GPR150

Summary

GPR150 (G protein-coupled receptor 150, HGNC:23628) is a protein-coding gene on chromosome 5q15, encoding Probable G-protein coupled receptor 150 (Q8NGU9). Orphan receptor.

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the vasopressin-like subfamily that also includes vasopressin and oxytocin receptors. The silencing of this gene, due to promoter methylation, is associated with ovarian cancer progression. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Source: NCBI Gene 285601 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 79 total
• Druggable target: yes
• MANE Select transcript: NM_199243

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23628
Approved symbol	GPR150
Name	G protein-coupled receptor 150
Location	5q15
Locus type	gene with protein product
Status	Approved
Aliases	PGR11
Ensembl gene	ENSG00000178015
Ensembl biotype	protein_coding
Entrez	285601

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000380007

RefSeq mRNA: 1 — MANE Select: NM_199243 NM_199243

CCDS: CCDS4074

Canonical transcript exons

ENST00000380007 — 1 exons

Exon	Start	End
ENSE00001483357	95620087	95622142

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 72.30.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2821 / max 11.9813, expressed in 127 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57624	0.1457	76
57623	0.1365	70

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	72.30	gold quality
stromal cell of endometrium	CL:0002255	70.08	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.22	gold quality
superior frontal gyrus	UBERON:0002661	67.16	gold quality
prefrontal cortex	UBERON:0000451	66.03	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.42	gold quality
pancreas	UBERON:0001264	64.93	gold quality
frontal cortex	UBERON:0001870	64.38	gold quality
anterior cingulate cortex	UBERON:0009835	62.87	gold quality
right frontal lobe	UBERON:0002810	61.84	gold quality
cerebral cortex	UBERON:0000956	61.52	gold quality
primary visual cortex	UBERON:0002436	60.03	gold quality
body of stomach	UBERON:0001161	58.36	gold quality
fundus of stomach	UBERON:0001160	55.63	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.35	gold quality
stomach	UBERON:0000945	53.99	gold quality
temporal lobe	UBERON:0001871	53.17	gold quality
amygdala	UBERON:0001876	52.94	gold quality
tibial nerve	UBERON:0001323	52.34	gold quality
brain	UBERON:0000955	52.03	gold quality
granulocyte	CL:0000094	51.95	gold quality
left coronary artery	UBERON:0001626	51.14	gold quality
adipose tissue	UBERON:0001013	50.91	gold quality
islet of Langerhans	UBERON:0000006	50.89	gold quality
lymph node	UBERON:0000029	50.62	gold quality
placenta	UBERON:0001987	50.09	gold quality
hypothalamus	UBERON:0001898	50.05	gold quality
nucleus accumbens	UBERON:0001882	49.89	gold quality
popliteal artery	UBERON:0002250	49.53	gold quality
tibial artery	UBERON:0007610	49.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
drosophila_melanogaster	CrzR	FBGN0036278
caenorhabditis_elegans		WBGENE00013642

Paralogs (16): NPFFR2 (ENSG00000056291), GNRHR (ENSG00000109163), CCKBR (ENSG00000110148), HCRTR1 (ENSG00000121764), AVPR2 (ENSG00000126895), GALR3 (ENSG00000128310), HCRTR2 (ENSG00000137252), NPFFR1 (ENSG00000148734), CCKAR (ENSG00000163394), AVPR1A (ENSG00000166148), GALR1 (ENSG00000166573), GPR22 (ENSG00000172209), OXTR (ENSG00000180914), FFAR4 (ENSG00000186188), QRFPR (ENSG00000186867), AVPR1B (ENSG00000198049)

Protein

Protein identifiers

Probable G-protein coupled receptor 150 — Q8NGU9 (reviewed: Q8NGU9)

All UniProt accessions (1): Q8NGU9

UniProt curated annotations — full annotation on UniProt →

Function. Orphan receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_954713* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF00001

UniProt features (21 total): topological domain 8, transmembrane region 7, compositionally biased region 3, region of interest 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGU9-F1	71.04	0.34

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-418555	G alpha (s) signalling events

MSigDB gene sets: 45 (showing top): BENPORATH_ES_WITH_H3K27ME3, NFKB_Q6, GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS, GOBP_RESPONSE_TO_HORMONE, RYTTCCTG_ETS2_B, HOXA4_Q2, YNGTTNNNATT_UNKNOWN, chr5q15, TGGAAA_NFAT_Q4_01, AP1FJ_Q2, ETS_Q4, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3, MEISSNER_NPC_HCP_WITH_H3K4ME2

GO Biological Process (3): G protein-coupled receptor signaling pathway (GO:0007186), cellular response to hormone stimulus (GO:0032870), signal transduction (GO:0007165)

GO Molecular Function (1): G protein-coupled receptor activity (GO:0004930)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
GPCR downstream signalling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	1
signal transduction	1
response to hormone	1
cellular response to chemical stimulus	1
cellular response to endogenous stimulus	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

702 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GPR150	GPR162	Q16538	571
GPR150	OXT	P01178	569
GPR150	GNRH2	O43555	548
GPR150	GPR176	Q14439	516
GPR150	GPR88	Q9GZN0	513
GPR150	GPR63	Q9BZJ6	501
GPR150	GPR26	Q8NDV2	492
GPR150	GPR82	Q96P67	491
GPR150	GPR52	Q9Y2T5	486
GPR150	GPR83	Q9NYM4	485
GPR150	GPR61	Q9BZJ8	474
GPR150	GPR139	Q6DWJ6	468
GPR150	GPR148	Q8TDV2	445
GPR150	GPR101	Q96P66	444
GPR150	GPR135	Q8IZ08	437

IntAct

3 interactions, top by confidence:

A	B	Type	Score
GPR150	PIK3CA	psi-mi:“MI:0914”(association)	0.350
C10orf90	GPR150	psi-mi:“MI:0914”(association)	0.350

BioGRID (9): INTS2 (Affinity Capture-MS), FANCL (Affinity Capture-MS), KLHL15 (Affinity Capture-MS), INTS1 (Affinity Capture-MS), PDXDC1 (Affinity Capture-MS), GPR150 (Affinity Capture-MS), PPTC7 (Affinity Capture-MS), PIK3CA (Affinity Capture-MS), ABHD17B (Affinity Capture-MS)

ESM2 similar proteins: A0A0U1RQ45, A0A0U1RQS6, A0A286YF58, A0A2R8YCJ5, A0A7I2V3R4, A2VDX9, A5D7M7, A5PJP1, A6NGB7, A6NKF7, A6NLJ0, A8MVW0, B2RU40, C9JH25, C9JTQ0, D4A9R4, P03971, P03972, P0DPE3, P27106, P27539, P79295, Q0VD38, Q14761, Q1HCM0, Q29RK8, Q29RM6, Q2M3V2, Q3SWY4, Q3TYP4, Q5BLP8, Q5T442, Q64697, Q674R7, Q6PEY1, Q6QNY0, Q6ZS72, Q80XF7, Q8BQU6, Q8C581

Diamond homologs: Q8BL07, Q8NGU9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	73
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

197 predictions. Top by Δscore:

Variant	Effect	Δscore
5:95621161:A:G	donor_gain	0.9800
5:95621234:G:GA	donor_gain	0.9800
5:95621236:T:TA	donor_gain	0.9800
5:95621233:T:TA	donor_gain	0.9700
5:95621251:G:GT	donor_gain	0.9600
5:95621237:C:CA	donor_gain	0.9300
5:95621342:AGGC:A	acceptor_gain	0.8700
5:95621342:AGGCG:A	acceptor_gain	0.8700
5:95621343:GGCG:G	acceptor_gain	0.8700
5:95621343:GGCGG:G	acceptor_gain	0.8700
5:95621184:G:GG	donor_gain	0.8600
5:95621263:G:GT	donor_gain	0.8500
5:95621192:GC:G	donor_gain	0.8200
5:95621343:GGC:G	acceptor_gain	0.8200
5:95621259:G:GT	donor_gain	0.8000
5:95620966:GTC:G	donor_gain	0.7900
5:95620967:TCT:T	donor_gain	0.7900
5:95621338:TTCCA:T	acceptor_loss	0.7900
5:95621339:TCCAG:T	acceptor_loss	0.7900
5:95621340:CCAGG:C	acceptor_loss	0.7900
5:95621341:CAGGC:C	acceptor_loss	0.7900
5:95621342:A:AG	acceptor_gain	0.7900
5:95621342:A:G	acceptor_loss	0.7900
5:95621343:G:GG	acceptor_gain	0.7900
5:95621343:G:GT	acceptor_loss	0.7900
5:95621181:GCT:G	donor_gain	0.7800
5:95621260:G:GT	donor_gain	0.7800
5:95621183:T:TG	donor_gain	0.7600
5:95621186:T:A	donor_gain	0.7600
5:95621191:GGC:G	donor_gain	0.7600

AlphaMissense

2684 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:95621164:A:C	S297R	0.978
5:95621166:C:A	S297R	0.978
5:95621166:C:G	S297R	0.978
5:95620936:T:C	F221L	0.957
5:95620938:C:A	F221L	0.957
5:95620938:C:G	F221L	0.957
5:95620937:T:G	F221C	0.955
5:95620780:T:A	W169R	0.953
5:95620780:T:C	W169R	0.953
5:95621575:T:C	F434L	0.951
5:95621577:C:A	F434L	0.951
5:95621577:C:G	F434L	0.951
5:95621152:A:C	S293R	0.945
5:95621154:C:A	S293R	0.945
5:95621154:C:G	S293R	0.945
5:95620956:G:C	W227C	0.931
5:95620956:G:T	W227C	0.931
5:95620996:T:C	F241L	0.931
5:95620998:C:A	F241L	0.931
5:95620998:C:G	F241L	0.931
5:95620553:A:T	D93V	0.929
5:95620777:G:C	G168R	0.921
5:95620455:C:A	N60K	0.920
5:95620455:C:G	N60K	0.920
5:95621338:T:C	F355L	0.915
5:95621340:C:A	F355L	0.915
5:95621340:C:G	F355L	0.915
5:95620553:A:C	D93A	0.907
5:95621327:T:A	V351D	0.903
5:95620554:C:A	D93E	0.896

dbSNP variants (sampled 300 via entrez): RS1000311297 (5:95619114 A>G), RS1000646336 (5:95620152 C>A), RS1000709356 (5:95618828 A>G,T), RS1001536102 (5:95619534 A>G), RS1001881986 (5:95619230 C>T), RS1002285896 (5:95620770 C>T), RS1002349881 (5:95622630 T>C), RS1003555427 (5:95622040 C>G), RS10038242 (5:95620079 A>G), RS1004246811 (5:95621909 G>A), RS1004341725 (5:95621525 G>A), RS1004446754 (5:95618120 A>G), RS1004497127 (5:95618414 A>G), RS1008721505 (5:95619913 G>C), RS1009210183 (5:95622365 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523898 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Class A Orphans with no pharmacology

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, decreases methylation	2
fluorene-9-bisphenol	increases expression	1
terbufos	increases methylation	1
arsenite	increases methylation	1
Resveratrol	affects cotreatment, decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Fonofos	increases methylation	1
Parathion	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Silicon Dioxide	decreases expression	1
Smoke	decreases expression	1
Aflatoxin B1	decreases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4883419	Binding	PRESTO-Tango GPCRome screening (GPR150)	Data for DCP probe UCSF924

Cellosaurus cell lines

2 cell lines: 1 spontaneously immortalized cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_KX40	PathHunter CHO-K1 GPR150 beta-arrestin	Spontaneously immortalized cell line	Female
CVCL_KZ52	PathHunter HEK 293 GPR150 beta-arrestin	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.