GPR37L1

Summary

GPR37L1 (G protein-coupled receptor 37 like 1, HGNC:14923) is a protein-coding gene on chromosome 1q32.1, encoding G-protein coupled receptor 37-like 1 (O60883). G-protein coupled receptor.

Enables G protein-coupled peptide receptor activity; peptide binding activity; and prosaposin receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and positive regulation of MAPK cascade. Located in plasma membrane. Part of receptor complex.

Source: NCBI Gene 9283 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 80 total
• Druggable target: yes
• MANE Select transcript: NM_004767

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14923
Approved symbol	GPR37L1
Name	G protein-coupled receptor 37 like 1
Location	1q32.1
Locus type	gene with protein product
Status	Approved
Aliases	ETBR-LP-2
Ensembl gene	ENSG00000170075
Ensembl biotype	protein_coding
OMIM	617630
Entrez	9283

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000367282, ENST00000682422, ENST00000682545, ENST00000682887, ENST00000683302, ENST00000683457, ENST00000683557

RefSeq mRNA: 1 — MANE Select: NM_004767 NM_004767

CCDS: CCDS1420

Canonical transcript exons

ENST00000367282 — 2 exons

Exon	Start	End
ENSE00001444058	202127741	202133592
ENSE00001444059	202122917	202123593

Expression profiles

Bgee: expression breadth ubiquitous, 146 present calls, max score 92.05.

FANTOM5 (CAGE): breadth broad, TPM avg 8.2464 / max 421.1318, expressed in 229 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
7781	6.0121	183
7780	1.0901	98
7779	0.3883	86
7782	0.3871	82
7778	0.3688	87

Top tissues by expression

271 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	92.05	silver quality
caudate nucleus	UBERON:0001873	91.16	gold quality
medial globus pallidus	UBERON:0002477	90.79	gold quality
amygdala	UBERON:0001876	90.28	gold quality
putamen	UBERON:0001874	89.94	gold quality
right frontal lobe	UBERON:0002810	89.70	gold quality
nucleus accumbens	UBERON:0001882	89.53	gold quality
endothelial cell	CL:0000115	89.16	gold quality
globus pallidus	UBERON:0001875	88.52	gold quality
primary visual cortex	UBERON:0002436	86.96	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	86.81	gold quality
cingulate cortex	UBERON:0003027	86.32	gold quality
anterior cingulate cortex	UBERON:0009835	86.17	gold quality
temporal lobe	UBERON:0001871	86.14	gold quality
right hemisphere of cerebellum	UBERON:0014890	86.04	gold quality
Brodmann (1909) area 9	UBERON:0013540	86.02	gold quality
lateral globus pallidus	UBERON:0002476	85.40	gold quality
Ammon’s horn	UBERON:0001954	85.19	gold quality
telencephalon	UBERON:0001893	85.01	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	84.97	gold quality
spinal cord	UBERON:0002240	84.89	gold quality
substantia nigra	UBERON:0002038	84.83	gold quality
prefrontal cortex	UBERON:0000451	84.76	gold quality
hypothalamus	UBERON:0001898	84.57	gold quality
frontal cortex	UBERON:0001870	84.26	gold quality
neocortex	UBERON:0001950	83.81	gold quality
cerebral cortex	UBERON:0000956	83.30	gold quality
midbrain	UBERON:0001891	83.14	gold quality
cerebellar cortex	UBERON:0002129	82.73	gold quality
cerebellar hemisphere	UBERON:0002245	82.70	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-84465	yes	25.55
E-ANND-3	yes	2.89
E-MTAB-6386	no	3.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

34 targeting GPR37L1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-513C-5P	99.50	68.42	1730
HSA-MIR-514B-5P	99.50	68.19	1766
HSA-MIR-4696	99.48	67.48	1040
HSA-MIR-196A-3P	99.19	67.34	1204
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-4695-5P	99.06	64.87	1151
HSA-MIR-5701	98.97	69.54	1502
HSA-MIR-4742-5P	98.89	68.41	1542
HSA-MIR-5197-3P	98.71	67.05	1905
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-4266	98.53	67.29	1035
HSA-MIR-6780A-3P	98.42	67.49	1518
HSA-MIR-4521	97.73	67.64	684
HSA-MIR-6791-3P	97.45	64.31	1123
HSA-MIR-6829-3P	97.45	64.31	1137

Literature-anchored findings (GeneRIF, showing 9)

• GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. (PMID:23690594)
• These findings provide evidence linking GPR37L1 and GPR37 to seizure etiology and demonstrate an association between a homozygous variant in GPR37L1 (c.1047G>T [Lys349Asn]) and a novel progressive myoclonus epilepsy. (PMID:28688853)
• Cross-correlation, indicating interaction between GPR37L1 and the short isoform of D2R, was also detected. (PMID:30423289)
• The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases. (PMID:33203955)
• Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins. (PMID:34100078)
• Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology. (PMID:34533400)
• G Protein-Coupled Receptor 37L1 Modulates Epigenetic Changes in Human Renal Proximal Tubule Cells. (PMID:36430934)
• Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis. (PMID:38530364)
• Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine. (PMID:38569927)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	gpr37l1a	ENSDARG00000006079
danio_rerio	gpr37l1b	ENSDARG00000056774
mus_musculus	Gpr37l1	ENSMUSG00000026424
rattus_norvegicus	Gpr37l1	ENSRNOG00000006237
caenorhabditis_elegans		WBGENE00019224

Paralogs (15): NTSR1 (ENSG00000101188), BRS3 (ENSG00000102239), MLNR (ENSG00000102539), GHSR (ENSG00000121853), GRPR (ENSG00000126010), NMUR2 (ENSG00000132911), NMBR (ENSG00000135577), EDNRB (ENSG00000136160), EDNRA (ENSG00000151617), NTSR2 (ENSG00000169006), GPR37 (ENSG00000170775), NMUR1 (ENSG00000171596), GPR148 (ENSG00000173302), TRHR (ENSG00000174417), GPR39 (ENSG00000183840)

Protein

Protein identifiers

G-protein coupled receptor 37-like 1 — O60883 (reviewed: O60883)

Alternative names: Endothelin B receptor-like protein 2

All UniProt accessions (5): O60883, A0A804HI82, A0A804HKD8, A0A804HKQ6, A0A804HLL0

UniProt curated annotations — full annotation on UniProt →

Function. G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. Regulates baseline blood pressure in females and protects against cardiovascular stress in males. Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity.

Subunit / interactions. Interacts with the PTCH1 receptor.

Subcellular location. Cell membrane. Cell projection. Cilium membrane.

Tissue specificity. Expressed in primary cortical astrocytes (at protein level). Expressed in the central nervous system.

Post-translational modifications. O-glycosylated. Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity. Ubiquitinated.

Domain organisation. The N-terminal region is required for constitutive signal transduction.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_004758* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR003909	GPR37_orph	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF00001

UniProt features (34 total): topological domain 8, transmembrane region 7, glycosylation site 6, sequence variant 4, region of interest 2, modified residue 2, sequence conflict 2, signal peptide 1, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O60883-F1	67.95	0.19

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 471, 479

Disulfide bonds (1): 203–286

Glycosylation sites (6): 79, 85, 86, 95, 105, 107

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-375276	Peptide ligand-binding receptors
R-HSA-418594	G alpha (i) signalling events

MSigDB gene sets: 137 (showing top): GOBP_HINDBRAIN_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION, MYOGENIN_Q6, GOBP_REGULATION_OF_BLOOD_PRESSURE, PAX4_01, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_NEGATIVE_REGULATION_OF_GLIOGENESIS, GCANCTGNY_MYOD_Q6, GOBP_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION, GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE, GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE, GOBP_NEUROGENESIS, GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND

GO Biological Process (12): negative regulation of systemic arterial blood pressure (GO:0003085), adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (GO:0007193), smoothened signaling pathway (GO:0007224), positive regulation of cerebellar granule cell precursor proliferation (GO:0021940), cellular response to reactive oxygen species (GO:0034614), positive regulation of MAPK cascade (GO:0043410), negative regulation of neuron differentiation (GO:0045665), negative regulation of smoothened signaling pathway (GO:0045879), negative regulation of astrocyte differentiation (GO:0048712), Bergmann glial cell differentiation (GO:0060020), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (5): G protein-coupled receptor activity (GO:0004930), G protein-coupled peptide receptor activity (GO:0008528), prosaposin receptor activity (GO:0036505), peptide binding (GO:0042277), protein binding (GO:0005515)

GO Cellular Component (5): plasma membrane (GO:0005886), membrane (GO:0016020), signaling receptor complex (GO:0043235), ciliary membrane (GO:0060170), cell projection (GO:0042995)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Class A/1 (Rhodopsin-like receptors)	1
GPCR downstream signalling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	3
astrocyte differentiation	2
binding	2
cellular anatomical structure	2
regulation of systemic arterial blood pressure	1
negative regulation of blood pressure	1
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	1
adenylate cyclase inhibitor activity	1
cell surface receptor signaling pathway	1
cerebellar granule cell precursor proliferation	1
regulation of cerebellar granule cell precursor proliferation	1
positive regulation of neural precursor cell proliferation	1
response to reactive oxygen species	1
cellular response to oxidative stress	1
cellular response to oxygen-containing compound	1
MAPK cascade	1
regulation of MAPK cascade	1
positive regulation of intracellular signal transduction	1
neuron differentiation	1
negative regulation of cell differentiation	1
regulation of neuron differentiation	1
smoothened signaling pathway	1
regulation of smoothened signaling pathway	1
negative regulation of signal transduction	1
negative regulation of glial cell differentiation	1
regulation of astrocyte differentiation	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
signal transduction	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
peptide receptor activity	1
membrane	1
cell periphery	1
protein-containing complex	1
cilium	1
cell projection membrane	1

Protein interactions and networks

STRING

1107 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GPR37L1	PSAP	P07292	868
GPR37L1	HEPACAM	Q14CZ8	520
GPR37L1	GRM8	O00222	511
GPR37L1	PTPRZ1	P23471	497
GPR37L1	BDKRB1	P46663	494
GPR37L1	BDKRB2	P30411	470
GPR37L1	HTR2A	P28223	425
GPR37L1	HTR5A	P47898	419
GPR37L1	NTRK2	Q16620	413
GPR37L1	GPR37	O15354	410
GPR37L1	IQCE	Q6IPM2	391
GPR37L1	NACC2	Q96BF6	379
GPR37L1	FGFR3	P22607	364
GPR37L1	TOM1L1	O75674	362
GPR37L1	SFXN5	Q8TD22	361
GPR37L1	DRAM2	Q6UX65	361

IntAct

164 interactions, top by confidence:

A	B	Type	Score
JAGN1	GPR37L1	psi-mi:“MI:0915”(physical association)	0.560
TMEM147	GPR37L1	psi-mi:“MI:0915”(physical association)	0.560
FXYD3	GPR37L1	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	FFAR2	psi-mi:“MI:0915”(physical association)	0.560
TMEM54	GPR37L1	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	CLEC2A	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	STOM	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	PDCD1LG2	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	AQP1	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	RPRM	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	TMEM52B	psi-mi:“MI:0915”(physical association)	0.560
ADGRB3	GPR37L1	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	TMEM54	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	TMEM97	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	TMEM86A	psi-mi:“MI:0915”(physical association)	0.560
GPR42	GPR37L1	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	ERG28	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	UPK1B	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	FAM209A	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	ARL13B	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	CLDN7	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	JAGN1	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	SEC22A	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	RNF122	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	INSIG2	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	GPX8	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (57): GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid), GPR37L1 (Two-hybrid)

ESM2 similar proteins: A2BGS3, A6NGA9, E7F594, O36364, O60478, O60883, O95800, O95838, P03208, P16849, P31389, P34590, P35367, P49219, Q03613, Q09351, Q09964, Q09965, Q14439, Q16950, Q16951, Q2KI97, Q3U3F9, Q5FVG1, Q5IXF8, Q5UAW9, Q60755, Q64017, Q66615, Q66H29, Q6P7G9, Q6SW98, Q6X632, Q7TSN5, Q7TSN6, Q80W35, Q80WT4, Q8BNQ3, Q8C206, Q8CIM5

Diamond homologs: A0T2N3, B0F9W3, B3G515, E9QJ73, F1MV99, O00590, O08707, O08858, O09027, O15218, O43613, O55197, O60883, O89039, O97666, P11613, P21109, P25106, P28646, P30872, P30873, P30935, P30936, P30937, P30938, P31391, P31392, P32745, P35346, P35414, P43142, P46092, P48145, P48146, P49660, P49681, P55919, P56479, P56485, P58825

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

80 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	74
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

507 predictions. Top by Δscore:

Variant	Effect	Δscore
1:202127727:C:G	acceptor_gain	1.0000
1:202127728:ATCCT:A	acceptor_gain	1.0000
1:202127729:T:G	acceptor_gain	1.0000
1:202128517:G:GT	donor_gain	1.0000
1:202123590:GGAG:G	donor_gain	0.9900
1:202123591:GAG:G	donor_gain	0.9900
1:202123591:GAGG:G	donor_gain	0.9900
1:202123592:AGGT:A	donor_loss	0.9900
1:202123594:G:GA	donor_loss	0.9900
1:202123594:G:GG	donor_gain	0.9900
1:202127726:A:AG	acceptor_gain	0.9900
1:202127728:A:AG	acceptor_gain	0.9900
1:202127732:T:A	acceptor_gain	0.9900
1:202127735:CCACA:C	acceptor_loss	0.9900
1:202127736:CACAG:C	acceptor_loss	0.9900
1:202127737:ACAGG:A	acceptor_loss	0.9900
1:202127738:CA:C	acceptor_loss	0.9900
1:202127739:A:G	acceptor_loss	0.9900
1:202124134:G:GT	donor_gain	0.9800
1:202128517:G:T	donor_gain	0.9800
1:202123562:AC:A	donor_gain	0.9600
1:202123589:TGGAG:T	donor_gain	0.9600
1:202123590:GGAGG:G	donor_gain	0.9600
1:202127739:A:AG	acceptor_gain	0.9600
1:202127740:G:GG	acceptor_gain	0.9600
1:202128518:G:T	donor_gain	0.9600
1:202123551:GCTAC:G	donor_gain	0.9500
1:202127740:GGTCT:G	acceptor_gain	0.9500
1:202124103:C:A	donor_gain	0.9400
1:202128482:G:GT	donor_gain	0.9400

AlphaMissense

3093 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:202127768:A:C	S220R	0.999
1:202127770:C:A	S220R	0.999
1:202127770:C:G	S220R	0.999
1:202123474:A:C	S171R	0.998
1:202123476:C:A	S171R	0.998
1:202123476:C:G	S171R	0.998
1:202128072:C:G	P321R	0.997
1:202128044:T:A	W312R	0.996
1:202128044:T:C	W312R	0.996
1:202128072:C:A	P321H	0.996
1:202123570:T:A	C203S	0.995
1:202123571:G:A	C203Y	0.995
1:202123571:G:C	C203S	0.995
1:202127753:G:A	G215R	0.995
1:202127753:G:C	G215R	0.995
1:202127882:G:C	G258R	0.995
1:202127904:C:A	P265H	0.995
1:202128056:T:C	C316R	0.995
1:202128065:T:C	C319R	0.995
1:202123393:G:C	G144R	0.994
1:202127774:T:C	C222R	0.994
1:202127876:T:A	W256R	0.994
1:202127876:T:C	W256R	0.994
1:202127883:G:A	G258D	0.994
1:202123570:T:C	C203R	0.993
1:202127886:C:A	S259Y	0.993
1:202127904:C:G	P265R	0.993
1:202128041:T:A	W311R	0.993
1:202128041:T:C	W311R	0.993
1:202128054:G:A	G315D	0.993

dbSNP variants (sampled 300 via entrez): RS1000000921 (1:202122461 A>C), RS1000115168 (1:202122135 G>A), RS1000115749 (1:202125881 C>T), RS1000299850 (1:202133299 C>T), RS1000415742 (1:202133576 A>G), RS1001004612 (1:202123709 G>A), RS1001376596 (1:202129434 C>T), RS1001635534 (1:202126464 C>T), RS1001976227 (1:202132002 C>T), RS1002062672 (1:202129675 C>T), RS1002089310 (1:202132255 C>T), RS1002521381 (1:202133773 T>C), RS1002720882 (1:202133437 T>C,G), RS1002756580 (1:202130191 C>T), RS1003163718 (1:202122728 C>T)

Disease associations

OMIM: gene MIM:617630 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): primary amenorrhea (MONDO:1060208)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST006479_11	Diverticular disease	7.000000e-06
GCST007335_2	Age at first sexual intercourse	4.000000e-08

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009959	diverticular disease
EFO:0009749	age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5892 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Class A Orphans with emerging pharmacology

Most potent curated ligand interactions (1 total), top 1:

Ligand	Action	Affinity	Parameter
prosaptide	Agonist	8.3	pEC50

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation	2
sotorasib	affects cotreatment, increases expression	1
propionaldehyde	increases expression	1
sulforaphane	decreases expression	1
butyraldehyde	increases expression	1
aflatoxin B2	decreases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment	1
abrine	increases expression	1
trametinib	affects cotreatment, increases expression	1
NVP-BKM120	affects cotreatment, increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Zoledronic Acid	increases expression	1
Calcitriol	increases expression, affects cotreatment	1
Folic Acid	decreases expression	1
Lipopolysaccharides	increases expression, affects response to substance, affects cotreatment	1
Plant Extracts	affects cotreatment, decreases expression	1
Testosterone	affects cotreatment, increases expression	1
Dronabinol	increases expression	1
Thiram	increases expression	1
Valproic Acid	increases methylation	1
Okadaic Acid	increases expression	1

ChEMBL screening assays

3 unique, capped per target: 2 binding, 1 functional

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4883450	Binding	PRESTO-Tango GPCRome screening (GPR37L1)	Data for DCP probe UCSF924
CHEMBL977827	Functional	Antagonist activity at ETB receptor	Antifungal substances against pathogenic fungi, talaroconvolutins, from talaromyces convolutus. — J Nat Prod

Cellosaurus cell lines

1 cell lines: 1 spontaneously immortalized cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_KX61	PathHunter CHO-K1 GPR37L1 beta-arrestin	Spontaneously immortalized cell line	Female

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT07164248	Not specified	COMPLETED	Evaluation of Bone Mineral Density Indications and Outcomes in Female Adolescents: Implications for Early Detection of Osteopenia/Osteoporosis and Gynecologic Practice