GRIK1-AS2

Summary

GRIK1-AS2 (GRIK1 antisense RNA 2, HGNC:1282) is a long non-coding RNA gene on chromosome 21q22.11.

At a glance

• Clinical variants (ClinVar): 1 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:1282
Approved symbol	GRIK1-AS2
Name	GRIK1 antisense RNA 2
Location	21q22.11
Locus type	RNA, long non-coding
Status	Approved
Entrez	100379661
RNAcentral	URS000075D82C — lncRNA, 1073 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000119200 (21:29624435 G>A,T), RS1000184149 (21:29615340 C>T), RS1000242067 (21:29609349 A>G), RS1000421437 (21:29603779 G>A), RS1000542265 (21:29610515 A>C), RS1000557428 (21:29615174 A>G), RS1000590200 (21:29595425 T>C), RS1000656751 (21:29610713 G>T), RS1000725970 (21:29625516 A>T), RS1000890921 (21:29610667 T>TGTTAGAG), RS1000928173 (21:29599654 C>T), RS1001129189 (21:29600621 A>G,T), RS1001142975 (21:29625976 T>A), RS1001149019 (21:29596705 T>A), RS1001158970 (21:29600488 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs2832407	GRIK1, GRIK1-AS2	3	2.50	1	topiramate

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Cadmium	increases abundance, increases expression	1
Cadmium Chloride	increases abundance, increases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.