GRK5-IT1

Summary

GRK5-IT1 (GRK5 intronic transcript 1, HGNC:49478) is a long non-coding RNA gene on chromosome 10q26.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49478
Approved symbol	GRK5-IT1
Name	GRK5 intronic transcript 1
Location	10q26.11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228485
Ensembl biotype	lncRNA
Entrez	101927868
RNAcentral	URS000050B7FE — lncRNA, 400 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000421206

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421206 — 2 exons

Exon	Start	End
ENSE00001706194	119208531	119208650
ENSE00001788409	119211481	119211760

Expression profiles

Bgee: expression breadth ubiquitous, 124 present calls, max score 82.72.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	82.72	gold quality
colonic epithelium	UBERON:0000397	80.14	gold quality
calcaneal tendon	UBERON:0003701	74.80	gold quality
bone marrow	UBERON:0002371	74.61	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.68	gold quality
cortical plate	UBERON:0005343	71.11	gold quality
sural nerve	UBERON:0015488	70.45	gold quality
bone marrow cell	CL:0002092	69.76	silver quality
left ovary	UBERON:0002119	68.40	gold quality
stromal cell of endometrium	CL:0002255	68.14	gold quality
ovary	UBERON:0000992	68.06	gold quality
corpus callosum	UBERON:0002336	67.45	gold quality
lung	UBERON:0002048	65.77	gold quality
skeletal muscle tissue	UBERON:0001134	65.30	silver quality
right ovary	UBERON:0002118	65.20	gold quality
ascending aorta	UBERON:0001496	64.94	gold quality
blood	UBERON:0000178	64.89	gold quality
thoracic aorta	UBERON:0001515	64.40	gold quality
gall bladder	UBERON:0002110	63.89	gold quality
right lung	UBERON:0002167	63.72	gold quality
urinary bladder	UBERON:0001255	63.29	gold quality
upper lobe of left lung	UBERON:0008952	62.93	gold quality
lymph node	UBERON:0000029	62.73	gold quality
tonsil	UBERON:0002372	61.77	gold quality
descending thoracic aorta	UBERON:0002345	61.55	gold quality
liver	UBERON:0002107	60.46	gold quality
placenta	UBERON:0001987	60.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	60.44	gold quality
right atrium auricular region	UBERON:0006631	60.16	gold quality
left coronary artery	UBERON:0001626	59.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.60

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.