	30405107	30405198
ENSE00001722992	30409919	30409966
ENSE00001730299	30400562	30403915
ENSE00001740008	30405630	30405705
ENSE00001748569	30404001	30404156
ENSE00001760181	30407275	30407531
ENSE00001778134	30412329	30412448
ENSE00001783777	30408188	30408295
ENSE00001794289	30409746	30409830
ENSE00001804569	30410229	30410267
ENSE00002596058	30414115	30414260

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 85.33.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	85.33	gold quality
right lobe of thyroid gland	UBERON:0001119	83.44	gold quality
thyroid gland	UBERON:0002046	80.71	gold quality
left lobe of thyroid gland	UBERON:0001120	80.67	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.96	gold quality
mucosa of stomach	UBERON:0001199	78.29	gold quality
left ovary	UBERON:0002119	76.34	gold quality
ovary	UBERON:0000992	75.69	gold quality
right ovary	UBERON:0002118	75.29	gold quality
descending thoracic aorta	UBERON:0002345	75.12	gold quality
stromal cell of endometrium	CL:0002255	74.48	gold quality
popliteal artery	UBERON:0002250	74.21	gold quality
tibial artery	UBERON:0007610	74.19	gold quality
apex of heart	UBERON:0002098	73.80	gold quality
bone marrow	UBERON:0002371	73.53	gold quality
right coronary artery	UBERON:0001625	73.50	gold quality
thoracic aorta	UBERON:0001515	73.48	gold quality
ascending aorta	UBERON:0001496	73.38	gold quality
pituitary gland	UBERON:0000007	73.36	gold quality
body of uterus	UBERON:0009853	73.04	gold quality
left testis	UBERON:0004533	72.96	gold quality
testis	UBERON:0000473	72.94	gold quality
body of pancreas	UBERON:0001150	72.64	gold quality
right testis	UBERON:0004534	72.33	gold quality
left coronary artery	UBERON:0001626	72.31	gold quality
skeletal muscle tissue	UBERON:0001134	71.98	gold quality
gastrocnemius	UBERON:0001388	71.85	gold quality
tibial nerve	UBERON:0001323	71.82	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.68	gold quality
muscle of leg	UBERON:0001383	71.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.03

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

108 targeting GOLGA8R, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 19.9% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	golga2	ENSDARG00000063197
mus_musculus	Golga2	ENSMUSG00000002546
rattus_norvegicus	Golga2l1	ENSRNOG00000050262
drosophila_melanogaster	GM130	FBGN0034697
caenorhabditis_elegans		WBGENE00018017

Paralogs (18): GOLGA6D (ENSG00000140478), GOLGA8F (ENSG00000153684), GOLGA6A (ENSG00000159289), GOLGA2 (ENSG00000167110), GOLGA6C (ENSG00000167195), GOLGA8A (ENSG00000175265), GOLGA8Q (ENSG00000178115), GOLGA8J (ENSG00000179938), GOLGA8G (ENSG00000183629), GOLGA8M (ENSG00000188626), GOLGA8O (ENSG00000206127), GOLGA6B (ENSG00000215186), GOLGA8B (ENSG00000215252), GOLGA8N (ENSG00000232653), GOLGA8K (ENSG00000249931), GOLGA8T (ENSG00000261247), GOLGA8S (ENSG00000261739), GOLGA8H (ENSG00000261794)

Protein

Protein identifiers

Golgin subfamily A member 8R — I6L899 (reviewed: I6L899)

All UniProt accessions (1): I6L899

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the GOLGA8 family.

Isoforms (2)

UniProt ID	Names	Canonical?
I6L899-1	1	yes
I6L899-2	2

RefSeq proteins (1): NP_001269413* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR024858	GOLGA	Family
IPR043937	GOLGA_C	Conserved_site
IPR043976	GOLGA_cons_dom	Domain

Pfam: PF15070, PF19046

UniProt features (14 total): region of interest 4, compositionally biased region 3, splice variant 3, coiled-coil region 3, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-I6L899-F1	71.22	0.40

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-9013148	CDC42 GTPase cycle
R-HSA-9013405	RHOD GTPase cycle

MSigDB gene sets: 39 (showing top): chr15q13, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, GOBP_GOLGI_ORGANIZATION, GOCC_GOLGI_STACK, GOCC_GOLGI_CISTERNA, GOCC_CIS_GOLGI_NETWORK, GOCC_GOLGI_CISTERNA_MEMBRANE, GOCC_ORGANELLE_SUBCOMPARTMENT, GOCC_GOLGI_CIS_CISTERNA, REACTOME_RHO_GTPASE_CYCLE, MIR3662, MIR520D_5P, MIR524_5P, MIR4262, MIR181A_5P_MIR181B_5P

GO Biological Process (1): Golgi organization (GO:0007030)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): Golgi cis cisterna (GO:0000137), cis-Golgi network (GO:0005801), Golgi cisterna membrane (GO:0032580), Golgi apparatus (GO:0005794)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RHO GTPase cycle	2

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
Golgi cisterna	2
intracellular membrane-bounded organelle	2
organelle organization	1
endomembrane system organization	1
binding	1
Golgi apparatus	1
organelle membrane	1
cytoplasm	1
endomembrane system	1

Protein interactions and networks

STRING

266 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GOLGA8R	CCDC144NL	Q6NUI1	570
GOLGA8R	MTMR10	Q9NXD2	419
GOLGA8R	CCDC142	Q17RM4	400
GOLGA8R	C16orf78	Q8WTQ4	391
GOLGA8R	ARHGAP11B	Q3KRB8	370
GOLGA8R	CHRFAM7A	Q494W8	354
GOLGA8R	OTUD7A	Q8TE49	353
GOLGA8R	OR51Q1	Q8NH59	350
GOLGA8R	C2orf81	A6NN90	348
GOLGA8R	BRICD5	Q6PL45	325
GOLGA8R	CDK11B	P21127	314
GOLGA8R	GALNT12	Q8IXK2	307
GOLGA8R	PRIM2	P49643	305
GOLGA8R	OR2L8	Q8NGY9	298
GOLGA8R	RNF151	Q2KHN1	296

IntAct

3 interactions, top by confidence:

A	B	Type	Score
Cul1	GPS1	psi-mi:“MI:0914”(association)	0.350
TENT5A	GOLGA8R	psi-mi:“MI:0914”(association)	0.350

BioGRID (8): GOLGA8R (Affinity Capture-MS), GOLGA8R (Affinity Capture-MS), GOLGA8R (Proximity Label-MS), GOLGA8R (Affinity Capture-MS), GOLGA8R (Affinity Capture-MS), GOLGA8R (Affinity Capture-MS), GOLGA8R (Affinity Capture-MS), GOLGA8R (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2VD12, A6NCC3, A6NN73, A6QLY7, D6RF30, E1U8D0, F8WBI6, H3BPF8, H3BQL2, H3BSY2, H3BV12, I6L899, O75154, P0DX52, P0DX53, P10354, Q0D2H9, Q0KK56, Q2NL23, Q2TAC2, Q2YDF7, Q3MI48, Q3TVI8, Q3UHU5, Q3UPH7, Q5DU05, Q5JYT7, Q5R6R3, Q5SX79, Q640L3, Q6P2H3, Q6PHN1, Q7Z591, Q7Z6P3, Q80VW7, Q8BWG4, Q8CB62, Q8CB87, Q8IY92, Q8N137

Diamond homologs: A0A1B0GV03, A1IH00, A6NC78, A6NCC3, A6NDK9, A6NDN3, A6NEF3, A6NEM1, A6NI86, A6NN73, A7E2F4, A8MQT2, A8MZA4, F8WBI6, H0YKK7, H0YM25, H3BPF8, H3BSY2, H3BV12, I6L899, P0CG33, P0CJ92, P0DX00, P0DX01, P0DX02, P0DX52, P0DX53, Q08379, Q62839, Q8N7Z2, Q8N9W4, Q921M4, Q9NYA3, A6NMD2, D6RF30, H3BQL2, Q0D2H9, Q9HBQ8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2807 predictions. Top by Δscore:

Variant	Effect	Δscore
15:30403916:C:CC	acceptor_gain	1.0000
15:30403997:TCA:T	donor_loss	1.0000
15:30403998:CAC:C	donor_loss	1.0000
15:30403999:A:AC	donor_gain	1.0000
15:30403999:A:AT	donor_loss	1.0000
15:30403999:AC:A	donor_gain	1.0000
15:30403999:ACCAC:A	donor_gain	1.0000
15:30404000:C:CC	donor_gain	1.0000
15:30404000:CC:C	donor_gain	1.0000
15:30404000:CCA:C	donor_gain	1.0000
15:30404000:CCACC:C	donor_gain	1.0000
15:30404152:TTCAC:T	acceptor_gain	1.0000
15:30404153:TCAC:T	acceptor_gain	1.0000
15:30404154:CAC:C	acceptor_gain	1.0000
15:30404154:CACC:C	acceptor_gain	1.0000
15:30404155:AC:A	acceptor_gain	1.0000
15:30404156:CC:C	acceptor_gain	1.0000
15:30404157:C:CA	acceptor_loss	1.0000
15:30404157:C:CC	acceptor_gain	1.0000
15:30404158:T:A	acceptor_loss	1.0000
15:30404250:A:AC	donor_gain	1.0000
15:30404251:C:CA	donor_loss	1.0000
15:30404251:C:CC	donor_gain	1.0000
15:30404263:C:A	donor_gain	1.0000
15:30404345:TTTTC:T	acceptor_gain	1.0000
15:30404346:TTTC:T	acceptor_gain	1.0000
15:30404346:TTTCC:T	acceptor_loss	1.0000
15:30404347:TTC:T	acceptor_gain	1.0000
15:30404350:C:CC	acceptor_gain	1.0000
15:30404351:T:G	acceptor_loss	1.0000

AlphaMissense

4154 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:30407441:A:G	L321P	0.854
15:30404086:G:C	F545L	0.849
15:30404086:G:T	F545L	0.849
15:30404088:A:G	F545L	0.849
15:30408218:C:A	W252C	0.797
15:30408218:C:G	W252C	0.797
15:30404461:G:C	F479L	0.795
15:30404461:G:T	F479L	0.795
15:30404463:A:G	F479L	0.795
15:30411141:A:G	L96P	0.787
15:30403773:A:C	F621L	0.784
15:30403773:A:T	F621L	0.784
15:30403775:A:G	F621L	0.784
15:30407462:A:G	L314P	0.780
15:30414121:C:A	K14N	0.779
15:30414121:C:G	K14N	0.779
15:30414126:C:G	A13P	0.779
15:30412447:A:G	L17S	0.778
15:30408220:A:G	W252R	0.775
15:30408220:A:T	W252R	0.775
15:30409623:A:G	L170P	0.771
15:30411120:A:G	L103S	0.758
15:30407284:G:C	F373L	0.754
15:30407284:G:T	F373L	0.754
15:30407286:A:G	F373L	0.754
15:30412443:T:A	K18N	0.751
15:30412443:T:G	K18N	0.751
15:30407474:A:G	L310P	0.737
15:30409823:A:G	I135T	0.732
15:30409645:A:G	S163P	0.726

dbSNP variants (sampled 300 via entrez): RS1002862017 (15:30410568 A>G), RS1003061081 (15:30408168 G>A,T), RS1006629780 (15:30411828 C>T), RS1007511816 (15:30415378 T>A), RS1008022458 (15:30403008 G>A,C,T), RS1008094509 (15:30400202 T>A,G), RS1011848706 (15:30413299 T>C), RS1012123056 (15:30411686 G>C), RS1012959976 (15:30403149 C>A,T), RS1013298886 (15:30407008 G>A), RS1019035519 (15:30400233 A>T), RS1021752652 (15:30408583 C>T), RS1021804945 (15:30411780 T>C), RS1022979092 (15:30407188 G>C), RS1023600372 (15:30403173 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
GSK-J4	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Okadaic Acid	decreases expression	1
S-Nitrosoglutathione	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.