GRINA

Summary

GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1, HGNC:4589) is a protein-coding gene on chromosome 8q24.3, encoding Protein lifeguard 1 (Q7Z429). Potential apoptotic regulator.

Predicted to enable calcium channel activity. Predicted to be involved in apoptotic signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of neuron apoptotic process. Predicted to act upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi membrane.

Source: NCBI Gene 2907 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 56 total
• MANE Select transcript: NM_001009184

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4589
Approved symbol	GRINA
Name	glutamate ionotropic receptor NMDA type subunit associated protein 1
Location	8q24.3
Locus type	gene with protein product
Status	Approved
Aliases	HNRGW, TMBIM3, LFG1
Ensembl gene	ENSG00000178719
Ensembl biotype	protein_coding
OMIM	138251
Entrez	2907

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 19 protein_coding, 3 retained_intron

ENST00000313269, ENST00000395068, ENST00000525513, ENST00000527194, ENST00000529301, ENST00000530898, ENST00000531992, ENST00000533044, ENST00000533377, ENST00000534791, ENST00000857578, ENST00000857579, ENST00000857580, ENST00000857581, ENST00000857582, ENST00000857583, ENST00000857584, ENST00000857585, ENST00000857586, ENST00000857587, ENST00000857588, ENST00000857589

RefSeq mRNA: 2 — MANE Select: NM_001009184 NM_000837, NM_001009184

CCDS: CCDS34961

Canonical transcript exons

ENST00000395068 — 7 exons

Exon	Start	End
ENSE00001319675	143991878	143992078
ENSE00001320349	143991692	143991804
ENSE00001423424	143991200	143991602
ENSE00001432342	143992692	143993415
ENSE00001520480	143990056	143990199
ENSE00003460558	143992465	143992608
ENSE00003790476	143992245	143992373

Expression profiles

Bgee: expression breadth ubiquitous, 281 present calls, max score 99.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 354.9275 / max 3901.4089, expressed in 1829 samples.

FANTOM5 promoters (16 alternative TSS)

Promoter ID	TPM avg	Samples expressed
91438	236.8918	1829
91437	71.0132	1826
91440	14.4910	1753
91439	12.7123	1761
91445	5.2356	1487
91443	2.6791	1286
91446	2.5303	1272
91442	1.8741	901
91449	1.8410	987
91444	1.5698	785

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	99.48	gold quality
right testis	UBERON:0004534	99.47	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.44	gold quality
stromal cell of endometrium	CL:0002255	99.40	gold quality
cerebellar hemisphere	UBERON:0002245	99.28	gold quality
right frontal lobe	UBERON:0002810	99.25	gold quality
cerebellar cortex	UBERON:0002129	99.23	gold quality
right lobe of liver	UBERON:0001114	99.08	gold quality
right adrenal gland cortex	UBERON:0035827	99.06	gold quality
right lobe of thyroid gland	UBERON:0001119	99.02	gold quality
left adrenal gland	UBERON:0001234	99.02	gold quality
left lobe of thyroid gland	UBERON:0001120	99.01	gold quality
left adrenal gland cortex	UBERON:0035825	99.00	gold quality
right adrenal gland	UBERON:0001233	98.99	gold quality
metanephros cortex	UBERON:0010533	98.95	gold quality
right lung	UBERON:0002167	98.94	gold quality
upper lobe of left lung	UBERON:0008952	98.93	gold quality
endocervix	UBERON:0000458	98.89	gold quality
omental fat pad	UBERON:0010414	98.89	gold quality
peritoneum	UBERON:0002358	98.86	gold quality
mucosa of stomach	UBERON:0001199	98.85	gold quality
cortical plate	UBERON:0005343	98.84	gold quality
right ovary	UBERON:0002118	98.69	gold quality
left uterine tube	UBERON:0001303	98.67	gold quality
right uterine tube	UBERON:0001302	98.61	gold quality
adenohypophysis	UBERON:0002196	98.61	gold quality
ectocervix	UBERON:0012249	98.59	gold quality
skin of leg	UBERON:0001511	98.58	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	98.58	gold quality
nucleus accumbens	UBERON:0001882	98.57	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-CURD-122	yes	69.76
E-ANND-3	yes	20.37
E-HCAD-13	yes	11.59
E-CURD-112	no	2.58

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

29 targeting GRINA, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-4779	99.86	66.50	1583
HSA-MIR-3177-5P	99.65	70.38	1174
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-17-3P	99.55	66.77	1311
HSA-MIR-4437	99.52	65.29	1266
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-6852-5P	99.17	66.69	2073
HSA-MIR-4292	99.16	65.57	1767
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-6868-5P	99.06	65.69	1284
HSA-MIR-5001-5P	99.05	66.76	1972
HSA-MIR-5088-5P	97.97	64.28	487
HSA-MIR-10526-3P	97.86	64.97	1342
HSA-MIR-4723-3P	97.67	65.91	1017
HSA-MIR-9851-5P	97.57	67.49	1067
HSA-MIR-6769B-3P	97.41	65.53	1036
HSA-MIR-3183	97.40	65.68	978
HSA-MIR-6859-3P	97.26	64.69	428
HSA-MIR-6869-5P	97.17	67.06	634
HSA-MIR-6762-5P	96.55	64.62	972
HSA-MIR-6845-5P	96.55	64.65	969
HSA-MIR-564	95.85	65.01	163
HSA-MIR-4524B-3P	95.52	64.12	964

Literature-anchored findings (GeneRIF, showing 10)

• The tmbim3 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments (PMID:18440869)
• Data showed that GRINA-C was associated with Gb3 synthase, and may demonstrate a new type of posttranscriptional regulation of glycosyltransferases. (PMID:20837469)
• The role of TMBIM3/GRINA in the control of cell death in cellular and animal models of ER stress possibly owing to the regulation of ER calcium homeostasis. (PMID:22240901)
• These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues (PMID:25764978)
• Extraintestinal manifestations of celiac disease are explained on the basis of 33-mer gliadin binding to glutamate receptor GRINA. (PMID:26990286)
• Human gastric cancers have increased levels of GRINA, which promotes growth of gastric cancer and inhibits tumor cells apoptosis. (PMID:30541591)
• PLEC encodes plectin, a cytoskeletal protein that maintains tissue integrity. GRINA encodes TMBIM3, which regulates cell survival. We hypothesized that in a joint predisposed to Osteoarthritis (OA), expression of these genes alters to combat aberrant biomechanics and is epigenetically regulated. However, carriage of the OA risk-conferring allele at this locus hinders this response and contributes to disease development. (PMID:30730609)
• The cytoplasmic N-terminal half of GRINA (which spans a Proline-rich domain) contains a potential DNA-binding sequence, in addition to cleavage target sites and probable PY-nuclear localization sequences, that may enable it to be released from the rest of the protein and enter the nucleus under suitable conditions, where it could participate in the transcription, alternative splicing, and mRNA export. [review] (PMID:31426446)
• Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1, a potential target of miR-296, facilitates proliferation and migration of rectal cancer cells. (PMID:32657216)
• Glutamate receptor, ionotropic, Nmethyl Daspartateassociated protein 1 promotes colorectal cancer cell proliferation and metastasis, and is negatively regulated by miR2963p. (PMID:34368871)

Cross-species orthologs

10 orthologs

Organism	Symbol	Gene ID
danio_rerio	grinaa	ENSDARG00000101317
mus_musculus	Grina	ENSMUSG00000022564
rattus_norvegicus	Grina	ENSRNOG00000029941
drosophila_melanogaster	Nmda1	FBGN0013305
drosophila_melanogaster	Lfg	FBGN0025692
drosophila_melanogaster	Recs1	FBGN0038209
drosophila_melanogaster	CG30379	FBGN0050379
caenorhabditis_elegans		WBGENE00006470
caenorhabditis_elegans		WBGENE00009580
caenorhabditis_elegans		WBGENE00021537

Paralogs (5): FAIM2 (ENSG00000135472), TMBIM1 (ENSG00000135926), TMBIM6 (ENSG00000139644), TMBIM4 (ENSG00000155957), GHITM (ENSG00000165678)

Protein

Protein identifiers

Protein lifeguard 1 — Q7Z429 (reviewed: Q7Z429)

Alternative names: Glutamate [NMDA] receptor-associated protein 1, NMDA receptor glutamate-binding subunit, Putative MAPK-activating protein PM02, Transmembrane BAX inhibitor motif-containing protein 3

All UniProt accessions (6): Q7Z429, E9PPG3, E9PQF8, H0YC98, H0YCP9, H0YEI4

UniProt curated annotations — full annotation on UniProt →

Function. Potential apoptotic regulator.

Subcellular location. Membrane.

Similarity. Belongs to the BI1 family. LFG subfamily.

RefSeq proteins (2): NP_000828, NP_001009184* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006214	Bax_inhibitor_1-related	Family

Pfam: PF01027

UniProt features (16 total): transmembrane region 7, compositionally biased region 3, sequence conflict 3, chain 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z429-F1	71.69	0.40

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 232 (showing top): GOBP_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS, MODY_HIPPOCAMPUS_POSTNATAL, MORF_RAB5A, XU_GH1_AUTOCRINE_TARGETS_UP, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, DACOSTA_UV_RESPONSE_VIA_ERCC3_UP, IVANOVA_HEMATOPOIESIS_MATURE_CELL, GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, PATIL_LIVER_CANCER, GOBP_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY

GO Biological Process (6): endoplasmic reticulum calcium ion homeostasis (GO:0032469), negative regulation of neuron apoptotic process (GO:0043524), apoptotic signaling pathway (GO:0097190), negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042), negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902236), calcium ion transmembrane transport (GO:0070588)

GO Molecular Function (3): calcium channel activity (GO:0005262), transmembrane transporter binding (GO:0044325), protein binding (GO:0005515)

GO Cellular Component (4): Golgi membrane (GO:0000139), endoplasmic reticulum (GO:0005783), Golgi apparatus (GO:0005794), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
endomembrane system	2
intracellular membrane-bounded organelle	2
endoplasmic reticulum	1
intracellular calcium ion homeostasis	1
negative regulation of apoptotic process	1
regulation of neuron apoptotic process	1
neuron apoptotic process	1
apoptotic process	1
signal transduction	1
extrinsic apoptotic signaling pathway via death domain receptors	1
regulation of extrinsic apoptotic signaling pathway via death domain receptors	1
negative regulation of extrinsic apoptotic signaling pathway	1
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	1
negative regulation of response to endoplasmic reticulum stress	1
negative regulation of intrinsic apoptotic signaling pathway	1
calcium ion transport	1
monoatomic cation transmembrane transport	1
monoatomic cation channel activity	1
calcium ion transmembrane transporter activity	1
protein binding	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1044 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
GRINA	TG	P01266	691
GRINA	TMBIM6	P55061	688
GRINA	GRIN2D	O15399	629
GRINA	PARP10	Q53GL7	593
GRINA	GHITM	Q9H3K2	591
GRINA	TMEM276	P0DTL5	519
GRINA	PLEC	Q15149	509
GRINA	ITPR3	Q14573	506
GRINA	ITPR1	Q14643	504
GRINA	GRIK4	Q16099	499
GRINA	PDCD6	O75340	479
GRINA	CALML5	Q9NZT1	469
GRINA	CALML3	P27482	460
GRINA	ARHGAP39	Q9C0H5	460
GRINA	MROH1	Q8NDA8	455

IntAct

26 interactions, top by confidence:

A	B	Type	Score
GRINA	GPX8	psi-mi:“MI:0915”(physical association)	0.560
TIAL1	GRINA	psi-mi:“MI:0915”(physical association)	0.560
KRTAP19-5	GRINA	psi-mi:“MI:0915”(physical association)	0.560
GGT6	GRINA	psi-mi:“MI:0915”(physical association)	0.560
KRTAP6-2	GRINA	psi-mi:“MI:0915”(physical association)	0.560
FMO1	GRINA	psi-mi:“MI:0915”(physical association)	0.560
GRINA	TMEM242	psi-mi:“MI:0915”(physical association)	0.560
GRINA	DRD2	psi-mi:“MI:0915”(physical association)	0.370
GRINA	GAMMAHV.M3	psi-mi:“MI:0915”(physical association)	0.370
TIAL1	GRINA	psi-mi:“MI:0915”(physical association)	0.000
GRINA	KRTAP6-2	psi-mi:“MI:0915”(physical association)	0.000
GRINA	FMO1	psi-mi:“MI:0915”(physical association)	0.000
GRINA	KRTAP19-5	psi-mi:“MI:0915”(physical association)	0.000
GRINA	GGT6	psi-mi:“MI:0915”(physical association)	0.000
GRINA	TMEM242	psi-mi:“MI:0915”(physical association)	0.000
GRINA		psi-mi:“MI:0915”(physical association)	0.000
ald1	GRINA	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (12): GRINA (PCA), GRINA (Affinity Capture-MS), GRINA (Two-hybrid), GRINA (Two-hybrid), GRINA (Two-hybrid), GRINA (Two-hybrid), KRTAP6-2 (Two-hybrid), KRTAP19-5 (Two-hybrid), TMEM242 (Two-hybrid), GRINA (Two-hybrid), GRINA (Proximity Label-MS), GRINA (Affinity Capture-RNA)

ESM2 similar proteins: A1KXE4, A8E639, D4AEP3, O95415, P0C0T0, P28662, P56603, P60486, P97765, Q0VFP2, Q15038, Q32L53, Q32L83, Q3SZ48, Q3T0K9, Q4R5H7, Q4V888, Q58D45, Q5BJ83, Q5EAU3, Q5HZN7, Q5PPK1, Q5R4K6, Q5R526, Q5RDV6, Q5U2U6, Q5XIH2, Q5ZIS9, Q6GMG8, Q6P6R0, Q6P828, Q7Z429, Q80XQ8, Q8AVW3, Q8CA71, Q8N114, Q8N4L2, Q8QGW7, Q8R478, Q969T9

Diamond homologs: F4JIE8, O25578, O31539, O74888, O88407, P0DXN1, P0DXN2, P0DXN3, Q11080, Q1LZ71, Q32L53, Q5R4I4, Q6P6R0, Q7Z429, Q8K097, Q94A20, Q9BWQ8, Q9DA39, Q9ESF4, Q9HC24, Q9KSA1, Q9M1V9, Q9PIQ8, Q9SA63, Q9ZKT1, Q9ZQX7, Q8BJZ3, Q969X1, Q9A2A3, P0AAC4, P0AAC5, P48558, Q5R7R1, Q03268, Q9CEU8, P55061

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

56 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	42
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1036 predictions. Top by Δscore:

Variant	Effect	Δscore
8:143991690:A:AG	acceptor_gain	1.0000
8:143991691:G:GA	acceptor_gain	1.0000
8:143991691:GC:G	acceptor_gain	1.0000
8:143991691:GCA:G	acceptor_gain	1.0000
8:143991691:GCAC:G	acceptor_gain	1.0000
8:143991691:GCACC:G	acceptor_gain	1.0000
8:143991800:GCAAG:G	donor_gain	1.0000
8:143991801:CAAG:C	donor_loss	1.0000
8:143991805:G:GG	donor_gain	1.0000
8:143991806:T:A	donor_loss	1.0000
8:143992240:T:A	acceptor_gain	1.0000
8:143992240:TGCAG:T	acceptor_loss	1.0000
8:143992241:GCA:G	acceptor_loss	1.0000
8:143992242:CAGTC:C	acceptor_loss	1.0000
8:143992243:A:AG	acceptor_gain	1.0000
8:143992243:AGTC:A	acceptor_gain	1.0000
8:143992244:G:GA	acceptor_gain	1.0000
8:143992244:GT:G	acceptor_gain	1.0000
8:143992244:GTC:G	acceptor_gain	1.0000
8:143992244:GTCG:G	acceptor_gain	1.0000
8:143992273:T:TA	acceptor_gain	1.0000
8:143992370:GCAG:G	donor_gain	1.0000
8:143992374:G:GA	donor_loss	1.0000
8:143992375:T:G	donor_loss	1.0000
8:143992457:A:AG	acceptor_gain	1.0000
8:143992460:TGCAG:T	acceptor_loss	1.0000
8:143992461:GCAGA:G	acceptor_loss	1.0000
8:143992462:CAGA:C	acceptor_loss	1.0000
8:143992463:A:AC	acceptor_loss	1.0000
8:143992463:A:AG	acceptor_gain	1.0000

AlphaMissense

2396 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:143991793:T:C	F161L	1.000
8:143991795:C:A	F161L	1.000
8:143991795:C:G	F161L	1.000
8:143991903:T:C	L173P	1.000
8:143992279:G:A	G243E	1.000
8:143992344:T:C	C265R	1.000
8:143992589:G:A	G316D	1.000
8:143991785:G:C	R158P	0.999
8:143991794:T:C	F161S	0.999
8:143991891:T:C	L169P	0.999
8:143991963:T:A	V193D	0.999
8:143992050:G:C	R222P	0.999
8:143992077:T:C	L231P	0.999
8:143992260:A:C	S237R	0.999
8:143992262:C:A	S237R	0.999
8:143992262:C:G	S237R	0.999
8:143992278:G:A	G243R	0.999
8:143992278:G:C	G243R	0.999
8:143992278:G:T	G243W	0.999
8:143992288:C:A	A246D	0.999
8:143992320:G:C	A257P	0.999
8:143992354:T:A	V268D	0.999
8:143992478:T:C	F279S	0.999
8:143992507:A:C	S289R	0.999
8:143992509:C:A	S289R	0.999
8:143992509:C:G	S289R	0.999
8:143992588:G:C	G316R	0.999
8:143992606:T:C	C322R	0.999
8:143992696:T:A	L324H	0.999
8:143992696:T:C	L324P	0.999

dbSNP variants (sampled 300 via entrez): RS1000602570 (8:143990929 A>G), RS1001264450 (8:143993141 G>A,T), RS1002271584 (8:143992192 A>C), RS1002850287 (8:143988529 G>A), RS1003404964 (8:143988715 G>A), RS1004071190 (8:143991936 C>G,T), RS1004523603 (8:143989938 T>C), RS1005741134 (8:143992953 A>G), RS1007691459 (8:143988398 C>T), RS1008381165 (8:143991572 C>T), RS1008953418 (8:143989878 G>C), RS1009755776 (8:143992454 C>T), RS1011380913 (8:143993198 C>T), RS1011915810 (8:143990894 G>C), RS1012443478 (8:143990654 G>A,C)

Disease associations

OMIM: gene MIM:138251 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002898_12	LDL cholesterol	2.000000e-10
GCST004121_35	Fibrinogen levels	5.000000e-08
GCST005993_43	Mean corpuscular hemoglobin	2.000000e-09
GCST006011_75	Mean corpuscular volume	1.000000e-08
GCST008103_86	Bipolar disorder	1.000000e-06
GCST008115_8	Bipolar I disorder	2.000000e-08
GCST010703_132	Brain morphology (MOSTest)	3.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004527	mean corpuscular hemoglobin
EFO:0009963	bipolar I disorder
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression, decreases expression, affects cotreatment	3
Benzo(a)pyrene	decreases expression, increases methylation	3
Valproic Acid	affects cotreatment, decreases expression	3
bisphenol A	affects expression, decreases methylation	2
tamibarotene	affects expression, increases expression	2
Air Pollutants	increases abundance, increases expression, decreases expression	2
Arsenic	affects cotreatment, increases abundance, increases expression, decreases expression	2
Tretinoin	decreases expression, increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
bisphenol F	affects cotreatment, increases expression	1
alpha phellandrene	increases expression	1
triphenyl phosphate	affects expression	1
manganese chloride	increases expression, affects cotreatment, increases abundance	1
cupric chloride	decreases expression	1
perfluorodecanoic acid	decreases expression	1
pinostrobin	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
MT19c compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	increases expression	1
Sunitinib	increases expression	1
Fulvestrant	increases methylation	1
Acetaminophen	increases expression	1
Atrazine	increases expression	1
Cisplatin	decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Diethylstilbestrol	increases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SQ53	HAP1 GRINA (-) 1	Cancer cell line	Male
CVCL_XP37	HAP1 GRINA (-) 2	Cancer cell line	Male
CVCL_XP38	HAP1 GRINA (-) 3	Cancer cell line	Male
CVCL_XP39	HAP1 GRINA (-) 4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.