GSEC

Summary

GSEC (G-quadruplex forming sequence containing lncRNA, HGNC:48645) is a long non-coding RNA gene on chromosome 11q24.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48645
Approved symbol	GSEC
Name	G-quadruplex forming sequence containing lncRNA
Location	11q24.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	DCPS-AS1, FLJ39051
Ensembl gene	ENSG00000280832
Ensembl biotype	lncRNA
Entrez	399972
RNAcentral	URS000075BEA1 — lncRNA, 753 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000626810, ENST00000629441, ENST00000702666, ENST00000801033, ENST00000801034, ENST00000801035

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000626810 — 3 exons

Exon	Start	End
ENSE00003761993	126354379	126354915
ENSE00003773645	126350172	126351777
ENSE00003986855	126355442	126355587

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 84.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.5074 / max 29.2694, expressed in 1238 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
123028	2.3937	1217
123027	0.1137	44

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	84.55	gold quality
blood	UBERON:0000178	83.18	gold quality
right adrenal gland	UBERON:0001233	80.66	gold quality
right adrenal gland cortex	UBERON:0035827	80.52	gold quality
left adrenal gland cortex	UBERON:0035825	79.96	gold quality
left adrenal gland	UBERON:0001234	79.73	gold quality
adrenal cortex	UBERON:0001235	79.07	gold quality
adrenal gland	UBERON:0002369	78.48	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.45	gold quality
right ovary	UBERON:0002118	74.12	gold quality
left ovary	UBERON:0002119	74.02	gold quality
ganglionic eminence	UBERON:0004023	73.59	gold quality
adrenal tissue	UBERON:0018303	73.47	gold quality
pigmented layer of retina	UBERON:0001782	73.38	gold quality
stromal cell of endometrium	CL:0002255	73.05	gold quality
spleen	UBERON:0002106	72.83	gold quality
granulocyte	CL:0000094	72.75	gold quality
ovary	UBERON:0000992	72.64	gold quality
germinal epithelium of ovary	UBERON:0001304	72.61	silver quality
cortical plate	UBERON:0005343	72.58	gold quality
ventricular zone	UBERON:0003053	72.10	gold quality
palpebral conjunctiva	UBERON:0001812	71.43	gold quality
bone marrow cell	CL:0002092	70.91	silver quality
right atrium auricular region	UBERON:0006631	70.73	gold quality
visceral pleura	UBERON:0002401	70.38	silver quality
cardiac atrium	UBERON:0002081	70.26	gold quality
right coronary artery	UBERON:0001625	69.69	gold quality
Brodmann (1909) area 23	UBERON:0013554	69.64	silver quality
vermiform appendix	UBERON:0001154	69.62	gold quality
leukocyte	CL:0000738	69.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.12

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• LncRNA GSEC promotes the proliferation, migration and invasion by sponging miR-588/ EIF5A2 axis in osteosarcoma. (PMID:32868080)
• Long noncoding RNA GSEC promotes neutrophil inflammatory activation by supporting PFKFB3-involved glycolytic metabolism in sepsis. (PMID:34907156)
• Involvement of plasma lncRNA GSEC in sepsis discrimination and prognosis, and its correlation with macrophage cell inflammation and proliferation. (PMID:36049364)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.