GSC-DT

Summary

GSC-DT (GSC divergent transcript, HGNC:53074) is a long non-coding RNA gene on chromosome 14q32.13.

Involved in endodermal cell differentiation.

Source: NCBI Gene 108868751 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53074
Approved symbol	GSC-DT
Name	GSC divergent transcript
Location	14q32.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	DIGIT
Ensembl gene	ENSG00000285205
Ensembl biotype	lncRNA
Entrez	108868751
RNAcentral	URS0000A77281 — lncRNA, 2226 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000643862

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000643862 — 1 exons

Exon	Start	End
ENSE00003824252	94770271	94774858

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 91.34.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortex of kidney	UBERON:0001225	91.34	gold quality
calcaneal tendon	UBERON:0003701	63.95	gold quality
body of uterus	UBERON:0009853	51.41	gold quality
saliva-secreting gland	UBERON:0001044	50.18	gold quality
blood	UBERON:0000178	49.16	gold quality
muscle of leg	UBERON:0001383	49.03	gold quality
cerebral cortex	UBERON:0000956	48.41	gold quality
right ovary	UBERON:0002118	47.92	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	47.60	gold quality
thoracic mammary gland	UBERON:0005200	47.03	gold quality
tibial artery	UBERON:0007610	46.18	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	44.10	silver quality
gastrocnemius	UBERON:0001388	44.00	silver quality
heart left ventricle	UBERON:0002084	42.83	silver quality
subcutaneous adipose tissue	UBERON:0002190	42.09	silver quality
adipose tissue	UBERON:0001013	41.58	silver quality
prostate gland	UBERON:0002367	40.94	silver quality
omental fat pad	UBERON:0010414	40.66	silver quality
thyroid gland	UBERON:0002046	40.42	silver quality
left lobe of thyroid gland	UBERON:0001120	40.33	silver quality
right lobe of thyroid gland	UBERON:0001119	39.67	silver quality
hypothalamus	UBERON:0001898	38.04	silver quality
tibial nerve	UBERON:0001323	37.80	silver quality
vagina	UBERON:0000996	37.29	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• We find that DIGIT is divergent to Goosecoid (GSC) and expressed during endoderm differentiation. Deletion of the SMAD3-occupied enhancer proximal to DIGIT inhibits DIGIT and GSC expression and definitive endoderm differentiation. (PMID:27705785)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.