GPR152

Summary

GPR152 (G protein-coupled receptor 152, HGNC:23622) is a protein-coding gene on chromosome 11q13.2, encoding Probable G-protein coupled receptor 152 (Q8TDT2). Orphan receptor.

Enables identical protein binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 390212 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 61 total
• Druggable target: yes
• MANE Select transcript: NM_206997

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23622
Approved symbol	GPR152
Name	G protein-coupled receptor 152
Location	11q13.2
Locus type	gene with protein product
Status	Approved
Aliases	PGR5
Ensembl gene	ENSG00000175514
Ensembl biotype	protein_coding
Entrez	390212

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000312457

RefSeq mRNA: 1 — MANE Select: NM_206997 NM_206997

CCDS: CCDS8165

Canonical transcript exons

ENST00000312457 — 1 exons

Exon	Start	End
ENSE00001185972	67451301	67452729

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 59.83.

Top tissues by expression

121 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	59.83	gold quality
granulocyte	CL:0000094	55.98	gold quality
bone marrow	UBERON:0002371	47.61	gold quality
colonic epithelium	UBERON:0000397	46.34	gold quality
sural nerve	UBERON:0015488	44.03	gold quality
spleen	UBERON:0002106	39.54	silver quality
tonsil	UBERON:0002372	39.11	gold quality
skeletal muscle tissue	UBERON:0001134	38.05	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
mucosa of transverse colon	UBERON:0004991	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
lymph node	UBERON:0000029	36.45	gold quality
monocyte	CL:0000576	35.82	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.65	gold quality
mucosa of stomach	UBERON:0001199	35.60	silver quality
small intestine Peyer’s patch	UBERON:0003454	35.60	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
vermiform appendix	UBERON:0001154	35.36	gold quality
small intestine	UBERON:0002108	35.28	gold quality
muscle tissue	UBERON:0002385	34.50	gold quality
liver	UBERON:0002107	31.91	gold quality
body of stomach	UBERON:0001161	30.29	silver quality
stomach	UBERON:0000945	30.24	silver quality
lung	UBERON:0002048	29.96	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
placenta	UBERON:0001987	29.61	gold quality
right uterine tube	UBERON:0001302	29.12	gold quality
uterine cervix	UBERON:0000002	28.99	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	28.88	gold quality
upper lobe of left lung	UBERON:0008952	28.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gpr152	ENSMUSG00000044724
rattus_norvegicus	Gpr152	ENSRNOG00000021912

Paralogs (10): MAS1 (ENSG00000130368), MRGPRX1 (ENSG00000170255), MRGPRF (ENSG00000172935), MRGPRD (ENSG00000172938), MRGPRX4 (ENSG00000179817), MRGPRX3 (ENSG00000179826), MRGPRG (ENSG00000182170), MRGPRX2 (ENSG00000183695), MRGPRE (ENSG00000184350), MAS1L (ENSG00000204687)

Protein

Protein identifiers

Probable G-protein coupled receptor 152 — Q8TDT2 (reviewed: Q8TDT2)

Alternative names: G-protein coupled receptor PGR5

All UniProt accessions (2): Q8TDT2, A0A0I9RJ67

UniProt curated annotations — full annotation on UniProt →

Function. Orphan receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_996880* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR026234	MRGPCRFAMILY	Family

Pfam: PF00001

UniProt features (23 total): topological domain 8, transmembrane region 7, compositionally biased region 3, region of interest 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TDT2-F1	71.72	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 104–182

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 23 (showing top): chr11q13, NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_DN, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D, RAO_BOUND_BY_SALL4_ISOFORM_B, GSE11924_TH2_VS_TH17_CD4_TCELL_DN, ZBED5_TARGET_GENES, ZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_CORRELATED_WITH_CD8_T_CELL_RESPONSE_3DY_NEGATIVE, GSE20366_CD103_KLRG1_DP_VS_DN_TREG_UP, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, GSE369_PRE_VS_POST_IL6_INJECTION_IFNG_WT_LIVER_UP, GSE8921_3H_VS_24H_TLR1_2_STIM_MONOCYTE_DN

GO Biological Process (2): G protein-coupled receptor signaling pathway (GO:0007186), signal transduction (GO:0007165)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	1
signal transduction	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
protein binding	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

666 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GPR152	GLIS3	Q8NEA6	791
GPR152	GPR108	Q9NPR9	632
GPR152	GPR171	O14626	578
GPR152	GPR158	Q5T848	525
GPR152	PPP1R26	Q5T8A7	524
GPR152	GPR148	Q8TDV2	514
GPR152	GPHRA	B7ZAQ6	508
GPR152	GPR162	Q16538	507
GPR152	PTRH1	Q86Y79	498
GPR152	GPR82	Q96P67	490
GPR152	GPR139	Q6DWJ6	480
GPR152	TMEM134	Q9H6X4	477
GPR152	CABP4	P57796	456
GPR152	TOR2A	Q5JU69	454
GPR152	GPR137	Q96N19	446

IntAct

577 interactions, top by confidence:

A	B	Type	Score
TMPPE	GPR152	psi-mi:“MI:0915”(physical association)	0.560
ABCG4	GPR152	psi-mi:“MI:0915”(physical association)	0.560
GPR152	SLC13A4	psi-mi:“MI:0915”(physical association)	0.000
GPR152	CLN5	psi-mi:“MI:0915”(physical association)	0.000
VAMP4	GPR152	psi-mi:“MI:0915”(physical association)	0.000
MGLL	GPR152	psi-mi:“MI:0915”(physical association)	0.000
MMD	GPR152	psi-mi:“MI:0915”(physical association)	0.000
TMEM208	GPR152	psi-mi:“MI:0915”(physical association)	0.000
EDDM3B	GPR152	psi-mi:“MI:0915”(physical association)	0.000
PIGF	GPR152	psi-mi:“MI:0915”(physical association)	0.000
TMEM97	GPR152	psi-mi:“MI:0915”(physical association)	0.000
TIMMDC1	GPR152	psi-mi:“MI:0915”(physical association)	0.000
TMEM243	GPR152	psi-mi:“MI:0915”(physical association)	0.000
INSIG2	GPR152	psi-mi:“MI:0915”(physical association)	0.000
TMEM50B	GPR152	psi-mi:“MI:0915”(physical association)	0.000
SYT15	GPR152	psi-mi:“MI:0915”(physical association)	0.000
SACM1L	GPR152	psi-mi:“MI:0915”(physical association)	0.000
CYB561A3	GPR152	psi-mi:“MI:0915”(physical association)	0.000
GPR152	ABHD16A	psi-mi:“MI:0915”(physical association)	0.000
RABAC1	GPR152	psi-mi:“MI:0915”(physical association)	0.000
LHFPL2	GPR152	psi-mi:“MI:0915”(physical association)	0.000
CLEC17A	GPR152	psi-mi:“MI:0915”(physical association)	0.000
IGF2	GPR152	psi-mi:“MI:0915”(physical association)	0.000
BNIP2	GPR152	psi-mi:“MI:0915”(physical association)	0.000
SMCO4	GPR152	psi-mi:“MI:0915”(physical association)	0.000
YIPF1	GPR152	psi-mi:“MI:0915”(physical association)	0.000
GJB2	GPR152	psi-mi:“MI:0915”(physical association)	0.000
CCDC167	GPR152	psi-mi:“MI:0915”(physical association)	0.000
PTPRN	GPR152	psi-mi:“MI:0915”(physical association)	0.000
LTC4S	GPR152	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (199): GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid), GPR152 (Two-hybrid)

ESM2 similar proteins: A0A0R4IP11, O00421, O14931, O15218, O15533, O35457, O60883, O88186, P33076, P61484, P79621, Q16570, Q16671, Q17QD8, Q3U3F9, Q5BK54, Q5TJE4, Q61790, Q6PZD2, Q7TQP4, Q7TSN6, Q7Z7M1, Q80SS6, Q80T02, Q863H8, Q8BL07, Q8BXQ3, Q8BXS7, Q8IZF5, Q8K1T1, Q8MII8, Q8MJ02, Q8N386, Q8TDT2, Q8TDU6, Q8TDV2, Q95LF2, Q95LF3, Q95LF4, Q95LF5

Diamond homologs: A0A4W3GG95, A0A6I8PUB9, B2GV46, B5X337, D4A7K7, E7FEL0, E9QJ73, F8VQN3, O00270, O08726, O08858, O14842, O14843, O15529, O42179, O43603, O46685, O60755, O77408, O88410, O88626, O88634, O88853, P21109, P23944, P25024, P25025, P35344, P35383, P35414, P41231, P41232, P46092, P46093, P49652, P49682, P49683, P50132, P51675, P51679

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 157 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
vesicle fusion	5	22.5×	2e-03
cholesterol biosynthetic process	5	15.7×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	10
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

60 predictions. Top by Δscore:

Variant	Effect	Δscore
11:67451834:C:CT	acceptor_gain	0.5000
11:67452135:T:TA	donor_gain	0.5000
11:67452142:T:TA	donor_gain	0.4500
11:67451829:C:CC	acceptor_gain	0.4100
11:67451902:C:CA	donor_gain	0.4000
11:67452636:C:CT	donor_gain	0.3900
11:67451828:A:AC	acceptor_gain	0.3700
11:67451642:GTTCA:G	donor_loss	0.3600
11:67451643:TTCA:T	donor_loss	0.3600
11:67451644:TCACC:T	donor_loss	0.3600
11:67451645:CAC:C	donor_loss	0.3600
11:67451646:A:T	donor_loss	0.3600
11:67451647:C:A	donor_loss	0.3600
11:67451648:C:A	donor_loss	0.3600
11:67451928:T:TA	donor_gain	0.3600
11:67451929:C:A	donor_gain	0.3600
11:67452213:T:TG	acceptor_gain	0.3600
11:67451649:T:C	donor_loss	0.3500
11:67451650:GAGGC:G	acceptor_gain	0.3500
11:67451835:A:C	acceptor_gain	0.3500
11:67452637:C:CT	donor_gain	0.3500
11:67451901:T:TA	donor_gain	0.3400
11:67452214:C:A	acceptor_gain	0.3400
11:67451610:G:C	donor_gain	0.3300
11:67451641:GGTTC:G	donor_loss	0.3300
11:67452197:C:CT	donor_gain	0.3300
11:67451599:G:C	donor_gain	0.3100
11:67451832:GCCA:G	acceptor_gain	0.3000
11:67451834:C:T	acceptor_gain	0.3000
11:67451832:G:A	donor_gain	0.2900

AlphaMissense

2982 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:67452434:C:A	W97C	0.995
11:67452434:C:G	W97C	0.995
11:67452509:G:C	S72R	0.992
11:67452509:G:T	S72R	0.992
11:67452511:T:G	S72R	0.992
11:67452236:G:C	S163R	0.990
11:67452236:G:T	S163R	0.990
11:67452238:T:G	S163R	0.990
11:67452347:G:C	S126R	0.989
11:67452347:G:T	S126R	0.989
11:67452349:T:G	S126R	0.989
11:67452414:C:T	C104Y	0.987
11:67452179:G:C	C182W	0.985
11:67452180:C:T	C182Y	0.985
11:67452436:A:G	W97R	0.985
11:67452436:A:T	W97R	0.985
11:67452413:G:C	C104W	0.983
11:67452414:C:G	C104S	0.983
11:67452415:A:T	C104S	0.983
11:67452180:C:G	C182S	0.982
11:67452181:A:T	C182S	0.982
11:67452181:A:G	C182R	0.981
11:67452598:C:G	G43R	0.981
11:67452598:C:T	G43R	0.981
11:67452259:A:G	W156R	0.978
11:67452259:A:T	W156R	0.978
11:67451861:G:C	S288R	0.977
11:67451861:G:T	S288R	0.977
11:67451863:T:G	S288R	0.977
11:67452415:A:G	C104R	0.976

dbSNP variants (sampled 300 via entrez): RS1000829672 (11:67453427 C>A), RS1002268917 (11:67452439 G>A,C), RS1002333604 (11:67450885 G>A,C), RS1003199431 (11:67454310 C>T), RS1003504971 (11:67452192 T>C), RS1003935148 (11:67451335 C>A,T), RS1006422325 (11:67450908 C>T), RS1008631970 (11:67453682 T>A,G), RS1011028115 (11:67451064 CTGTG>C,CTG), RS1011176578 (11:67452944 C>G,T), RS1013205351 (11:67450850 G>A), RS1013487922 (11:67452393 C>T), RS1014073489 (11:67454505 G>A), RS1014542338 (11:67454293 G>A,C), RS1015129780 (11:67451159 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003810_1	Non-response to citalopram or escitalopram and depression	1.000000e-06
GCST010002_241	Refractive error	3.000000e-13

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523900 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Class A Orphans with no pharmacology

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	increases methylation	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4883421	Binding	PRESTO-Tango GPCRome screening (GPR152)	Data for DCP probe UCSF924

Cellosaurus cell lines

2 cell lines: 1 spontaneously immortalized cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_KX42	PathHunter CHO-K1 GPR152 beta-arrestin	Spontaneously immortalized cell line	Female
CVCL_KZ53	PathHunter HEK 293 GPR152 beta-arrestin	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.