GOLT1B

Summary

GOLT1B (golgi transport 1B, HGNC:20175) is a protein-coding gene on chromosome 12p12.1, encoding Vesicle transport protein GOT1B (Q9Y3E0). May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Involved in positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum. Part of protein-containing complex.

Source: NCBI Gene 51026 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 24 total
• Druggable target: yes
• MANE Select transcript: NM_016072

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20175
Approved symbol	GOLT1B
Name	golgi transport 1B
Location	12p12.1
Locus type	gene with protein product
Status	Approved
Aliases	CGI-141, YMR292W, GOT1
Ensembl gene	ENSG00000111711
Ensembl biotype	protein_coding
OMIM	615078
Entrez	51026

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 4 protein_coding, 3 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000229314, ENST00000535593, ENST00000539025, ENST00000539663, ENST00000540141, ENST00000542038, ENST00000542194, ENST00000545093, ENST00000545113, ENST00000631252

RefSeq mRNA: 1 — MANE Select: NM_016072 NM_016072

CCDS: CCDS8689

Canonical transcript exons

ENST00000229314 — 5 exons

Exon	Start	End
ENSE00000994911	21515669	21518408
ENSE00003486969	21508383	21508561
ENSE00003633372	21506885	21506976
ENSE00003639140	21512295	21512376
ENSE00003841751	21501789	21501948

Expression profiles

Bgee: expression breadth ubiquitous, 284 present calls, max score 99.14.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 47.7259 / max 1063.6702, expressed in 1819 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124666	41.3772	1816
124668	3.3284	1314
124667	2.2830	1176
124669	0.7373	398

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.14	gold quality
oocyte	CL:0000023	97.51	gold quality
tibia	UBERON:0000979	96.86	gold quality
islet of Langerhans	UBERON:0000006	94.82	gold quality
endothelial cell	CL:0000115	94.80	gold quality
palpebral conjunctiva	UBERON:0001812	94.55	gold quality
substantia nigra pars reticulata	UBERON:0001966	94.54	gold quality
lateral globus pallidus	UBERON:0002476	94.42	gold quality
cartilage tissue	UBERON:0002418	94.41	gold quality
substantia nigra pars compacta	UBERON:0001965	94.15	gold quality
synovial joint	UBERON:0002217	94.10	gold quality
eye	UBERON:0000970	94.04	gold quality
calcaneal tendon	UBERON:0003701	93.91	gold quality
stromal cell of endometrium	CL:0002255	93.73	gold quality
epithelium of nasopharynx	UBERON:0001951	93.47	gold quality
subthalamic nucleus	UBERON:0001906	93.28	gold quality
lateral nuclear group of thalamus	UBERON:0002736	93.16	gold quality
parietal pleura	UBERON:0002400	93.12	gold quality
superficial temporal artery	UBERON:0001614	93.05	gold quality
pericardium	UBERON:0002407	92.85	gold quality
body of pancreas	UBERON:0001150	92.79	gold quality
pancreas	UBERON:0001264	92.78	gold quality
endometrium	UBERON:0001295	92.76	gold quality
visceral pleura	UBERON:0002401	92.68	gold quality
decidua	UBERON:0002450	92.66	gold quality
skin of hip	UBERON:0001554	92.61	gold quality
placenta	UBERON:0001987	92.61	gold quality
superior vestibular nucleus	UBERON:0007227	92.59	gold quality
pigmented layer of retina	UBERON:0001782	92.56	gold quality
pons	UBERON:0000988	92.38	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7249	no	1578.95
E-MTAB-7303	no	46.32
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

199 targeting GOLT1B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-4775	99.98	75.00	6394
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-3148	99.97	75.06	6478

Cross-species orthologs

28 orthologs

Organism	Symbol	Gene ID
danio_rerio	golt1ba	ENSDARG00000022795
danio_rerio	golt1bb	ENSDARG00000059308
mus_musculus	Golt1b	ENSMUSG00000030245
rattus_norvegicus	Golt1b	ENSRNOG00000058386
drosophila_melanogaster	CG32576	FBGN0052576
caenorhabditis_elegans		WBGENE00007112
caenorhabditis_elegans		WBGENE00008042
caenorhabditis_elegans		WBGENE00008043
caenorhabditis_elegans		WBGENE00008044
caenorhabditis_elegans		WBGENE00009237
caenorhabditis_elegans		WBGENE00013035
caenorhabditis_elegans		WBGENE00013037
caenorhabditis_elegans		WBGENE00013044
caenorhabditis_elegans		WBGENE00013101
caenorhabditis_elegans		WBGENE00013949
caenorhabditis_elegans		WBGENE00013950
caenorhabditis_elegans		WBGENE00015775
caenorhabditis_elegans		WBGENE00017764
caenorhabditis_elegans		WBGENE00019029
caenorhabditis_elegans		WBGENE00019269
caenorhabditis_elegans		WBGENE00019368
caenorhabditis_elegans		WBGENE00020341
caenorhabditis_elegans		WBGENE00020393
caenorhabditis_elegans		WBGENE00020662
caenorhabditis_elegans		WBGENE00021601
caenorhabditis_elegans	Y110A7A.7	WBGENE00022457
caenorhabditis_elegans		WBGENE00044488
caenorhabditis_elegans		WBGENE00189950

Paralogs (3): DAGLA (ENSG00000134780), DAGLB (ENSG00000164535), GOLT1A (ENSG00000174567)

Protein

Protein identifiers

Vesicle transport protein GOT1B — Q9Y3E0 (reviewed: Q9Y3E0)

Alternative names: Germ cell tumor 2, Golgi transport 1 homolog B, Putative NF-kappa-B-activating protein 470, hGOT1a

All UniProt accessions (5): Q9Y3E0, F5GWD8, F5GXH6, F5H6U7, G3V1U5

UniProt curated annotations — full annotation on UniProt →

Function. May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Subcellular location. Golgi apparatus membrane.

Tissue specificity. Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.

Similarity. Belongs to the GOT1 family.

RefSeq proteins (1): NP_057156* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007305	Vesicle_transpt_Got1/SFT2	Family
IPR045176	Got1	Family

Pfam: PF04178

UniProt features (13 total): topological domain 5, transmembrane region 4, sequence conflict 2, chain 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y3E0-F1	88.17	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 1

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 528 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, MODULE_52, GOBP_MEMBRANE_DEPOLARIZATION, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, MULLIGHAN_NPM1_SIGNATURE_3_UP, GOBP_GLUTAMINE_FAMILY_AMINO_ACID_BIOSYNTHETIC_PROCESS, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_RESPONSE_TO_IMMOBILIZATION_STRESS, GOBP_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_RESPONSE_TO_CORTICOSTEROID, TTTGTAG_MIR520D, GOBP_ALPHA_AMINO_ACID_METABOLIC_PROCESS, KEGG_CYSTEINE_AND_METHIONINE_METABOLISM

GO Biological Process (5): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), protein transport (GO:0015031), retrograde transport, endosome to Golgi (GO:0042147), positive regulation of canonical NF-kappaB signal transduction (GO:0043123), vesicle-mediated transport (GO:0016192)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (8): Golgi membrane (GO:0000139), endoplasmic reticulum (GO:0005783), cytosol (GO:0005829), membrane (GO:0016020), protein-containing complex (GO:0032991), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), endomembrane system (GO:0012505)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
cellular anatomical structure	4
intercellular transport	2
transport	2
endomembrane system	2
intracellular membrane-bounded organelle	2
intracellular transport	1
Golgi vesicle transport	1
intracellular protein localization	1
establishment of protein localization	1
endosomal transport	1
cytosolic transport	1
canonical NF-kappaB signal transduction	1
regulation of canonical NF-kappaB signal transduction	1
positive regulation of intracellular signal transduction	1
cellular process	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
cellular_component	1
intracellular anatomical structure	1
vacuole	1
plasma membrane	1

Protein interactions and networks

STRING

2324 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GOLT1B	INTS13	Q9NVM9	720
GOLT1B	SPRYD3	Q8NCJ5	494
GOLT1B	SERTAD4	Q9NUC0	488
GOLT1B	PYROXD1	Q8WU10	469
GOLT1B	GTPBP10	A4D1E9	452
GOLT1B	GOLM2	Q6P4E1	442
GOLT1B	GYS2	P54840	426
GOLT1B	SLC30A1	Q9Y6M5	394
GOLT1B	OSER1	Q9NX31	385
GOLT1B	MANF	P55145	381
GOLT1B	GPANK1	O95872	379
GOLT1B	RCOR3	Q9P2K3	378
GOLT1B	TMED2	Q15363	370
GOLT1B	KCNJ8	Q15842	360
GOLT1B	PLEKHA5	Q9HAU0	359

IntAct

63 interactions, top by confidence:

A	B	Type	Score
GOLT1B	SH3GL3	psi-mi:“MI:0915”(physical association)	0.560
SDCBP	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
SPG21	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
INPP5K	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
SHISAL2A	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
SAR1A	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
GPR152	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
SH3GL3	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
MUC1	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
CREB3L1	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
SLC10A6	GOLT1B	psi-mi:“MI:0915”(physical association)	0.560
TMEM30B	KLRG2	psi-mi:“MI:0914”(association)	0.530
	GOLT1B	psi-mi:“MI:0915”(physical association)	0.400
Tmem109	ASXL2	psi-mi:“MI:0914”(association)	0.350
Uso1	SLC30A6	psi-mi:“MI:0914”(association)	0.350
REEP5	CNOT1	psi-mi:“MI:0914”(association)	0.350
NABP1	XPO1	psi-mi:“MI:0914”(association)	0.350
KATNA1	KATNBL1	psi-mi:“MI:0914”(association)	0.350
GOLT1B		psi-mi:“MI:0914”(association)	0.350
	ESYT2	psi-mi:“MI:0914”(association)	0.350
E5	ESYT2	psi-mi:“MI:0914”(association)	0.350
ORF28	PEX19	psi-mi:“MI:0914”(association)	0.350
OCRL	MYO1C	psi-mi:“MI:0914”(association)	0.350
RAC1		psi-mi:“MI:0914”(association)	0.350
	HLA-C	psi-mi:“MI:0914”(association)	0.350
GOLT1B	NBAS	psi-mi:“MI:0914”(association)	0.350
BSCL2	TMEM223	psi-mi:“MI:0914”(association)	0.350

BioGRID (260): GOLT1B (Affinity Capture-MS), GOLT1B (Proximity Label-MS), GOLT1B (Proximity Label-MS), ANXA1 (Affinity Capture-MS), ATP1A1 (Affinity Capture-MS), ATP2A2 (Affinity Capture-MS), ATP5A1 (Affinity Capture-MS), ATP5B (Affinity Capture-MS), ATP5J (Affinity Capture-MS), ATP6V1A (Affinity Capture-MS), ATP6V1B2 (Affinity Capture-MS), ATP6V1E1 (Affinity Capture-MS), ATP6V0A1 (Affinity Capture-MS), ATP6AP1 (Affinity Capture-MS), ATP5O (Affinity Capture-MS)

ESM2 similar proteins: A1CKG4, A3LPS1, A4R2N5, A5DEQ7, A5DSM9, A6QRX6, A6RRF7, A6ZMD0, A7EMV1, A7S6Y0, A7TS55, B2AR67, B3M9W1, B3NDM7, B4GRI8, B4HIJ8, B4J043, B4L0H1, B4LIH0, B4MXW6, B4PD01, B4QLP9, O74375, O95562, Q03554, Q04767, Q0CNZ5, Q0V0G4, Q1E1E0, Q20263, Q2NKV8, Q2YDE3, Q4FZV2, Q54CL4, Q5APC0, Q5SSN7, Q5U3Y5, Q60EA5, Q6BWE7, Q6CC06

Diamond homologs: Q03554, Q20263, Q2NKV8, Q2YDE3, Q54CL4, Q6NMM1, Q6ZVE7, Q9CR60, Q9DCQ3, Q9USJ2, Q9Y3E0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

24 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	9
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1953 predictions. Top by Δscore:

Variant	Effect	Δscore
10:99397682:CTTGG:C	acceptor_gain	1.0000
10:99397687:C:CC	acceptor_gain	1.0000
10:99397690:T:C	acceptor_gain	1.0000
10:99397690:T:TC	acceptor_gain	1.0000
10:99397698:C:CT	acceptor_gain	1.0000
10:99402578:A:AC	donor_gain	1.0000
10:99402579:C:CC	donor_gain	1.0000
10:99402721:TC:T	acceptor_gain	1.0000
10:99402722:CC:C	acceptor_gain	1.0000
10:99403472:T:A	donor_gain	1.0000
10:99403520:C:CA	donor_gain	1.0000
10:99403635:C:CC	acceptor_gain	1.0000
10:99403722:A:AC	donor_gain	1.0000
10:99403723:C:CC	donor_gain	1.0000
10:99405752:TTA:T	donor_loss	1.0000
10:99405755:C:CA	donor_loss	1.0000
10:99405861:C:CC	acceptor_gain	1.0000
10:99406132:CCCA:C	donor_loss	1.0000
10:99406133:CCA:C	donor_loss	1.0000
10:99406134:CA:C	donor_loss	1.0000
10:99406135:A:C	donor_loss	1.0000
10:99406136:C:CA	donor_loss	1.0000
10:99406220:C:CT	acceptor_gain	1.0000
10:99406221:A:T	acceptor_gain	1.0000
10:99406246:TTCT:T	acceptor_gain	1.0000
10:99406248:CT:C	acceptor_gain	1.0000
10:99406250:C:CC	acceptor_gain	1.0000
10:99406251:T:G	acceptor_loss	1.0000
10:99406254:A:AC	acceptor_gain	1.0000
10:99406254:A:C	acceptor_gain	1.0000

AlphaMissense

905 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:21506905:G:A	G16R	0.999
12:21506905:G:C	G16R	0.999
12:21506912:G:A	G18E	0.999
12:21506972:G:T	G38V	0.999
12:21506906:G:A	G16E	0.998
12:21506911:G:A	G18R	0.998
12:21506911:G:C	G18R	0.998
12:21506933:G:A	G25E	0.998
12:21506971:G:A	G38R	0.998
12:21506971:G:C	G38R	0.998
12:21506972:G:A	G38E	0.998
12:21506976:T:A	N39K	0.998
12:21506976:T:G	N39K	0.998
12:21508398:G:C	G45R	0.998
12:21508521:G:C	G86R	0.998
12:21508522:G:A	G86D	0.998
12:21508543:G:A	G93E	0.998
12:21506890:G:A	G11R	0.997
12:21506890:G:C	G11R	0.997
12:21506896:G:A	G13R	0.997
12:21506896:G:C	G13R	0.997
12:21506932:G:A	G25R	0.997
12:21506932:G:C	G25R	0.997
12:21506933:G:T	G25V	0.997
12:21508399:G:A	G45D	0.997
12:21508485:G:C	G74R	0.997
12:21508542:G:A	G93R	0.997
12:21508542:G:C	G93R	0.997
12:21512299:T:C	F101L	0.997
12:21512301:C:A	F101L	0.997

dbSNP variants (sampled 300 via entrez): RS1000209483 (12:21511986 T>A), RS1000300399 (12:21510608 T>G), RS1000575319 (12:21499900 C>A), RS1000678648 (12:21518512 A>G), RS1000728860 (12:21511676 G>A), RS1001418717 (12:21510191 T>C), RS1001441652 (12:21508834 A>G), RS1001607032 (12:21502757 T>C), RS1001647251 (12:21515901 TAAG>T), RS1001973375 (12:21516133 A>G), RS1002319432 (12:21504836 A>T), RS1002421610 (12:21511432 A>C), RS1002446117 (12:21507046 C>T), RS1002653414 (12:21516197 A>G,T), RS1002876081 (12:21504105 A>C)

Disease associations

OMIM: gene MIM:615078 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066348 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.01	Kd	96.96	nM	CHEMBL5653589
7.01	ED50	96.96	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148450: Binding affinity to human GOLT1B incubated for 45 mins by Kinobead based pull down assay	kd	0.0970	uM

CTD chemical–gene interactions

50 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases expression	3
Cyclosporine	increases expression	3
bisphenol A	decreases expression, decreases methylation	2
sodium arsenite	increases abundance, increases expression	2
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, decreases expression	2
Tobacco Smoke Pollution	increases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
bisphenol F	increases expression	1
dicrotophos	decreases expression	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	increases oxidation, increases abundance, affects cotreatment	1
decabromobiphenyl ether	increases expression	1
beta-lapachone	decreases expression	1
arsenite	increases reaction, affects binding	1
methylparaben	increases expression	1
tetrabromobisphenol A	increases expression	1
ochratoxin A	affects cotreatment, increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
CGP 52608	affects binding, increases reaction	1
K 7174	increases expression	1
ICG 001	increases expression	1
bisphenol B	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	increases expression	1
hexabrominated diphenyl ether 153	increases expression	1
jinfukang	decreases expression	1
picoxystrobin	increases expression	1
NSC 689534	affects binding, increases expression	1
Resveratrol	affects cotreatment, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651492	Binding	Binding affinity to human GOLT1B incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D7QT	Ubigene A-549 GOLT1B KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.