GPR180

Summary

GPR180 (G protein-coupled receptor 180, HGNC:28899) is a protein-coding gene on chromosome 13q32.1, encoding Integral membrane protein GPR180 (Q86V85).

This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling.

Source: NCBI Gene 160897 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 62 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_180989

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28899
Approved symbol	GPR180
Name	G protein-coupled receptor 180
Location	13q32.1
Locus type	gene with protein product
Status	Approved
Aliases	ITR
Ensembl gene	ENSG00000152749
Ensembl biotype	protein_coding
OMIM	607787
Entrez	160897

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000376958, ENST00000884206, ENST00000936762, ENST00000954032

RefSeq mRNA: 1 — MANE Select: NM_180989 NM_180989

CCDS: CCDS9472

Canonical transcript exons

ENST00000376958 — 9 exons

Exon	Start	End
ENSE00001006910	94619150	94619330
ENSE00001101639	94621078	94621235
ENSE00001101655	94623109	94623300
ENSE00001101657	94605391	94605549
ENSE00001101662	94625966	94626043
ENSE00001248743	94619468	94619517
ENSE00001295332	94612190	94612390
ENSE00001472245	94627013	94634661
ENSE00001472278	94601857	94602072

Expression profiles

Bgee: expression breadth ubiquitous, 216 present calls, max score 99.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.9681 / max 119.9135, expressed in 1771 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
135672	13.3309	1767
135671	0.6372	363

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	99.53	gold quality
epithelial cell of pancreas	CL:0000083	91.14	silver quality
oviduct epithelium	UBERON:0004804	87.53	gold quality
pigmented layer of retina	UBERON:0001782	83.75	gold quality
endothelial cell	CL:0000115	81.73	silver quality
tibia	UBERON:0000979	81.54	gold quality
islet of Langerhans	UBERON:0000006	80.09	gold quality
Brodmann (1909) area 23	UBERON:0013554	79.67	gold quality
germinal epithelium of ovary	UBERON:0001304	77.63	gold quality
epithelium of nasopharynx	UBERON:0001951	77.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.37	gold quality
stromal cell of endometrium	CL:0002255	77.06	gold quality
middle temporal gyrus	UBERON:0002771	76.73	gold quality
primary visual cortex	UBERON:0002436	76.42	gold quality
calcaneal tendon	UBERON:0003701	75.37	gold quality
ventricular zone	UBERON:0003053	74.55	gold quality
pancreas	UBERON:0001264	74.27	gold quality
pancreatic ductal cell	CL:0002079	73.96	silver quality
prefrontal cortex	UBERON:0000451	73.80	gold quality
parietal pleura	UBERON:0002400	73.78	gold quality
ileal mucosa	UBERON:0000331	73.20	gold quality
amniotic fluid	UBERON:0000173	72.99	gold quality
smooth muscle tissue	UBERON:0001135	72.92	gold quality
adipose tissue	UBERON:0001013	72.42	gold quality
cartilage tissue	UBERON:0002418	72.39	gold quality
cerebellar cortex	UBERON:0002129	72.36	gold quality
cerebellar hemisphere	UBERON:0002245	72.32	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.25	gold quality
endometrium	UBERON:0001295	72.14	gold quality
right lobe of liver	UBERON:0001114	72.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.03

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

329 targeting GPR180, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3162-3P	100.00	65.37	363
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-4455	100.00	65.48	1587
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-3646	100.00	73.56	5283
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-6833-3P	100.00	70.63	3197

Literature-anchored findings (GeneRIF, showing 5)

• 22 SNPs were isolated from the ITR locus by systematically screening genomic DNA from 48 healthy Japanese individuals (PMID:12730718)
• A null GPR180 mutation segregates over two generations with iridocorneal angle dysgenesis, consistent with the view that deletions of this gene are the cause of MCOR. (PMID:25772937)
• Microcoria due to first duplication of 13q32.1 including the GPR180 gene and maternal mosaicism. (PMID:32200002)
• GPR180 is a component of TGFbeta signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1. (PMID:34880217)
• Lack of GPR180 ameliorates hepatic lipid depot via downregulation of mTORC1 signaling. (PMID:36726016)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	GPR180	ENSDARG00000099851
mus_musculus	Gpr180	ENSMUSG00000022131
rattus_norvegicus	Gpr180	ENSRNOG00000009766
drosophila_melanogaster	CG9304	FBGN0034674
caenorhabditis_elegans		WBGENE00011441

Paralogs (1): TMEM145 (ENSG00000167619)

Protein

Protein identifiers

Integral membrane protein GPR180 — Q86V85 (reviewed: Q86V85)

Alternative names: Intimal thickness-related receptor

All UniProt accessions (1): Q86V85

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

RefSeq proteins (1): NP_851320* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019336	GPR180/TMEM145_TM	Domain
IPR047831	GPR180/TMEM145	Family
IPR053880	GPR180-like_N	Domain

Pfam: PF10192, PF21870

UniProt features (12 total): transmembrane region 7, glycosylation site 2, signal peptide 1, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86V85-F1	81.16	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 110, 105

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 168 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_UP, GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_RESPONSE_TO_FOOD, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, CATTTCA_MIR203, GOBP_LIPID_METABOLIC_PROCESS, GOBP_FAT_CELL_DIFFERENTIATION, FISCHER_DREAM_TARGETS, CAAGGAT_MIR362, CTTTGTA_MIR524, IVANOVA_HEMATOPOIESIS_INTERMEDIATE_PROGENITOR, XU_GH1_AUTOCRINE_TARGETS_DN, chr13q32, XU_GH1_EXOGENOUS_TARGETS_DN

GO Biological Process (7): generation of precursor metabolites and energy (GO:0006091), lipid metabolic process (GO:0006629), G protein-coupled receptor signaling pathway (GO:0007186), gene expression (GO:0010467), response to pheromone (GO:0019236), response to food (GO:0032094), fat cell differentiation (GO:0045444)

GO Molecular Function (0):

GO Cellular Component (1): membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
response to chemical	2
metabolic process	1
primary metabolic process	1
G protein-coupled receptor activity	1
signal transduction	1
macromolecule biosynthetic process	1
response to nutrient levels	1
cell differentiation	1
cellular anatomical structure	1

Protein interactions and networks

STRING

338 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GPR180	TGDS	O95455	671
GPR180	RHO	P08100	530
GPR180	OCIAD2	Q56VL3	448
GPR180	PARP6	Q2NL67	418
GPR180	GPR107	Q5VW38	388
GPR180	SOX21	P35715	378
GPR180	ABCC4	O15439	356
GPR180	GPRC5C	Q9NQ84	344
GPR180	GPR50	Q13585	330
GPR180	SMIM13	P0DJ93	325
GPR180	PPP1R12C	Q9BZL4	321
GPR180	RNF113B	Q8IZP6	320
GPR180	HS6ST3	Q8IZP7	316
GPR180	GPR176	Q14439	315
GPR180	GPR137B	O60478	301

IntAct

41 interactions, top by confidence:

A	B	Type	Score
SGCA	GPR180	psi-mi:“MI:0914”(association)	0.530
CD40	EXOC5	psi-mi:“MI:0914”(association)	0.530
TMEM63A	AP3D1	psi-mi:“MI:0914”(association)	0.530
CCR6	PODXL	psi-mi:“MI:0914”(association)	0.530
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
GPC1	SNAP23	psi-mi:“MI:0915”(physical association)	0.400
GPC1	GANAB	psi-mi:“MI:0915”(physical association)	0.400
SGCA	ACP2	psi-mi:“MI:0914”(association)	0.350
SPPL2B	GPR89A	psi-mi:“MI:0914”(association)	0.350
FFAR1	SLC12A8	psi-mi:“MI:0914”(association)	0.350
OSBPL8	ESYT2	psi-mi:“MI:0914”(association)	0.350
ENTPD7	TMEM120B	psi-mi:“MI:0914”(association)	0.350
SGCA	TMEM131L	psi-mi:“MI:0914”(association)	0.350
ATP2A3	UBXN8	psi-mi:“MI:0914”(association)	0.350
SPPL2B	HAS3	psi-mi:“MI:0914”(association)	0.350
P2RY1	EI24	psi-mi:“MI:0914”(association)	0.350
LPAR2	EI24	psi-mi:“MI:0914”(association)	0.350
TPST2	NDC80	psi-mi:“MI:0914”(association)	0.350
S1PR1	TNPO2	psi-mi:“MI:0914”(association)	0.350
FPR2	SCAMP3	psi-mi:“MI:0914”(association)	0.350
ENTPD2	CLGN	psi-mi:“MI:0914”(association)	0.350
S1PR4	NPC1	psi-mi:“MI:0914”(association)	0.350
APLNR	TTI1	psi-mi:“MI:0914”(association)	0.350
CCR9	ABCC4	psi-mi:“MI:0914”(association)	0.350
CD40	IPO5	psi-mi:“MI:0914”(association)	0.350
CXCR3	RIMOC1	psi-mi:“MI:0914”(association)	0.350
S1PR3	STXBP3	psi-mi:“MI:0914”(association)	0.350
MFSD5	ILVBL	psi-mi:“MI:0914”(association)	0.350
SLC15A3	GXYLT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (45): CLU (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Proximity Label-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS), GPR180 (Affinity Capture-MS)

ESM2 similar proteins: A0JPH4, A7MBC7, D3ZWZ9, F1M8G0, F1QFU0, F4JTN2, O14524, P0C152, P49653, Q08DA4, Q0IJ20, Q148L1, Q28EW0, Q3TPR7, Q4V8X0, Q5HYA8, Q5M7W4, Q5R9R1, Q5RDB4, Q5RH73, Q5U308, Q5VW38, Q5ZKN3, Q6AXF6, Q6P6V6, Q6Q3F5, Q6ZQE4, Q7L1W4, Q7ZYA0, Q86V85, Q8BGR2, Q8BKU8, Q8BPS4, Q8BR76, Q8BUV8, Q8BXN9, Q8CB19, Q8N3S3, Q8NBN3, Q8R4P4

Diamond homologs: Q5FWM8, Q86V85, Q8BPS4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 63 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Lysosphingolipid and LPA receptors	5	88.5×	4e-07
Class A/1 (Rhodopsin-like receptors)	8	13.8×	1e-05
GPCR ligand binding	8	11.9×	2e-05
G alpha (i) signalling events	9	8.2×	6e-05
Signaling by GPCR	8	7.5×	4e-04
GPCR downstream signalling	7	7.1×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	6	22.3×	4e-05
positive regulation of cytosolic calcium ion concentration	9	17.9×	8e-07
transport across blood-brain barrier	5	15.2×	2e-03
chemotaxis	5	11.5×	4e-03
adenylate cyclase-activating G protein-coupled receptor signaling pathway	6	11.5×	2e-03
phospholipase C-activating G protein-coupled receptor signaling pathway	5	11.2×	4e-03
G protein-coupled receptor signaling pathway	12	7.4×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

62 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	39
Likely benign	6
Benign	6

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
989396	Single allele	Pathogenic

SpliceAI

1659 predictions. Top by Δscore:

Variant	Effect	Δscore
13:94612307:TGG:T	donor_gain	1.0000
13:94623107:A:AG	acceptor_gain	1.0000
13:94623107:AGAGT:A	acceptor_gain	1.0000
13:94623108:G:GG	acceptor_gain	1.0000
13:94623108:GA:G	acceptor_gain	1.0000
13:94623108:GAGT:G	acceptor_gain	1.0000
13:94623108:GAGTG:G	acceptor_gain	1.0000
13:94623260:G:GT	donor_gain	1.0000
13:94623276:G:GT	donor_gain	1.0000
13:94623276:G:T	donor_gain	1.0000
13:94623277:G:T	donor_gain	1.0000
13:94623301:G:GG	donor_gain	1.0000
13:94623313:A:T	donor_gain	1.0000
13:94625960:TTTCA:T	acceptor_loss	1.0000
13:94625961:TTCA:T	acceptor_loss	1.0000
13:94625962:TCA:T	acceptor_loss	1.0000
13:94625963:CAG:C	acceptor_loss	1.0000
13:94625964:A:AG	acceptor_gain	1.0000
13:94625964:AG:A	acceptor_gain	1.0000
13:94625964:AGG:A	acceptor_gain	1.0000
13:94625965:G:A	acceptor_loss	1.0000
13:94625965:G:GT	acceptor_gain	1.0000
13:94625965:GG:G	acceptor_gain	1.0000
13:94625965:GGG:G	acceptor_gain	1.0000
13:94625965:GGGC:G	acceptor_gain	1.0000
13:94625965:GGGCT:G	acceptor_gain	1.0000
13:94626040:CAAGG:C	donor_loss	1.0000
13:94626041:AAGGT:A	donor_loss	1.0000
13:94626042:AGGTA:A	donor_loss	1.0000
13:94626043:GGT:G	donor_loss	1.0000

AlphaMissense

2899 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:94623280:T:C	F356L	0.997
13:94623282:C:A	F356L	0.997
13:94623282:C:G	F356L	0.997
13:94627096:G:C	W416C	0.995
13:94627096:G:T	W416C	0.995
13:94625978:T:A	W367R	0.993
13:94625978:T:C	W367R	0.993
13:94627094:T:A	W416R	0.993
13:94627094:T:C	W416R	0.993
13:94627085:A:C	S413R	0.991
13:94627087:T:A	S413R	0.991
13:94627087:T:G	S413R	0.991
13:94623262:A:C	S350R	0.990
13:94623264:T:A	S350R	0.990
13:94623264:T:G	S350R	0.990
13:94623273:A:C	K353N	0.989
13:94623273:A:T	K353N	0.989
13:94623281:T:C	F356S	0.989
13:94602066:T:C	F47L	0.988
13:94602068:C:A	F47L	0.988
13:94602068:C:G	F47L	0.988
13:94625969:T:C	C364R	0.988
13:94627103:T:C	S419P	0.988
13:94621122:A:C	S261R	0.987
13:94621124:T:A	S261R	0.987
13:94621124:T:G	S261R	0.987
13:94623109:A:C	S299R	0.987
13:94623111:T:A	S299R	0.987
13:94623111:T:G	S299R	0.987
13:94627071:T:C	L408P	0.987

dbSNP variants (sampled 300 via entrez): RS1000087597 (13:94634717 CT>C), RS1000087898 (13:94633134 A>G), RS1000282830 (13:94620997 AAAAG>A), RS1000521783 (13:94634348 A>G), RS1000743337 (13:94601877 C>A,G,T), RS1000819351 (13:94629815 T>C), RS1000948503 (13:94604339 T>A), RS1001147982 (13:94621281 G>A,T), RS1001251834 (13:94608136 A>G), RS1001343202 (13:94615893 G>C), RS1001358574 (13:94601289 T>A,C,G), RS1001417146 (13:94609528 G>T), RS1001419330 (13:94628713 G>C), RS1001590726 (13:94632679 T>C), RS1001626450 (13:94612578 G>A,C)

Disease associations

OMIM: gene MIM:607787 | disease phenotypes: MIM:156600

GenCC curated gene-disease

Mondo (1): congenital microcoria (MONDO:0007989)

Orphanet (1): Congenital microcoria (Orphanet:566)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST003815_29	Late-onset Alzheimer’s disease	6.000000e-06
GCST004237_21	Triglyceride levels	3.000000e-08
GCST006016_25	Serum alkaline phosphatase levels	2.000000e-08
GCST010173_123	Triglyceride levels	3.000000e-11
GCST010241_299	Apolipoprotein A1 levels	1.000000e-08
GCST010244_323	Triglyceride levels	2.000000e-14
GCST011353_19	Serum alkaline phosphatase levels	7.000000e-14
GCST012501_5	Achilles tendon injury	3.000000e-08
GCST90011900_108	Serum alkaline phosphatase levels	2.000000e-52

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:1001870	late-onset Alzheimers disease
EFO:0004530	triglyceride measurement
EFO:0004533	alkaline phosphatase measurement
EFO:0004614	apolipoprotein A 1 measurement
EFO:0600078	Achilles tendon injury

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C537550	Microcoria, congenital (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066399 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.55	Kd	284.5	nM	CHEMBL5653589
6.50	ED50	317.4	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148456: Binding affinity to human GPR180 incubated for 45 mins by Kinobead based pull down assay	kd	0.2845	uM

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
perfluorooctane sulfonic acid	increases expression, decreases expression	2
Benzo(a)pyrene	decreases expression, affects methylation	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
butyraldehyde	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	decreases expression, increases response to substance	1
jinfukang	decreases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Vorinostat	increases expression	1
Arsenic	affects methylation	1
Demecolcine	decreases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	decreases expression	1
Formaldehyde	decreases expression	1
Naled	affects expression	1
Valproic Acid	decreases expression	1
Vincristine	decreases expression	1
Aflatoxin B1	decreases expression	1
Aflatoxin M1	decreases expression	1
Antirheumatic Agents	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651498	Binding	Binding affinity to human GPR180 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.