GPAT4-AS1

Summary

GPAT4-AS1 (GPAT4 and GINS4 antisense RNA 1, HGNC:55539) is a long non-coding RNA gene on chromosome 8p11.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55539
Approved symbol	GPAT4-AS1
Name	GPAT4 and GINS4 antisense RNA 1
Location	8p11.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	GIAT4RA
Ensembl gene	ENSG00000253133
Ensembl biotype	lncRNA
Entrez	102723729
RNAcentral	URS00007E4426 — lncRNA, 409 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000523081

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000523081 — 4 exons

Exon	Start	End
ENSE00002099367	41537071	41537310
ENSE00002106241	41533687	41534410
ENSE00002124393	41578306	41578421
ENSE00003862238	41509593	41512545

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 71.21.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3332 / max 139.1061, expressed in 73 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
92820	0.3286	70
92821	0.0045	2

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	71.21	silver quality
leukocyte	CL:0000738	62.36	gold quality
ventricular zone	UBERON:0003053	62.03	gold quality
ganglionic eminence	UBERON:0004023	61.55	gold quality
cortical plate	UBERON:0005343	59.85	silver quality
liver	UBERON:0002107	59.48	gold quality
skeletal muscle tissue	UBERON:0001134	57.66	silver quality
cortex of kidney	UBERON:0001225	55.90	gold quality
prefrontal cortex	UBERON:0000451	55.15	gold quality
blood	UBERON:0000178	53.45	gold quality
muscle tissue	UBERON:0002385	52.28	silver quality
stromal cell of endometrium	CL:0002255	51.61	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	50.99	gold quality
frontal cortex	UBERON:0001870	50.13	gold quality
islet of Langerhans	UBERON:0000006	50.10	gold quality
placenta	UBERON:0001987	49.25	silver quality
lymph node	UBERON:0000029	48.95	silver quality
vermiform appendix	UBERON:0001154	48.04	gold quality
right adrenal gland	UBERON:0001233	47.49	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	47.10	silver quality
duodenum	UBERON:0002114	46.51	silver quality
adrenal gland	UBERON:0002369	46.42	gold quality
right adrenal gland cortex	UBERON:0035827	46.39	gold quality
urinary bladder	UBERON:0001255	46.35	silver quality
left adrenal gland	UBERON:0001234	46.14	gold quality
gall bladder	UBERON:0002110	46.13	gold quality
right lobe of liver	UBERON:0001114	45.75	silver quality
cerebral cortex	UBERON:0000956	45.55	gold quality
primary visual cortex	UBERON:0002436	45.51	silver quality
endocervix	UBERON:0000458	45.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• GIAT4RA, a poorly characterized lncRNA LOC102723729, plays a critical role in non-small cell lung cancer adenocarcinoma as a ubiquitination regulator and tumor suppressor. (PMID:31417184)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.