GREM1-AS1

Summary

GREM1-AS1 (GREM1 antisense RNA 1, HGNC:55411) is a long non-coding RNA gene on chromosome 15q13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55411
Approved symbol	GREM1-AS1
Name	GREM1 antisense RNA 1
Location	15q13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259721
Ensembl biotype	lncRNA
Entrez	100131315
RNAcentral	URS000075D5FB — lncRNA, 585 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000558441, ENST00000560363

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558441 — 1 exons

Exon	Start	End
ENSE00002540943	32717270	32719007

Expression profiles

Bgee: expression breadth broad, 91 present calls, max score 73.24.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4604 / max 15.7477, expressed in 145 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149148	0.4604	145

Top tissues by expression

91 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	73.24	gold quality
mucosa of stomach	UBERON:0001199	69.16	gold quality
colonic epithelium	UBERON:0000397	67.12	silver quality
cortical plate	UBERON:0005343	66.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.84	gold quality
urinary bladder	UBERON:0001255	59.91	gold quality
right lobe of liver	UBERON:0001114	59.90	gold quality
liver	UBERON:0002107	59.24	gold quality
prefrontal cortex	UBERON:0000451	58.05	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	57.84	gold quality
endometrium	UBERON:0001295	56.64	gold quality
smooth muscle tissue	UBERON:0001135	56.51	gold quality
lymph node	UBERON:0000029	56.27	gold quality
endocervix	UBERON:0000458	55.21	gold quality
anterior cingulate cortex	UBERON:0009835	55.09	gold quality
lower esophagus	UBERON:0013473	55.05	gold quality
lower esophagus muscularis layer	UBERON:0035833	54.98	gold quality
gall bladder	UBERON:0002110	53.46	gold quality
duodenum	UBERON:0002114	53.27	gold quality
frontal cortex	UBERON:0001870	53.06	gold quality
blood	UBERON:0000178	52.44	gold quality
esophagus	UBERON:0001043	52.13	gold quality
stomach	UBERON:0000945	51.74	gold quality
superior frontal gyrus	UBERON:0002661	51.47	gold quality
pancreas	UBERON:0001264	51.38	gold quality
body of pancreas	UBERON:0001150	51.09	gold quality
cerebral cortex	UBERON:0000956	50.95	gold quality
vermiform appendix	UBERON:0001154	50.71	gold quality
body of stomach	UBERON:0001161	50.60	gold quality
ovary	UBERON:0000992	50.09	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.28

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.