GPR50

Summary

GPR50 (G protein-coupled receptor 50, HGNC:4506) is a protein-coding gene on chromosome Xq28, encoding Melatonin-related receptor (Q13585). G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration.

This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women.

Source: NCBI Gene 9248 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 96 total
• Druggable target: yes
• MANE Select transcript: NM_004224

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4506
Approved symbol	GPR50
Name	G protein-coupled receptor 50
Location	Xq28
Locus type	gene with protein product
Status	Approved
Aliases	H9, Mel1c
Ensembl gene	ENSG00000102195
Ensembl biotype	protein_coding
OMIM	300207
Entrez	9248

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000218316

RefSeq mRNA: 1 — MANE Select: NM_004224 NM_004224

CCDS: CCDS44012

Canonical transcript exons

ENST00000218316 — 2 exons

Exon	Start	End
ENSE00000677604	151176584	151176908
ENSE00001306006	151179771	151181465

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 81.66.

FANTOM5 (CAGE): breadth broad, TPM avg 5.1861 / max 578.3263, expressed in 290 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
197982	5.1328	290
197983	0.0271	14
197984	0.0262	14

Top tissues by expression

267 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	81.66	gold quality
pituitary gland	UBERON:0000007	80.65	gold quality
lower lobe of lung	UBERON:0008949	53.41	silver quality
pancreatic ductal cell	CL:0002079	52.59	silver quality
epithelial cell of pancreas	CL:0000083	49.91	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.62	gold quality
deltoid	UBERON:0001476	49.40	gold quality
cervix squamous epithelium	UBERON:0006922	49.20	gold quality
hair follicle	UBERON:0002073	49.18	gold quality
quadriceps femoris	UBERON:0001377	49.08	gold quality
olfactory bulb	UBERON:0002264	48.92	gold quality
myocardium	UBERON:0002349	48.87	gold quality
type B pancreatic cell	CL:0000169	48.83	gold quality
cardiac muscle of right atrium	UBERON:0003379	48.55	gold quality
CA1 field of hippocampus	UBERON:0003881	48.50	gold quality
vastus lateralis	UBERON:0001379	48.39	gold quality
left ventricle myocardium	UBERON:0006566	48.24	gold quality
orbitofrontal cortex	UBERON:0004167	48.20	gold quality
upper arm skin	UBERON:0004263	48.06	gold quality
cervix epithelium	UBERON:0004801	48.04	gold quality
oviduct epithelium	UBERON:0004804	48.00	gold quality
tongue squamous epithelium	UBERON:0006919	47.92	gold quality
mucosa of urinary bladder	UBERON:0001259	47.80	gold quality
metanephric glomerulus	UBERON:0004736	47.45	gold quality
thymus	UBERON:0002370	47.42	gold quality
kidney epithelium	UBERON:0004819	47.39	gold quality
nephron tubule	UBERON:0001231	47.30	gold quality
diaphragm	UBERON:0001103	47.05	gold quality
gluteal muscle	UBERON:0002000	47.03	gold quality
triceps brachii	UBERON:0001509	47.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• Polymorphisms in GPR50 were compared in bipolar affective disorder (BD), major depressive disorder (MDD), schizophrenia (SCZ) and controls. GPR50(Delta502-505) or a variant is a sex-specific risk factor for susceptibility to BD and SCZ. (PMID:15452587)
• Results describe sequence variants in the melatonin-related receptor gene (GPR50) that associate with circulating triglyceride and HDL levels. (PMID:16436372)
• GPR50, an orphan GPCR, heterodimerizes constitutively and specifically with MT(1) and MT(2) melatonin receptors (PMID:16778767)
• No evidence for an association for this gene with mood disorders in a Hungarian population. (PMID:18075476)
• Results identify neurite outgrowth inhibitor NOGO-A as an interacting partner of GPR50 and found an enrichment of both Gpr50 and neuronal Nogo-A at the synapse. (PMID:19699797)
• Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus. (PMID:20210849)
• This is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus. (PMID:20371266)
• we found 2 polymorphisms in the GPR50 receptor of patients with adolescent idiopathic scoliosis, but they were not present at a highly significant frequency when compared with controls (PMID:20733416)
• Positive expression of melatonin receptor can be found in human hypertrophic scar and normal skin, but it is higher in scar. (PMID:20737950)
• study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 in females. (PMID:21565467)
• The results provide deeper insight into the functional evolution of GPR50 in mammals at the molecular level (PMID:25730005)
• There was only weak female-specific association between GPR50 variants in late-life depression. No significant associations were observed in men. (PMID:25798330)
• Pre-eclampsia (PE) plasma IgG1 anti-Epstein-Barr virus nuclear antigen 1 (EBNA-1) antibody cross-reacts with placental protein G protein-coupled receptor 50 (GPR50). (PMID:27181993)
• GPR50 is a TbetaRI co-receptor with potential impact on cancer development (PMID:29572483)
• GPR50 promoter methylation level was decreased in the male Alzheimer’s disease group compared with the male control group. (PMID:31173244)
• GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors. (PMID:31900622)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mtnr1c	ENSDARG00000035609
mus_musculus	Gpr50	ENSMUSG00000056380
rattus_norvegicus	Gpr50	ENSRNOG00000011335

Paralogs (33): TACR2 (ENSG00000075073), PROKR2 (ENSG00000101292), TACR1 (ENSG00000115353), GPR75 (ENSG00000119737), PRLHR (ENSG00000119973), GPR83 (ENSG00000123901), MCHR1 (ENSG00000128285), OR11H1 (ENSG00000130538), MTNR1B (ENSG00000134640), MCHR2 (ENSG00000152034), NPY1R (ENSG00000164128), NPY5R (ENSG00000164129), MTNR1A (ENSG00000168412), PROKR1 (ENSG00000169618), TACR3 (ENSG00000169836), OR9G1 (ENSG00000174914), OR11H4 (ENSG00000176198), OR11H6 (ENSG00000176219), OR9A2 (ENSG00000179468), GPR88 (ENSG00000181656), GPR19 (ENSG00000183150), NPY2R (ENSG00000185149), OR11G2 (ENSG00000196832), NPY4R (ENSG00000204174), OR11A1 (ENSG00000204694), OR9A1P (ENSG00000237621), OR11H12 (ENSG00000257115), OR9A4 (ENSG00000258083), OR11H2 (ENSG00000258453), OR11H7 (ENSG00000258806), NPY4R2 (ENSG00000264717), OR10X1 (ENSG00000279111), OR51F1 (ENSG00000280021)

Protein

Protein identifiers

Melatonin-related receptor — Q13585 (reviewed: Q13585)

Alternative names: G protein-coupled receptor 50, H9

All UniProt accessions (1): Q13585

UniProt curated annotations — full annotation on UniProt →

Function. G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration. Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways. Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation. Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration. Upon cleavage by CAPN1, functions as a scaffold in the nucleus for interacting partners such as GTF2I to promote FOS promoter activation.

Subunit / interactions. Homodimer, and heterodimer with MTNR1A and MTNR1B. Interacts with KAT5. Interacts with RTN4 isoform A/NOGO-A. Interacts with TGFBR1. Interacts with GTF2I.

Subcellular location. Cell membrane. Postsynaptic density Nucleus.

Tissue specificity. Hypothalamus and pituitary.

Post-translational modifications. Cleaved by CAPN1 in a calcium-dependent manner.

Induction. By TGFB.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_004215* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000025	Melatonin_rcpt	Family
IPR000276	GPCR_Rhodpsn	Family
IPR002280	Mel_rcpt_1X	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF00001

UniProt features (28 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 2, region of interest 2, compositionally biased region 2, sequence conflict 2, site 1, disulfide bond 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
9L9O	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13585-F1	67.35	0.32

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 408–409 (cleavage; by calpain-1/capn1)

Disulfide bonds (1): 101–178

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 55 (showing top): RACCACAR_AML_Q6, GOBP_CELL_CELL_SIGNALING, KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION, TATA_C, AACTTT_UNKNOWN, TTCNRGNNNNTTC_HSF_Q6, GOCC_POSTSYNAPSE, GOCC_SYNAPSE, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, CHENG_IMPRINTED_BY_ESTRADIOL, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MEISSNER_BRAIN_HCP_WITH_H3K27ME3, MEISSNER_NPC_HCP_WITH_H3K4ME2, MIKKELSEN_MEF_HCP_WITH_H3_UNMETHYLATED, chrXq28

GO Biological Process (3): G protein-coupled receptor signaling pathway (GO:0007186), cell-cell signaling (GO:0007267), signal transduction (GO:0007165)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), melatonin receptor activity (GO:0008502), protein binding (GO:0005515)

GO Cellular Component (6): nucleoplasm (GO:0005654), plasma membrane (GO:0005886), postsynaptic density (GO:0014069), nucleus (GO:0005634), membrane (GO:0016020), synapse (GO:0045202)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	2
cell communication	2
signaling	2
cellular anatomical structure	2
signal transduction	1
cellular process	1
regulation of cellular process	1
cellular response to stimulus	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
binding	1
nuclear lumen	1
membrane	1
cell periphery	1
asymmetric synapse	1
postsynaptic specialization	1
intracellular membrane-bounded organelle	1
cell junction	1

Protein interactions and networks

STRING

822 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GPR50	ASMT	P46597	598
GPR50	AANAT	Q16613	577
GPR50	F9	P00740	548
GPR50	QRFP	P83859	533
GPR50	GPR62	Q9BZJ7	497
GPR50	PRL	P01236	490
GPR50	NQO2	P16083	479
GPR50	KAT5	Q92993	467
GPR50	RARRES2	Q99969	446
GPR50	GPR88	Q9GZN0	445
GPR50	GPR26	Q8NDV2	441
GPR50	CAND2	O75155	438
GPR50	NPVF	Q9HCQ7	438
GPR50	KRT74	Q7RTS7	434
GPR50	FKBP1A	P20071	426

IntAct

73 interactions, top by confidence:

A	B	Type	Score
IFT27	IFT56	psi-mi:“MI:0914”(association)	0.690
HLA-C	HLA-A	psi-mi:“MI:0914”(association)	0.670
ATP5F1B	ATP5PD	psi-mi:“MI:0914”(association)	0.670
GPR50	ZNF572	psi-mi:“MI:0915”(physical association)	0.560
ZNF572	GPR50	psi-mi:“MI:0915”(physical association)	0.560
LPAR1	TMEM223	psi-mi:“MI:0914”(association)	0.530
IPPK	TMEM223	psi-mi:“MI:0914”(association)	0.530
HTR2C	KLRG2	psi-mi:“MI:0914”(association)	0.530
ADGRG5	KLRG2	psi-mi:“MI:0914”(association)	0.530
MAS1	POTEF	psi-mi:“MI:0914”(association)	0.530
TMEM171	THAP12	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
TMEM9	ESYT2	psi-mi:“MI:0914”(association)	0.530
GPR21	TMEM120B	psi-mi:“MI:0914”(association)	0.530
GPR50	MT1A	psi-mi:“MI:0915”(physical association)	0.520
GPR50	MT1A	psi-mi:“MI:2364”(proximity)	0.520
GPR50	MT1A	psi-mi:“MI:0403”(colocalization)	0.520
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
GPR50	GPR50	psi-mi:“MI:0915”(physical association)	0.470
GPR50	MT2A	psi-mi:“MI:0915”(physical association)	0.470
GPR50	GPR50	psi-mi:“MI:2364”(proximity)	0.470
GPR50	MT2A	psi-mi:“MI:2364”(proximity)	0.470
GPR50	H2BC21	psi-mi:“MI:0915”(physical association)	0.400
ADAM17	GPR50	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (83): ZNF572 (Two-hybrid), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS), GPR50 (Affinity Capture-MS)

ESM2 similar proteins: A9RZ57, E7EM37, F5HET1, O01670, O12000, O57422, O75121, O77408, O88495, O95800, P09256, P11322, P15792, P16751, P16849, P20905, P22270, P34590, P49219, Q03613, Q10042, Q13585, Q14439, Q16950, Q18775, Q18LE5, Q25190, Q25414, Q28558, Q2KNE5, Q4R1I4, Q61H86, Q64017, Q6AYF7, Q6RYS9, Q6SW98, Q6X632, Q7Z2Y5, Q804Q2, Q804X9

Diamond homologs: A5A4K9, A5A4L1, C3ZQF9, F1MV99, G4WMX4, O02835, O02836, O08725, O42179, O43614, O54799, O62729, O62809, O70342, O77408, P0DQD5, P11617, P20288, P22270, P24053, P24628, P25929, P25931, P28336, P29274, P30731, P30938, P30975, P32251, P35346, P35371, P41143, P47211, P47751, P49146, P49219, P49285, P49288, P49683, P50391

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
GPR50	“up-regulates activity”	ADAM17	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 89 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
G alpha (q) signalling events	8	8.3×	3e-04
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	5	7.9×	3e-03
Peptide ligand-binding receptors	5	6.7×	6e-03

GO biological processes:

GO term	Partners	Fold	FDR
adenylate cyclase-activating G protein-coupled receptor signaling pathway	10	14.9×	8e-07
phospholipase C-activating G protein-coupled receptor signaling pathway	7	12.1×	4e-04
cell surface receptor signaling pathway	8	6.7×	4e-03
G protein-coupled receptor signaling pathway	13	6.2×	5e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

96 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	80
Likely benign	8
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

267 predictions. Top by Δscore:

Variant	Effect	Δscore
X:151179761:T:G	acceptor_gain	1.0000
X:151179766:TTCA:T	acceptor_loss	1.0000
X:151179768:CA:C	acceptor_loss	1.0000
X:151179769:A:AG	acceptor_gain	1.0000
X:151179769:A:C	acceptor_loss	1.0000
X:151179770:G:GG	acceptor_gain	1.0000
X:151179756:C:A	acceptor_gain	0.9900
X:151179760:A:AG	acceptor_gain	0.9900
X:151179760:AT:A	acceptor_gain	0.9900
X:151179761:T:TA	acceptor_gain	0.9900
X:151179769:AG:A	acceptor_gain	0.9900
X:151179770:GG:G	acceptor_gain	0.9900
X:151179770:GGC:G	acceptor_gain	0.9900
X:151179770:GGCA:G	acceptor_gain	0.9900
X:151179770:GGCAA:G	acceptor_gain	0.9900
X:151177634:GTCC:G	donor_gain	0.9800
X:151177630:CAAG:C	donor_loss	0.9700
X:151177631:AAG:A	donor_loss	0.9700
X:151177638:G:GG	donor_gain	0.9700
X:151177632:AGGTC:A	donor_gain	0.9600
X:151177346:T:G	donor_gain	0.9500
X:151177637:C:CG	donor_gain	0.9500
X:151179013:C:T	donor_gain	0.9500
X:151176909:G:GG	donor_gain	0.9400
X:151177631:AAGGT:A	donor_gain	0.9400
X:151177633:GGTC:G	donor_gain	0.9400
X:151176905:TCTGG:T	donor_loss	0.9300
X:151176909:GTAA:G	donor_loss	0.9300
X:151176910:T:A	donor_loss	0.9300
X:151177635:T:A	donor_gain	0.9300

AlphaMissense

4093 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:151179788:A:C	S69R	0.999
X:151179790:T:A	S69R	0.999
X:151179790:T:G	S69R	0.999
X:151180484:T:C	F301L	0.998
X:151180486:C:A	F301L	0.998
X:151180486:C:G	F301L	0.998
X:151180485:T:C	F301S	0.997
X:151179960:G:C	R126P	0.996
X:151180442:A:C	S287R	0.996
X:151180444:C:A	S287R	0.996
X:151180444:C:G	S287R	0.996
X:151180467:G:A	G295E	0.996
X:151180485:T:G	F301C	0.996
X:151176876:C:A	A52D	0.994
X:151180040:T:A	W153R	0.994
X:151180040:T:C	W153R	0.994
X:151180115:T:C	C178R	0.994
X:151180117:C:G	C178W	0.994
X:151180319:T:C	F246L	0.994
X:151180321:T:A	F246L	0.994
X:151180321:T:G	F246L	0.994
X:151180488:G:C	R302P	0.994
X:151176854:G:C	G45R	0.993
X:151176855:G:A	G45D	0.993
X:151176859:C:A	N46K	0.993
X:151176859:C:G	N46K	0.993
X:151179884:T:A	C101S	0.993
X:151179885:G:C	C101S	0.993
X:151179951:C:A	A123D	0.993
X:151180116:G:A	C178Y	0.993

dbSNP variants (sampled 300 via entrez): RS1000717126 (X:151177236 C>T), RS1000864690 (X:151179502 A>G), RS1001255852 (X:151174808 G>C), RS1001355813 (X:151182230 A>G), RS1001623658 (X:151175153 T>C), RS1002895906 (X:151176821 G>A), RS1003331674 (X:151180781 G>A), RS1003337508 (X:151176428 T>C,G), RS1004841500 (X:151181744 CTT>C), RS1005337522 (X:151175984 C>G), RS1006170655 (X:151182301 A>G), RS1006513049 (X:151182621 C>G,T), RS1006904065 (X:151183331 C>A,G,T), RS1007142279 (X:151177134 A>G,T), RS1007729245 (X:151174783 C>G)

Disease associations

OMIM: gene MIM:300207 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL3341577 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Class A Orphans with no pharmacology

Most potent curated ligand interactions (1 total), top 1:

Ligand	Action	Affinity	Parameter
LittleLEN	Agonist	7.32	pEC50

CTD chemical–gene interactions

18 total (human), top 18 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression	2
methylmercuric chloride	increases expression	1
decabromobiphenyl ether	increases expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
tetrabromobisphenol A	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
tetrachlorodian	increases expression	1
abrine	increases expression	1
bisphenol S	decreases methylation	1
(+)-JQ1 compound	increases expression	1
Calcitriol	increases expression	1
Doxorubicin	increases expression	1
Estradiol	increases expression	1
Lipopolysaccharides	affects response to substance, increases expression	1
Nicotine	increases expression, increases splicing	1
Valproic Acid	increases expression	1
Okadaic Acid	increases expression	1
Acrylamide	increases expression	1

ChEMBL screening assays

3 unique, capped per target: 3 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3383679	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor at 10 uM	Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus. — J Med Chem

Cellosaurus cell lines

2 cell lines: 1 transformed cell line, 1 spontaneously immortalized cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D7GK	Ubigene HEK293T GPR50 KO	Transformed cell line	Female
CVCL_KX65	PathHunter CHO-K1 GPR50 beta-arrestin	Spontaneously immortalized cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.