GOSR1

Summary

GOSR1 (golgi SNAP receptor complex member 1, HGNC:4430) is a protein-coding gene on chromosome 17q11.2, encoding Golgi SNAP receptor complex member 1 (O95249). Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport.

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Source: NCBI Gene 9527 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 61 total
• MANE Select transcript: NM_001007025

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4430
Approved symbol	GOSR1
Name	golgi SNAP receptor complex member 1
Location	17q11.2
Locus type	gene with protein product
Status	Approved
Aliases	GOS28, P28, GS28, GOS-28, GOLIM2
Ensembl gene	ENSG00000108587
Ensembl biotype	protein_coding
OMIM	604026
Entrez	9527

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 8 protein_coding, 4 retained_intron, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000225724, ENST00000414833, ENST00000427274, ENST00000451249, ENST00000467337, ENST00000467635, ENST00000477885, ENST00000491489, ENST00000494918, ENST00000537788, ENST00000579905, ENST00000581721, ENST00000870797, ENST00000915315, ENST00000955362

RefSeq mRNA: 3 — MANE Select: NM_001007025 NM_001007024, NM_001007025, NM_004871

CCDS: CCDS11258, CCDS45643, CCDS45644

Canonical transcript exons

ENST00000451249 — 9 exons

Exon	Start	End
ENSE00002357787	30492679	30492753
ENSE00002701917	30522254	30527592
ENSE00002708653	30477408	30477464
ENSE00002817429	30490126	30490217
ENSE00003465732	30519939	30520021
ENSE00003495989	30510880	30510909
ENSE00003578422	30484214	30484301
ENSE00003619334	30481143	30481257
ENSE00003619882	30484663	30484770

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 96.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.8498 / max 566.0642, expressed in 1816 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
160138	37.8498	1816

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	96.99	gold quality
nipple	UBERON:0002030	95.90	gold quality
tibia	UBERON:0000979	95.88	gold quality
visceral pleura	UBERON:0002401	95.84	gold quality
caput epididymis	UBERON:0004358	95.81	gold quality
calcaneal tendon	UBERON:0003701	95.75	gold quality
pancreatic ductal cell	CL:0002079	95.74	gold quality
parietal pleura	UBERON:0002400	95.19	gold quality
corpus epididymis	UBERON:0004359	95.18	gold quality
pleura	UBERON:0000977	94.93	gold quality
cauda epididymis	UBERON:0004360	94.88	gold quality
paraflocculus	UBERON:0005351	94.84	gold quality
pylorus	UBERON:0001166	94.72	gold quality
trabecular bone tissue	UBERON:0002483	94.58	gold quality
cranial nerve II	UBERON:0000941	94.53	gold quality
renal medulla	UBERON:0000362	94.36	gold quality
islet of Langerhans	UBERON:0000006	94.34	gold quality
mucosa of paranasal sinus	UBERON:0005030	94.10	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.76	gold quality
cardia of stomach	UBERON:0001162	93.71	gold quality
bronchial epithelial cell	CL:0002328	93.55	gold quality
middle temporal gyrus	UBERON:0002771	93.44	gold quality
frontal pole	UBERON:0002795	93.43	gold quality
middle frontal gyrus	UBERON:0002702	93.39	gold quality
palpebral conjunctiva	UBERON:0001812	93.35	gold quality
epithelium of bronchus	UBERON:0002031	93.32	gold quality
mammalian vulva	UBERON:0000997	93.27	gold quality
bronchus	UBERON:0002185	93.27	gold quality
lower lobe of lung	UBERON:0008949	93.00	gold quality
adult organism	UBERON:0007023	92.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.97

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GLI1

miRNA regulators (miRDB)

214 targeting GOSR1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-548AJ-3P	99.96	73.38	5345

Literature-anchored findings (GeneRIF, showing 9)

• Data suggest that GS15 exists in a distinct SNARE complex that contains syntaxin5, GS28, and Ykt6, and may be involved in both ER-to-Golgi and intra-Golgi transport. (PMID:12388752)
• RINT-1 coordinates the localization and function of ZW10 by serving as a link between ZW10 and the SNARE complex comprising syntaxin 18. (PMID:16571679)
• Apolipoprotein E, growth factor receptor-bound protein 2, Golgi SNAP receptor complex member 1, and glucosidase, beta, acid may play a neurodegenerative role in stress urinary incontinence development. (PMID:20700730)
• ORP7 negatively regulates GS28 protein stability via sequestration of GATE-16, and may mediate the effect of 25-OH on GS28 and Golgi function. (PMID:21669198)
• GS28 may potentiate cells to DNA-damage-induced apoptosis by inhibiting the ubiquitination and degradation of p53. (PMID:22397410)
• Golgi vesicles, presumably with COPI, serve to inhibit intra-Golgi transport by the extraction of GS27 and GS28 from the Golgi cisternae, which blocks the formation of inter-cisternal connections (PMID:23387339)
• High nuclear expression of GS28 is associated with poor prognosis in early-stage cervical cancer patients. GS28 might be a novel prognostic marker and a potential therapeutic target in cervical cancer treatment. (PMID:27611086)
• these results indicate that GS28 nuclear predominant expression could serve as a prognostic marker for colorectal cancer (CRC) and may help in identifying aggressive forms of CRC (PMID:28638266)
• Diverse Role of SNARE Protein GS28 in Vesicle Trafficking and Diseases. (PMID:36924089)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	gosr1	ENSDARG00000026654
mus_musculus	Gosr1	ENSMUSG00000010392
rattus_norvegicus	Gosr1	ENSRNOG00000070572
drosophila_melanogaster	Gos28	FBGN0044871
caenorhabditis_elegans		WBGENE00017273

Protein

Protein identifiers

Golgi SNAP receptor complex member 1 — O95249 (reviewed: O95249)

Alternative names: 28 kDa Golgi SNARE protein, 28 kDa cis-Golgi SNARE p28

All UniProt accessions (6): O95249, B4DQA8, E9PCW1, F6RU00, G5E9T8, K7EJC8

UniProt curated annotations — full annotation on UniProt →

Function. Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.

Subunit / interactions. Component of several multiprotein Golgi SNARE complexes. Identified in a SNARE complex with BET1, STX5 and YKT6, in a SNARE complex with BET1L, STX5 and YKT6, in a SNARE complex with STX5, GOSR2, SEC22B and BET1, and in complex with STX5 and COG3. Interacts with GABARAPL2.

Subcellular location. Golgi apparatus membrane.

Induction. Expression induced by hydrogen peroxide in neuronal cells. By monocrotaline in pulmonary epithelial cells (at protein level). Negatively regulated by OSBPL7 via GABARAPL2 leading to degradation on proteasomes (at protein level).

Similarity. Belongs to the GOSR1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
O95249-1	1	yes
O95249-2	2

RefSeq proteins (3): NP_001007025, NP_001007026, NP_004862 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR023601	Golgi_SNAP_su1	Family

Pfam: PF12352

UniProt features (16 total): sequence conflict 5, coiled-coil region 2, modified residue 2, initiator methionine 1, chain 1, splice variant 1, topological domain 1, transmembrane region 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O95249-F1	84.74	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 141

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6807878	COPI-mediated anterograde transport
R-HSA-6811438	Intra-Golgi traffic

MSigDB gene sets: 188 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, JI_RESPONSE_TO_FSH_UP, TGCACTT_MIR519C_MIR519B_MIR519A, GOBP_VESICLE_ORGANIZATION, GOBP_MEMBRANE_FUSION, TGACCTY_ERR1_Q2, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, chr17q11, GOBP_INTRA_GOLGI_VESICLE_MEDIATED_TRANSPORT, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, FOSTER_TOLERANT_MACROPHAGE_DN, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_ORGANELLE_MEMBRANE_FUSION, SCHLOSSER_SERUM_RESPONSE_DN

GO Biological Process (7): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), intra-Golgi vesicle-mediated transport (GO:0006891), vesicle fusion (GO:0006906), protein transport (GO:0015031), retrograde transport, endosome to Golgi (GO:0042147), inter-Golgi cisterna vesicle-mediated transport (GO:0048219), vesicle-mediated transport (GO:0016192)

GO Molecular Function (1): SNAP receptor activity (GO:0005484)

GO Cellular Component (8): Golgi membrane (GO:0000139), Golgi apparatus (GO:0005794), Golgi medial cisterna (GO:0005797), cis-Golgi network (GO:0005801), cytosol (GO:0005829), membrane (GO:0016020), transport vesicle (GO:0030133), SNARE complex (GO:0031201)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
ER to Golgi Anterograde Transport	1
Intra-Golgi and retrograde Golgi-to-ER traffic	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
intercellular transport	2
Golgi vesicle transport	2
transport	2
Golgi apparatus	2
endomembrane system	2
intracellular membrane-bounded organelle	2
cellular anatomical structure	2
intracellular transport	1
vesicle organization	1
vesicle-mediated transport	1
organelle membrane fusion	1
intracellular protein localization	1
establishment of protein localization	1
endosomal transport	1
cytosolic transport	1
intra-Golgi vesicle-mediated transport	1
cellular process	1
protein-macromolecule adaptor activity	1
membrane fusion	1
fusogenic activity	1
bounding membrane of organelle	1
Golgi cisterna	1
cytoplasmic vesicle	1
membrane protein complex	1

Protein interactions and networks

STRING

1968 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GOSR1	STX5	Q13190	999
GOSR1	YKT6	O15498	994
GOSR1	GOSR2	O14653	972
GOSR1	BET1	O15155	969
GOSR1	SEC22B	O75396	961
GOSR1	SCFD1	Q8WVM8	936
GOSR1	VTI1B	Q9UEU0	922
GOSR1	VAMP5	O95183	838
GOSR1	VTI1A	Q96AJ9	768
GOSR1	BET1L	Q9NYM9	755
GOSR1	GABARAPL2	P60520	753
GOSR1	COG7	P83436	752
GOSR1	STX16	O14662	736
GOSR1	STX6	O43752	731
GOSR1	SEC22A	Q96IW7	696

IntAct

121 interactions, top by confidence:

A	B	Type	Score
GOSR2	BET1	psi-mi:“MI:0914”(association)	0.810
NAPA	SNAP23	psi-mi:“MI:0914”(association)	0.780
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
FAM9C	NDC80	psi-mi:“MI:0914”(association)	0.670
STX6	GOSR2	psi-mi:“MI:0914”(association)	0.670
USE1	NBAS	psi-mi:“MI:0914”(association)	0.640
STX7	SNAP23	psi-mi:“MI:0914”(association)	0.640
STX12	SNAP23	psi-mi:“MI:0914”(association)	0.640
TRDN	TMEM223	psi-mi:“MI:0914”(association)	0.640
GOSR1	SEC22B	psi-mi:“MI:0914”(association)	0.530
VAMP5	NBAS	psi-mi:“MI:0914”(association)	0.530
MRAP2	GOLIM4	psi-mi:“MI:0914”(association)	0.530
CSGALNACT2	GOLIM4	psi-mi:“MI:0914”(association)	0.530
STX11	EXOC5	psi-mi:“MI:0914”(association)	0.530
STX3	YKT6	psi-mi:“MI:0914”(association)	0.530
NAPA	NBAS	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
STX3	NBAS	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
BET1	SNAP23	psi-mi:“MI:0914”(association)	0.420
ORF55	GOSR1	psi-mi:“MI:0915”(physical association)	0.400
ATAD1	GOSR1	psi-mi:“MI:0915”(physical association)	0.400
GOSR1	GPR182	psi-mi:“MI:0915”(physical association)	0.370
OCRL	MYO1C	psi-mi:“MI:0914”(association)	0.350

BioGRID (223): GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-Western), GOSR1 (Co-fractionation), GOSR1 (Proximity Label-MS), GOSR1 (Proximity Label-MS), GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-MS), GOSR1 (Affinity Capture-MS)

ESM2 similar proteins: G3V7P1, O08522, O14662, O15400, O22151, O43752, O49377, O60499, O64791, O70257, O70439, O70480, O75379, O88384, O88630, O88983, O95249, P58200, Q08851, Q08DB5, Q13190, Q2KIU0, Q2TBU3, Q32L97, Q3T075, Q3ZBT5, Q5R602, Q5R6Q2, Q5RBL6, Q5RBW6, Q5RF94, Q5SRX1, Q5ZL19, Q62931, Q63635, Q86Y82, Q8BVI5, Q8K1E0, Q944A9, Q946Y7

Diamond homologs: A8XLW0, O08522, O22151, O88630, O95249, Q2TBU3, Q5RBL6, Q62931, Q95ZW1, Q9VE50, Q9LMP7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 126 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Intra-Golgi traffic	7	23.3×	7e-06
Regulation of RAS by GAPs	5	12.4×	8e-04
COPII-mediated vesicle transport	5	10.5×	1e-03
ER-Phagosome pathway	6	10.0×	6e-04
Intra-Golgi and retrograde Golgi-to-ER traffic	7	9.4×	3e-04
RAC3 GTPase cycle	5	7.6×	4e-03
COPI-mediated anterograde transport	5	7.0×	4e-03
Membrane Trafficking	12	5.7×	9e-05

GO biological processes:

GO term	Partners	Fold	FDR
obsolete vesicle docking	6	41.8×	2e-06
zinc ion transmembrane transport	6	38.3×	2e-06
vesicle fusion	6	32.8×	3e-06
intracellular zinc ion homeostasis	7	30.6×	2e-06
intracellular protein transport	9	5.3×	3e-03
protein transport	12	4.8×	7e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1813 predictions. Top by Δscore:

Variant	Effect	Δscore
17:30477462:A:T	donor_gain	1.0000
17:30481135:T:TA	acceptor_gain	1.0000
17:30481140:A:G	acceptor_gain	1.0000
17:30481141:A:G	acceptor_gain	1.0000
17:30481141:AG:A	acceptor_loss	1.0000
17:30481142:G:GG	acceptor_gain	1.0000
17:30481142:GAT:G	acceptor_gain	1.0000
17:30484212:A:AG	acceptor_gain	1.0000
17:30484213:G:GT	acceptor_gain	1.0000
17:30484213:GT:G	acceptor_gain	1.0000
17:30484213:GTT:G	acceptor_gain	1.0000
17:30484213:GTTC:G	acceptor_gain	1.0000
17:30484213:GTTCT:G	acceptor_gain	1.0000
17:30484299:AGG:A	donor_gain	1.0000
17:30484300:GG:G	donor_gain	1.0000
17:30484300:GGG:G	donor_gain	1.0000
17:30484301:GG:G	donor_gain	1.0000
17:30484302:G:GG	donor_gain	1.0000
17:30484302:GTAA:G	donor_loss	1.0000
17:30484303:T:A	donor_loss	1.0000
17:30484661:A:AG	acceptor_gain	1.0000
17:30484662:G:GA	acceptor_gain	1.0000
17:30492673:TCCCA:T	acceptor_loss	1.0000
17:30492674:CCCA:C	acceptor_loss	1.0000
17:30492675:CCAG:C	acceptor_loss	1.0000
17:30492677:A:T	acceptor_loss	1.0000
17:30492678:G:GA	acceptor_loss	1.0000
17:30492750:GAAA:G	donor_gain	1.0000
17:30492754:G:GG	donor_gain	1.0000
17:30510908:AG:A	donor_loss	1.0000

AlphaMissense

1643 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:30481191:T:C	L27P	1.000
17:30484664:T:C	L81P	1.000
17:30484751:G:C	R110P	1.000
17:30519943:G:C	A184P	1.000
17:30481149:G:T	R13M	0.999
17:30481157:G:C	A16P	0.999
17:30481158:C:A	A16D	0.999
17:30481161:G:C	R17P	0.999
17:30481171:A:C	E20D	0.999
17:30481171:A:T	E20D	0.999
17:30481179:T:C	L23P	0.999
17:30484685:T:G	M88R	0.999
17:30484753:C:G	H111D	0.999
17:30484754:A:C	H111P	0.999
17:30490190:T:C	L138P	0.999
17:30519944:C:A	A184D	0.999
17:30519949:G:C	A186P	0.999
17:30522326:G:A	G234E	0.999
17:30522337:G:A	G238R	0.999
17:30522337:G:C	G238R	0.999
17:30522343:T:C	C240R	0.999
17:30481170:A:T	E20V	0.998
17:30481182:A:T	D24V	0.998
17:30481191:T:A	L27Q	0.998
17:30484685:T:A	M88K	0.998
17:30484685:T:C	M88T	0.998
17:30484738:C:G	H106D	0.998
17:30484763:T:A	I114K	0.998
17:30492747:T:C	L170P	0.998
17:30510881:T:C	S173P	0.998

dbSNP variants (sampled 300 via entrez): RS1000061385 (17:30497825 G>A), RS1000064144 (17:30492006 T>C), RS1000069182 (17:30498792 G>C), RS1000115678 (17:30494344 T>G), RS1000153508 (17:30476658 A>G), RS1000164838 (17:30520148 G>A), RS1000350184 (17:30524044 T>G), RS1000359804 (17:30485588 C>T), RS1000362691 (17:30479716 G>T), RS1000469031 (17:30481947 T>G), RS1000480798 (17:30523073 G>A,C,T), RS1000621239 (17:30510771 A>C,G), RS1000623762 (17:30475530 A>G), RS1000676137 (17:30475893 A>G), RS1000705617 (17:30511100 A>C)

Disease associations

OMIM: gene MIM:604026 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
sodium arsenite	affects binding, increases reaction	1
cobaltous chloride	increases expression	1
butyraldehyde	decreases expression	1
ochratoxin A	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	increases expression	1
Sunitinib	increases expression	1
Vehicle Emissions	increases expression, increases abundance	1
Cadmium	decreases expression, increases abundance	1
Deferoxamine	affects reaction, decreases phosphorylation, decreases reaction	1
Doxorubicin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Nitroprusside	decreases phosphorylation, decreases reaction, decreases expression, affects reaction	1
Selenium	decreases expression	1
Testosterone	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	affects expression	1
Vitamin E	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1
Thapsigargin	decreases expression	1
Palmitic Acid	decreases phosphorylation	1
Copper Sulfate	increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.