H1-10

Summary

H1-10 (H1.10 linker histone, HGNC:4722) is a protein-coding gene on chromosome 3q21.3, encoding Histone H1.10 (Q92522). Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family.

Source: NCBI Gene 8971 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 31 total
• Druggable target: yes
• MANE Select transcript: NM_006026

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4722
Approved symbol	H1-10
Name	H1.10 linker histone
Location	3q21.3
Locus type	gene with protein product
Status	Approved
Aliases	MGC15959, MGC8350, H1X
Ensembl gene	ENSG00000184897
Ensembl biotype	protein_coding
OMIM	602785
Entrez	8971

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000333762, ENST00000704995

RefSeq mRNA: 1 — MANE Select: NM_006026 NM_006026

CCDS: CCDS3057

Canonical transcript exons

ENST00000333762 — 1 exons

Exon	Start	End
ENSE00001300166	129314771	129316286

Expression profiles

Bgee: expression breadth ubiquitous, 275 present calls, max score 99.39.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 379.6171 / max 3718.0195, expressed in 1827 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44507	378.3323	1827
44508	1.2848	915

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	99.39	gold quality
ganglionic eminence	UBERON:0004023	99.36	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.97	gold quality
embryo	UBERON:0000922	98.88	gold quality
thymus	UBERON:0002370	98.86	gold quality
cortical plate	UBERON:0005343	98.76	gold quality
ectocervix	UBERON:0012249	98.14	gold quality
right ovary	UBERON:0002118	98.12	gold quality
skin of abdomen	UBERON:0001416	98.09	gold quality
right uterine tube	UBERON:0001302	98.03	gold quality
left ovary	UBERON:0002119	98.00	gold quality
left uterine tube	UBERON:0001303	97.99	gold quality
skin of leg	UBERON:0001511	97.89	gold quality
endometrium epithelium	UBERON:0004811	97.73	gold quality
endocervix	UBERON:0000458	97.69	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.62	gold quality
right lung	UBERON:0002167	97.48	gold quality
adenohypophysis	UBERON:0002196	97.27	gold quality
descending thoracic aorta	UBERON:0002345	97.23	gold quality
body of uterus	UBERON:0009853	97.18	gold quality
cerebellar cortex	UBERON:0002129	97.16	gold quality
cerebellar hemisphere	UBERON:0002245	97.15	gold quality
monocyte	CL:0000576	97.11	gold quality
granulocyte	CL:0000094	97.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	97.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	97.07	gold quality
lower esophagus	UBERON:0013473	97.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.00	gold quality
paraflocculus	UBERON:0005351	96.91	gold quality
mononuclear cell	CL:0000842	96.90	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 7.

Experiment	Marker?	Max mean expression
E-CURD-79	yes	1405.11
E-MTAB-8205	yes	557.57
E-HCAD-4	yes	57.00
E-CURD-46	yes	38.24
E-CURD-122	yes	17.13
E-ANND-3	yes	15.80
E-GEOD-125970	yes	7.26
E-HCAD-6	no	42.53

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

23 targeting H1-10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-7515	99.31	68.22	1795
HSA-MIR-4650-3P	99.01	68.39	1062
HSA-MIR-3132	97.96	67.91	711
HSA-MIR-4665-5P	97.91	67.69	1536
HSA-MIR-197-5P	97.23	68.10	596
HSA-MIR-939-5P	97.10	65.80	1579
HSA-MIR-550B-2-5P	96.56	64.61	646
HSA-MIR-1343-5P	96.48	66.06	1506

Literature-anchored findings (GeneRIF, showing 5)

• comparison of primary aa sequence with other human H1 subtypes, and H1x from different species, generation of specific antibody, expression in different cell lines (PMID:16006241)
• These results suggest that the differential localization of H1x provides a mechanism for a control of H1x activity by means of shuttling between nuclear subcompartments instead of a controlled turnover of the protein. (PMID:17868027)
• study concludes that the high expression of histone H1x in neuroendocrine tumours is probably due to the abundance of this protein in the cells from which these tumours originate (PMID:19108733)
• Genomic profiling of six human somatic histone H1 variants denotes that H1X accumulates at recently incorporated transposable elements. (PMID:38261975)
• MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation. (PMID:38609001)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	h1-10	ENSDARG00000054058
mus_musculus	H1f10	ENSMUSG00000044927
rattus_norvegicus	H1f10	ENSRNOG00000027722
caenorhabditis_elegans		WBGENE00001853
caenorhabditis_elegans		WBGENE00001854
caenorhabditis_elegans		WBGENE00001855
caenorhabditis_elegans	hil-5	WBGENE00001856
caenorhabditis_elegans		WBGENE00001857

Paralogs (9): H1-3 (ENSG00000124575), H1-1 (ENSG00000124610), H1-4 (ENSG00000168298), H1-8 (ENSG00000178804), H1-5 (ENSG00000184357), H1-7 (ENSG00000187166), H1-6 (ENSG00000187475), H1-2 (ENSG00000187837), H1-0 (ENSG00000189060)

Protein

Protein identifiers

Histone H1.10 — Q92522 (reviewed: Q92522)

Alternative names: Histone H1x

All UniProt accessions (2): A0A994J4R3, Q92522

UniProt curated annotations — full annotation on UniProt →

Function. Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex.

Subunit / interactions. Associates with nucleosomes, promoting condensation into higher-order structured chromatin. Interacts with RRP1B.

Subcellular location. Nucleus. Nucleolus. Chromosome.

Tissue specificity. Expressed ubiquitously.

Post-translational modifications. Citrullination at Arg-62 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.

Induction. Expression is activated by transcription factor CRAMP1, in collaboration with NPAT and GON4L.

Similarity. Belongs to the histone H1/H5 family.

RefSeq proteins (1): NP_006017* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005818	Histone_H1/H5_H15	Domain
IPR005819	H1/H5	Family
IPR036388	WH-like_DNA-bd_sf	Homologous_superfamily
IPR036390	WH_DNA-bd_sf	Homologous_superfamily

Pfam: PF00538

UniProt features (27 total): modified residue 9, compositionally biased region 5, helix 3, turn 3, strand 2, region of interest 2, initiator methionine 1, chain 1, domain 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
6L9Z	X-RAY DIFFRACTION	2.5
8YTI	X-RAY DIFFRACTION	2.7
7K63	ELECTRON MICROSCOPY	3.03
7K60	ELECTRON MICROSCOPY	3.12
2LSO	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92522-F1	66.44	0.36

Antibody-complex structures (SAbDab): 2 — 7K60, 7K63

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 2, 2, 31, 33, 47, 62, 94, 115, 188

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 194 (showing top): GOBP_CHROMOSOME_ORGANIZATION, GOBP_REGULATION_OF_DNA_RECOMBINATION, PAX4_01, DAZARD_UV_RESPONSE_CLUSTER_G4, GOBP_NEGATIVE_REGULATION_OF_DNA_RECOMBINATION, AP2_Q3, GOBP_CHROMOSOME_CONDENSATION, OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP, NF1_Q6_01, BLALOCK_ALZHEIMERS_DISEASE_UP, PU1_Q6, TGGNNNNNNKCCAR_UNKNOWN, MODULE_98, LIU_CMYB_TARGETS_UP, chr3q21

GO Biological Process (3): nucleosome assembly (GO:0006334), chromosome condensation (GO:0030261), negative regulation of DNA recombination (GO:0045910)

GO Molecular Function (6): double-stranded DNA binding (GO:0003690), RNA binding (GO:0003723), structural constituent of chromatin (GO:0030527), nucleosomal DNA binding (GO:0031492), cadherin binding (GO:0045296), DNA binding (GO:0003677)

GO Cellular Component (5): nucleosome (GO:0000786), nucleus (GO:0005634), nucleoplasm (GO:0005654), chromosome (GO:0005694), nucleolus (GO:0005730)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nucleic acid binding	2
chromatin	2
nuclear lumen	2
intracellular membraneless organelle	2
chromatin organization	1
nucleosome organization	1
protein-DNA complex assembly	1
chromosome organization	1
regulation of DNA recombination	1
DNA recombination	1
negative regulation of DNA metabolic process	1
DNA binding	1
structural molecule activity	1
chromatin DNA binding	1
nucleosome binding	1
cell adhesion molecule binding	1
protein-DNA complex	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1096 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
H1-10	H1-7	Q75WM6	946
H1-10	H1-8	Q8IZA3	942
H1-10	H1-6	P22492	903
H1-10	TACC2	O95359	465
H1-10	ZNF16	P17020	461
H1-10	H2AC19	P20670	439
H1-10	SRSF3	P23152	437
H1-10	H2AC20	Q16777	437
H1-10	SRSF7	Q16629	436
H1-10	LMOD1	P29536	425
H1-10	ANXA7	P20073	423
H1-10	RALY	Q9UKM9	415
H1-10	FAXDC2	Q96IV6	408
H1-10	H2BC21	Q16778	407
H1-10	GYG1	P46976	406

IntAct

278 interactions, top by confidence:

A	B	Type	Score
MAP3K14	CHUK	psi-mi:“MI:0914”(association)	0.950
NS	PIK3R2	psi-mi:“MI:0914”(association)	0.750
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
EPN1	PHGDH	psi-mi:“MI:0914”(association)	0.710
FAM90A1	KPNA3	psi-mi:“MI:0914”(association)	0.670
CFTR	HAX1	psi-mi:“MI:0914”(association)	0.610
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
N	RBM47	psi-mi:“MI:0914”(association)	0.530
CBX6	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
KPNB1	POM121C	psi-mi:“MI:0914”(association)	0.530
MAP4K4	STRN	psi-mi:“MI:0914”(association)	0.530
RPL13	RPLP1	psi-mi:“MI:0914”(association)	0.530
RRP1B	NPM1	psi-mi:“MI:0914”(association)	0.510
H1-10	RRP1B	psi-mi:“MI:0403”(colocalization)	0.510
FNBP1	FNBP1L	psi-mi:“MI:0914”(association)	0.500
CFTR	PLEKHG3	psi-mi:“MI:0914”(association)	0.480
AIFM1	SEC16A	psi-mi:“MI:2364”(proximity)	0.420
H3C1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.410
H1-10		psi-mi:“MI:0915”(physical association)	0.400
RNF168	H1-10	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (348): H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Co-fractionation), H1FX (Co-fractionation), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS), H1FX (Affinity Capture-MS)

ESM2 similar proteins: B0B8W9, D0KZ81, K9NVA6, O31163, O52340, O61016, P06228, P07242, P0C9X7, P0C9X8, P0C9X9, P0C9Y0, P0CE15, P10156, P12305, P20538, P25886, P40268, P47914, P55549, P69110, P69112, P69113, P69114, P69115, P69119, P69120, P69121, P69122, P69123, P69125, Q06281, Q29187, Q45881, Q46204, Q54BQ3, Q54LW6, Q5UPU2, Q75C22, Q86HQ8

Diamond homologs: A7MAZ5, D3ZBN0, D3ZZW6, D4A3K5, G3N131, O01833, O16277, P02251, P02252, P02253, P02254, P02255, P02256, P02257, P02258, P02259, P06144, P06348, P06349, P06350, P06513, P06892, P06893, P06894, P07305, P07796, P08284, P08285, P08286, P08287, P08288, P09426, P09987, P10412, P10922, P15796, P15864, P15865, P15866, P15867

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 206 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of the ternary complex, and subsequently, the 43S complex	8	11.5×	2e-05
SRP-dependent cotranslational protein targeting to membrane	17	11.3×	8e-11
Eukaryotic Translation Termination	14	11.2×	3e-09
Formation of a pool of free 40S subunits	15	11.2×	8e-10
Peptide chain elongation	13	11.0×	1e-08
Viral mRNA Translation	13	11.0×	1e-08
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	14	11.0×	3e-09
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	13	10.9×	1e-08

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	16	16.4×	3e-12
ribosomal small subunit biogenesis	7	8.8×	4e-03
negative regulation of translation	8	8.7×	2e-03
translation	15	8.5×	2e-07
rRNA processing	9	7.0×	2e-03
protein import into nucleus	8	6.4×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

31 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	31
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

248 predictions. Top by Δscore:

Variant	Effect	Δscore
3:129315263:A:AC	donor_gain	0.9900
3:129315264:C:CC	donor_gain	0.9900
3:129315275:TGGGC:T	donor_gain	0.9500
3:129315246:G:T	donor_gain	0.9400
3:129315264:CTTG:C	donor_gain	0.9100
3:129315321:G:A	donor_gain	0.9100
3:129315267:G:A	donor_gain	0.9000
3:129315317:T:A	donor_gain	0.9000
3:129315193:CG:C	donor_gain	0.8900
3:129315351:G:A	donor_gain	0.8900
3:129315267:GCGGC:G	donor_gain	0.8800
3:129315268:CGGCC:C	donor_gain	0.8800
3:129315213:CAAAA:C	donor_gain	0.8400
3:129315214:AAAAA:A	donor_gain	0.8400
3:129315217:A:AC	donor_gain	0.8400
3:129315243:T:TA	donor_gain	0.8400
3:129315244:CTG:C	donor_gain	0.8300
3:129315250:G:T	donor_gain	0.8300
3:129315271:C:A	donor_gain	0.8100
3:129315341:T:TA	donor_gain	0.8000
3:129315249:C:CT	donor_gain	0.7800
3:129315065:AACC:A	acceptor_loss	0.7500
3:129315068:CTA:C	acceptor_loss	0.7500
3:129315219:C:CT	donor_gain	0.7500
3:129315232:ACG:A	donor_gain	0.7400
3:129315233:CGC:C	donor_gain	0.7400
3:129315195:TC:T	donor_gain	0.7300
3:129315224:AAAAG:A	donor_gain	0.7300
3:129315310:TTCAC:T	donor_loss	0.7300
3:129315311:TCACC:T	donor_loss	0.7300

AlphaMissense

1361 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:129315561:G:C	F114L	1.000
3:129315561:G:T	F114L	1.000
3:129315562:A:C	F114C	1.000
3:129315562:A:G	F114S	1.000
3:129315563:A:G	F114L	1.000
3:129315568:C:T	G112D	1.000
3:129315569:C:G	G112R	1.000
3:129315577:C:T	G109D	1.000
3:129315583:C:T	G107D	1.000
3:129315584:C:G	G107R	1.000
3:129315598:A:G	L102P	1.000
3:129315598:A:T	L102H	1.000
3:129315616:A:G	L96P	1.000
3:129315625:A:T	I93N	1.000
3:129315631:T:C	Y91C	1.000
3:129315632:A:C	Y91D	1.000
3:129315632:A:G	Y91H	1.000
3:129315637:A:G	L89P	1.000
3:129315637:A:T	L89H	1.000
3:129315641:A:C	Y88D	1.000
3:129315649:C:T	G85E	1.000
3:129315663:G:C	F80L	1.000
3:129315663:G:T	F80L	1.000
3:129315664:A:G	F80S	1.000
3:129315665:A:G	F80L	1.000
3:129315712:C:A	G64V	1.000
3:129315712:C:T	G64D	1.000
3:129315713:C:G	G64R	1.000
3:129315736:A:T	I56N	1.000
3:129315760:T:C	Y48C	1.000

dbSNP variants (sampled 300 via entrez): RS1000300176 (3:129314955 C>G), RS1000650884 (3:129314784 C>A,T), RS1001035078 (3:129316140 A>G), RS1001267679 (3:129315042 G>A), RS1001404877 (3:129314905 C>T), RS1001805744 (3:129315125 C>G,T), RS1001962182 (3:129315325 C>A,T), RS1002941395 (3:129316446 C>T), RS1003414254 (3:129317442 G>A), RS1003572993 (3:129317634 G>A), RS1003751029 (3:129317173 C>A,G), RS1003764547 (3:129317175 G>A,C), RS1003817117 (3:129317401 A>G), RS1004862631 (3:129316278 C>A,T), RS1005291660 (3:129317145 C>G,T)

Disease associations

OMIM: gene MIM:602785 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST002647_15	Height	8.000000e-25
GCST005863_10	Menopause (age at onset)	2.000000e-18
GCST005863_3	Menopause (age at onset)	1.000000e-16
GCST005956_82	Waist-to-hip ratio adjusted for BMI	2.000000e-07
GCST005958_5	Waist-to-hip ratio adjusted for BMI (age >50)	4.000000e-10
GCST005962_16	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	2.000000e-11
GCST011122_47	Walking pace	6.000000e-11
GCST90000025_948	Appendicular lean mass	2.000000e-33
GCST90020025_589	Waist-to-hip ratio adjusted for BMI	2.000000e-10
GCST90020027_366	Waist-hip index	6.000000e-10

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004704	age at menopause
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067287 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

4 potent at pChembl≥5 of 4 total, top 4 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.78	Kd	16.72	nM	CHEMBL5653589
7.78	ED50	16.72	nM	CHEMBL5653589
5.14	Kd	7240	nM	CHEMBL3752910
5.14	ED50	7240	nM	CHEMBL3752910

PubChem BioAssay actives

2 with measured affinity, of 4 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148480: Binding affinity to human H1FX incubated for 45 mins by Kinobead based pull down assay	kd	0.0167	uM
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148480: Binding affinity to human H1FX incubated for 45 mins by Kinobead based pull down assay	kd	7.2395	uM

CTD chemical–gene interactions

68 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression	3
sodium arsenite	decreases expression, increases abundance, increases expression	3
Valproic Acid	affects expression, decreases expression, increases expression	3
deoxynivalenol	increases expression	2
(+)-JQ1 compound	increases expression	2
Acetaminophen	increases expression	2
Cisplatin	decreases expression	2
Smoke	increases abundance, increases expression, decreases expression	2
Tobacco Smoke Pollution	decreases expression	2
Cadmium Chloride	decreases expression, increases expression	2
Particulate Matter	affects cotreatment, increases abundance, increases expression, decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	decreases phosphorylation	1
urushiol	decreases expression	1
glycidyl methacrylate	increases expression	1
lead acetate	increases expression	1
trichostatin A	affects expression	1
cobaltous chloride	decreases expression	1
perfluorooctanoic acid	increases expression	1
zinc chromate	decreases expression, increases abundance	1
periodate-oxidized adenosine	affects expression	1
nickel sulfate	increases expression	1
cupric oxide	decreases expression	1
chromium hexavalent ion	increases abundance, decreases expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
nutlin 3	affects cotreatment, increases secretion	1
belinostat	increases expression	1
bisphenol B	increases expression	1
LDN 193189	affects cotreatment, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651522	Binding	Binding affinity to human H1FX incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

14 cell lines: 14 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_C0CA	WAe001-A-78	Embryonic stem cell	Male
CVCL_C9JR	WAe001-A-82	Embryonic stem cell	Male
CVCL_C9K4	WAe001-A-96	Embryonic stem cell	Male
CVCL_C9K5	WAe001-A-97	Embryonic stem cell	Male
CVCL_C9K6	WAe001-A-98	Embryonic stem cell	Male
CVCL_C9K7	WAe001-A-99	Embryonic stem cell	Male
CVCL_C9K8	WAe001-A-A	Embryonic stem cell	Male
CVCL_C9K9	WAe001-A-B	Embryonic stem cell	Male
CVCL_C9KA	WAe001-A-C	Embryonic stem cell	Male
CVCL_C9KB	WAe001-A-D	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.