H2AC21

Summary

H2AC21 (H2A clustered histone 21, HGNC:20508) is a protein-coding gene on chromosome 1q21.2, encoding Histone H2A type 2-B (Q8IUE6). Core component of nucleosome.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.

Source: NCBI Gene 317772 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 25 total
• Druggable target: yes
• MANE Select transcript: NM_175065

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20508
Approved symbol	H2AC21
Name	H2A clustered histone 21
Location	1q21.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000184270
Ensembl biotype	protein_coding
OMIM	615014
Entrez	317772

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000331128

RefSeq mRNA: 1 — MANE Select: NM_175065 NM_175065

CCDS: CCDS938

Canonical transcript exons

ENST00000331128 — 1 exons

Exon	Start	End
ENSE00001433520	149887469	149887965

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 97.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 264.2373 / max 3834.0868, expressed in 1817 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14258	264.2373	1817

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	97.98	gold quality
bone marrow cell	CL:0002092	97.24	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.35	silver quality
corpus callosum	UBERON:0002336	88.64	gold quality
adrenal tissue	UBERON:0018303	86.56	gold quality
colonic epithelium	UBERON:0000397	86.13	gold quality
bone marrow	UBERON:0002371	83.04	gold quality
granulocyte	CL:0000094	68.06	gold quality
sural nerve	UBERON:0015488	67.50	gold quality
tonsil	UBERON:0002372	64.77	gold quality
blood	UBERON:0000178	56.24	gold quality
urinary bladder	UBERON:0001255	54.63	gold quality
skeletal muscle tissue	UBERON:0001134	53.65	gold quality
ventricular zone	UBERON:0003053	53.24	gold quality
uterine cervix	UBERON:0000002	53.21	gold quality
leukocyte	CL:0000738	52.02	gold quality
hindlimb stylopod muscle	UBERON:0004252	51.97	gold quality
primary visual cortex	UBERON:0002436	51.51	gold quality
monocyte	CL:0000576	51.23	gold quality
mucosa of stomach	UBERON:0001199	49.44	gold quality
skin of abdomen	UBERON:0001416	48.90	gold quality
thoracic mammary gland	UBERON:0005200	47.84	gold quality
zone of skin	UBERON:0000014	47.61	gold quality
kidney	UBERON:0002113	46.74	gold quality
lung	UBERON:0002048	46.68	gold quality
skin of leg	UBERON:0001511	46.36	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	46.04	gold quality
muscle tissue	UBERON:0002385	45.97	gold quality
ectocervix	UBERON:0012249	45.79	gold quality
ganglionic eminence	UBERON:0004023	45.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.51

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Monoubiquitylation of H2A forms part of the cellular response to UV damage and suggest a role of this modification in DNA repair-induced chromatin remodeling. (PMID:16702407)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
		ENSDARG00000098739
mus_musculus	H2ac21	ENSMUSG00000063689
caenorhabditis_elegans		WBGENE00014240

Paralogs (27): MACROH2A2 (ENSG00000099284), H2AZ2 (ENSG00000105968), MACROH2A1 (ENSG00000113648), H2AZ1 (ENSG00000164032), H2AC1 (ENSG00000164508), H2AC6 (ENSG00000180573), H2AC25 (ENSG00000181218), H2AC20 (ENSG00000184260), H2AX (ENSG00000188486), H2AC13 (ENSG00000196747), H2AC11 (ENSG00000196787), H2AC7 (ENSG00000196866), H2AL3 (ENSG00000229674), H2AJ (ENSG00000246705), H2AL1Q (ENSG00000249467), H2AB1 (ENSG00000274183), H2AC12 (ENSG00000274997), H2AC15 (ENSG00000275221), H2AC14 (ENSG00000276368), H2AC16 (ENSG00000276903), H2AC8 (ENSG00000277075), H2AB3 (ENSG00000277745), H2AB2 (ENSG00000277858), H2AC4 (ENSG00000278463), H2AC17 (ENSG00000278677), H2AC18 (ENSG00000288825), H2AC19 (ENSG00000288859)

Protein

Protein identifiers

Histone H2A type 2-B — Q8IUE6 (reviewed: Q8IUE6)

Alternative names: H2A-clustered histone 21

All UniProt accessions (1): Q8IUE6

UniProt curated annotations — full annotation on UniProt →

Function. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit / interactions. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Subcellular location. Nucleus. Chromosome.

Post-translational modifications. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of ‘Lys-27’ of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers. Following DNA double-strand breaks (DSBs), it is ubiquitinated through ‘Lys-63’ linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and ‘Lys-63’-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend ‘Lys-63’-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired. H2AK119Ub and ionizing radiation-induced ‘Lys-63’-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.

Similarity. Belongs to the histone H2A family.

RefSeq proteins (1): NP_778235* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002119	Histone_H2A	Family
IPR007125	H2A/H2B/H3	Domain
IPR009072	Histone-fold	Homologous_superfamily
IPR032454	Histone_H2A_C	Domain
IPR032458	Histone_H2A_CS	Conserved_site

Pfam: PF00125, PF16211

UniProt features (41 total): modified residue 32, cross-link 3, initiator methionine 1, chain 1, region of interest 1, compositionally biased region 1, sequence variant 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IUE6-F1	90.98	0.80

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (35): 10, 10, 10, 10, 14, 14, 16, 37, 37, 37, 37, 75, 76, 96, 96, 96, 96, 96, 105, 119 …

Mutagenesis-validated functional residues (1):

Position	Phenotype
2	blocks the inhibition of transcription by rps6ka5/msk1.

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-3214815	HDACs deacetylate histones
R-HSA-3214847	HATs acetylate histones
R-HSA-3214858	RMTs methylate histone arginines
R-HSA-5689603	UCH proteinases
R-HSA-5689880	Ub-specific processing proteases
R-HSA-5689901	Metalloprotease DUBs
R-HSA-9609690	HCMV Early Events
R-HSA-9610379	HCMV Late Events
R-HSA-9918481	Dengue Virus-Host Interactions

MSigDB gene sets: 84 (showing top): FISCHER_G1_S_CELL_CYCLE, GGGTGGRR_PAX4_03, MISSIAGLIA_REGULATED_BY_METHYLATION_UP, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, CREB_Q3, FISCHER_DREAM_TARGETS, OCT1_B, GOBP_CHROMATIN_REMODELING, GOBP_HETEROCHROMATIN_ORGANIZATION, TTTNNANAGCYR_UNKNOWN, GOBP_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, TGGAAA_NFAT_Q4_01, chr1q21, GOCC_PROTEIN_DNA_COMPLEX, CAMPS_COLON_CANCER_COPY_NUMBER_DN

GO Biological Process (1): heterochromatin formation (GO:0031507)

GO Molecular Function (4): DNA binding (GO:0003677), structural constituent of chromatin (GO:0030527), protein heterodimerization activity (GO:0046982), protein binding (GO:0005515)

GO Cellular Component (4): nucleosome (GO:0000786), nucleus (GO:0005634), extracellular exosome (GO:0070062), chromosome (GO:0005694)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Chromatin modifying enzymes	3
Deubiquitination	3
HCMV Infection	2
Dengue Virus Infection	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
chromatin	2
cellular component assembly	1
heterochromatin boundary formation	1
negative regulation of gene expression, epigenetic	1
heterochromatin organization	1
nucleic acid binding	1
structural molecule activity	1
protein dimerization activity	1
binding	1
protein-DNA complex	1
intracellular membrane-bounded organelle	1
extracellular vesicle	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1230 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
H2AC21	H2BC21	Q16778	464
H2AC21	H1-1	Q02539	451
H2AC21	H1-2	P16403	396
H2AC21	H1-5	P16401	391
H2AC21	ZNF532	Q9HCE3	369
H2AC21	H4C16	P02304	334
H2AC21	GUF1	Q8N442	324
H2AC21	DDX3Y	O15523	318
H2AC21	H2BC26	Q8N257	301
H2AC21	CD4	P01730	290
H2AC21	PRSS3	P15951	278
H2AC21	PKN2	Q16513	277
H2AC21	H1-0	P07305	275
H2AC21	LYSET	Q8N6I4	275
H2AC21	KRTAP6-3	Q3LI67	272

IntAct

179 interactions, top by confidence:

A	B	Type	Score
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
H2AX	PPM1G	psi-mi:“MI:0914”(association)	0.730
XPC	CETN3	psi-mi:“MI:0914”(association)	0.730
H2AC21	H1-1	psi-mi:“MI:0915”(physical association)	0.670
HMGA1	H2AC21	psi-mi:“MI:0915”(physical association)	0.670
HMGA1	H2AC21	psi-mi:“MI:0914”(association)	0.670
H2AC4	PPM1G	psi-mi:“MI:0914”(association)	0.670
H2BC1	PPM1G	psi-mi:“MI:0914”(association)	0.640
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
H1-5	H2AC21	psi-mi:“MI:0915”(physical association)	0.560
H1-2	H2AC21	psi-mi:“MI:0915”(physical association)	0.560
H2AC21	H1-0	psi-mi:“MI:0915”(physical association)	0.560
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
ZNF398	LRP4	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
ZCRB1	DKC1	psi-mi:“MI:0914”(association)	0.530
ZNF491	CST4	psi-mi:“MI:0914”(association)	0.530
POLB	PARP1	psi-mi:“MI:0914”(association)	0.530
SSRP1	PARP1	psi-mi:“MI:0914”(association)	0.530
NAP1L1	RPL17	psi-mi:“MI:0914”(association)	0.530
MED27	POLR2D	psi-mi:“MI:0914”(association)	0.530

BioGRID (311): HIST2H2AB (Affinity Capture-RNA), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS), HIST2H2AB (Affinity Capture-MS)

ESM2 similar proteins: A0A1W2PP81, A0A1W2PPE2, A0A1W2PPH5, A0A1W2PPL8, A0A1W2PR64, A0A1W2PRV1, A0A3B3IU63, A4QVR2, A5DQL2, A9UMV8, F4HR03, O35216, P06898, P0C1H6, P0C5Y9, P0C5Z0, P0DW11, P0DW12, P0DW13, P0DW14, P0DW85, P35061, P48003, P49450, Q00728, Q3SZB8, Q3ZBX9, Q4IMD1, Q5M8Q2, Q5TKR9, Q64522, Q64598, Q7Z2G1, Q803H4, Q873G4, Q8BRB7, Q8BZ21, Q8CGP5, Q8IUE6, Q8R1M2

Diamond homologs: A0A097I1R9, A0A097I2B5, A0A0D2UG83, A1A4R1, A1CJ10, A1D8G8, A3LXE7, A3LZZ0, A5DBG4, A5DJJ2, A5DWF1, A5DXC6, A9UMV8, C0HKE1, C0HKE2, C0HKE3, C0HKE4, C0HKE5, C0HKE6, C0HKE7, C0HKE8, C0HKE9, L7HZV6, O74268, P02262, P02263, P02264, P04908, P04909, P04910, P04911, P04912, P06897, P07793, P08844, P0C0S8, P0C0S9, P0C169, P0C170, P0C952

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
SLBP	“up-regulates quantity by expression”	H2AC21	“translation regulation”
DZIP3	“up-regulates activity”	H2AC21	monoubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 208 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	6	30.1×	2e-07
Peptide chain elongation	23	21.8×	8e-23
Viral mRNA Translation	23	21.8×	8e-23
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	23	21.5×	8e-23
Selenocysteine synthesis	23	20.6×	2e-22
Eukaryotic Translation Termination	23	20.6×	2e-22
SIRT1 negatively regulates rRNA expression	16	20.4×	1e-15
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	23	20.2×	2e-22

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of DNA recombination	8	47.8×	3e-10
chromosome condensation	8	35.9×	3e-09
cytoplasmic translation	24	23.6×	1e-23
heterochromatin formation	13	17.7×	8e-11
nucleosome assembly	21	15.7×	6e-17
ribosomal large subunit biogenesis	6	14.2×	3e-04
translation	24	13.1×	2e-17
ribosomal small subunit biogenesis	10	12.1×	1e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

25 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	19
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

56 predictions. Top by Δscore:

Variant	Effect	Δscore
1:149887963:TGGA:T	donor_gain	0.7600
1:149887803:G:A	donor_gain	0.6600
1:149887526:A:AC	donor_gain	0.6400
1:149887527:C:CC	donor_gain	0.6400
1:149887934:T:G	donor_gain	0.6400
1:149887552:T:A	donor_gain	0.5800
1:149887536:G:A	donor_gain	0.5700
1:149887890:G:A	donor_gain	0.5400
1:149887799:AGTTG:A	donor_gain	0.5200
1:149887748:CGAGG:C	donor_gain	0.5100
1:149887829:G:A	donor_gain	0.5100
1:149887894:C:A	donor_gain	0.5000
1:149887655:CGG:C	donor_gain	0.4500
1:149887649:T:A	donor_gain	0.4300
1:149887650:C:A	donor_gain	0.4200
1:149887879:G:C	donor_gain	0.4200
1:149887953:G:GT	donor_gain	0.4200
1:149887965:G:GT	donor_gain	0.4000
1:149887691:T:TA	donor_gain	0.3900
1:149887524:TTAC:T	donor_loss	0.3600
1:149887525:TAC:T	donor_loss	0.3600
1:149887526:ACTT:A	donor_loss	0.3600
1:149887527:C:T	donor_loss	0.3600
1:149887628:A:C	donor_gain	0.3400
1:149887954:A:T	donor_gain	0.3400
1:149887528:T:C	donor_gain	0.3200
1:149887725:C:CT	acceptor_gain	0.3200
1:149887720:A:T	acceptor_gain	0.3000
1:149887527:CTT:C	donor_gain	0.2900
1:149887724:C:G	acceptor_gain	0.2900

AlphaMissense

813 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:149887597:C:T	G107D	1.000
1:149887598:C:G	G107R	1.000
1:149887601:C:G	G106R	1.000
1:149887645:T:A	D91V	1.000
1:149887645:T:C	D91G	1.000
1:149887645:T:G	D91A	1.000
1:149887646:C:G	D91H	1.000
1:149887657:G:T	A87D	1.000
1:149887660:A:G	L86P	1.000
1:149887673:G:T	R82S	1.000
1:149887681:A:T	I79N	1.000
1:149887699:T:A	D73V	1.000
1:149887705:G:T	A71D	1.000
1:149887706:C:G	A71P	1.000
1:149887714:C:A	G68V	1.000
1:149887714:C:T	G68D	1.000
1:149887715:C:A	G68C	1.000
1:149887715:C:G	G68R	1.000
1:149887720:A:G	L66P	1.000
1:149887724:C:T	E65K	1.000
1:149887726:A:G	L64P	1.000
1:149887732:T:A	E62V	1.000
1:149887736:C:G	A61P	1.000
1:149887741:A:G	L59P	1.000
1:149887745:A:G	Y58H	1.000
1:149887747:T:A	E57V	1.000
1:149887784:C:A	G45W	1.000
1:149887831:C:T	G29E	1.000
1:149887846:A:T	L24H	1.000
1:149887570:A:G	L116P	0.999

dbSNP variants (sampled 300 via entrez): RS1002658115 (1:149889842 T>C), RS1003013948 (1:149889510 G>A), RS1006397744 (1:149889439 C>T), RS1006450550 (1:149889717 A>G), RS1008980388 (1:149887855 C>T), RS1009859394 (1:149889962 T>C), RS1010919551 (1:149888781 G>A), RS1012800960 (1:149888479 C>T), RS1014554334 (1:149887856 G>A), RS1019184517 (1:149888899 T>C), RS1019322798 (1:149889069 C>T), RS1022220927 (1:149888615 T>C), RS1022273428 (1:149888815 T>C), RS1023521665 (1:149889457 C>G), RS1024103141 (1:149888270 T>A)

Disease associations

OMIM: gene MIM:615014 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5724676 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression, decreases reaction, increases abundance	3
Air Pollutants	decreases expression, increases abundance	3
potassium chromate(VI)	affects cotreatment, decreases expression	2
Tretinoin	affects cotreatment, increases expression, decreases expression	2
Particulate Matter	increases abundance, decreases expression	2
ginger extract	decreases reaction, increases abundance, increases expression	1
2,4,6-tribromophenol	decreases expression	1
propionaldehyde	decreases expression	1
decabromobiphenyl ether	decreases expression	1
2-methyl-4-isothiazolin-3-one	decreases expression	1
2,4,5,2’,4’,5’-hexachlorobiphenyl	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	affects cotreatment, increases expression	1
cobaltous chloride	decreases expression	1
tetrabromobisphenol A	decreases expression	1
cupric oxide	increases expression	1
hydroquinone	decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
polyoxyethyleneamine	decreases expression	1
chromium hexavalent ion	decreases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
abrine	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
licochalcone B	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
incobotulinumtoxinA	decreases expression	1

ChEMBL screening assays

6 unique, capped per target: 6 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5697247	Binding	Inhibition of HIST2H2BA (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.