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H1-1

gene
On this page

Also known as H1.1H1a

Summary

H1-1 (H1.1 linker histone, cluster member, HGNC:4715) is a protein-coding gene on chromosome 6p22.2, encoding Histone H1.1 (Q02539). Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Source: NCBI Gene 3024 — RefSeq curated summary.

At a glance

  • GWAS associations: 17
  • Clinical variants (ClinVar): 87 total — 1 pathogenic
  • MANE Select transcript: NM_005325

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:4715
Approved symbolH1-1
NameH1.1 linker histone, cluster member
Location6p22.2
Locus typegene with protein product
StatusApproved
AliasesH1.1, H1a
Ensembl geneENSG00000124610
Ensembl biotypeprotein_coding
OMIM142709
Entrez3024

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000244573

RefSeq mRNA: 1 — MANE Select: NM_005325 NM_005325

CCDS: CCDS4569

Canonical transcript exons

ENST00000244573 — 1 exons

ExonStartEnd
ENSE000008484112601703226017787

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 98.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 72.3610 / max 3859.4261, expressed in 1254 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
7229170.46391237
722891.4305436
722900.4666201

Top tissues by expression

260 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
oocyteCL:000002398.32gold quality
secondary oocyteCL:000065595.13gold quality
buccal mucosa cellCL:000233688.63silver quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047385.43gold quality
tendon of biceps brachiiUBERON:000818884.92gold quality
calcaneal tendonUBERON:000370177.64gold quality
tendonUBERON:000004377.62gold quality
diaphragmUBERON:000110374.53gold quality
adrenal tissueUBERON:001830374.50gold quality
endometrium epitheliumUBERON:000481169.15gold quality
paraflocculusUBERON:000535168.37gold quality
skeletal muscle tissue of rectus abdominisUBERON:000451168.26gold quality
middle frontal gyrusUBERON:000270268.25gold quality
frontal poleUBERON:000279567.94gold quality
cervix squamous epitheliumUBERON:000692264.98gold quality
Brodmann (1909) area 10UBERON:001354163.91gold quality
cerebellar vermisUBERON:000472062.84gold quality
tongue squamous epitheliumUBERON:000691962.65gold quality
gingival epitheliumUBERON:000194962.01gold quality
superficial temporal arteryUBERON:000161461.88gold quality
hair follicleUBERON:000207361.86gold quality
bone marrow cellCL:000209261.38silver quality
vastus lateralisUBERON:000137961.08gold quality
quadriceps femorisUBERON:000137760.46gold quality
gingivaUBERON:000182860.17gold quality
squamous epitheliumUBERON:000691460.15gold quality
jejunal mucosaUBERON:000039959.58gold quality
biceps brachiiUBERON:000150758.97gold quality
myocardiumUBERON:000234958.18gold quality
gluteal muscleUBERON:000200057.86gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

ExperimentMarker?Max mean expression
E-MTAB-3929yes1533.29
E-HCAD-56yes1137.80
E-ANND-3no1.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

  • the C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo (PMID:14985337)
  • confirmed N-terminal acetylation on all isoforms plus a single internal acetylation site; phosphorylation sites were located on peptides containing the cyclin dependent kinase (CDK) consensus motif (PMID:15595731)
  • histone H2A.X phosphorylation by DNA-dependent protein kinase is not affected by core histone acetylation, but it alters nucleosome stability and histone H1 binding (PMID:20356835)
  • Data show that the multifunctional histone chaperone NPM1 interacts with linker histone H1 through its first acidic stretch (residues 120-132). (PMID:21425800)
  • fluorescence recovery after photobleaching analyses suggested that TAF-I beta enhances the dissociation of H1.1 from chromatin in the living cell (PMID:21940793)
  • Integration with apoptotic intermediates (via C-terminal tail interactions) may constitute a more generalized function of linker histone isoforms in apoptotic cascades. (PMID:24525734)
  • Results suggest the potential for histone H1 phosphorylation at threonine 146 as a clinical biomarker in breast cancer. (PMID:24601643)
  • HIST1 cluster PcG methylation has a role in epigenesis in acute myeloid leukemia (PMID:25482132)
  • Proper binding of histone H1.1 to chromatin is determined by the simultaneous and synergistic binding of its folded wing helix domain -C-terminal domains to the nucleosome. (PMID:26182371)
  • Data indicate that IgGs possessing an affinity to histone H1 were isolated by affinity chromatography and size exclusion chromatography. (PMID:28361854)
  • Brain age estimation at tract group level and its association with daily life measures, cardiac risk factors and genetic variants. (PMID:34663856)

Cross-species orthologs

6 orthologs

OrganismSymbolGene ID
mus_musculusH1f1ENSMUSG00000049539
caenorhabditis_elegansWBGENE00001853
caenorhabditis_elegansWBGENE00001854
caenorhabditis_elegansWBGENE00001855
caenorhabditis_eleganshil-5WBGENE00001856
caenorhabditis_elegansWBGENE00001857

Paralogs (9): H1-3 (ENSG00000124575), H1-4 (ENSG00000168298), H1-8 (ENSG00000178804), H1-5 (ENSG00000184357), H1-10 (ENSG00000184897), H1-7 (ENSG00000187166), H1-6 (ENSG00000187475), H1-2 (ENSG00000187837), H1-0 (ENSG00000189060)

Protein

Protein identifiers

Histone H1.1 — Q02539 (reviewed: Q02539)

Alternative names: Histone H1a

All UniProt accessions (1): Q02539

UniProt curated annotations — full annotation on UniProt →

Function. Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.

Subunit / interactions. Associates with nucleosomes, promoting condensation into higher-order structured chromatin. Interacts with DFFB.

Subcellular location. Nucleus. Chromosome.

Post-translational modifications. Deamidation of Asn-79 and Asn-80 by CTPS1 in response to DNA damage promotes subsequent acetylation of histone H1 at Lys-78 (H1K75ac). Acetylated at Lys-78 (H1K75ac) by EP300 following deamidation of Asn-79 and Asn-80 by CTPS1 in response to DNA damage, thereby increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins. H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.

Domain organisation. The C-terminal domain is required for high-affinity binding to chromatin.

Similarity. Belongs to the histone H1/H5 family.

RefSeq proteins (1): NP_005316* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR005818Histone_H1/H5_H15Domain
IPR005819H1/H5Family
IPR036388WH-like_DNA-bd_sfHomologous_superfamily
IPR036390WH_DNA-bd_sfHomologous_superfamily

Pfam: PF00538

UniProt features (45 total): modified residue 31, compositionally biased region 4, sequence variant 3, region of interest 2, mutagenesis site 2, initiator methionine 1, chain 1, domain 1

Structure

Experimental structures (PDB)

1 structures.

PDBMethodResolution (Å)
9J8OELECTRON MICROSCOPY4.05

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q02539-F164.400.31

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (31): 2, 12, 17, 26, 37, 37, 44, 55, 55, 57, 66, 67, 67, 78, 79, 80, 88, 88, 93, 93 …

Mutagenesis-validated functional residues (2):

PositionPhenotype
152significant destabilization of binding to chromatin.
183significant destabilization of binding to chromatin.

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

IDPathway
R-HSA-140342Apoptosis induced DNA fragmentation
R-HSA-2559584Formation of Senescence-Associated Heterochromatin Foci (SAHF)

MSigDB gene sets: 126 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN, GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, GOBP_CHROMOSOME_ORGANIZATION, REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION, GOBP_REGULATION_OF_DNA_RECOMBINATION, GOBP_POSITIVE_REGULATION_OF_ENDOCYTOSIS, CMYB_01, GOBP_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION, GOCC_CELL_SURFACE, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_MALE_GAMETE_GENERATION, GOBP_POSITIVE_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS, GOBP_CHROMOSOME_CONDENSATION, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_RECEPTOR_MEDIATED_ENDOCYTOSIS

GO Biological Process (5): nucleosome assembly (GO:0006334), spermatogenesis (GO:0007283), chromosome condensation (GO:0030261), negative regulation of DNA recombination (GO:0045910), positive regulation of receptor-mediated endocytosis (GO:0048260)

GO Molecular Function (7): double-stranded DNA binding (GO:0003690), heparin binding (GO:0008201), structural constituent of chromatin (GO:0030527), chromatin DNA binding (GO:0031490), nucleosomal DNA binding (GO:0031492), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (8): chromatin (GO:0000785), nucleosome (GO:0000786), euchromatin (GO:0000791), nucleus (GO:0005634), nucleoplasm (GO:0005654), cell surface (GO:0009986), vesicle (GO:0031982), chromosome (GO:0005694)

Reactome top-level categories

Rollup of top-2 pathways:

CategoryPathways
Apoptotic execution phase1
DNA Damage/Telomere Stress Induced Senescence1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
chromatin3
cellular anatomical structure3
DNA binding2
chromatin organization1
nucleosome organization1
protein-DNA complex assembly1
developmental process involved in reproduction1
male gamete generation1
chromosome organization1
regulation of DNA recombination1
DNA recombination1
negative regulation of DNA metabolic process1
receptor-mediated endocytosis1
positive regulation of endocytosis1
regulation of receptor-mediated endocytosis1
glycosaminoglycan binding1
sulfur compound binding1
structural molecule activity1
chromatin binding1
chromatin DNA binding1
nucleosome binding1
nucleic acid binding1
binding1
chromosome1
protein-DNA complex1
intracellular membrane-bounded organelle1
nuclear lumen1
membrane-bounded organelle1
intracellular membraneless organelle1

Protein interactions and networks

STRING

1022 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
H1-1H2AC19P20670994
H1-1H2AC20Q16777994
H1-1H2BC21Q16778983
H1-1H1-7Q75WM6922
H1-1H1-8Q8IZA3856
H1-1H1-5P16401851
H1-1CXCL11O14625776
H1-1H2AC1Q96QV6747
H1-1H2AC8P04908743
H1-1H2AC13P02261739
H1-1H2AC25Q7L7L0731
H1-1HOMER1Q86YM7704
H1-1ZNHIT1O43257586
H1-1H3C1P02295568
H1-1H3-4Q16695563

IntAct

242 interactions, top by confidence:

ABTypeScore
CDKN2DCDK4psi-mi:“MI:0914”(association)0.970
PRKAB2PRKAG1psi-mi:“MI:0914”(association)0.940
NSPIK3R2psi-mi:“MI:0914”(association)0.750
H2AC21H1-1psi-mi:“MI:0915”(physical association)0.670
PSMF1PSMA7psi-mi:“MI:0914”(association)0.660
H1-1RRP8psi-mi:“MI:0914”(association)0.640
PSMF1PSMB1psi-mi:“MI:0914”(association)0.640
CCDC120AIPpsi-mi:“MI:0914”(association)0.640
UTP3H1-1psi-mi:“MI:0915”(physical association)0.560
TPPPH1-1psi-mi:“MI:0915”(physical association)0.560
PMPCAH1-1psi-mi:“MI:0915”(physical association)0.560
ZNF331USP9Ypsi-mi:“MI:0914”(association)0.530
MDKSETD1Apsi-mi:“MI:0914”(association)0.530
PRR11NVLpsi-mi:“MI:0914”(association)0.530
ZNF71NVLpsi-mi:“MI:0914”(association)0.530
ZBTB48ZBTB24psi-mi:“MI:0914”(association)0.530
E4F1ZBTB24psi-mi:“MI:0914”(association)0.530
ZCRB1DKC1psi-mi:“MI:0914”(association)0.530
FGF10ITIH2psi-mi:“MI:0914”(association)0.530
MRPS34ZZEF1psi-mi:“MI:0914”(association)0.530
PMPCAPMPCBpsi-mi:“MI:0914”(association)0.530
AIFM1SEC16Apsi-mi:“MI:2364”(proximity)0.420

BioGRID (867): HIST1H1A (Biochemical Activity), HIST1H1A (Biochemical Activity), HIST1H1A (Biochemical Activity), HIST1H1A (Biochemical Activity), HIST1H1A (Biochemical Activity), HIST1H1A (Biochemical Activity), HIST1H1A (Affinity Capture-Western), HIST1H1A (Biochemical Activity), CTR9 (Affinity Capture-MS), LEO1 (Affinity Capture-MS), PAF1 (Affinity Capture-MS), CDC73 (Affinity Capture-MS), WDR61 (Affinity Capture-MS), CUL4A (Affinity Capture-MS), DDB1 (Affinity Capture-MS)

ESM2 similar proteins: A0LRM5, A0QL13, A1KGI7, A5U092, A5U6Z7, A9NEE4, B0B8W9, C1AL40, G3N131, O33125, P02256, P02257, P02258, P02259, P06513, P0A3H7, P0A3H8, P0CE15, P22845, P26568, P26569, P32103, P37218, P38020, P40269, P40270, P40273, P40274, P61180, P9WHC0, P9WHC1, P9WMK6, P9WMK7, Q02539, Q05831, Q06280, Q06281, Q45881, Q46204, Q46397

Diamond homologs: A7MAZ5, D3ZBN0, D3ZZW6, D4A3K5, G3N131, O01833, O16277, P02251, P02252, P02253, P02254, P02255, P02256, P02257, P02258, P02259, P06144, P06348, P06349, P06350, P06513, P06892, P06893, P06894, P07305, P07796, P08284, P08285, P08286, P08287, P08288, P09426, P09987, P10412, P10922, P15796, P15864, P15865, P15866, P15867

SIGNOR signaling

1 interactions.

AEffectBMechanism
ELOCup-regulatesH1-1phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 223 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Formation of Senescence-Associated Heterochromatin Foci (SAHF)523.0×5e-05
Metalloprotease DUBs714.4×2e-05
Packaging Of Telomere Ends913.5×4e-06
Recognition and association of DNA glycosylase with site containing an affected purine912.6×4e-06
Cleavage of the damaged purine912.6×4e-06
Recognition and association of DNA glycosylase with site containing an affected pyrimidine911.3×7e-06
Cleavage of the damaged pyrimidine911.3×7e-06
ChAHP complex assembly911.3×7e-06

GO biological processes:

GO termPartnersFoldFDR
negative regulation of DNA recombination527.4×3e-04
chromosome condensation624.7×6e-05
NLS-bearing protein import into nucleus519.6×1e-03
nucleosome assembly149.6×3e-07
heterochromatin formation78.7×4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic1
Likely pathogenic0
Uncertain significance75
Likely benign11
Benign0

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
1341201GRCh37/hg19 6p22.2(chr6:26008259-26168230)x1Pathogenic

SpliceAI

70 predictions. Top by Δscore:

VariantEffectΔscore
6:26017457:GCTTA:Gdonor_loss0.7600
6:26017458:CTT:Cdonor_loss0.7600
6:26017459:TTACC:Tdonor_loss0.7600
6:26017460:TA:Tdonor_loss0.7600
6:26017461:A:ACdonor_gain0.7200
6:26017462:C:CCdonor_gain0.7200
6:26017462:CCAGG:Cdonor_gain0.6900
6:26017087:A:ACdonor_gain0.6600
6:26017088:C:CCdonor_gain0.6600
6:26017338:G:Adonor_gain0.5900
6:26017472:AATG:Adonor_gain0.5900
6:26017484:A:ACdonor_gain0.5400
6:26017354:C:CTdonor_gain0.5200
6:26017455:TTGC:Tdonor_loss0.5200
6:26017456:TGCT:Tdonor_loss0.5200
6:26017265:AG:Adonor_gain0.5100
6:26017353:G:Cdonor_gain0.5100
6:26017472:AATGC:Adonor_gain0.5100
6:26017355:C:CTdonor_gain0.5000
6:26017480:G:Cdonor_gain0.5000
6:26017566:T:Adonor_gain0.5000
6:26017243:T:Adonor_gain0.4900
6:26017344:G:Cdonor_gain0.4500
6:26017332:CCCG:Cdonor_gain0.4400
6:26017513:AG:Adonor_gain0.4400
6:26017088:CT:Cdonor_gain0.4300
6:26017662:G:Adonor_gain0.4000
6:26017198:T:Adonor_gain0.3900
6:26017463:C:Adonor_loss0.3900
6:26017343:A:ACdonor_gain0.3800

AlphaMissense

1365 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
6:26017409:G:CF108L0.999
6:26017409:G:TF108L0.999
6:26017410:A:GF108S0.999
6:26017411:A:GF108L0.999
6:26017425:C:TG103E0.999
6:26017416:C:TG106D0.998
6:26017432:C:GG101R0.998
6:26017446:A:GL96S0.998
6:26017485:A:CI83S0.998
6:26017485:A:GI83T0.998
6:26017535:T:AK66N0.998
6:26017535:T:GK66N0.998
6:26017410:A:CF108C0.997
6:26017431:C:TG101D0.997
6:26017432:C:AG101C0.997
6:26017488:C:GR82P0.997
6:26017489:G:TR82S0.997
6:26017414:A:GS107P0.996
6:26017417:C:GG106R0.996
6:26017473:A:CI87S0.996
6:26017485:A:TI83N0.996
6:26017593:A:TI47N0.996
6:26017406:C:AK109N0.995
6:26017406:C:GK109N0.995
6:26017422:G:TA104D0.995
6:26017536:T:AK66I0.995
6:26017585:C:GA50P0.995
6:26017593:A:CI47S0.995
6:26017432:C:TG101S0.994
6:26017464:A:GL90P0.994

dbSNP variants (sampled 300 via entrez): RS1000185520 (6:26016751 T>C), RS1001157548 (6:26018849 A>T), RS1001186755 (6:26017476 C>T), RS1002187606 (6:26018159 G>A,T), RS1004266136 (6:26017498 T>C), RS1004647356 (6:26017736 G>A,T), RS1004872684 (6:26016895 T>A,C,G), RS1005240998 (6:26018992 C>T), RS1005417115 (6:26016632 A>G,T), RS1005532784 (6:26018120 A>C,G), RS1007093517 (6:26016995 T>C), RS1007167125 (6:26017160 T>C,G), RS1009094456 (6:26018465 T>G), RS1010627708 (6:26017724 T>C,G), RS1011533918 (6:26018397 C>T)

Disease associations

OMIM: gene MIM:142709 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

StudyTraitp-value
GCST004521_113Autism spectrum disorder or schizophrenia3.000000e-19
GCST004521_169Autism spectrum disorder or schizophrenia4.000000e-14
GCST004521_69Autism spectrum disorder or schizophrenia8.000000e-24
GCST004521_83Autism spectrum disorder or schizophrenia1.000000e-13
GCST004748_55Lung cancer1.000000e-09
GCST004749_111Lung cancer in ever smokers6.000000e-08
GCST008568_14IgA levels2.000000e-06
GCST008746_9Estimated glomerular filtration rate in diabetes3.000000e-08
GCST010002_50Refractive error4.000000e-34
GCST010142_16Fish- and plant-related diet2.000000e-10
GCST010142_19Fish- and plant-related diet4.000000e-10
GCST010142_34Fish- and plant-related diet7.000000e-09
GCST010142_35Fish- and plant-related diet8.000000e-09
GCST010142_42Fish- and plant-related diet1.000000e-08
GCST010142_7Fish- and plant-related diet3.000000e-12
GCST010702_75Subcortical volume (MOSTest)3.000000e-11
GCST010703_272Brain morphology (MOSTest)7.000000e-16

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0008111diet measurement
EFO:0004346neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

ChemicalActions (top 5)PubMed papers
bisphenol Adecreases expression2
sodium arseniteincreases expression, decreases expression2
Air Pollutantsdecreases expression, increases abundance, increases expression2
Particulate Matterdecreases expression, increases abundance, increases expression2
2-methyl-4-isothiazolin-3-onedecreases expression1
kojic acidincreases expression1
cobaltous chloridedecreases expression1
potassium chromate(VI)affects cotreatment, decreases expression1
versicolorin Aincreases expression1
epigallocatechin gallateaffects cotreatment, decreases expression1
CGP 52608affects binding, increases reaction1
abrineincreases expression1
Dasatinibdecreases expression1
Resveratrolincreases expression, affects cotreatment1
Acetaminophendecreases expression1
Arbutinincreases expression1
Arsenicdecreases methylation1
Benzo(a)pyrenedecreases methylation1
Cadmiumdecreases expression, increases abundance1
Copperaffects cotreatment, increases expression1
Dichlorodiphenyl Dichloroethyleneincreases expression1
Oxygendecreases expression1
Pesticidesincreases methylation1
Plant Oilsdecreases expression1
Silicon Dioxidedecreases expression1
Tobacco Smoke Pollutiondecreases expression1
Triclosanincreases methylation1
Cadmium Chloridedecreases expression, increases abundance1

Cellosaurus cell lines

14 cell lines: 14 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_C9JTWAe001-A-84Embryonic stem cellMale
CVCL_C9JVWAe001-A-86Embryonic stem cellMale
CVCL_C9K6WAe001-A-98Embryonic stem cellMale
CVCL_C9K7WAe001-A-99Embryonic stem cellMale
CVCL_C9KGWAe001-A-IEmbryonic stem cellMale
CVCL_C9KHWAe001-A-JEmbryonic stem cellMale
CVCL_C9KRWAe001-A-SEmbryonic stem cellMale
CVCL_C9KSWAe001-A-TEmbryonic stem cellMale
CVCL_C9KTWAe001-A-UEmbryonic stem cellMale
CVCL_C9KUWAe001-A-VEmbryonic stem cellMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

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BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot