GRAPL-AS1

Summary

GRAPL-AS1 (GRAPL antisense RNA 1, HGNC:26214) is a long non-coding RNA gene on chromosome 17p11.2.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26214
Approved symbol	GRAPL-AS1
Name	GRAPL antisense RNA 1
Location	17p11.2
Locus type	RNA, long non-coding
Status	Approved
Entrez	79999
RNAcentral	URS0000E60A59 — lncRNA, 1793 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 22 (showing top): MODULE_255, MODULE_317, MODULE_69, MODULE_37, BRCA1_DN.V1_UP, DCA_UP.V1_UP, IL15_UP.V1_DN, KRAS.600.LUNG.BREAST_UP.V1_UP, MODULE_532, GSE1432_CTRL_VS_IFNG_1H_MICROGLIA_UP, MODULE_459, GSE3982_CTRL_VS_LPS_1H_NEUTROPHIL_UP, GSE6269_FLU_VS_E_COLI_INF_PBMC_DN, GSE9006_1MONTH_VS_4MONTH_POST_TYPE_1_DIABETES_DX_PBMC_DN, MODULE_179

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

805 predictions. Top by Δscore:

Variant	Effect	Δscore
17:19127683:G:GT	donor_gain	1.0000
17:19127694:CAAGG:C	donor_loss	1.0000
17:19127696:AGG:A	donor_loss	1.0000
17:19127697:GGTA:G	donor_loss	1.0000
17:19127698:GT:G	donor_loss	1.0000
17:19127699:T:A	donor_loss	1.0000
17:19132637:CACA:C	acceptor_loss	1.0000
17:19132638:ACAG:A	acceptor_loss	1.0000
17:19132639:CA:C	acceptor_loss	1.0000
17:19132640:A:AG	acceptor_gain	1.0000
17:19132641:G:GA	acceptor_gain	1.0000
17:19132641:G:T	acceptor_loss	1.0000
17:19132641:GA:G	acceptor_gain	1.0000
17:19132641:GATC:G	acceptor_gain	1.0000
17:19132740:G:GG	donor_gain	1.0000
17:19138549:A:T	donor_gain	1.0000
17:19138550:GA:G	donor_gain	1.0000
17:19138552:G:GG	donor_gain	1.0000
17:19138568:G:GT	donor_gain	1.0000
17:19138584:GTGAA:G	donor_gain	1.0000
17:19138586:G:GT	donor_gain	1.0000
17:19138586:GAA:G	donor_gain	1.0000
17:19138589:G:GG	donor_gain	1.0000
17:19127698:G:GG	donor_gain	0.9900
17:19132633:T:A	acceptor_gain	0.9900
17:19132636:CCACA:C	acceptor_loss	0.9900
17:19132639:C:G	acceptor_gain	0.9900
17:19132641:GAT:G	acceptor_gain	0.9900
17:19132641:GATCC:G	acceptor_gain	0.9900
17:19132736:ATCC:A	donor_gain	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 87 via entrez): RS112369299 (17:19161227 A>T), RS1201885257 (17:19154203 C>T), RS1205665694 (17:19164602 G>C), RS1220933350 (17:19154440 G>A,T), RS1226760035 (17:19154290 G>A,T), RS1228295538 (17:19154485 G>A), RS1288149824 (17:19154505 C>T), RS1294904409 (17:19158224 T>C), RS1308764000 (17:19164479 A>C), RS1309572315 (17:19154526 T>A), RS1322828431 (17:19154299 C>T), RS1334244352 (17:19154598 G>A), RS1337990305 (17:19164234 C>T), RS1352530606 (17:19164477 T>C), RS1356636712 (17:19154413 T>TA)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Endosulfan	increases expression	1
Smoke	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.