H2AC25

Summary

H2AC25 (H2A clustered histone 25, HGNC:20507) is a protein-coding gene on chromosome 1q42.13, encoding Histone H2A type 3 (Q7L7L0). Core component of nucleosome.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.

Source: NCBI Gene 92815 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 29 total
• MANE Select transcript: NM_033445

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20507
Approved symbol	H2AC25
Name	H2A clustered histone 25
Location	1q42.13
Locus type	gene with protein product
Status	Approved
Aliases	MGC3165
Ensembl gene	ENSG00000181218
Ensembl biotype	protein_coding
OMIM	615015
Entrez	92815

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 nonsense_mediated_decay

ENST00000366695, ENST00000689584, ENST00000691624

RefSeq mRNA: 1 — MANE Select: NM_033445 NM_033445

CCDS: CCDS1573

Canonical transcript exons

ENST00000645741 — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 94.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 78.9401 / max 2437.4950, expressed in 1719 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17842	78.9401	1719

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar hemisphere	UBERON:0002245	94.17	gold quality
cerebellum	UBERON:0002037	94.16	gold quality
cerebellar cortex	UBERON:0002129	94.15	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.27	gold quality
ganglionic eminence	UBERON:0004023	91.75	gold quality
cortical plate	UBERON:0005343	91.53	gold quality
left adrenal gland cortex	UBERON:0035825	90.19	gold quality
apex of heart	UBERON:0002098	89.81	gold quality
left adrenal gland	UBERON:0001234	89.52	gold quality
right adrenal gland	UBERON:0001233	89.23	gold quality
right adrenal gland cortex	UBERON:0035827	89.16	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.57	gold quality
adrenal gland	UBERON:0002369	86.29	gold quality
ventricular zone	UBERON:0003053	85.96	gold quality
nucleus accumbens	UBERON:0001882	85.15	gold quality
prefrontal cortex	UBERON:0000451	84.79	gold quality
putamen	UBERON:0001874	84.07	gold quality
brain	UBERON:0000955	83.90	gold quality
frontal cortex	UBERON:0001870	83.64	gold quality
heart left ventricle	UBERON:0002084	83.53	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.45	gold quality
caudate nucleus	UBERON:0001873	83.23	gold quality
cerebral cortex	UBERON:0000956	83.06	gold quality
vagina	UBERON:0000996	82.94	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	82.78	gold quality
right frontal lobe	UBERON:0002810	82.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.49	gold quality
skin of abdomen	UBERON:0001416	82.36	gold quality
Ammon’s horn	UBERON:0001954	82.36	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-6505	yes	22578.60
E-MTAB-5061	yes	6.05
E-ANND-3	no	0.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Overexpression of HIST3H2A reversed the anti-proliferation effects induced by miR-516a-5p in non-small cell lung cancer cells. (PMID:30966836)
• HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis. (PMID:38684944)

Cross-species orthologs

22 orthologs

Organism	Symbol	Gene ID
mus_musculus	H2ac25	ENSMUSG00000078851
rattus_norvegicus	H2ac25	ENSRNOG00000064520
drosophila_melanogaster	His2A:CG31618	FBGN0051618
drosophila_melanogaster	His2A:CG33808	FBGN0053808
drosophila_melanogaster	His2A:CG33814	FBGN0053814
drosophila_melanogaster	His2A:CG33817	FBGN0053817
drosophila_melanogaster	His2A:CG33820	FBGN0053820
drosophila_melanogaster	His2A:CG33823	FBGN0053823
drosophila_melanogaster	His2A:CG33826	FBGN0053826
drosophila_melanogaster	His2A:CG33829	FBGN0053829
drosophila_melanogaster	His2A:CG33832	FBGN0053832
drosophila_melanogaster	His2A:CG33835	FBGN0053835
drosophila_melanogaster	His2A:CG33838	FBGN0053838
drosophila_melanogaster	His2A:CG33841	FBGN0053841
drosophila_melanogaster	His2A:CG33844	FBGN0053844
drosophila_melanogaster	His2A:CG33847	FBGN0053847
drosophila_melanogaster	His2A:CG33850	FBGN0053850
drosophila_melanogaster	His2A:CG33853	FBGN0053853
drosophila_melanogaster	His2A:CG33856	FBGN0053856
drosophila_melanogaster	His2A:CG33859	FBGN0053859
drosophila_melanogaster	His2A:CG33862	FBGN0053862
drosophila_melanogaster	His2A:CG33865	FBGN0053865

Paralogs (27): MACROH2A2 (ENSG00000099284), H2AZ2 (ENSG00000105968), MACROH2A1 (ENSG00000113648), H2AZ1 (ENSG00000164032), H2AC1 (ENSG00000164508), H2AC6 (ENSG00000180573), H2AC20 (ENSG00000184260), H2AC21 (ENSG00000184270), H2AX (ENSG00000188486), H2AC13 (ENSG00000196747), H2AC11 (ENSG00000196787), H2AC7 (ENSG00000196866), H2AL3 (ENSG00000229674), H2AJ (ENSG00000246705), H2AL1Q (ENSG00000249467), H2AB1 (ENSG00000274183), H2AC12 (ENSG00000274997), H2AC15 (ENSG00000275221), H2AC14 (ENSG00000276368), H2AC16 (ENSG00000276903), H2AC8 (ENSG00000277075), H2AB3 (ENSG00000277745), H2AB2 (ENSG00000277858), H2AC4 (ENSG00000278463), H2AC17 (ENSG00000278677), H2AC18 (ENSG00000288825), H2AC19 (ENSG00000288859)

Protein

Protein identifiers

Histone H2A type 3 — Q7L7L0 (reviewed: Q7L7L0)

Alternative names: H2A-clustered histone 25

All UniProt accessions (1): Q7L7L0

UniProt curated annotations — full annotation on UniProt →

Function. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit / interactions. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Subcellular location. Nucleus. Chromosome.

Post-translational modifications. Deiminated on Arg-4 in granulocytes upon calcium entry. Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of ‘Lys-27’ of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers. Following DNA double-strand breaks (DSBs), it is ubiquitinated through ‘Lys-63’ linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and ‘Lys-63’-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend ‘Lys-63’-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired. H2AK119Ub and ionizing radiation-induced ‘Lys-63’-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.

Similarity. Belongs to the histone H2A family.

RefSeq proteins (1): NP_254280* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002119	Histone_H2A	Family
IPR007125	H2A/H2B/H3	Domain
IPR009072	Histone-fold	Homologous_superfamily
IPR032454	Histone_H2A_C	Domain
IPR032458	Histone_H2A_CS	Conserved_site

Pfam: PF00125, PF16211

UniProt features (53 total): modified residue 35, helix 5, cross-link 3, strand 3, turn 2, initiator methionine 1, chain 1, region of interest 1, compositionally biased region 1, mutagenesis site 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
9ECP	ELECTRON MICROSCOPY	1.91
9FH9	ELECTRON MICROSCOPY	2.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7L7L0-F1	91.20	0.80

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (38): 10, 10, 10, 10, 14, 14, 16, 37, 37, 37, 37, 75, 76, 96, 96, 96, 96, 96, 105, 119 …

Mutagenesis-validated functional residues (1):

Position	Phenotype
2	blocks the inhibition of transcription by rps6ka5/msk1.

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-3214815	HDACs deacetylate histones
R-HSA-3214847	HATs acetylate histones
R-HSA-3214858	RMTs methylate histone arginines
R-HSA-5689603	UCH proteinases
R-HSA-5689880	Ub-specific processing proteases
R-HSA-5689901	Metalloprotease DUBs
R-HSA-9609690	HCMV Early Events
R-HSA-9610379	HCMV Late Events
R-HSA-9918481	Dengue Virus-Host Interactions

MSigDB gene sets: 217 (showing top): RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, CCAWYNNGAAR_UNKNOWN, GOBP_CELLULAR_RESPONSE_TO_UV, FISCHER_G1_S_CELL_CYCLE, GOBP_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, GOBP_RESPONSE_TO_UV, GOBP_DNA_DAMAGE_RESPONSE, GOBP_RESPONSE_TO_RADIATION, HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS

GO Biological Process (3): nucleosome disassembly (GO:0006337), heterochromatin formation (GO:0031507), UV-damage excision repair (GO:0070914)

GO Molecular Function (4): DNA binding (GO:0003677), structural constituent of chromatin (GO:0030527), protein heterodimerization activity (GO:0046982), protein binding (GO:0005515)

GO Cellular Component (4): nucleosome (GO:0000786), nucleus (GO:0005634), extracellular exosome (GO:0070062), chromosome (GO:0005694)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Chromatin modifying enzymes	3
Deubiquitination	3
HCMV Infection	2
Dengue Virus Infection	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
chromatin	2
protein-DNA complex disassembly	1
nucleosome organization	1
cellular component assembly	1
heterochromatin boundary formation	1
negative regulation of gene expression, epigenetic	1
heterochromatin organization	1
DNA repair	1
cellular response to UV	1
nucleic acid binding	1
structural molecule activity	1
protein dimerization activity	1
binding	1
protein-DNA complex	1
intracellular membrane-bounded organelle	1
extracellular vesicle	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1192 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
H2AC25	H1-1	Q02539	731
H2AC25	H2BC21	Q16778	550
H2AC25	H2BC26	Q8N257	509
H2AC25	H3C1	P02295	497
H2AC25	H1-4	P10412	458
H2AC25	H1-5	P16401	444
H2AC25	PCDHB4	Q9Y5E5	433
H2AC25	H2BC1	Q96A08	431
H2AC25	PCDHB7	Q9Y5E2	426
H2AC25	PCDHB3	Q9Y5E6	425
H2AC25	CDK5R2	Q13319	418
H2AC25	EEF1A1	P04719	401
H2AC25	PCDHB10	Q9UN67	392
H2AC25	NRARP	Q7Z6K4	384
H2AC25	DHTKD1	Q96HY7	380

IntAct

51 interactions, top by confidence:

A	B	Type	Score
OPG044	DDX3X	psi-mi:“MI:0914”(association)	0.730
H2AC25		psi-mi:“MI:0407”(direct interaction)	0.620
	H2AC25	psi-mi:“MI:0407”(direct interaction)	0.620
	H2AC25	psi-mi:“MI:0915”(physical association)	0.560
H2AC25		psi-mi:“MI:0915”(physical association)	0.560
HSF2BP	H2AC25	psi-mi:“MI:0915”(physical association)	0.560
H2AC25	NDUFV2	psi-mi:“MI:0915”(physical association)	0.560
P/V/C	KPNA3	psi-mi:“MI:0914”(association)	0.530
UBE2B	H2AC25	psi-mi:“MI:0407”(direct interaction)	0.520
NOP1	H2AC25	psi-mi:“MI:0213”(methylation reaction)	0.440
RNF168	H2AC25	psi-mi:“MI:0407”(direct interaction)	0.440
SPT16	H2AC25	psi-mi:“MI:0915”(physical association)	0.400
ORF73	ECI2	psi-mi:“MI:0914”(association)	0.350
CHD1L	H2BC12	psi-mi:“MI:0914”(association)	0.350
UBE2B	Ubr2	psi-mi:“MI:0914”(association)	0.350
H2AC25	SSRP1	psi-mi:“MI:0914”(association)	0.350
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350
RALBP1	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
PRKCB	HNRNPDL	psi-mi:“MI:0914”(association)	0.350
MYLK2		psi-mi:“MI:0914”(association)	0.350
ELK4	MYO1C	psi-mi:“MI:0914”(association)	0.350
RPS6KA3	BAG2	psi-mi:“MI:0914”(association)	0.350
PRKCB	CHEK1	psi-mi:“MI:0914”(association)	0.350
CAMK2A	SEC16A	psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350

BioGRID (157): KRTAP10-3 (Two-hybrid), HIST3H2A (Affinity Capture-MS), HIST3H2A (Two-hybrid), HIST3H2A (Affinity Capture-MS), HIST3H2A (Affinity Capture-MS), HIST3H2A (Affinity Capture-MS), HIST3H2A (Affinity Capture-MS), HIST3H2A (Affinity Capture-MS), HIST3H2A (Affinity Capture-MS), HIST3H2A (Affinity Capture-MS), HIST3H2A (Affinity Capture-RNA), HIST3H2A (Reconstituted Complex), HIST3H2A (Affinity Capture-MS), HIST3H2A (Affinity Capture-MS), HIST3H2A (Two-hybrid)

ESM2 similar proteins: A1A4R1, A9UMV8, C0HKE1, C0HKE2, C0HKE3, C0HKE4, C0HKE5, C0HKE6, C0HKE7, C0HKE8, C0HKE9, P02262, P02263, P02270, P04908, P06897, P0C0S8, P0C0S9, P0C169, P0C170, P0CC09, P13912, P19178, P20671, P21896, P27325, P35061, P35062, P70082, P84052, Q07135, Q16777, Q3ZBX9, Q4FZT6, Q4R3X5, Q64522, Q64523, Q64598, Q6FI13, Q6GSS7

Diamond homologs: A0A097I1R9, A0A097I2B5, A0A0D2UG83, A1A4R1, A1CJ10, A1D8G8, A3LXE7, A3LZZ0, A5DBG4, A5DJJ2, A5DWF1, A5DXC6, A9UMV8, C0HKE1, C0HKE2, C0HKE3, C0HKE4, C0HKE5, C0HKE6, C0HKE7, C0HKE8, C0HKE9, L7HZV6, O74268, P02262, P02263, P02264, P04908, P04909, P04910, P04911, P04912, P06897, P07793, P08844, P0C0S8, P0C0S9, P0C169, P0C170, P0C952

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
SLBP	“up-regulates quantity by expression”	H2AW	“translation regulation”
DZIP3	“up-regulates activity”	H2AW	monoubiquitination
RPS6KA5	“up-regulates activity”	H2AW	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

29 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	28
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

125 predictions. Top by Δscore:

Variant	Effect	Δscore
1:228457648:TCGAG:T	donor_gain	0.6200
1:228457649:CGAGC:C	donor_gain	0.6200
1:228457774:G:C	donor_gain	0.5600
1:228457773:AG:A	donor_gain	0.5500
1:228457431:G:A	donor_gain	0.5400
1:228457430:TGCCC:T	donor_gain	0.4900
1:228457431:GCCCT:G	donor_gain	0.4700
1:228457432:CCCTT:C	donor_gain	0.4500
1:228457185:C:A	donor_gain	0.4400
1:228457167:C:CT	donor_gain	0.4300
1:228457166:C:CT	donor_gain	0.4200
1:228457212:A:G	donor_gain	0.4100
1:228457213:C:T	donor_gain	0.4100
1:228457427:A:AC	donor_gain	0.4100
1:228457428:C:CC	donor_gain	0.4100
1:228457214:C:T	donor_gain	0.4000
1:228457432:C:CA	donor_gain	0.4000
1:228457474:ACGG:A	donor_gain	0.4000
1:228457475:CGGC:C	donor_gain	0.4000
1:228457592:T:TA	donor_gain	0.4000
1:228457453:T:A	donor_gain	0.3900
1:228457429:TTGCC:T	donor_gain	0.3800
1:228457209:C:T	donor_gain	0.3700
1:228457211:CACCT:C	donor_gain	0.3700
1:228457194:TAACA:T	donor_gain	0.3600
1:228457208:GCCCA:G	donor_gain	0.3600
1:228457209:CCCA:C	donor_loss	0.3600
1:228457210:CCAC:C	donor_loss	0.3600
1:228457210:CCACC:C	donor_gain	0.3600
1:228457211:CAC:C	donor_loss	0.3600

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000238442 (1:228458768 T>A,C), RS1001050817 (1:228458095 C>A,G,T), RS1002053230 (1:228457187 CTGT>C), RS1002084351 (1:228457042 G>T), RS1003133451 (1:228457383 C>A,G,T), RS1003578151 (1:228459643 G>A), RS1003611386 (1:228459394 C>T), RS1003893672 (1:228457092 T>C,G), RS1003987150 (1:228456898 T>C), RS1005427562 (1:228458307 A>G), RS1006021664 (1:228459412 C>T), RS1006164175 (1:228459062 C>G,T), RS1006483586 (1:228459274 C>G,T), RS1007247054 (1:228458986 C>A,T), RS1007334703 (1:228458782 C>T)

Disease associations

OMIM: gene MIM:615015 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003833_18	Adult asthma	7.000000e-08
GCST003833_2	Adult asthma	1.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, increases methylation	3
Estradiol	affects cotreatment, decreases expression	2
Particulate Matter	decreases expression, increases abundance	2
aristolochic acid I	increases expression	1
GSK-J4	increases expression	1
propionaldehyde	decreases expression	1
trichostatin A	affects expression	1
sodium arsenite	decreases expression, increases abundance	1
cobaltous chloride	increases expression	1
ferrous chloride	increases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
pentanal	decreases expression	1
abrine	increases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	increases expression, increases response to substance	1
NSC 689534	affects binding, increases expression	1
(+)-JQ1 compound	increases expression	1
Sunitinib	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	decreases expression, increases abundance	1
Berberine	decreases expression	1
Bilirubin	increases expression	1
Cisplatin	increases expression	1
Copper	affects binding, increases expression	1
Coumestrol	affects cotreatment, decreases expression	1
Dieldrin	increases expression	1
Dimethyl Sulfoxide	increases expression	1
Hydrogen Peroxide	affects expression	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Thiram	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.