GPRC5D-AS1

Summary

GPRC5D-AS1 (GPRC5D and HEBP1 antisense RNA 1, HGNC:53599) is a long non-coding RNA gene on chromosome 12p13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53599
Approved symbol	GPRC5D-AS1
Name	GPRC5D and HEBP1 antisense RNA 1
Location	12p13.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-392P7.6
Ensembl gene	ENSG00000247498
Ensembl biotype	lncRNA
Entrez	100506314
RNAcentral	URS000075B988 — lncRNA, 1743 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000394742, ENST00000499948, ENST00000536029, ENST00000538231, ENST00000540198, ENST00000542078, ENST00000543515, ENST00000545914, ENST00000607894, ENST00000660059, ENST00000786992, ENST00000786993, ENST00000786994, ENST00000786995, ENST00000786996, ENST00000786997, ENST00000786998, ENST00000786999, ENST00000787000, ENST00000787001, ENST00000787003, ENST00000787004, ENST00000787005

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000394742 — 3 exons

Exon	Start	End
ENSE00001627266	12952738	12952831
ENSE00002242781	12953740	12953957
ENSE00002307837	12947151	12947238

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 88.06.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4674 / max 32.9292, expressed in 650 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124396	1.4454	650
124398	0.0220	3

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	88.06	gold quality
islet of Langerhans	UBERON:0000006	87.65	gold quality
right testis	UBERON:0004534	87.38	gold quality
testis	UBERON:0000473	86.07	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.53	gold quality
body of pancreas	UBERON:0001150	84.88	gold quality
left lobe of thyroid gland	UBERON:0001120	84.31	gold quality
pancreas	UBERON:0001264	83.85	gold quality
upper lobe of left lung	UBERON:0008952	83.73	gold quality
right lobe of thyroid gland	UBERON:0001119	83.14	gold quality
thyroid gland	UBERON:0002046	82.95	gold quality
minor salivary gland	UBERON:0001830	82.51	gold quality
left adrenal gland cortex	UBERON:0035825	81.81	gold quality
adenohypophysis	UBERON:0002196	81.60	gold quality
left adrenal gland	UBERON:0001234	81.51	gold quality
esophagus mucosa	UBERON:0002469	81.41	gold quality
right adrenal gland cortex	UBERON:0035827	80.98	gold quality
right adrenal gland	UBERON:0001233	80.83	gold quality
upper lobe of lung	UBERON:0008948	80.51	gold quality
right lung	UBERON:0002167	80.19	gold quality
pituitary gland	UBERON:0000007	79.75	gold quality
skin of abdomen	UBERON:0001416	79.19	gold quality
body of stomach	UBERON:0001161	79.13	gold quality
right lobe of liver	UBERON:0001114	78.79	gold quality
adrenal gland	UBERON:0002369	78.79	gold quality
adrenal cortex	UBERON:0001235	78.77	gold quality
adrenal tissue	UBERON:0018303	78.72	gold quality
skin of leg	UBERON:0001511	78.70	gold quality
metanephros cortex	UBERON:0010533	78.66	gold quality
gall bladder	UBERON:0002110	78.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.27

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• These findings indicate that rs10845671 may contribute to the susceptibility to colorectal cancer and be a candidate biomarker for colorectal cancer risk prediction.[RNA RP11-392P7.6] (PMID:28612367)
• Increased Expression of Long Noncoding RNA LOC100506314 in T cells from Patients with Nonsegmental Vitiligo and Its Contribution to Vitiligo Pathogenesis. (PMID:37731844)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.