GPR107

Summary

GPR107 (G protein-coupled receptor 107, HGNC:17830) is a protein-coding gene on chromosome 9q34.11, encoding Protein GPR107 (Q5VW38). Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor.

Predicted to enable clathrin heavy chain binding activity. Predicted to be involved in clathrin-dependent endocytosis. Located in Golgi apparatus and nucleoplasm.

Source: NCBI Gene 57720 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 114 total
• Druggable target: yes
• MANE Select transcript: NM_020960

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17830
Approved symbol	GPR107
Name	G protein-coupled receptor 107
Location	9q34.11
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1624, RP11-88G17, FLJ20998, LUSTR1
Ensembl gene	ENSG00000148358
Ensembl biotype	protein_coding
OMIM	618490
Entrez	57720

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 8 protein_coding, 3 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000347136, ENST00000372406, ENST00000372410, ENST00000415344, ENST00000462907, ENST00000483935, ENST00000493417, ENST00000873677, ENST00000873678, ENST00000873679, ENST00000937032, ENST00000943042

RefSeq mRNA: 4 — MANE Select: NM_020960 NM_001136557, NM_001136558, NM_001287346, NM_020960

CCDS: CCDS35162, CCDS48041, CCDS48042

Canonical transcript exons

ENST00000347136 — 18 exons

Exon	Start	End
ENSE00001234115	130077299	130077378
ENSE00001352284	130128640	130128761
ENSE00001457727	130135025	130140164
ENSE00003463792	130101106	130101223
ENSE00003466485	130090876	130090983
ENSE00003480933	130104420	130104550
ENSE00003491172	130099457	130099532
ENSE00003498148	130083565	130083602
ENSE00003524548	130079630	130079769
ENSE00003533007	130124915	130124964
ENSE00003573602	130086420	130086476
ENSE00003615466	130100629	130100702
ENSE00003622933	130092248	130092381
ENSE00003669299	130127483	130127566
ENSE00003671035	130107496	130107539
ENSE00003697780	130076412	130076462
ENSE00003699486	130075636	130075749
ENSE00003908301	130053906	130054073

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 96.70.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 45.1083 / max 217.0966, expressed in 1827 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
98986	44.1213	1827
98985	0.8202	461
98991	0.1029	37
98984	0.0639	20

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium epithelium	UBERON:0004811	96.70	gold quality
olfactory bulb	UBERON:0002264	96.03	gold quality
tendon of biceps brachii	UBERON:0008188	95.97	gold quality
type B pancreatic cell	CL:0000169	95.05	gold quality
middle frontal gyrus	UBERON:0002702	94.41	gold quality
paraflocculus	UBERON:0005351	93.66	gold quality
medial globus pallidus	UBERON:0002477	93.46	gold quality
inferior olivary complex	UBERON:0002127	93.42	gold quality
corpus callosum	UBERON:0002336	93.33	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	93.33	gold quality
globus pallidus	UBERON:0001875	93.03	gold quality
stromal cell of endometrium	CL:0002255	92.55	gold quality
dorsal root ganglion	UBERON:0000044	92.37	gold quality
islet of Langerhans	UBERON:0000006	92.29	gold quality
tendon	UBERON:0000043	92.09	gold quality
inferior vagus X ganglion	UBERON:0005363	91.92	gold quality
trigeminal ganglion	UBERON:0001675	91.80	gold quality
tongue squamous epithelium	UBERON:0006919	91.78	gold quality
medulla oblongata	UBERON:0001896	91.63	gold quality
superior vestibular nucleus	UBERON:0007227	91.62	gold quality
subthalamic nucleus	UBERON:0001906	91.59	gold quality
dorsal plus ventral thalamus	UBERON:0001897	91.52	gold quality
nasal cavity epithelium	UBERON:0005384	91.51	gold quality
frontal pole	UBERON:0002795	91.34	gold quality
substantia nigra pars reticulata	UBERON:0001966	91.24	gold quality
pylorus	UBERON:0001166	91.15	gold quality
saphenous vein	UBERON:0007318	91.11	gold quality
lateral nuclear group of thalamus	UBERON:0002736	90.94	gold quality
upper arm skin	UBERON:0004263	90.89	gold quality
pons	UBERON:0000988	90.85	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.25
E-MTAB-6058	no	189.38

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

167 targeting GPR107, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-6753-3P	99.93	66.57	637
HSA-MIR-7107-3P	99.93	66.73	627
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4756-5P	99.84	64.98	1809

Literature-anchored findings (GeneRIF, showing 4)

• The 18-exon human GPR107 gene is located at 9q34.2-3 and spans 86.4 kb and the cDNA encodes a 552 residue protein; murine Gpr108 cDNA encodes a 562 residue protein that has 49% identity to human GPR107. (PMID:17454009)
• GPR107 is a promising candidate receptor for neuronostatin, and neuronostatin, interacting with GPR107, may play an important role in the central control of cardiovascular function. (PMID:22933024)
• The N-terminal region of GPR107 is critical for its biological function. GPR107 might be one of the long-sought receptors that associates with G-proteins to regulate intracellular vesicular transport (PMID:25031321)
• Changes in expression of orphan receptors GPR99 and GPR107 during the development and establishment of hypertension in spontaneously hypertensive rats. (PMID:33121311)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	gpr107	ENSDARG00000103200
mus_musculus	Gpr107	ENSMUSG00000000194
rattus_norvegicus	Gpr107	ENSRNOG00000023589
drosophila_melanogaster	CG12121	FBGN0030109
drosophila_melanogaster	CG17660	FBGN0031356
caenorhabditis_elegans		WBGENE00015801
caenorhabditis_elegans		WBGENE00016867

Paralogs (3): TMEM87A (ENSG00000103978), GPR108 (ENSG00000125734), TMEM87B (ENSG00000153214)

Protein

Protein identifiers

Protein GPR107 — Q5VW38 (reviewed: Q5VW38)

Alternative names: Lung seven transmembrane receptor 1

All UniProt accessions (3): Q5VW38, G5E994, U3KQD2

UniProt curated annotations — full annotation on UniProt →

Function. Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucagon in response to low glucose. (Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.

Subcellular location. Cell membrane. Golgi apparatus. trans-Golgi network membrane.

Post-translational modifications. Cleaved by FURIN to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.

Similarity. Belongs to the LU7TM family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q5VW38-1	1	yes
Q5VW38-2	2
Q5VW38-3	3

RefSeq proteins (4): NP_001130029, NP_001130030, NP_001274275, NP_066011* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009637	GPR107/GPR108-like	Family
IPR053937	GOST_TM	Domain

Pfam: PF06814

UniProt features (32 total): topological domain 8, transmembrane region 7, glycosylation site 3, splice variant 3, sequence conflict 3, compositionally biased region 2, signal peptide 1, chain 1, region of interest 1, disulfide bond 1, sequence variant 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VW38-F1	71.54	0.18

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 109–228

Glycosylation sites (3): 70, 169, 211

Mutagenesis-validated functional residues (1):

Position	Phenotype
182	loss of furin cleavage.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 164 (showing top): GCM_MAP4K4, MORF_RAB5A, GOBP_VESICLE_MEDIATED_TRANSPORT, ONKEN_UVEAL_MELANOMA_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, GOCC_COATED_VESICLE, LIAO_METASTASIS, GCM_CALM1, FOXJ2_02, RGAGGAARY_PU1_Q6, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, GOBP_IMPORT_INTO_CELL, GOBP_ENDOCYTOSIS, NERF_Q2, EVI1_04

GO Biological Process (1): clathrin-dependent endocytosis (GO:0072583)

GO Molecular Function (1): clathrin heavy chain binding (GO:0032050)

GO Cellular Component (6): nucleoplasm (GO:0005654), early endosome (GO:0005769), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), membrane (GO:0016020), clathrin-coated vesicle (GO:0030136)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
receptor-mediated endocytosis	1
clathrin binding	1
nuclear lumen	1
endosome	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
membrane	1
cell periphery	1
coated vesicle	1

Protein interactions and networks

STRING

1156 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GPR107	LMX1B	O60663	726
GPR107	GPR146	Q96CH1	665
GPR107	AMY2A	P04746	547
GPR107	GPR137B	O60478	520
GPR107	GPR137C	Q8N3F9	519
GPR107	TPRA1	Q86W33	499
GPR107	GPR157	Q5UAW9	483
GPR107	TMEM87A	Q8NBN3	477
GPR107	GPRC5C	Q9NQ84	445
GPR107	GPR87	Q9BY21	424
GPR107	SUFU	Q9UMX1	423
GPR107	LIN52	Q52LA3	414
GPR107	TMEM87B	Q96K49	406
GPR107	TXNDC11	Q6PKC3	404
GPR107	GPR137	Q96N19	400

IntAct

40 interactions, top by confidence:

A	B	Type	Score
CCM2	KRIT1	psi-mi:“MI:0914”(association)	0.960
PRSS22	PPM1A	psi-mi:“MI:0914”(association)	0.560
LAMP3	METTL15	psi-mi:“MI:0914”(association)	0.530
CSGALNACT2	TPST1	psi-mi:“MI:0914”(association)	0.530
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
GPR107	SLC25A4	psi-mi:“MI:0915”(physical association)	0.400
GPR107	JTB	psi-mi:“MI:0914”(association)	0.350
SYAP1	GPR107	psi-mi:“MI:0914”(association)	0.350
GPR107	ETV3	psi-mi:“MI:0914”(association)	0.350
LRIT3	TRAF2	psi-mi:“MI:0914”(association)	0.350
GPR182	SLC12A8	psi-mi:“MI:0914”(association)	0.350
CLEC2D	ESYT2	psi-mi:“MI:0914”(association)	0.350
BTNL2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
SGCA	TMEM131L	psi-mi:“MI:0914”(association)	0.350
PRKCSH	KLRG2	psi-mi:“MI:0914”(association)	0.350
TUBB2B	POTEF	psi-mi:“MI:0914”(association)	0.350
CD48	POTEF	psi-mi:“MI:0914”(association)	0.350
B3GALT4		psi-mi:“MI:0914”(association)	0.350
ATP2A3	UBXN8	psi-mi:“MI:0914”(association)	0.350
NAAA	HAX1	psi-mi:“MI:0914”(association)	0.350
DNASE1L1	QSOX1	psi-mi:“MI:0914”(association)	0.350
EFNA2	MGST3	psi-mi:“MI:0914”(association)	0.350
AGK	RAB29	psi-mi:“MI:0914”(association)	0.350
S1PR4	NPC1	psi-mi:“MI:0914”(association)	0.350
B4GAT1	KCNN4	psi-mi:“MI:0914”(association)	0.350
NXPH1	RAD51C	psi-mi:“MI:0914”(association)	0.350
QTRT1	ACSL4	psi-mi:“MI:0914”(association)	0.350
ARL11	NMT2	psi-mi:“MI:0914”(association)	0.350
KLK5	LRP5	psi-mi:“MI:0914”(association)	0.350
DECR2	ATP1A3	psi-mi:“MI:0914”(association)	0.350

BioGRID (70): GPR107 (Proximity Label-MS), GPR107 (Proximity Label-MS), TRAF2 (Affinity Capture-MS), BIRC2 (Affinity Capture-MS), LNPEP (Affinity Capture-MS), GPR107 (Affinity Capture-MS), NDUFA12 (Affinity Capture-MS), NEK7 (Affinity Capture-MS), GPR107 (Proximity Label-MS), GPR107 (Proximity Label-MS), GPR107 (Proximity Label-MS), GPR107 (Synthetic Lethality), GPR107 (Affinity Capture-MS), GPR107 (Proximity Label-MS), GPR107 (Proximity Label-MS)

ESM2 similar proteins: A0JPH4, A3KFU9, A6H7H1, A7UA95, B9U3F2, D3ZWZ9, D4A6L0, E1BBQ2, F1M8G0, O15040, O54828, O75129, O88974, P49805, P97260, Q00M95, Q12770, Q13370, Q14432, Q15047, Q3B7M3, Q3B7T1, Q4ZIN3, Q5MNU5, Q5R9R1, Q5T848, Q5VW38, Q5ZKN3, Q61409, Q62865, Q63085, Q6A0A9, Q6F6B3, Q6GQV7, Q6L8S8, Q6P6V6, Q6PJF5, Q80WQ6, Q80Z10, Q86XL3

Diamond homologs: D3ZWZ9, F4JY11, Q148L1, Q5VW38, Q6P6V6, Q8BUV8, Q91WD0, Q9LZ39, Q9NPR9, Q8N769, O14628, O94966, Q3ZCU0, Q6B4Z3, Q6ZUF6, Q96ET8, Q9H2J1, Q9NV72, Q9Y2Z0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

114 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	78
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3542 predictions. Top by Δscore:

Variant	Effect	Δscore
9:130075746:GACT:G	donor_gain	1.0000
9:130075747:ACTGT:A	donor_loss	1.0000
9:130075748:CT:C	donor_gain	1.0000
9:130075748:CTGT:C	donor_loss	1.0000
9:130075749:TGT:T	donor_loss	1.0000
9:130075750:G:GG	donor_gain	1.0000
9:130075750:GT:G	donor_loss	1.0000
9:130075751:TAAG:T	donor_loss	1.0000
9:130075752:AAG:A	donor_loss	1.0000
9:130075753:AG:A	donor_loss	1.0000
9:130079628:AG:A	acceptor_gain	1.0000
9:130079629:GG:G	acceptor_gain	1.0000
9:130083601:AGGT:A	donor_loss	1.0000
9:130083603:G:GG	donor_gain	1.0000
9:130083603:GTA:G	donor_loss	1.0000
9:130083604:T:A	donor_loss	1.0000
9:130086418:A:AG	acceptor_gain	1.0000
9:130086419:G:GG	acceptor_gain	1.0000
9:130090874:A:AG	acceptor_gain	1.0000
9:130090875:G:GA	acceptor_gain	1.0000
9:130090875:GT:G	acceptor_gain	1.0000
9:130090875:GTT:G	acceptor_gain	1.0000
9:130090875:GTTT:G	acceptor_gain	1.0000
9:130090875:GTTTT:G	acceptor_gain	1.0000
9:130090981:GAT:G	donor_gain	1.0000
9:130090981:GATGT:G	donor_loss	1.0000
9:130090982:ATGTG:A	donor_loss	1.0000
9:130090983:TGTG:T	donor_loss	1.0000
9:130090984:G:GG	donor_gain	1.0000
9:130090984:GTG:G	donor_loss	1.0000

AlphaMissense

3627 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:130092356:T:A	W280R	1.000
9:130092356:T:C	W280R	1.000
9:130099486:T:A	M298K	1.000
9:130099486:T:G	M298R	1.000
9:130099487:G:A	M298I	1.000
9:130099487:G:C	M298I	1.000
9:130099487:G:T	M298I	1.000
9:130099495:T:A	L301H	1.000
9:130100702:T:C	L338P	1.000
9:130101113:G:A	G341R	1.000
9:130101113:G:C	G341R	1.000
9:130101113:G:T	G341W	1.000
9:130101114:G:A	G341E	1.000
9:130101120:T:C	L343P	1.000
9:130101123:T:C	L344P	1.000
9:130101125:T:C	F345L	1.000
9:130101126:T:C	F345S	1.000
9:130101127:C:A	F345L	1.000
9:130101127:C:G	F345L	1.000
9:130101141:T:A	L350H	1.000
9:130101141:T:C	L350P	1.000
9:130101144:T:A	I351N	1.000
9:130101146:G:C	G352R	1.000
9:130101146:G:T	G352C	1.000
9:130101147:G:A	G352D	1.000
9:130101152:G:C	G354R	1.000
9:130101152:G:T	G354C	1.000
9:130101153:G:A	G354D	1.000
9:130101153:G:T	G354V	1.000
9:130101161:T:C	F357L	1.000

dbSNP variants (sampled 300 via entrez): RS1000014147 (9:130085167 A>G), RS1000024941 (9:130052890 G>A), RS1000059841 (9:130131746 T>C), RS1000132430 (9:130054622 C>A), RS1000141742 (9:130103307 T>C), RS1000157599 (9:130109285 C>G,T), RS1000179409 (9:130068209 C>A,T), RS1000232935 (9:130084444 T>C), RS1000277076 (9:130074065 G>A), RS1000285096 (9:130073981 T>A), RS1000306943 (9:130114832 A>G,T), RS1000312352 (9:130126085 C>T), RS1000324123 (9:130120546 G>C), RS1000476900 (9:130079691 G>A,T), RS1000526213 (9:130096963 C>T)

Disease associations

OMIM: gene MIM:618490 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST012490_155	Femur bone mineral density x serum urate levels interaction	2.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4630835 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Other non-GPCR 7TM proteins

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects binding, increases reaction, increases expression	2
Valproic Acid	affects expression	2
beta-lapachone	decreases expression, increases expression	1
epigallocatechin gallate	increases expression	1
abrine	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
eprenetapopt	affects expression	1
Benzo(a)pyrene	decreases expression	1
Cadmium	increases expression	1
Methyl Methanesulfonate	increases expression	1
Selenium	increases expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Thiram	increases expression	1
Tretinoin	increases expression	1
Vitamin E	increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	decreases methylation	1
Copper Sulfate	increases expression	1
tert-Butylhydroperoxide	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4605747	ADMET	Binding affinity to GPR107 in SILAC labeled human H1299 cells incubated for 3 hrs followed by compound washout twice with PBS buffer to remove excess compound and further irradiated with UV-light at 365 nm for 20 mins by LC-MS/MS analysis	Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. — ACS Med Chem Lett

Cellosaurus cell lines

1 cell lines: 1 spontaneously immortalized cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_KX21	PathHunter CHO-K1 GPR107 beta-arrestin	Spontaneously immortalized cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.