GPR148

Summary

GPR148 (G protein-coupled receptor 148, HGNC:23623) is a protein-coding gene on chromosome 2q21.1, encoding Probable G-protein coupled receptor 148 (Q8TDV2). Orphan receptor.

Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Located in plasma membrane.

Source: NCBI Gene 344561 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 74 total
• Druggable target: yes
• Dosage sensitivity (ClinGen): haploinsufficiency no evidence, triplosensitivity no evidence
• MANE Select transcript: NM_207364

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23623
Approved symbol	GPR148
Name	G protein-coupled receptor 148
Location	2q21.1
Locus type	gene with protein product
Status	Approved
Aliases	PGR6
Ensembl gene	ENSG00000173302
Ensembl biotype	protein_coding
Entrez	344561

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000309926

RefSeq mRNA: 1 — MANE Select: NM_207364 NM_207364

CCDS: CCDS2163

Canonical transcript exons

ENST00000309926 — 1 exons

Exon	Start	End
ENSE00001205329	130729070	130730336

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 67.63.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	67.63	gold quality
cerebellum	UBERON:0002037	49.44	gold quality
cerebellar hemisphere	UBERON:0002245	49.41	gold quality
right hemisphere of cerebellum	UBERON:0014890	49.34	gold quality
cerebellar cortex	UBERON:0002129	49.27	silver quality
pituitary gland	UBERON:0000007	46.99	gold quality
pancreas	UBERON:0001264	46.61	gold quality
adenohypophysis	UBERON:0002196	45.20	gold quality
granulocyte	CL:0000094	39.35	gold quality
primary visual cortex	UBERON:0002436	39.31	silver quality
bone marrow cell	CL:0002092	38.18	gold quality
sural nerve	UBERON:0015488	38.01	gold quality
Brodmann (1909) area 9	UBERON:0013540	37.78	silver quality
hypothalamus	UBERON:0001898	37.36	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
brain	UBERON:0000955	36.97	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
rectum	UBERON:0001052	36.28	silver quality
superior frontal gyrus	UBERON:0002661	36.21	gold quality
prefrontal cortex	UBERON:0000451	36.04	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	35.98	silver quality
frontal cortex	UBERON:0001870	35.70	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
right frontal lobe	UBERON:0002810	35.18	silver quality
anterior cingulate cortex	UBERON:0009835	35.16	silver quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
duodenum	UBERON:0002114	33.05	silver quality
bone marrow	UBERON:0002371	32.78	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

7 targeting GPR148, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-5580-3P	99.70	69.41	2052
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-4318	99.38	66.94	1505
HSA-MIR-4263	99.18	69.25	2236
HSA-MIR-4272	98.76	68.74	1810

Functional genomics

ClinGen dosage: haploinsufficiency 0 (no evidence), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Literature-anchored findings (GeneRIF, showing 1)

• Small rare recurrent deletions and reciprocal duplications in 2q21.1, including brain-specific GPR148 (PMID:22543972)

Cross-species orthologs

0 orthologs

Paralogs (15): NTSR1 (ENSG00000101188), BRS3 (ENSG00000102239), MLNR (ENSG00000102539), GHSR (ENSG00000121853), GRPR (ENSG00000126010), NMUR2 (ENSG00000132911), NMBR (ENSG00000135577), EDNRB (ENSG00000136160), EDNRA (ENSG00000151617), NTSR2 (ENSG00000169006), GPR37L1 (ENSG00000170075), GPR37 (ENSG00000170775), NMUR1 (ENSG00000171596), TRHR (ENSG00000174417), GPR39 (ENSG00000183840)

Protein

Protein identifiers

Probable G-protein coupled receptor 148 — Q8TDV2 (reviewed: Q8TDV2)

Alternative names: Brain and testis restricted GPCR, G-protein coupled receptor PGR6

All UniProt accessions (1): Q8TDV2

UniProt curated annotations — full annotation on UniProt →

Function. Orphan receptor.

Subcellular location. Cell membrane.

Tissue specificity. Expression restricted to nervous system and testis. Is also detected in several tumors types, most notably prostate cancer.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_997247* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR052921	GPCR1_Superfamily_Member	Family

Pfam: PF00001

UniProt features (27 total): sequence conflict 9, topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TDV2-F1	73.27	0.10

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 34

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 25 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, FOSTER_TOLERANT_MACROPHAGE_DN, CHO_NR4A1_TARGETS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, KATSANOU_ELAVL1_TARGETS_UP, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES, LMTK3_TARGET_GENES

GO Biological Process (3): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (4): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), odorant binding (GO:0005549), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
binding	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

294 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GPR148	CDH17	Q12864	717
GPR148	HCAR3	P49019	595
GPR148	GPR162	Q16538	526
GPR148	GPR152	Q8TDT2	514
GPR148	HCAR1	Q9BXC0	507
GPR148	GPR139	Q6DWJ6	476
GPR148	AMER3	Q8N944	475
GPR148	GPKOW	Q92917	447
GPR148	GPR141	Q7Z602	447
GPR148	GPR150	Q8NGU9	445
GPR148	GPR146	Q96CH1	439
GPR148	GPR142	Q7Z601	435
GPR148	CRY1	Q16526	418
GPR148	SLC4A11	Q8NBS3	411
GPR148	FAM168B	A1KXE4	406

IntAct

8 interactions, top by confidence:

A	B	Type	Score
EXOC3L2	GPR148	psi-mi:“MI:0915”(physical association)	0.560
GPR148	A2ML1	psi-mi:“MI:0915”(physical association)	0.400
GPR148	RAMP1	psi-mi:“MI:0915”(physical association)	0.400
RAMP2	GPR148	psi-mi:“MI:0915”(physical association)	0.400
GPR148	RAMP3	psi-mi:“MI:0915”(physical association)	0.400
EXOC3L2	GPR148	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (2): EXOC3L2 (Two-hybrid), A2ML1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IM31, A0A0R4IP11, E9QJ73, F8VQN3, O00270, O00421, O15218, O35457, O97663, P31392, P32302, P34997, P43142, P49685, Q04683, Q0II78, Q0VDU3, Q149R9, Q16570, Q3ZC80, Q67ES2, Q6XKD3, Q75ZH0, Q7TMA4, Q7TQA9, Q7TQP4, Q7TSN5, Q7TSN6, Q863H8, Q8BZR0, Q8TDV2, Q95LF2, Q95LF3, Q95LF4, Q95LF5, Q95LF7, Q95LF9, Q95LG5, Q96CH1, Q96G91

Diamond homologs: Q8TDV2, Q93126

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

204 predictions. Top by Δscore:

Variant	Effect	Δscore
2:130729147:G:GT	donor_gain	0.8000
2:130729744:G:GT	donor_gain	0.7900
2:130729745:A:T	donor_gain	0.7100
2:130729786:G:T	donor_gain	0.6700
2:130729743:G:GT	donor_gain	0.6500
2:130729826:G:GG	donor_gain	0.6400
2:130729722:G:GT	donor_gain	0.6300
2:130729786:G:GT	donor_gain	0.6300
2:130729803:A:AG	donor_gain	0.6300
2:130729740:C:T	donor_gain	0.6200
2:130729649:G:GT	donor_gain	0.5800
2:130729802:C:A	donor_gain	0.5700
2:130729737:G:GT	donor_gain	0.5600
2:130729734:G:GT	donor_gain	0.5500
2:130729769:C:T	donor_gain	0.5400
2:130729712:C:T	donor_gain	0.5200
2:130729871:G:GT	donor_gain	0.5200
2:130729874:GATC:G	donor_gain	0.5100
2:130729596:G:GT	donor_gain	0.5000
2:130729801:T:TA	donor_gain	0.5000
2:130729675:T:TA	donor_gain	0.4900
2:130729804:T:G	donor_gain	0.4800
2:130729676:G:GA	donor_gain	0.4600
2:130729653:G:GT	donor_gain	0.4500
2:130729842:T:TA	acceptor_gain	0.4300
2:130729155:GGGGA:G	donor_gain	0.4200
2:130729846:C:G	acceptor_gain	0.4100
2:130729847:A:AG	acceptor_gain	0.4100
2:130729848:G:GG	acceptor_gain	0.4100
2:130729488:G:GA	donor_gain	0.4000

AlphaMissense

2215 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:130729989:T:C	F280L	0.802
2:130729991:C:A	F280L	0.802
2:130729991:C:G	F280L	0.802
2:130729350:A:C	S67R	0.791
2:130729352:C:A	S67R	0.791
2:130729352:C:G	S67R	0.791
2:130729536:T:C	F129L	0.781
2:130729538:C:A	F129L	0.781
2:130729538:C:G	F129L	0.781
2:130729551:A:C	S134R	0.779
2:130729553:C:A	S134R	0.779
2:130729553:C:G	S134R	0.779
2:130729566:T:C	F139L	0.735
2:130729568:C:A	F139L	0.735
2:130729568:C:G	F139L	0.735
2:130729974:A:C	S275R	0.730
2:130729976:C:A	S275R	0.730
2:130729976:C:G	S275R	0.730
2:130729866:T:C	F239L	0.728
2:130729868:C:A	F239L	0.728
2:130729868:C:G	F239L	0.728
2:130729668:T:A	W173R	0.680
2:130729668:T:C	W173R	0.680
2:130729686:T:C	F179L	0.600
2:130729688:C:A	F179L	0.600
2:130729688:C:G	F179L	0.600
2:130729827:T:C	C226R	0.586
2:130730181:T:C	F344L	0.576
2:130730183:T:A	F344L	0.576
2:130730183:T:G	F344L	0.576

dbSNP variants (sampled 300 via entrez): RS1001359097 (2:130729688 C>T), RS1002397711 (2:130730328 G>A,C), RS1003036273 (2:130728303 A>C), RS1003836663 (2:130727310 G>C), RS1004281422 (2:130727328 G>C), RS1004526493 (2:130728446 G>A), RS1005682026 (2:130727578 G>A,C,T), RS1006269080 (2:130728652 C>A,T), RS1006325582 (2:130729414 T>C), RS1006654465 (2:130728338 A>G), RS1007111676 (2:130728576 A>C,T), RS1008032979 (2:130728689 C>T), RS1008060873 (2:130728909 G>A), RS1010165880 (2:130730457 G>A), RS1010667844 (2:130727675 G>A,C,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523901 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Class A Orphans with no pharmacology

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4883416	Binding	PRESTO-Tango GPCRome screening (GPR148)	Data for DCP probe UCSF924

Cellosaurus cell lines

1 cell lines: 1 spontaneously immortalized cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_KX37	PathHunter CHO-K1 GPR148 beta-arrestin	Spontaneously immortalized cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.