GTPBP10
gene geneOn this page
Also known as DKFZP686A10121FLJ38242OBGH2
Summary
GTPBP10 (GTP binding protein 10, HGNC:25106) is a protein-coding gene on chromosome 7q21.13, encoding GTP-binding protein 10 (A4D1E9). May be involved in the ribosome maturation process. It is a selective cancer dependency (DepMap: 15.7% of cell lines).
Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).
Source: NCBI Gene 85865 — RefSeq curated summary.
At a glance
- Clinical variants (ClinVar): 69 total
- Druggable target: yes
- Cancer dependency (DepMap): dependent in 15.7% of screened cell lines
- MANE Select transcript:
NM_033107
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:25106 |
| Approved symbol | GTPBP10 |
| Name | GTP binding protein 10 |
| Location | 7q21.13 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | DKFZP686A10121, FLJ38242, OBGH2 |
| Ensembl gene | ENSG00000105793 |
| Ensembl biotype | protein_coding |
| OMIM | 610920 |
| Entrez | 85865 |
Gene structure
Transcript identifiers
Ensembl transcripts: 17 — 10 protein_coding, 4 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 1 retained_intron
ENST00000222511, ENST00000257659, ENST00000380058, ENST00000417207, ENST00000421719, ENST00000426366, ENST00000439832, ENST00000450619, ENST00000453512, ENST00000469675, ENST00000474503, ENST00000477972, ENST00000861578, ENST00000861579, ENST00000927587, ENST00000959248, ENST00000959249
RefSeq mRNA: 2 — MANE Select: NM_033107
NM_001042717, NM_033107
CCDS: CCDS43614, CCDS5617
Canonical transcript exons
ENST00000222511 — 10 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001272201 | 90346716 | 90346774 |
| ENSE00001901407 | 90384892 | 90391453 |
| ENSE00003251405 | 90352816 | 90353009 |
| ENSE00003316618 | 90354458 | 90354549 |
| ENSE00003473543 | 90355086 | 90355230 |
| ENSE00003497778 | 90377507 | 90377614 |
| ENSE00003520965 | 90372155 | 90372228 |
| ENSE00003603161 | 90378134 | 90378211 |
| ENSE00003674067 | 90382956 | 90383079 |
| ENSE00003693787 | 90374302 | 90374354 |
Expression profiles
Bgee: expression breadth ubiquitous, 268 present calls, max score 89.86.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.6748 / max 344.4867, expressed in 1795 samples.
FANTOM5 promoters (1 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 79448 | 23.6748 | 1795 |
Top tissues by expression
297 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| corpus epididymis | UBERON:0004359 | 89.86 | gold quality |
| primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 88.89 | gold quality |
| calcaneal tendon | UBERON:0003701 | 88.56 | gold quality |
| cauda epididymis | UBERON:0004360 | 87.94 | gold quality |
| secondary oocyte | CL:0000655 | 87.77 | gold quality |
| caput epididymis | UBERON:0004358 | 87.71 | gold quality |
| skeletal muscle tissue of biceps brachii | UBERON:0004502 | 86.57 | gold quality |
| islet of Langerhans | UBERON:0000006 | 86.46 | gold quality |
| adrenal tissue | UBERON:0018303 | 86.42 | gold quality |
| right lobe of liver | UBERON:0001114 | 86.24 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 85.85 | gold quality |
| gastrocnemius | UBERON:0001388 | 85.32 | gold quality |
| biceps brachii | UBERON:0001507 | 85.30 | gold quality |
| rectum | UBERON:0001052 | 85.22 | gold quality |
| hindlimb stylopod muscle | UBERON:0004252 | 85.11 | gold quality |
| muscle of leg | UBERON:0001383 | 84.95 | gold quality |
| monocyte | CL:0000576 | 84.55 | gold quality |
| granulocyte | CL:0000094 | 84.51 | gold quality |
| leukocyte | CL:0000738 | 84.31 | gold quality |
| mononuclear cell | CL:0000842 | 84.24 | gold quality |
| colonic epithelium | UBERON:0000397 | 83.59 | gold quality |
| tendon | UBERON:0000043 | 83.51 | gold quality |
| body of pancreas | UBERON:0001150 | 83.48 | gold quality |
| corpus callosum | UBERON:0002336 | 83.43 | gold quality |
| pancreas | UBERON:0001264 | 83.32 | gold quality |
| heart right ventricle | UBERON:0002080 | 83.23 | gold quality |
| olfactory segment of nasal mucosa | UBERON:0005386 | 83.01 | gold quality |
| skin of abdomen | UBERON:0001416 | 82.99 | gold quality |
| heart left ventricle | UBERON:0002084 | 82.99 | gold quality |
| cardiac ventricle | UBERON:0002082 | 82.93 | gold quality |
Single-cell (SCXA)
Detected in 2 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | yes | 5.73 |
| E-MTAB-7303 | no | 112.53 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
225 targeting GTPBP10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-1277-5P | 100.00 | 73.95 | 5056 |
| HSA-MIR-5692B | 100.00 | 71.32 | 2622 |
| HSA-MIR-5692C | 100.00 | 71.32 | 2622 |
| HSA-MIR-5011-5P | 100.00 | 83.46 | 5820 |
| HSA-MIR-190A-3P | 100.00 | 80.35 | 5520 |
| HSA-MIR-200B-3P | 100.00 | 73.31 | 2693 |
| HSA-MIR-200C-3P | 100.00 | 73.35 | 2685 |
| HSA-MIR-429 | 100.00 | 73.44 | 2698 |
| HSA-MIR-5692A | 100.00 | 74.40 | 6850 |
| HSA-MIR-6873-3P | 100.00 | 71.42 | 2626 |
| HSA-MIR-4262 | 100.00 | 73.26 | 3931 |
| HSA-MIR-3646 | 100.00 | 73.56 | 5283 |
| HSA-MIR-4282 | 99.99 | 75.36 | 6408 |
| HSA-MIR-548C-3P | 99.99 | 74.01 | 7587 |
| HSA-MIR-3662 | 99.99 | 73.82 | 5684 |
| HSA-MIR-6870-5P | 99.99 | 68.55 | 2115 |
| HSA-MIR-186-5P | 99.99 | 70.83 | 3707 |
| HSA-MIR-4803 | 99.98 | 71.99 | 3117 |
| HSA-MIR-4775 | 99.98 | 75.00 | 6394 |
| HSA-MIR-4482-3P | 99.98 | 72.50 | 3147 |
| HSA-MIR-103A-3P | 99.98 | 69.14 | 1595 |
| HSA-MIR-107 | 99.98 | 69.14 | 1595 |
| HSA-MIR-19A-3P | 99.98 | 75.33 | 2762 |
| HSA-MIR-19B-3P | 99.98 | 75.44 | 2754 |
| HSA-MIR-3148 | 99.97 | 75.06 | 6478 |
| HSA-MIR-607 | 99.97 | 73.62 | 5593 |
| HSA-MIR-4723-5P | 99.97 | 68.70 | 2034 |
| HSA-MIR-5698 | 99.97 | 68.49 | 2029 |
| HSA-MIR-7111-5P | 99.97 | 68.48 | 2062 |
| HSA-MIR-302C-5P | 99.97 | 72.56 | 3642 |
Functional genomics
DepMap (CRISPR cell-line fitness): dependent in 15.7% of screened cell lines.
Literature-anchored findings (GeneRIF, showing 3)
- Knock-down of ObgH1 by RNAi induced mitochondria elongation, whereas knock-down of ObgH2 resulted in the disorganization of the nucleolar architecture. (PMID:17054726)
- Our results suggest that GTPBP10 is a ribosome biogenesis factor of the mtLSU required for late stages of maturation. (PMID:30085210)
- GTPBP10 primarily ensures proper mtLSU maturation and ultimately serves to coordinate mtSSU and mtLSU accumulation (PMID:30321378)
Cross-species orthologs
5 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | gtpbp10 | ENSDARG00000040300 |
| mus_musculus | Gtpbp10 | ENSMUSG00000040464 |
| rattus_norvegicus | Gtpbp10 | ENSRNOG00000007098 |
| drosophila_melanogaster | CG10628 | FBGN0032818 |
| caenorhabditis_elegans | WBGENE00016145 |
Paralogs (4): MTG2 (ENSG00000101181), GTPBP4 (ENSG00000107937), DRG2 (ENSG00000108591), DRG1 (ENSG00000185721)
Protein
Protein identifiers
GTP-binding protein 10 — A4D1E9 (reviewed: A4D1E9)
Alternative names: Protein obg homolog 2
All UniProt accessions (7): A4D1E9, C9J8R7, C9JEQ8, C9JNI1, F8WBB5, F8WBY0, F8WCN4
UniProt curated annotations — full annotation on UniProt →
Function. May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed.
Subcellular location. Nucleus. Nucleolus. Chromosome.
Similarity. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Isoforms (3)
| UniProt ID | Names | Canonical? |
|---|---|---|
| A4D1E9-1 | 1 | yes |
| A4D1E9-2 | 2 | |
| A4D1E9-3 | 3 |
RefSeq proteins (2): NP_001036182, NP_149098* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR006073 | GTP-bd | Domain |
| IPR006169 | GTP1_OBG_dom | Domain |
| IPR014100 | GTP-bd_Obg/CgtA | Family |
| IPR027417 | P-loop_NTPase | Homologous_superfamily |
| IPR031167 | G_OBG | Domain |
| IPR036726 | GTP1_OBG_dom_sf | Homologous_superfamily |
| IPR045086 | OBG_GTPase | Family |
Pfam: PF01018, PF01926
UniProt features (14 total): sequence variant 4, binding site 3, splice variant 3, domain 2, chain 1, sequence conflict 1
Structure
Experimental structures (PDB)
2 structures.
| PDB | Method | Resolution (Å) |
|---|---|---|
| 8PK0 | ELECTRON MICROSCOPY | 3.03 |
| 7OI6 | ELECTRON MICROSCOPY | 5.7 |
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-A4D1E9-F1 | 79.97 | 0.40 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Ligand- & substrate-binding residues (3): 155–162; 202–206; 278–281
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 119 (showing top):
GSE45365_NK_CELL_VS_BCELL_DN, GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_RIBOSOME_ASSEMBLY, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_ORGANELLE_ASSEMBLY, DODD_NASOPHARYNGEAL_CARCINOMA_UP, ZHANG_BREAST_CANCER_PROGENITORS_UP, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, GOBP_RIBOSOMAL_LARGE_SUBUNIT_BIOGENESIS, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, GRADE_COLON_AND_RECTAL_CANCER_UP
GO Biological Process (2): mitochondrial large ribosomal subunit assembly (GO:1902775), ribosome biogenesis (GO:0042254)
GO Molecular Function (8): magnesium ion binding (GO:0000287), RNA binding (GO:0003723), GTPase activity (GO:0003924), GTP binding (GO:0005525), rRNA binding (GO:0019843), mitochondrial large ribosomal subunit binding (GO:0140978), nucleotide binding (GO:0000166), protein binding (GO:0005515)
GO Cellular Component (5): chromosome (GO:0005694), nucleolus (GO:0005730), mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759), nucleus (GO:0005634)
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| intracellular membraneless organelle | 2 |
| intracellular membrane-bounded organelle | 2 |
| ribosomal large subunit assembly | 1 |
| mitochondrial ribosome assembly | 1 |
| ribonucleoprotein complex biogenesis | 1 |
| metal ion binding | 1 |
| nucleic acid binding | 1 |
| ribonucleoside triphosphate phosphatase activity | 1 |
| guanyl ribonucleotide binding | 1 |
| purine ribonucleoside triphosphate binding | 1 |
| RNA binding | 1 |
| ribosomal large subunit binding | 1 |
| mitochondrial ribosome binding | 1 |
| nucleoside phosphate binding | 1 |
| heterocyclic compound binding | 1 |
| binding | 1 |
| nuclear lumen | 1 |
| cytoplasm | 1 |
| mitochondrion | 1 |
| intracellular organelle lumen | 1 |
Protein interactions and networks
STRING
1830 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| GTPBP10 | MKI67 | P46013 | 840 |
| GTPBP10 | MALSU1 | Q96EH3 | 835 |
| GTPBP10 | MTG1 | Q9BT17 | 832 |
| GTPBP10 | GTPBP6 | O43824 | 763 |
| GTPBP10 | DDX28 | Q9NUL7 | 754 |
| GTPBP10 | ERAL1 | O75616 | 728 |
| GTPBP10 | MTERF4 | Q7Z6M4 | 720 |
| GTPBP10 | MRM2 | Q9UI43 | 710 |
| GTPBP10 | GTPBP8 | Q8N3Z3 | 709 |
| GTPBP10 | NSUN4 | Q96CB9 | 681 |
| GTPBP10 | NGRN | Q9NPE2 | 676 |
| GTPBP10 | MRM3 | Q9HC36 | 661 |
| GTPBP10 | TRUB2 | O95900 | 647 |
| GTPBP10 | NOA1 | Q8NC60 | 646 |
| GTPBP10 | RPUSD4 | Q96CM3 | 635 |
IntAct
124 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| CFTR | ESYT2 | psi-mi:“MI:2364”(proximity) | 0.710 |
| MRPS30 | GTPBP10 | psi-mi:“MI:0914”(association) | 0.640 |
| PNMA1 | GTPBP10 | psi-mi:“MI:0915”(physical association) | 0.600 |
| GTPBP10 | PNMA1 | psi-mi:“MI:0915”(physical association) | 0.600 |
| GOLGA2 | GTPBP10 | psi-mi:“MI:0915”(physical association) | 0.560 |
| GTPBP10 | MTUS2 | psi-mi:“MI:0915”(physical association) | 0.560 |
| MTUS2 | GTPBP10 | psi-mi:“MI:0915”(physical association) | 0.560 |
| PLEKHO1 | UBA6 | psi-mi:“MI:0914”(association) | 0.530 |
| BPNT1 | GTPBP10 | psi-mi:“MI:0914”(association) | 0.530 |
| FGF3 | GTPBP10 | psi-mi:“MI:0914”(association) | 0.530 |
| MECP2 | GTPBP10 | psi-mi:“MI:0914”(association) | 0.530 |
| MRPL50 | GTPBP10 | psi-mi:“MI:0914”(association) | 0.530 |
| MAGEB10 | GTPBP10 | psi-mi:“MI:0914”(association) | 0.530 |
| MRPL2 | GTPBP10 | psi-mi:“MI:0914”(association) | 0.530 |
| MRPL13 | GTPBP10 | psi-mi:“MI:0914”(association) | 0.530 |
| MRPL18 | GTPBP10 | psi-mi:“MI:0914”(association) | 0.530 |
BioGRID (161): GTPBP10 (Two-hybrid), GTPBP10 (Two-hybrid), GTPBP10 (Two-hybrid), PCBP4 (Affinity Capture-MS), GTPBP10 (Affinity Capture-MS), GTPBP10 (Two-hybrid), GTPBP10 (Two-hybrid), GTPBP10 (Affinity Capture-MS), GTPBP10 (Affinity Capture-MS), GTPBP10 (Affinity Capture-MS), GTPBP10 (Affinity Capture-MS), GTPBP10 (Affinity Capture-MS), GTPBP10 (Affinity Capture-MS), GTPBP10 (Affinity Capture-MS), PCBP4 (Affinity Capture-MS)
ESM2 similar proteins: A4D1E9, A4IHT9, A6QLJ3, A6QPU5, A9JTX2, B1H116, B3RXR7, E1BMP7, E3TDS3, I0IUP3, O23617, O80738, P06801, P13697, P31754, P32296, P51530, Q0E671, Q16798, Q1LZ83, Q29K06, Q2KI15, Q2TAA5, Q3MHG6, Q4V7N2, Q503J2, Q5M8V6, Q5R7Z6, Q5RDW1, Q5U528, Q5VV42, Q6DHF7, Q6NS23, Q6NS26, Q6P4Y0, Q6PI48, Q7SYM0, Q8BIP0, Q8BMF3, Q8C3X4
Diamond homologs: A0AIY6, A0M5C6, A0Q1T4, A0RJ47, A4D1E9, A4IRC7, A4J7I9, A4XJS8, A5D410, A5GD29, A5I666, A5ITG8, A5VJ99, A6QHI6, A6TQJ6, A6U2B2, A7FXU6, A7GHK2, A7X361, A7Z781, A8FFS8, A8MHK8, A8Z2H2, A9AXD9, A9VIR5, B0K414, B0KAB8, B0TBW1, B1ILY5, B1KZR3, B2G6R9, B2KAW2, B2V968, B3E609, B5E958, B5YEQ1, B5YJ65, B7GIR2, B7HE73, B7HQJ8
SIGNOR signaling
0 interactions.
Enriched among interaction partners
Reactome pathways and GO biological processes over-represented among this gene’s 95 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.
Reactome pathways:
| Pathway | Partners | Fold | FDR |
|---|---|---|---|
| Peptide chain elongation | 13 | 23.9× | 5e-13 |
| Viral mRNA Translation | 13 | 23.9× | 5e-13 |
| PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA | 13 | 23.6× | 5e-13 |
| Mitochondrial ribosome-associated quality control | 13 | 23.1× | 5e-13 |
| Selenocysteine synthesis | 13 | 22.6× | 5e-13 |
| Eukaryotic Translation Termination | 13 | 22.6× | 5e-13 |
| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | 13 | 22.2× | 5e-13 |
| ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA | 13 | 22.2× | 5e-13 |
GO biological processes:
| GO term | Partners | Fold | FDR |
|---|---|---|---|
| mitochondrial translation | 14 | 28.0× | 1e-14 |
| cytoplasmic translation | 13 | 27.7× | 1e-13 |
| translation | 20 | 23.6× | 1e-19 |
| negative regulation of translation | 7 | 15.8× | 3e-05 |
Disease & clinical
Clinical variants and AI predictions
ClinVar
69 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 47 |
| Likely benign | 2 |
| Benign | 0 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
1350 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 7:90353006:GCAA:G | donor_gain | 1.0000 |
| 7:90353010:G:GG | donor_gain | 1.0000 |
| 7:90372225:GCAT:G | donor_gain | 1.0000 |
| 7:90372229:G:GG | donor_gain | 1.0000 |
| 7:90374300:A:AG | acceptor_gain | 1.0000 |
| 7:90374301:G:GA | acceptor_gain | 1.0000 |
| 7:90377612:GTT:G | donor_gain | 1.0000 |
| 7:90377615:G:GG | donor_gain | 1.0000 |
| 7:90378212:G:GG | donor_gain | 1.0000 |
| 7:90382946:T:TA | acceptor_gain | 1.0000 |
| 7:90382952:A:AG | acceptor_gain | 1.0000 |
| 7:90382952:AAAG:A | acceptor_gain | 1.0000 |
| 7:90382953:A:AG | acceptor_gain | 1.0000 |
| 7:90382953:AAG:A | acceptor_gain | 1.0000 |
| 7:90382954:A:AG | acceptor_gain | 1.0000 |
| 7:90382954:AG:A | acceptor_gain | 1.0000 |
| 7:90382955:G:GA | acceptor_gain | 1.0000 |
| 7:90382955:GG:G | acceptor_gain | 1.0000 |
| 7:90382955:GGA:G | acceptor_gain | 1.0000 |
| 7:90382955:GGAGT:G | acceptor_gain | 1.0000 |
| 7:90383077:AAGGT:A | donor_loss | 1.0000 |
| 7:90383078:AGGTA:A | donor_loss | 1.0000 |
| 7:90383080:G:GA | donor_loss | 1.0000 |
| 7:90383080:G:GG | donor_gain | 1.0000 |
| 7:90383081:T:G | donor_loss | 1.0000 |
| 7:90385038:G:GT | donor_gain | 1.0000 |
| 7:90385039:A:T | donor_gain | 1.0000 |
| 7:90346756:T:G | donor_gain | 0.9900 |
| 7:90352813:A:AG | acceptor_gain | 0.9900 |
| 7:90352814:A:G | acceptor_gain | 0.9900 |
AlphaMissense
2552 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 7:90372228:T:C | F180L | 0.990 |
| 7:90374303:T:A | F180L | 0.990 |
| 7:90374303:T:G | F180L | 0.990 |
| 7:90377573:T:C | F220L | 0.989 |
| 7:90377575:C:A | F220L | 0.989 |
| 7:90377575:C:G | F220L | 0.989 |
| 7:90372172:A:T | K161I | 0.987 |
| 7:90383014:A:T | K279I | 0.979 |
| 7:90352916:T:A | V45D | 0.977 |
| 7:90353005:A:C | S75R | 0.974 |
| 7:90353007:C:A | S75R | 0.974 |
| 7:90353007:C:G | S75R | 0.974 |
| 7:90377516:G:C | A201P | 0.973 |
| 7:90377517:C:A | A201D | 0.970 |
| 7:90378149:T:C | F239L | 0.969 |
| 7:90378151:T:A | F239L | 0.969 |
| 7:90378151:T:G | F239L | 0.969 |
| 7:90372171:A:G | K161E | 0.967 |
| 7:90355157:T:C | F131L | 0.966 |
| 7:90355159:C:A | F131L | 0.966 |
| 7:90355159:C:G | F131L | 0.966 |
| 7:90377523:T:C | L203P | 0.966 |
| 7:90377532:T:C | L206S | 0.966 |
| 7:90372172:A:C | K161T | 0.965 |
| 7:90372173:A:C | K161N | 0.963 |
| 7:90372173:A:T | K161N | 0.963 |
| 7:90383015:A:C | K279N | 0.963 |
| 7:90383015:A:T | K279N | 0.963 |
| 7:90352874:G:A | G31D | 0.962 |
| 7:90372171:A:C | K161Q | 0.962 |
dbSNP variants (sampled 300 via entrez): RS1000003266 (7:90370153 C>T), RS1000111796 (7:90376533 C>T), RS1000235077 (7:90348850 A>G), RS1000253799 (7:90355136 G>A,C), RS1000264669 (7:90379824 A>G), RS1000320132 (7:90347505 A>G), RS1000352131 (7:90385652 T>G), RS1000368718 (7:90354775 T>C), RS1000496000 (7:90368051 G>C,T), RS1000556802 (7:90374854 G>A), RS1000581220 (7:90364507 G>A), RS1000655657 (7:90391523 G>A), RS1000710672 (7:90387834 C>A), RS1000732390 (7:90347803 G>A), RS1000737493 (7:90381061 C>A)
Disease associations
OMIM: gene MIM:610920 | disease phenotypes:
GenCC curated gene-disease
Mondo (0):
Orphanet (0):
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
0 associations (top):
Drugs & pharmacology
Drug and pharmacology data
Is drug target: yes
ChEMBL targets (1): CHEMBL6066355 (SINGLE PROTEIN)
PharmGKB: 1 entry (VIP=true, CPIC=false)
ChEMBL bioactivities
2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).
| pChembl | Type | Value | Unit | Molecule |
|---|---|---|---|---|
| 7.23 | Kd | 58.31 | nM | CHEMBL5653589 |
| 7.19 | ED50 | 63.95 | nM | CHEMBL5653589 |
PubChem BioAssay actives
1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.
| Compound | Assay | Type | Value | Unit |
|---|---|---|---|---|
| 4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide | 2148477: Binding affinity to human GTPBP10 incubated for 45 mins by Kinobead based pull down assay | kd | 0.0583 | uM |
CTD chemical–gene interactions
26 total (human), top 26 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Air Pollutants | decreases expression, affects cotreatment, increases abundance, increases oxidation | 2 |
| triphenyl phosphate | affects expression | 1 |
| alpha-pinene | affects cotreatment, increases oxidation, increases abundance | 1 |
| pirinixic acid | affects binding, increases activity, increases expression | 1 |
| deoxynivalenol | increases expression | 1 |
| beta-lapachone | increases expression | 1 |
| sodium arsenite | affects cotreatment, decreases expression | 1 |
| methacrylaldehyde | increases abundance, affects cotreatment, increases oxidation | 1 |
| di-n-butylphosphoric acid | affects expression | 1 |
| MT19c compound | increases expression | 1 |
| Acrolein | increases abundance, affects cotreatment, increases oxidation | 1 |
| Benzo(a)pyrene | decreases methylation | 1 |
| Coal | decreases expression, increases abundance | 1 |
| Gallic Acid | decreases expression | 1 |
| Methyl Methanesulfonate | increases expression | 1 |
| Ozone | affects cotreatment, increases oxidation, increases abundance | 1 |
| Phenobarbital | affects expression | 1 |
| Ribonucleotides | affects binding | 1 |
| Smoke | decreases expression, increases abundance | 1 |
| Tretinoin | affects cotreatment, decreases expression | 1 |
| Urethane | decreases expression | 1 |
| Cyclosporine | increases expression | 1 |
| Aflatoxin M1 | decreases expression | 1 |
| Antirheumatic Agents | decreases expression | 1 |
| Cadmium Chloride | decreases expression | 1 |
| Volatile Organic Compounds | affects cotreatment, increases oxidation | 1 |
ChEMBL screening assays
1 unique, capped per target: 1 binding
Representative assays (with source publication via chembl_document):
| Assay ID | Type | Description | Source paper |
|---|---|---|---|
| CHEMBL5651519 | Binding | Binding affinity to human GTPBP10 incubated for 45 mins by Kinobead based pull down assay | NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem |
Clinical trials (associated diseases)
0 trials via MONDO — disease-level, not drug-specific.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.