GPR162

Summary

GPR162 (G protein-coupled receptor 162, HGNC:16693) is a protein-coding gene on chromosome 12p13, encoding Probable G-protein coupled receptor 162 (Q16538). Orphan receptor.

This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified.

Source: NCBI Gene 27239 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 103 total
• Druggable target: yes
• MANE Select transcript: NM_019858

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16693
Approved symbol	GPR162
Name	G protein-coupled receptor 162
Location	12p13
Locus type	gene with protein product
Status	Approved
Aliases	A-2, GRCA
Ensembl gene	ENSG00000250510
Ensembl biotype	protein_coding
Entrez	27239

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 6 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000311268, ENST00000382315, ENST00000428545, ENST00000535220, ENST00000541431, ENST00000542330, ENST00000545321, ENST00000856740, ENST00000956280

RefSeq mRNA: 2 — MANE Select: NM_019858 NM_014449, NM_019858

CCDS: CCDS44819, CCDS8563

Canonical transcript exons

ENST00000311268 — 5 exons

Exon	Start	End
ENSE00000866957	6823468	6824765
ENSE00002228461	6821821	6821900
ENSE00002322538	6826653	6827421
ENSE00003696761	6826196	6826353
ENSE00003699643	6825484	6825673

Expression profiles

Bgee: expression breadth ubiquitous, 195 present calls, max score 99.03.

FANTOM5 (CAGE): breadth broad, TPM avg 2.5419 / max 110.1714, expressed in 562 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123760	2.1565	495
123758	0.1889	92
123759	0.1583	82
123761	0.0382	9

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	99.03	gold quality
cerebellar hemisphere	UBERON:0002245	98.80	gold quality
cerebellar cortex	UBERON:0002129	98.67	gold quality
right frontal lobe	UBERON:0002810	98.10	gold quality
cerebellum	UBERON:0002037	96.90	gold quality
cingulate cortex	UBERON:0003027	96.57	gold quality
anterior cingulate cortex	UBERON:0009835	96.54	gold quality
prefrontal cortex	UBERON:0000451	95.98	gold quality
right uterine tube	UBERON:0001302	95.77	gold quality
Brodmann (1909) area 9	UBERON:0013540	95.71	gold quality
amygdala	UBERON:0001876	94.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	94.08	gold quality
neocortex	UBERON:0001950	93.36	gold quality
cortical plate	UBERON:0005343	93.20	gold quality
frontal cortex	UBERON:0001870	93.17	gold quality
adenohypophysis	UBERON:0002196	92.50	gold quality
nucleus accumbens	UBERON:0001882	92.44	gold quality
cerebral cortex	UBERON:0000956	91.56	gold quality
pituitary gland	UBERON:0000007	91.27	gold quality
caudate nucleus	UBERON:0001873	91.09	gold quality
telencephalon	UBERON:0001893	90.60	gold quality
brain	UBERON:0000955	90.46	gold quality
forebrain	UBERON:0001890	90.42	gold quality
central nervous system	UBERON:0001017	90.31	gold quality
Ammon’s horn	UBERON:0001954	90.13	gold quality
hypothalamus	UBERON:0001898	90.10	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.89	gold quality
paraflocculus	UBERON:0005351	89.78	gold quality
Brodmann (1909) area 10	UBERON:0013541	89.14	gold quality
putamen	UBERON:0001874	89.06	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.03
E-HCAD-13	no	2.91

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GATA1, GATA3

miRNA regulators (miRDB)

20 targeting GPR162, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-3614-5P	99.30	65.25	837
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-4279	99.19	66.70	2437
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-6871-5P	98.90	66.67	671
HSA-MIR-214-3P	98.71	68.12	2128
HSA-MIR-761	98.71	68.07	2051
HSA-MIR-499B-5P	98.35	68.39	988
HSA-MIR-3680-5P	98.06	66.20	394
HSA-MIR-1225-3P	97.29	64.60	876
HSA-MIR-3663-5P	97.01	64.84	713
HSA-MIR-6782-5P	96.45	64.42	612
HSA-MIR-4761-3P	96.27	66.26	524
HSA-MIR-3918	96.13	64.65	1300

Literature-anchored findings (GeneRIF, showing 1)

• Data show certain SNPs variants in GPR162 gene associated with impairments in glucose homeostasis in obese patients. (PMID:26827797)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gpr162	ENSMUSG00000038390
rattus_norvegicus	Gpr162	ENSRNOG00000016143

Paralogs (1): GPR153 (ENSG00000158292)

Protein

Protein identifiers

Probable G-protein coupled receptor 162 — Q16538 (reviewed: Q16538)

Alternative names: Gene-rich cluster gene A protein

All UniProt accessions (4): A0A0I9QPQ8, J3KPJ9, Q16538, U3KQI6

UniProt curated annotations — full annotation on UniProt →

Function. Orphan receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q16538-1	1, A-2	yes
Q16538-2	2, A-1

RefSeq proteins (2): NP_055264, NP_062832* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR022347	GCR_153/162	Family
IPR022348	GPR162	Family

Pfam: PF00001

UniProt features (25 total): topological domain 8, transmembrane region 7, region of interest 2, modified residue 2, splice variant 2, chain 1, compositionally biased region 1, glycosylation site 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q16538-F1	64.46	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 413, 435

Glycosylation sites (1): 86

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 116 (showing top): RNGTGGGC_UNKNOWN, MYOGENIN_Q6, GCANCTGNY_MYOD_Q6, AP4_Q6, TGACCTY_ERR1_Q2, GGGTGGRR_PAX4_03, CAGCTG_AP4_Q5, EFC_Q6, SRF_Q5_01, IRF7_01, MYOD_01, ROZANOV_MMP14_TARGETS_UP, SMID_BREAST_CANCER_LUMINAL_B_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, TGACATY_UNKNOWN

GO Biological Process (2): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1986 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GPR162	GPR26	Q8NDV2	653
GPR162	GPR68	Q15743	575
GPR162	GPR150	Q8NGU9	571
GPR162	GPR82	Q96P67	560
GPR162	GPR62	Q9BZJ7	557
GPR162	GPR148	Q8TDV2	526
GPR162	GPR146	Q96CH1	523
GPR162	GPR139	Q6DWJ6	519
GPR162	ADGRA1	Q86SQ6	510
GPR162	TMEM221	A6NGB7	509
GPR162	GPR152	Q8TDT2	507
GPR162	FAM162B	Q5T6X4	491
GPR162	LPAR1	P78351	482
GPR162	TMEM167A	Q8TBQ9	480
GPR162	RIMBP3C	A6NJZ7	473

IntAct

8 interactions, top by confidence:

A	B	Type	Score
GPR162	UBQLN1	psi-mi:“MI:0915”(physical association)	0.560
GPR162	UBQLN2	psi-mi:“MI:0915”(physical association)	0.560
GPR162	SHANK3	psi-mi:“MI:0915”(physical association)	0.370
GPR162	UBQLN1	psi-mi:“MI:0915”(physical association)	0.000
GPR162	UBQLN2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (5): GPR162 (Two-hybrid), GPR162 (Two-hybrid), GPR162 (Affinity Capture-RNA), GPR162 (Two-hybrid), GPR162 (Negative Genetic)

ESM2 similar proteins: A0A2R9YJI3, A3KFU9, A6QLU6, B2ZHY2, B4XF06, D3Z7H4, D3ZK93, D4A6L0, E1BBQ2, O43194, O75204, P51810, P70259, P82352, Q14714, Q16538, Q17QQ5, Q2T9K0, Q3UN16, Q49LS8, Q4V922, Q5E9H8, Q5MNU5, Q5T848, Q5U431, Q62147, Q6NV75, Q6PI62, Q6UXU4, Q7RTS5, Q7TQN9, Q80ZU9, Q86SQ6, Q8BGE9, Q8BGP5, Q8C419, Q8C4G9, Q8K0Z9, Q8NBV4, Q8VHW3

Diamond homologs: Q16538, Q3UN16, Q6NV75, Q8K0Z9, P31389, P70174, P31390

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

103 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	93
Likely benign	1
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1409 predictions. Top by Δscore:

Variant	Effect	Δscore
12:6825658:G:GT	donor_gain	1.0000
12:6825661:G:GT	donor_gain	1.0000
12:6825681:G:GT	donor_gain	1.0000
12:6825684:GGGC:G	donor_gain	1.0000
12:6826193:TA:T	acceptor_loss	1.0000
12:6826194:A:AG	acceptor_gain	1.0000
12:6826194:AGAT:A	acceptor_gain	1.0000
12:6826194:AGATG:A	acceptor_gain	1.0000
12:6826195:G:GA	acceptor_gain	1.0000
12:6826195:GA:G	acceptor_gain	1.0000
12:6826195:GAT:G	acceptor_gain	1.0000
12:6826195:GATG:G	acceptor_gain	1.0000
12:6826195:GATGG:G	acceptor_gain	1.0000
12:6826349:TACAG:T	donor_loss	1.0000
12:6826350:ACAG:A	donor_loss	1.0000
12:6826351:CAGG:C	donor_loss	1.0000
12:6826352:AGGTA:A	donor_loss	1.0000
12:6826353:GG:G	donor_loss	1.0000
12:6826354:GT:G	donor_loss	1.0000
12:6826355:T:A	donor_loss	1.0000
12:6829848:C:CA	acceptor_gain	1.0000
12:6829855:TCA:T	acceptor_loss	1.0000
12:6829857:A:AG	acceptor_gain	1.0000
12:6829857:AGTT:A	acceptor_gain	1.0000
12:6829858:G:GT	acceptor_gain	1.0000
12:6829858:GT:G	acceptor_gain	1.0000
12:6829858:GTT:G	acceptor_gain	1.0000
12:6829858:GTTG:G	acceptor_gain	1.0000
12:6829858:GTTGA:G	acceptor_gain	1.0000
12:6829943:GC:G	donor_gain	1.0000

AlphaMissense

3740 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:6824095:C:A	P66H	1.000
12:6824095:C:G	P66R	1.000
12:6824151:T:A	W85R	1.000
12:6824151:T:C	W85R	1.000
12:6824153:G:C	W85C	1.000
12:6824153:G:T	W85C	1.000
12:6824166:T:A	C90S	1.000
12:6824166:T:C	C90R	1.000
12:6824167:G:A	C90Y	1.000
12:6824167:G:C	C90S	1.000
12:6824167:G:T	C90F	1.000
12:6824168:C:G	C90W	1.000
12:6824171:G:C	K91N	1.000
12:6824171:G:T	K91N	1.000
12:6824175:T:C	F93L	1.000
12:6824177:C:A	F93L	1.000
12:6824177:C:G	F93L	1.000
12:6824322:T:A	W142R	1.000
12:6824322:T:C	W142R	1.000
12:6824331:A:C	S145R	1.000
12:6824333:C:A	S145R	1.000
12:6824333:C:G	S145R	1.000
12:6824341:T:A	L148H	1.000
12:6824352:C:A	P152T	1.000
12:6824352:C:T	P152S	1.000
12:6824353:C:A	P152H	1.000
12:6824353:C:G	P152R	1.000
12:6824353:C:T	P152L	1.000
12:6824362:G:A	G155D	1.000
12:6824364:T:A	W156R	1.000

dbSNP variants (sampled 300 via entrez): RS1000128122 (12:6821419 A>C), RS1000506439 (12:6825330 G>A), RS1000577100 (12:6826327 C>T), RS1001516582 (12:6821496 A>G), RS1001850396 (12:6820075 G>A), RS1002121747 (12:6826114 T>C), RS1002523018 (12:6822528 G>A), RS1002596567 (12:6822866 C>A), RS1002774305 (12:6827749 A>G), RS1003215409 (12:6827561 G>A), RS1004124925 (12:6823460 C>G), RS1004537150 (12:6823163 G>T), RS1004644248 (12:6827019 C>G,T), RS1006647429 (12:6825018 G>A), RS1006877083 (12:6824939 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523871 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Class A Orphans with emerging pharmacology

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	decreases expression, increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation, increases expression	2
Particulate Matter	increases abundance, affects cotreatment, decreases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
beta-methylcholine	affects expression	1
pentanal	increases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
bisphenol S	decreases methylation	1
theaflavin-3,3’-digallate	affects expression	1
Decitabine	decreases expression, affects reaction	1
Acetaminophen	decreases expression	1
Ethanol	affects cotreatment, decreases expression, increases abundance	1
Estradiol	affects cotreatment, decreases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Lead	affects expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
Smoke	increases abundance, increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Aflatoxin B1	decreases methylation	1
1-Butanol	increases abundance, affects cotreatment, decreases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4883428	Binding	PRESTO-Tango GPCRome screening (GPR162)	Data for DCP probe UCSF924

Cellosaurus cell lines

1 cell lines: 1 spontaneously immortalized cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_KX45	PathHunter CHO-K1 GPR162 beta-arrestin	Spontaneously immortalized cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.