GOLIM4

Summary

GOLIM4 (golgi integral membrane protein 4, HGNC:15448) is a protein-coding gene on chromosome 3q26.2, encoding Golgi integral membrane protein 4 (O00461). Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus.

Source: NCBI Gene 27333 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 133 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_014498

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15448
Approved symbol	GOLIM4
Name	golgi integral membrane protein 4
Location	3q26.2
Locus type	gene with protein product
Status	Approved
Aliases	GPP130, GIMPC, P138
Ensembl gene	ENSG00000173905
Ensembl biotype	protein_coding
OMIM	606805
Entrez	27333

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 18 protein_coding, 1 retained_intron

ENST00000309027, ENST00000470487, ENST00000479415, ENST00000852497, ENST00000852498, ENST00000852499, ENST00000852500, ENST00000852501, ENST00000852502, ENST00000852503, ENST00000852504, ENST00000852505, ENST00000852506, ENST00000852507, ENST00000920079, ENST00000959312, ENST00000959313, ENST00000959314, ENST00000959315

RefSeq mRNA: 2 — MANE Select: NM_014498 NM_001308155, NM_014498

CCDS: CCDS3204, CCDS77854

Canonical transcript exons

ENST00000470487 — 16 exons

Exon	Start	End
ENSE00001204601	168010743	168010823
ENSE00001204604	168024526	168024594
ENSE00001204608	168024928	168025095
ENSE00001204611	168027728	168027837
ENSE00001204614	168029223	168029302
ENSE00001204618	168029780	168030036
ENSE00001204623	168032520	168032852
ENSE00001204627	168036836	168036994
ENSE00001204630	168040786	168040869
ENSE00001204634	168041392	168041474
ENSE00001204646	168046950	168046999
ENSE00001204652	168048291	168048365
ENSE00001204660	168095099	168095924
ENSE00001835996	168008689	168010418
ENSE00003473297	168043379	168043529
ENSE00003573621	168044828	168044881

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 99.25.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.1906 / max 234.7217, expressed in 1749 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
45483	10.6259	1711
45477	2.1286	933
45481	1.1426	560
45482	1.0690	528
45473	0.5769	273
45474	0.3249	133
45472	0.2164	82
45480	0.1063	39

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	99.25	gold quality
tendon	UBERON:0000043	98.29	gold quality
tibia	UBERON:0000979	98.11	gold quality
calcaneal tendon	UBERON:0003701	98.05	gold quality
jejunal mucosa	UBERON:0000399	97.91	gold quality
germinal epithelium of ovary	UBERON:0001304	97.26	gold quality
mucosa of sigmoid colon	UBERON:0004993	96.86	gold quality
buccal mucosa cell	CL:0002336	96.58	gold quality
colonic mucosa	UBERON:0000317	95.98	gold quality
duodenum	UBERON:0002114	95.86	gold quality
rectum	UBERON:0001052	95.50	gold quality
colonic epithelium	UBERON:0000397	95.44	gold quality
stromal cell of endometrium	CL:0002255	95.40	gold quality
jejunum	UBERON:0002115	95.30	gold quality
sural nerve	UBERON:0015488	95.17	gold quality
medial globus pallidus	UBERON:0002477	95.10	gold quality
cranial nerve II	UBERON:0000941	95.03	gold quality
epithelium of nasopharynx	UBERON:0001951	94.74	gold quality
synovial joint	UBERON:0002217	94.39	gold quality
visceral pleura	UBERON:0002401	94.12	gold quality
pericardium	UBERON:0002407	94.06	gold quality
skin of hip	UBERON:0001554	93.99	gold quality
globus pallidus	UBERON:0001875	93.80	gold quality
heart right ventricle	UBERON:0002080	93.28	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	93.24	gold quality
ventricular zone	UBERON:0003053	93.08	gold quality
mammary duct	UBERON:0001765	92.83	gold quality
corpus callosum	UBERON:0002336	92.82	gold quality
lower lobe of lung	UBERON:0008949	92.79	gold quality
trigeminal ganglion	UBERON:0001675	92.17	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-HCAD-10	yes	37.85
E-GEOD-137537	yes	29.44
E-MTAB-7316	yes	26.90
E-MTAB-6678	yes	23.79
E-CURD-112	yes	13.61
E-GEOD-76312	no	738.00
E-MTAB-4850	no	312.67
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

123 targeting GOLIM4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753

Literature-anchored findings (GeneRIF, showing 10)

• both the translation and transcription are regulated independent of the cell cycle and dissociated from the duplication of the centrosome (PMID:12207053)
• GPP130 mediates exit from endosomes and thereby underlies Shiga toxin invasion and retrieval-based targeting of other cycling Golgi proteines (PMID:15331763)
• Multiple pH-regulated steps affect the trafficking of GPP130. (PMID:17605763)
• the stem domain of GPP130 is a novel Mn sensor in the Golgi lumen of mammalian cells (PMID:20130081)
• Characteristics of GPP130 and its STx/STx1 binding interface. (PMID:23761068)
• Findings suggest the unexpected presence of quality control in the Golgi that recognizes aggregated Golgi proteins, GPP130, and targets them for degradation in lysosomes. (PMID:26446839)
• Authors provide evidence that Mn-induced exit of GPP130 from the trans-Golgi network (TGN) toward lysosomes is mediated by the sorting receptor sortilin interacting with the lumenal stem domain of GPP130. (PMID:28768823)
• MiR-105-3p acts as an oncogene to promote the proliferation and metastasis of breast cancer cells by targeting GOLIM4. (PMID:33722196)
• RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis. (PMID:34180133)
• CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer. (PMID:36054164)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	zgc:66479	ENSDARG00000008732
mus_musculus	Golim4	ENSMUSG00000034109
rattus_norvegicus	Golim4	ENSRNOG00000024213

Protein

Protein identifiers

Golgi integral membrane protein 4 — O00461 (reviewed: O00461)

Alternative names: Golgi integral membrane protein, cis, Golgi phosphoprotein 4, Golgi-localized phosphoprotein of 130 kDa

All UniProt accessions (2): O00461, F8W785

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.

Subcellular location. Golgi apparatus. Golgi stack membrane. Endosome membrane. Membrane.

Post-translational modifications. Phosphorylated probably by c-AMP-dependent kinases in its lumenal part. O-glycosylated; modified by sialic acid residues. N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.

Similarity. Belongs to the GOLIM4 family.

RefSeq proteins (2): NP_001295084, NP_055313* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR042336	GOLIM4	Family

UniProt features (34 total): compositionally biased region 14, region of interest 6, modified residue 5, topological domain 2, initiator methionine 1, chain 1, coiled-coil region 1, transmembrane region 1, lipid moiety-binding region 1, glycosylation site 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O00461-F1	68.20	0.39

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 364, 538, 613, 626, 673, 2

Glycosylation sites (1): 257

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6811438	Intra-Golgi traffic

MSigDB gene sets: 188 (showing top): BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_UP, GOLDRATH_IMMUNE_MEMORY, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, IVANOVA_HEMATOPOIESIS_MATURE_CELL, REACTOME_MEMBRANE_TRAFFICKING, chr3q26, PUJANA_CHEK2_PCC_NETWORK, BROWNE_HCMV_INFECTION_48HR_DN, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, BLALOCK_ALZHEIMERS_DISEASE_UP, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, MODULE_99, JAATINEN_HEMATOPOIETIC_STEM_CELL_UP, GRUETZMANN_PANCREATIC_CANCER_UP, IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (10): Golgi membrane (GO:0000139), Golgi apparatus (GO:0005794), Golgi lumen (GO:0005796), cis-Golgi network (GO:0005801), endosome membrane (GO:0010008), membrane (GO:0016020), transport vesicle (GO:0030133), endocytic vesicle (GO:0030139), Golgi cisterna membrane (GO:0032580), endosome (GO:0005768)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Intra-Golgi and retrograde Golgi-to-ER traffic	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
Golgi apparatus	3
endomembrane system	3
cytoplasmic vesicle	3
bounding membrane of organelle	2
intracellular membrane-bounded organelle	2
cytoplasm	1
intracellular organelle lumen	1
endosome	1
cytoplasmic vesicle membrane	1
cellular anatomical structure	1
organelle membrane	1
Golgi cisterna	1

Protein interactions and networks

STRING

724 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GOLIM4	GOLPH3	Q9H4A6	715
GOLIM4	STX5	Q13190	705
GOLIM4	GOLGB1	Q14789	668
GOLIM4	STX1A	Q16623	604
GOLIM4	GOLGA5	Q8TBA6	578
GOLIM4	TGOLN2	O43493	575
GOLIM4	GOSR1	O95249	571
GOLIM4	GOLM1	Q8NBJ4	545
GOLIM4	TMEM165	Q9HC07	527
GOLIM4	GOLGA1	Q92805	511
GOLIM4	COG4	Q9H9E3	508
GOLIM4	COG3	Q96JB2	507
GOLIM4	GOLGA2	Q08379	507
GOLIM4	COG8	Q96MW5	506
GOLIM4	PDIA3	P30101	502

IntAct

160 interactions, top by confidence:

A	B	Type	Score
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
B3GAT3	GOLIM4	psi-mi:“MI:0914”(association)	0.640
ASPH	STXBP3	psi-mi:“MI:0914”(association)	0.640
POMK	TMEM120B	psi-mi:“MI:0914”(association)	0.530
GDPD5	GOLIM4	psi-mi:“MI:0914”(association)	0.530
KCNS3	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
FUT1	GOLIM4	psi-mi:“MI:0914”(association)	0.530
FCGRT	GOLIM4	psi-mi:“MI:0914”(association)	0.530
SPACA1	GOLIM4	psi-mi:“MI:0914”(association)	0.530
UST	GOLIM4	psi-mi:“MI:0914”(association)	0.530
PTPN1	GOLIM4	psi-mi:“MI:0914”(association)	0.530
SLC39A4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
HLA-DPA1	TYW5	psi-mi:“MI:0914”(association)	0.530
PBXIP1	GOLIM4	psi-mi:“MI:0914”(association)	0.530
MRAP2	GOLIM4	psi-mi:“MI:0914”(association)	0.530
CSGALNACT2	GOLIM4	psi-mi:“MI:0914”(association)	0.530
DCAF12	GOLIM4	psi-mi:“MI:0914”(association)	0.530
PTPRU	GOLIM4	psi-mi:“MI:0914”(association)	0.530

BioGRID (166): GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS), GOLIM4 (Affinity Capture-MS)

ESM2 similar proteins: A2AM05, A2BDC9, A2VD12, A2VE10, A5D8S1, B1AJZ9, O00461, O75071, P04233, P04441, P07106, P10247, P24054, P70663, Q08D19, Q14515, Q32N32, Q4KLH6, Q4V9H3, Q5BJK8, Q5PQS2, Q5R5X4, Q5R6R3, Q5R8Y4, Q5R9L2, Q5T8D3, Q5TB80, Q5ZHQ6, Q5ZKQ5, Q5ZM60, Q640L3, Q6P2L7, Q6P4E1, Q6Y685, Q6ZQ06, Q70YC5, Q86TE4, Q8BG89, Q8BMK4, Q8BVV7

Diamond homologs: O00461, Q08D19, Q5BJK8, Q8BXA1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 164 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SLC-mediated transmembrane transport	9	5.6×	9e-03

GO biological processes:

GO term	Partners	Fold	FDR
zinc ion transmembrane transport	5	27.0×	2e-04
intracellular zinc ion homeostasis	6	22.2×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

133 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	95
Likely benign	6
Benign	6

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
686844	GRCh37/hg19 3q26.1-26.2(chr3:165603872-168796960)x1	Pathogenic

SpliceAI

3429 predictions. Top by Δscore:

Variant	Effect	Δscore
3:168010414:TCAGT:T	acceptor_gain	1.0000
3:168010415:CAGT:C	acceptor_gain	1.0000
3:168010415:CAGTC:C	acceptor_gain	1.0000
3:168010416:AGTC:A	acceptor_loss	1.0000
3:168010417:GT:G	acceptor_gain	1.0000
3:168010417:GTC:G	acceptor_loss	1.0000
3:168010418:TCTT:T	acceptor_loss	1.0000
3:168010419:C:CC	acceptor_gain	1.0000
3:168010420:T:C	acceptor_gain	1.0000
3:168010420:T:TC	acceptor_gain	1.0000
3:168010426:T:C	acceptor_gain	1.0000
3:168010426:T:TC	acceptor_gain	1.0000
3:168010741:A:AC	donor_gain	1.0000
3:168010742:C:CC	donor_gain	1.0000
3:168024527:T:TA	donor_gain	1.0000
3:168024542:T:TA	donor_gain	1.0000
3:168024922:GCTTA:G	donor_loss	1.0000
3:168024924:TTACC:T	donor_loss	1.0000
3:168024925:TACCA:T	donor_loss	1.0000
3:168024926:A:AG	donor_loss	1.0000
3:168024927:C:CA	donor_loss	1.0000
3:168024927:CCA:C	donor_gain	1.0000
3:168025091:GCCCT:G	acceptor_gain	1.0000
3:168025092:CCCT:C	acceptor_gain	1.0000
3:168025092:CCCTC:C	acceptor_gain	1.0000
3:168025093:CCT:C	acceptor_gain	1.0000
3:168025093:CCTC:C	acceptor_gain	1.0000
3:168025094:CT:C	acceptor_gain	1.0000
3:168025094:CTC:C	acceptor_gain	1.0000
3:168025095:TCTG:T	acceptor_loss	1.0000

AlphaMissense

4649 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:168041405:A:G	L196P	0.998
3:168041438:A:G	L185P	0.998
3:168043513:A:G	L128P	0.998
3:168046976:C:G	A96P	0.998
3:168048341:A:G	L71S	0.998
3:168040791:C:G	A227P	0.997
3:168048333:A:G	S74P	0.997
3:168095104:A:G	L61S	0.997
3:168048348:A:G	S69P	0.996
3:168048353:T:G	H67P	0.996
3:168025033:A:C	F562L	0.995
3:168025033:A:T	F562L	0.995
3:168025035:A:G	F562L	0.995
3:168040803:C:G	A223P	0.995
3:168041430:C:G	A188P	0.995
3:168043417:A:G	L160P	0.995
3:168044853:A:G	L114P	0.995
3:168095116:A:G	L57P	0.995
3:168095200:C:T	G29D	0.995
3:168036969:A:G	L237P	0.994
3:168046983:C:A	K93N	0.994
3:168046983:C:G	K93N	0.994
3:168048354:G:C	H67D	0.994
3:168040832:A:G	L213P	0.993
3:168043384:A:G	L171P	0.993
3:168044875:A:G	S107P	0.993
3:168095201:C:G	G29R	0.993
3:168095212:C:T	G25D	0.993
3:168095213:C:G	G25R	0.993
3:168040799:A:G	L224P	0.992

dbSNP variants (sampled 300 via entrez): RS1000055971 (3:168023153 T>C), RS1000062286 (3:168033485 T>C), RS1000142322 (3:168048166 C>T), RS1000156834 (3:168053087 C>T), RS1000195406 (3:168048550 G>A), RS1000237090 (3:168068355 C>T), RS1000262241 (3:168051014 G>A), RS1000289931 (3:168091318 T>C), RS1000378434 (3:168062557 G>A), RS1000413443 (3:168033270 A>G), RS1000414638 (3:168014224 C>G,T), RS1000416059 (3:168082567 G>A), RS1000486883 (3:168056528 A>G), RS1000498152 (3:168065892 T>A,C,G), RS1000597834 (3:168059549 C>A,G)

Disease associations

OMIM: gene MIM:606805 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST000175_48	Height	7.000000e-06
GCST001859_28	Thiazide-induced adverse metabolic effects in hypertensive patients	6.000000e-08
GCST002547_3	Epilepsy	4.000000e-07
GCST003791_8	Response to metformin (IC50)	7.000000e-06
GCST005758_6	Dimensional psychopathology (Arousal)	1.000000e-07
GCST006991_1	Cerebrospinal fluid t-tau levels in Alzheimer’s disease dementia	5.000000e-07
GCST012489_132	Heel bone mineral density x serum urate levels interaction	1.000000e-09

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0004530	triglyceride measurement
EFO:0006952	cytotoxicity measurement
EFO:0009099	arousal domain measurement
EFO:0004760	t-tau measurement
EFO:0004531	urate measurement
EFO:0009270	heel bone mineral density

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067059 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.57	Kd	2711	nM	CHEMBL5653589
5.57	ED50	2711	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148449: Binding affinity to human GOLIM4 incubated for 45 mins by Kinobead based pull down assay	kd	2.7108	uM

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, increases methylation	3
bisphenol S	decreases expression, decreases methylation	2
Estradiol	decreases expression, increases expression	2
Cyclosporine	decreases expression	2
Cadmium Chloride	decreases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	affects cotreatment, increases expression	1
geldanamycin	increases expression	1
testosterone enanthate	affects expression	1
chloroacetaldehyde	decreases expression	1
quercitrin	increases expression	1
sodium arsenite	decreases expression	1
cobaltous chloride	increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
cylindrospermopsin	decreases expression	1
K 7174	increases expression	1
torcetrapib	increases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Rosiglitazone	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Cidofovir	decreases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases mutagenesis	1
Cisplatin	decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651491	Binding	Binding affinity to human GOLIM4 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

4 cell lines: 3 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2Y0	Abcam HEK293T GOLIM4 KO	Transformed cell line	Female
CVCL_E1Y8	HAP1 GOLIM4 (-) 1	Cancer cell line	Male
CVCL_E1Y9	HAP1 GOLIM4 (-) 2	Cancer cell line	Male
CVCL_E1YA	HAP1 GOLIM4 (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.