GPX8

Summary

GPX8 (glutathione peroxidase 8 (putative), HGNC:33100) is a protein-coding gene on chromosome 5q11.2, encoding Probable glutathione peroxidase 8 (Q8TED1). It is a selective cancer dependency (DepMap: 11.7% of cell lines).

Enables peroxidase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in endoplasmic reticulum lumen.

Source: NCBI Gene 493869 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 2 total
• Cancer dependency (DepMap): dependent in 11.7% of screened cell lines
• MANE Select transcript: NM_001008397

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33100
Approved symbol	GPX8
Name	glutathione peroxidase 8 (putative)
Location	5q11.2
Locus type	gene with protein product
Status	Approved
Aliases	UNQ847, EPLA847
Ensembl gene	ENSG00000164294
Ensembl biotype	protein_coding
OMIM	617172
Entrez	493869

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 4 protein_coding, 4 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000296734, ENST00000502733, ENST00000503787, ENST00000505096, ENST00000506123, ENST00000511617, ENST00000514317, ENST00000515370, ENST00000851835

RefSeq mRNA: 4 — MANE Select: NM_001008397 NM_001008397, NM_001306197, NM_001306198, NM_001306201

CCDS: CCDS34156, CCDS78009, CCDS82997

Canonical transcript exons

ENST00000503787 — 3 exons

Exon	Start	End
ENSE00002046254	55164055	55167297
ENSE00002078711	55160171	55160396
ENSE00003498491	55160994	55161255

Expression profiles

Bgee: expression breadth ubiquitous, 227 present calls, max score 97.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 76.6671 / max 1263.1084, expressed in 1399 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
56461	76.6671	1399

Top tissues by expression

257 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	97.41	gold quality
oviduct epithelium	UBERON:0004804	95.03	gold quality
tibia	UBERON:0000979	93.60	gold quality
germinal epithelium of ovary	UBERON:0001304	92.98	gold quality
placenta	UBERON:0001987	92.65	gold quality
smooth muscle tissue	UBERON:0001135	92.60	gold quality
calcaneal tendon	UBERON:0003701	92.35	gold quality
adrenal tissue	UBERON:0018303	92.05	gold quality
parietal pleura	UBERON:0002400	91.92	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.68	gold quality
layer of synovial tissue	UBERON:0007616	91.22	gold quality
corpus epididymis	UBERON:0004359	91.16	gold quality
descending thoracic aorta	UBERON:0002345	91.10	gold quality
cauda epididymis	UBERON:0004360	91.10	gold quality
pericardium	UBERON:0002407	90.82	gold quality
endometrium	UBERON:0001295	90.79	gold quality
thoracic aorta	UBERON:0001515	90.57	gold quality
ascending aorta	UBERON:0001496	90.54	gold quality
tendon	UBERON:0000043	89.95	gold quality
decidua	UBERON:0002450	89.86	gold quality
right coronary artery	UBERON:0001625	89.74	gold quality
synovial joint	UBERON:0002217	89.27	gold quality
visceral pleura	UBERON:0002401	89.20	gold quality
tendon of biceps brachii	UBERON:0008188	88.85	gold quality
gall bladder	UBERON:0002110	88.73	gold quality
fallopian tube	UBERON:0003889	88.61	gold quality
uterus	UBERON:0000995	88.54	gold quality
caput epididymis	UBERON:0004358	88.18	gold quality
bronchial epithelial cell	CL:0002328	87.86	gold quality
skin of hip	UBERON:0001554	87.72	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-MTAB-6701	yes	56.64
E-CURD-112	yes	16.73
E-ANND-3	yes	16.22
E-GEOD-83139	yes	7.69
E-ENAD-27	yes	7.25

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

105 targeting GPX8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-4697-3P	99.89	67.09	1123

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 11.7% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 15)

• GPx8 labeled as secreted glutathione peroxidase, is actually endoplasmic reticulum-resident protein disulfide isomerase peroxidase (PMID:21215271)
• Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. (PMID:23929719)
• Along with the induction of GPX8 in ER-stressed cells, these findings question a ubiquitous role of Ero1alpha as a producer of cytoplasmic ROS under ER stress (PMID:24566470)
• GPX8 is transcriptionally regulated by HIFalpha and modulates growth factor signaling in HeLa cells. (PMID:25557012)
• Study provides evidence that the conserved N-terminal transmembrane domain of GPX8, in addition to its enzymatic activity, is essential for regulating Ca(2+) dynamics revealing a novel level of integration between redox-related proteins and Ca(2+) signaling/homeostasis. (PMID:28129698)
• Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data. (PMID:32392186)
• Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding. (PMID:32719007)
• The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. (PMID:32817494)
• GPX8 promotes migration and invasion by regulating epithelial characteristics in non-small cell lung cancer. (PMID:32975378)
• GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway. (PMID:35288240)
• GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma. (PMID:36052280)
• GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells. (PMID:37170591)
• GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses. (PMID:37795080)
• GPX8[+] cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment. (PMID:38515109)
• Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration. (PMID:38607517)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	gpx8	ENSDARG00000013302
mus_musculus	Gpx8	ENSMUSG00000021760
rattus_norvegicus	Gpx8	ENSRNOG00000010461
caenorhabditis_elegans		WBGENE00007516
caenorhabditis_elegans		WBGENE00007517
caenorhabditis_elegans		WBGENE00011045
caenorhabditis_elegans	gpx-8	WBGENE00018850
caenorhabditis_elegans		WBGENE00022377

Paralogs (7): GPX7 (ENSG00000116157), GPX4 (ENSG00000167468), GPX2 (ENSG00000176153), GPX6 (ENSG00000198704), GPX3 (ENSG00000211445), GPX5 (ENSG00000224586), GPX1 (ENSG00000233276)

Protein

Protein identifiers

Probable glutathione peroxidase 8 — Q8TED1 (reviewed: Q8TED1)

All UniProt accessions (3): E7ETY7, Q8TED1, J3KNB5

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Similarity. Belongs to the glutathione peroxidase family.

RefSeq proteins (4): NP_001008398, NP_001293126, NP_001293127, NP_001293130 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000889	Glutathione_peroxidase	Family
IPR013376	Glut_perox_Gpx7	Family
IPR029760	GPX_CS	Conserved_site
IPR036249	Thioredoxin-like_sf	Homologous_superfamily

Pfam: PF00255

Enzyme classification (BRENDA):

• EC 1.11.1.9 — glutathione peroxidase (BRENDA: 58 organisms, 96 substrates, 65 inhibitors, 63 Km, 23 kcat entries)

Substrate kinetics (BRENDA)

12 substrates with measured Km, best-characterized 12. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
H2O2	0.0023–19.08	19
GSH	0.033–11.1	18
CUMENE HYDROPEROXIDE	0.006–7.8	6
TERT-BUTYL HYDROPEROXIDE	0.059–7.9	6
GLUTATHIONE	0.022–1.73	4
CUMENE PEROXIDE	0.09–0.42	2
L-ALPHA-PHOSPHATIDYLCHOLINE HYDROPEROXIDE	0.026–9.7	2
LINOLENIC ACID HYDROPEROXIDE	0.007–3.8	2
CHOLESTEROL 5ALPHA-HYDROPEROXIDE	0.004	1
CHOLESTEROL 7ALPHA-HYDROPEROXIDE	0.011	1
CHOLESTEROL 7BETA-HYDROPEROXIDE	0.003	1
TERT-BUTYLHYDROPEROXIDE	0.024	1

Catalyzed reactions (Rhea), 1 shown:

• 2 glutathione + H2O2 = glutathione disulfide + 2 H2O (RHEA:16833)

UniProt features (20 total): strand 7, helix 7, chain 1, transmembrane region 1, turn 1, active site 1, modified residue 1, sequence variant 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
3KIJ	X-RAY DIFFRACTION	1.8
3CYN	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TED1-F1	93.29	0.84

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 79

Post-translational modifications (1): 1

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-3299685	Detoxification of Reactive Oxygen Species

MSigDB gene sets: 135 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, GSE45365_NK_CELL_VS_CD8A_DC_UP, TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, SENESE_HDAC1_AND_HDAC2_TARGETS_DN, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, GOBP_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE, GOBP_DETOXIFICATION, LIAO_METASTASIS, CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_DN, GOMF_ANTIOXIDANT_ACTIVITY, GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PEROXIDE_AS_ACCEPTOR, GOBP_RESPONSE_TO_TOXIC_SUBSTANCE, CERVERA_SDHB_TARGETS_1_UP

GO Biological Process (3): cellular response to oxidative stress (GO:0034599), response to oxidative stress (GO:0006979), cellular oxidant detoxification (GO:0098869)

GO Molecular Function (4): peroxidase activity (GO:0004601), glutathione peroxidase activity (GO:0004602), protein binding (GO:0005515), oxidoreductase activity (GO:0016491)

GO Cellular Component (2): endoplasmic reticulum lumen (GO:0005788), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Cellular response to chemical stress	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
response to oxidative stress	1
cellular response to chemical stress	1
response to stress	1
cellular detoxification	1
antioxidant activity	1
oxidoreductase activity, acting on peroxide as acceptor	1
peroxidase activity	1
binding	1
catalytic activity	1
endoplasmic reticulum	1
intracellular organelle lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

3706 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GPX8	GSR	P00390	970
GPX8	TXN	P10599	900
GPX8	XDH	P47989	884
GPX8	SOD2	P04179	858
GPX8	F5H3C5	F5H3C5	857
GPX8	GLRX	P35754	841
GPX8	HMOX1	P09601	838
GPX8	TXNRD1	Q16881	828
GPX8	SOD1	P00441	826
GPX8	GPT	P24298	814
GPX8	G6PD	P11413	804
GPX8	H6PD	O95479	804
GPX8	NFE2L2	Q16236	800
GPX8	CASP3	P42574	771
GPX8	CYCS	P00001	760

IntAct

559 interactions, top by confidence:

A	B	Type	Score
GPX8	GAPDHS	psi-mi:“MI:0915”(physical association)	0.590
UNC50	GPX8	psi-mi:“MI:0915”(physical association)	0.560
VTI1B	GPX8	psi-mi:“MI:0915”(physical association)	0.560
RTP2	GPX8	psi-mi:“MI:0915”(physical association)	0.560
PAEP	GPX8	psi-mi:“MI:0915”(physical association)	0.560
KLRG1	GPX8	psi-mi:“MI:0915”(physical association)	0.560
MGST2	GPX8	psi-mi:“MI:0915”(physical association)	0.560
SNORC	GPX8	psi-mi:“MI:0915”(physical association)	0.560
CHST6	CANX	psi-mi:“MI:0914”(association)	0.530
GPR101	GPX8	psi-mi:“MI:0915”(physical association)	0.400
DNAJB6	GPX8	psi-mi:“MI:0915”(physical association)	0.400
		psi-mi:“MI:0914”(association)	0.350
	ESYT2	psi-mi:“MI:0914”(association)	0.350
E5	ESYT2	psi-mi:“MI:0914”(association)	0.350
	PGRMC1	psi-mi:“MI:0914”(association)	0.350
LMP2	WWP2	psi-mi:“MI:0914”(association)	0.350
	HAX1	psi-mi:“MI:0914”(association)	0.350
BVLF1	VWA8	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
ORF74	MGAT5	psi-mi:“MI:0914”(association)	0.350
MAD2L2		psi-mi:“MI:0914”(association)	0.350
SLC39A12	POM121C	psi-mi:“MI:0914”(association)	0.350
HTR3A	GPAA1	psi-mi:“MI:0914”(association)	0.350
TMEM107	GPX8	psi-mi:“MI:0915”(physical association)	0.000
AQP2	GPX8	psi-mi:“MI:0915”(physical association)	0.000
PLN	GPX8	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (314): GAPDHS (Affinity Capture-MS), GPX8 (PCA), GPX8 (Affinity Capture-MS), GAPDHS (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS), GPX8 (Affinity Capture-MS)

ESM2 similar proteins: E7E2N8, G9JJU2, O18994, O22850, O46607, O75715, P00435, P04041, P11352, P11909, P18283, P21765, P22352, P23764, P28714, P30710, P35666, P36014, P36968, P37141, P46412, P52033, P54996, P59796, P67877, P67878, P83645, Q0EF98, Q2NL01, Q4AEH0, Q4AEH1, Q4AEH3, Q4AEH4, Q4AEH5, Q4AEH7, Q4AEH8, Q4AEH9, Q4AEI0, Q59WD3, Q5RFG3

Diamond homologs: A1KV41, A6QLY2, G9JJU2, O02621, O04922, O08368, O18994, O22448, O22850, O23814, O23968, O23970, O24031, O24296, O32770, O46607, O48646, O49069, O59858, O62327, O70325, O75715, P00435, P04041, P06610, P07203, P0A0T4, P0A0T5, P0C2T0, P11352, P11909, P18283, P21765, P22352, P28714, P30708, P30710, P35666, P36014, P36968

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 141 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Asparagine N-linked glycosylation	8	6.1×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	2
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

523 predictions. Top by Δscore:

Variant	Effect	Δscore
5:55160397:G:GG	donor_gain	1.0000
5:55160392:GCAAA:G	donor_gain	0.9900
5:55160966:C:A	acceptor_gain	0.9900
5:55160988:C:A	acceptor_gain	0.9900
5:55160989:G:A	acceptor_gain	0.9900
5:55161114:A:AG	acceptor_gain	0.9900
5:55161150:G:GT	donor_gain	0.9900
5:55160396:AG:A	donor_loss	0.9800
5:55160397:GTA:G	donor_loss	0.9800
5:55160398:TAAGT:T	donor_loss	0.9800
5:55161180:G:GT	donor_gain	0.9800
5:55160393:C:T	donor_gain	0.9700
5:55160393:CAAA:C	donor_gain	0.9700
5:55160399:AAGTT:A	donor_loss	0.9700
5:55164049:TTTTA:T	acceptor_loss	0.9700
5:55164050:TTTAG:T	acceptor_loss	0.9700
5:55164051:TTA:T	acceptor_loss	0.9700
5:55164052:TA:T	acceptor_loss	0.9700
5:55164053:A:AG	acceptor_gain	0.9700
5:55164054:G:GG	acceptor_gain	0.9700
5:55161252:GTTG:G	donor_gain	0.9600
5:55162752:A:G	donor_gain	0.9600
5:55164048:ATTTT:A	acceptor_loss	0.9600
5:55160394:AAA:A	donor_gain	0.9500
5:55160395:AA:A	donor_gain	0.9500
5:55161118:A:AG	acceptor_gain	0.9300
5:55161119:G:GG	acceptor_gain	0.9300
5:55161187:C:G	donor_gain	0.9300
5:55161251:TGTTG:T	donor_loss	0.9000
5:55161252:GTTGG:G	donor_loss	0.9000

AlphaMissense

1360 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:55164100:T:A	V171D	0.994
5:55164084:T:C	F166L	0.993
5:55164086:T:A	F166L	0.993
5:55164086:T:G	F166L	0.993
5:55161105:T:C	F106L	0.992
5:55161107:T:A	F106L	0.992
5:55161107:T:G	F106L	0.992
5:55161011:C:A	N74K	0.991
5:55161011:C:G	N74K	0.991
5:55161004:T:A	V72D	0.990
5:55161091:T:C	F101S	0.990
5:55161106:T:C	F106S	0.989
5:55161120:T:C	F111L	0.989
5:55161122:T:A	F111L	0.989
5:55161122:T:G	F111L	0.989
5:55161189:T:C	F134L	0.989
5:55161191:C:A	F134L	0.989
5:55161191:C:G	F134L	0.989
5:55161001:T:C	L71P	0.988
5:55161064:T:C	L92P	0.988
5:55161097:T:A	V103E	0.985
5:55161250:T:A	L154H	0.985
5:55161055:T:C	L89P	0.984
5:55164092:G:C	K168N	0.984
5:55164092:G:T	K168N	0.984
5:55164097:T:C	L170P	0.984
5:55161113:C:G	C108W	0.982
5:55161240:T:C	F151L	0.982
5:55161242:T:A	F151L	0.982
5:55161242:T:G	F151L	0.982

dbSNP variants (sampled 300 via entrez): RS1000064221 (5:55161974 G>A,T), RS1000204806 (5:55163201 T>C), RS1000459556 (5:55163629 C>T), RS1000543736 (5:55161750 A>G), RS1000654791 (5:55161307 A>G,T), RS1001055749 (5:55163314 G>A), RS1001109569 (5:55163040 A>G), RS1002058121 (5:55165122 C>T), RS1002110756 (5:55164636 C>T), RS1002636930 (5:55159293 A>C,G), RS1003004147 (5:55161264 C>T), RS1003860806 (5:55159384 T>A,C), RS1004038814 (5:55161092 C>G,T), RS1004627991 (5:55158960 T>G), RS1004639177 (5:55165891 G>T)

Disease associations

OMIM: gene MIM:617172 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST008399_7	Cocaine dependence	8.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

61 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	3
monomethylarsonous acid	affects expression, decreases expression	2
Valproic Acid	affects expression, decreases expression	2
Cyclosporine	affects expression, increases expression	2
Aflatoxin B1	decreases expression, increases methylation	2
Particulate Matter	decreases reaction, increases expression, decreases expression, increases abundance	2
aristolochic acid I	decreases expression	1
bisphenol F	increases expression	1
bismuth tripotassium dicitrate	increases expression	1
bufotalin	increases expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
cylindrospermopsin	decreases expression	1
chloropicrin	increases expression	1
perfluoro-n-nonanoic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
perfluorohexanesulfonic acid	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	decreases expression	1
ICG 001	increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases reaction, increases expression	1
eprenetapopt	affects expression, affects reaction	1
LDN 193189	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_F1Q7	HyCyte Hep-G2 KO-hGPX8	Cancer cell line	Male
CVCL_KT60	HeLa SilenciX GPX8	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.