GRHL2-DT

Summary

GRHL2-DT (GRHL2 divergent transcript, HGNC:55466) is a long non-coding RNA gene on chromosome 8q22.3.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55466
Approved symbol	GRHL2-DT
Name	GRHL2 divergent transcript
Location	8q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	BX357664
Entrez	107986962
RNAcentral	URS00026A228B — lncRNA, 916 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 23 (showing top): GOZGIT_ESR1_TARGETS_DN, SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN, chr8q22, CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP, DODD_NASOPHARYNGEAL_CARCINOMA_DN, ATF6_TARGET_GENES, CSHL1_TARGET_GENES, E2F2_TARGET_GENES, GREB1_TARGET_GENES, NKX2_3_TARGET_GENES, SNAI1_TARGET_GENES, TEAD2_TARGET_GENES, WDHD1_TARGET_GENES, ZFHX3_TARGET_GENES, AHRR_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

194 predictions. Top by Δscore:

Variant	Effect	Δscore
8:101492790:G:GG	donor_gain	1.0000
8:101492785:GACAA:G	donor_gain	0.9900
8:101492787:CAAG:C	donor_loss	0.9800
8:101492788:AAG:A	donor_loss	0.9800
8:101492789:AG:A	donor_loss	0.9800
8:101492791:TAAGT:T	donor_loss	0.9800
8:101492792:A:AT	donor_loss	0.9800
8:101492793:A:AC	donor_loss	0.9700
8:101493189:C:G	donor_gain	0.9600
8:101492508:G:GT	donor_gain	0.9500
8:101492794:G:C	donor_loss	0.9500
8:101493180:G:GT	donor_gain	0.9500
8:101492550:T:G	donor_gain	0.9400
8:101492787:CAA:C	donor_gain	0.9300
8:101492855:T:G	donor_gain	0.9300
8:101492788:AA:A	donor_gain	0.9100
8:101492786:ACAA:A	donor_gain	0.8900
8:101493105:T:TA	donor_gain	0.8900
8:101493106:A:AA	donor_gain	0.8900
8:101492556:G:T	donor_gain	0.8600
8:101492555:G:GT	donor_gain	0.8300
8:101492671:C:A	acceptor_gain	0.7900
8:101493309:G:GT	donor_gain	0.7900
8:101492582:GC:G	donor_gain	0.7700
8:101492583:C:G	donor_gain	0.7600
8:101493100:TTT:T	donor_gain	0.7600
8:101493310:A:T	donor_gain	0.7600
8:101492551:G:GG	donor_gain	0.7100
8:101493101:TTG:T	donor_gain	0.7000
8:101492844:C:T	donor_gain	0.6900

AlphaMissense

0 scored. Top likely-pathogenic:

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.