H2BC15

Summary

H2BC15 (H2B clustered histone 15, HGNC:4749) is a protein-coding gene on chromosome 6p22.1, encoding Histone H2B type 1-N (Q99877). Core component of nucleosome. It is a common-essential gene (DepMap: required in 99.2% of cancer cell lines).

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

Source: NCBI Gene 8341 — RefSeq curated summary.

At a glance

• GWAS associations: 22
• Clinical variants (ClinVar): 11 total
• Cancer dependency (DepMap): dependent in 99.2% of screened cell lines (common-essential)
• MANE Select transcript: NM_003520

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4749
Approved symbol	H2BC15
Name	H2B clustered histone 15
Location	6p22.1
Locus type	gene with protein product
Status	Approved
Aliases	H2B/d
Ensembl gene	ENSG00000233822
Ensembl biotype	protein_coding
OMIM	602801
Entrez	8341

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 nonsense_mediated_decay

ENST00000449538, ENST00000606613, ENST00000612898, ENST00000898165

RefSeq mRNA: 1 — MANE Select: NM_003520 NM_003520

CCDS: CCDS4633

Canonical transcript exons

ENST00000612898 — 1 exons

Exon	Start	End
ENSE00003727920	27838569	27839110

Expression profiles

Bgee: expression breadth ubiquitous, 166 present calls, max score 86.23.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 390.4226 / max 11250.1302, expressed in 1825 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66593	365.8806	1825
66594	10.9697	1303
66592	5.4917	1439
66590	3.5539	1127
66595	1.7442	668
66591	1.5831	520
66596	1.1185	509
203929	0.0808	44

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	86.23	gold quality
bone marrow cell	CL:0002092	82.78	gold quality
colonic epithelium	UBERON:0000397	80.96	gold quality
monocyte	CL:0000576	78.74	gold quality
mononuclear cell	CL:0000842	78.15	gold quality
leukocyte	CL:0000738	77.11	gold quality
myocardium	UBERON:0002349	75.32	gold quality
left ventricle myocardium	UBERON:0006566	74.97	gold quality
calcaneal tendon	UBERON:0003701	74.75	gold quality
cardiac muscle of right atrium	UBERON:0003379	73.98	gold quality
diaphragm	UBERON:0001103	73.40	gold quality
triceps brachii	UBERON:0001509	72.31	gold quality
gluteal muscle	UBERON:0002000	72.17	gold quality
stromal cell of endometrium	CL:0002255	71.39	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	69.82	gold quality
inferior olivary complex	UBERON:0002127	69.63	gold quality
vastus lateralis	UBERON:0001379	69.57	gold quality
bone marrow	UBERON:0002371	69.42	gold quality
quadriceps femoris	UBERON:0001377	68.74	gold quality
tonsil	UBERON:0002372	68.69	gold quality
ventricular zone	UBERON:0003053	68.44	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.87	gold quality
spinal cord	UBERON:0002240	66.09	gold quality
hair follicle	UBERON:0002073	66.04	gold quality
heart right ventricle	UBERON:0002080	65.78	gold quality
muscle tissue	UBERON:0002385	65.30	gold quality
skeletal muscle tissue	UBERON:0001134	65.10	gold quality
cervix squamous epithelium	UBERON:0006922	64.82	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	64.80	gold quality
vena cava	UBERON:0004087	64.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.36

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.2% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• Hypomethylation of ATG4A and HIST1H2BN in ovarian tumor-initiating cells predicts a poor prognosis for ovarian cancer patients. (PMID:24256813)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	H2bc3	ENSMUSG00000075031

Paralogs (21): H2BW2 (ENSG00000101812), H2BW1 (ENSG00000123569), H2BC11 (ENSG00000124635), H2BC1 (ENSG00000146047), H2BC5 (ENSG00000158373), H2BC4 (ENSG00000180596), H2BC21 (ENSG00000184678), H2BC13 (ENSG00000185130), H2BC26 (ENSG00000196890), H2BC12 (ENSG00000197903), H2BC18 (ENSG00000203814), H2BC12L (ENSG00000234289), H2BC14 (ENSG00000273703), H2BC8 (ENSG00000273802), H2BC6 (ENSG00000274290), H2BC17 (ENSG00000274641), H2BC9 (ENSG00000275713), H2BC3 (ENSG00000276410), H2BC7 (ENSG00000277224), H2BC10 (ENSG00000278588), H2BK1 (ENSG00000285480)

Protein

Protein identifiers

Histone H2B type 1-N — Q99877 (reviewed: Q99877)

Alternative names: Histone H2B.d

All UniProt accessions (2): Q99877, U3KQK0

UniProt curated annotations — full annotation on UniProt →

Function. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit / interactions. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Subcellular location. Nucleus. Chromosome.

Post-translational modifications. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 ‘Lys-4’ (H3K4me) and ‘Lys-79’ (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ‘Lys-4’ and ‘Lys-79’ methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons. Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription. Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes. ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage. H2BS6ADPr promotes recruitment of CHD1L. Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks. Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.

Similarity. Belongs to the histone H2B family.

RefSeq proteins (1): NP_003511* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000558	Histone_H2B	Family
IPR007125	H2A/H2B/H3	Domain
IPR009072	Histone-fold	Homologous_superfamily
IPR055333	HISTONE_H2B_site	Conserved_site

Pfam: PF00125

UniProt features (106 total): modified residue 91, helix 4, cross-link 4, initiator methionine 1, chain 1, turn 1, strand 1, region of interest 1, compositionally biased region 1, glycosylation site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8OL1	ELECTRON MICROSCOPY	3.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q99877-F1	87.68	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (95): 6, 6, 6, 6, 7, 12, 12, 12, 12, 12, 12, 13, 13, 13, 15, 16, 16, 16, 16, 17 …

Glycosylation sites (1): 113

Function

Pathways and Gene Ontology

Reactome pathways

59 pathways

ID	Pathway
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329	Cleavage of the damaged pyrimidine
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331	Cleavage of the damaged purine
R-HSA-1221632	Meiotic synapsis
R-HSA-171306	Packaging Of Telomere Ends
R-HSA-1912408	Pre-NOTCH Transcription and Translation
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex
R-HSA-212300	PRC2 methylates histones and DNA
R-HSA-2299718	Condensation of Prophase Chromosomes
R-HSA-2559580	Oxidative Stress Induced Senescence
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence
R-HSA-3214815	HDACs deacetylate histones
R-HSA-3214847	HATs acetylate histones
R-HSA-427359	SIRT1 negatively regulates rRNA expression
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413	NoRC negatively regulates rRNA expression
R-HSA-5250924	B-WICH complex positively regulates rRNA expression
R-HSA-5334118	DNA methylation
R-HSA-5578749	Transcriptional regulation by small RNAs
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5689880	Ub-specific processing proteases
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)
R-HSA-5693607	Processing of DNA double-strand break ends
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68616	Assembly of the ORC complex at the origin of replication
R-HSA-69473	G2/M DNA damage checkpoint

MSigDB gene sets: 199 (showing top): REACTOME_MEIOTIC_RECOMBINATION, REACTOME_DNA_REPLICATION, REACTOME_SIGNALING_BY_NOTCH, GOBP_ANTIMICROBIAL_HUMORAL_RESPONSE, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_MEIOTIC_SYNAPSIS, ENK_UV_RESPONSE_KERATINOCYTE_UP, REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT, GOBP_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE, REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_INNATE_IMMUNE_RESPONSE_IN_MUCOSA, GOBP_HUMORAL_IMMUNE_RESPONSE, GOBP_PROTEIN_DNA_COMPLEX_ORGANIZATION, REACTOME_DNA_REPAIR

GO Biological Process (1): nucleosome assembly (GO:0006334)

GO Molecular Function (4): DNA binding (GO:0003677), structural constituent of chromatin (GO:0030527), protein heterodimerization activity (GO:0046982), protein binding (GO:0005515)

GO Cellular Component (6): nucleosome (GO:0000786), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829), extracellular exosome (GO:0070062), chromosome (GO:0005694)

Reactome top-level categories

Rollup of top-12 pathways:

Category	Pathways
Cellular Senescence	3
Depyrimidination	2
Depurination	2
Epigenetic regulation of gene expression	2
Chromatin modifying enzymes	2
Negative epigenetic regulation of rRNA expression	2
Positive epigenetic regulation of rRNA expression	2
Meiosis	1
Telomere Maintenance	1
Pre-NOTCH Expression and Processing	1
TCF dependent signaling in response to WNT	1
Mitotic Prophase	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
chromatin	2
cellular anatomical structure	2
chromatin organization	1
nucleosome organization	1
protein-DNA complex assembly	1
nucleic acid binding	1
structural molecule activity	1
protein dimerization activity	1
binding	1
protein-DNA complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1
extracellular vesicle	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

2258 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
H2BC15	PLG	P00747	867
H2BC15	RNF20	Q5VTR2	835
H2BC15	H3C1	P02295	813
H2BC15	H3C14	Q71DI3	809
H2BC15	H3-5	Q6NXT2	809
H2BC15	H3-4	Q16695	809
H2BC15	H3-7	Q5TEC6	809
H2BC15	H3-3A	P06351	808
H2BC15	RNF40	O75150	772
H2BC15	H4C16	P02304	745
H2BC15	H4C7	Q99525	743
H2BC15	H2AC20	Q16777	733
H2BC15	H2AC19	P20670	733
H2BC15	DET1	Q7L5Y6	725
H2BC15	USP22	Q9UPT9	722

IntAct

32 interactions, top by confidence:

A	B	Type	Score
MAPK7	PFDN6	psi-mi:“MI:0914”(association)	0.640
ING4	KAT7	psi-mi:“MI:0914”(association)	0.530
GRB2	ARHGEF35	psi-mi:“MI:0914”(association)	0.530
H1-6	H2BC15	psi-mi:“MI:0915”(physical association)	0.400
TMEM196	H2BC15	psi-mi:“MI:0915”(physical association)	0.400
H2AC4	H2BC15	psi-mi:“MI:0915”(physical association)	0.400
JPH2	H2BC15	psi-mi:“MI:0915”(physical association)	0.400
H3-4	H2BC15	psi-mi:“MI:0915”(physical association)	0.400
TMA7	H2BC15	psi-mi:“MI:0915”(physical association)	0.400
CWF19L1	H2BC15	psi-mi:“MI:0915”(physical association)	0.400
CROCCP2	H2BC15	psi-mi:“MI:0915”(physical association)	0.400
DRAP1	H2BC15	psi-mi:“MI:0915”(physical association)	0.400
EWSR1	H2BC15	psi-mi:“MI:0915”(physical association)	0.370
H2BC15	BCCIP	psi-mi:“MI:0915”(physical association)	0.370
Ktn1	ESYT2	psi-mi:“MI:0914”(association)	0.350
APP	ESYT2	psi-mi:“MI:0914”(association)	0.350
DOK2	MYO1C	psi-mi:“MI:0914”(association)	0.350
PRKCB	HNRNPDL	psi-mi:“MI:0914”(association)	0.350
ELK4	MYO1C	psi-mi:“MI:0914”(association)	0.350
PRKCB	CHEK1	psi-mi:“MI:0914”(association)	0.350
LCK	UQCRQ	psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
NS	H2BC12	psi-mi:“MI:0914”(association)	0.350
NS	IGF2BP3	psi-mi:“MI:0914”(association)	0.350
US11		psi-mi:“MI:0914”(association)	0.350
OPG199	IRS4	psi-mi:“MI:0914”(association)	0.350
VP35		psi-mi:“MI:0914”(association)	0.350
P/V/C	KPNA3	psi-mi:“MI:0914”(association)	0.350

BioGRID (308): HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), BCCIP (Two-hybrid), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-MS), HIST1H2BN (Affinity Capture-RNA), HIST1H2BN (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8Y619, O97484, P02284, P02285, P02286, P02287, P02288, P04255, P04913, P07794, P07795, P0C1H4, P16888, P16889, P16890, P19374, P21897, P23527, P27326, P30757, P33778, P35067, P35068, P35069, P48557, P57053, P62807, P62808, P70696, P83863, Q00715, Q00729, Q16778, Q27894, Q32L48, Q5QNW6, Q5R893, Q5RCP8, Q64475, Q64478

Diamond homologs: A0A2R8Y619, A2WKT1, A2WKT4, A2WWU2, A2XF66, A2YWI3, A3AGM4, O22582, O60814, O65819, P02281, P02283, P02284, P02285, P02286, P02287, P02288, P02289, P02290, P04255, P06145, P06899, P06900, P07794, P07795, P0C1H3, P0C1H4, P0C1H5, P10853, P10854, P14001, P16888, P16889, P16890, P17271, P19374, P21897, P23527, P27326, P27807

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
SLBP	“up-regulates quantity by expression”	H2BC15	“translation regulation”
“MSL acetyltransferase”	“down-regulates activity”	H2BC15	monoubiquitination

Disease & clinical

Clinical variants and AI predictions

ClinVar

11 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	11
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

74 predictions. Top by Δscore:

Variant	Effect	Δscore
6:27838637:A:AG	acceptor_gain	0.8300
6:27838638:A:G	acceptor_gain	0.7500
6:27838648:A:AG	acceptor_gain	0.6600
6:27838649:G:GG	acceptor_gain	0.6600
6:27838644:C:CA	acceptor_gain	0.6400
6:27838649:GTTA:G	acceptor_gain	0.5900
6:27838645:G:A	acceptor_gain	0.5800
6:27838638:A:AG	acceptor_loss	0.5600
6:27838647:CAGTT:C	acceptor_loss	0.5600
6:27838648:A:T	acceptor_loss	0.5600
6:27838649:G:GA	acceptor_loss	0.5600
6:27838649:GT:G	acceptor_gain	0.5500
6:27838649:GTT:G	acceptor_gain	0.4800
6:27838649:GTTAC:G	acceptor_gain	0.4600
6:27838644:CGGCA:C	acceptor_gain	0.4100
6:27838645:GGCAG:G	acceptor_gain	0.4100
6:27838646:GCAG:G	acceptor_gain	0.3900
6:27838648:AGTT:A	acceptor_gain	0.3900
6:27838647:CAG:C	acceptor_gain	0.3700
6:27838795:TGCTG:T	donor_gain	0.3700
6:27838623:T:TA	acceptor_loss	0.3300
6:27838594:GCG:G	donor_gain	0.3200
6:27838649:G:T	acceptor_gain	0.3200
6:27838601:GTTGA:G	acceptor_loss	0.3100
6:27838612:T:TA	acceptor_gain	0.3100
6:27838613:A:AA	acceptor_gain	0.3100
6:27838652:A:AG	acceptor_loss	0.3100
6:27838833:A:AC	acceptor_gain	0.3100
6:27838614:C:A	acceptor_gain	0.3000
6:27838818:ACC:A	acceptor_gain	0.3000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000325118 (6:27838750 G>A), RS1000705005 (6:27837000 G>A,C,T), RS1003496755 (6:27837167 G>A,C,T), RS1003529689 (6:27837384 C>G), RS1004472846 (6:27837221 TTATG>T), RS1005117359 (6:27837358 T>C), RS1006814442 (6:27839334 T>C,G), RS1006888623 (6:27838297 C>G,T), RS1008671799 (6:27836909 T>C), RS1009125385 (6:27839068 C>G), RS1009160954 (6:27839297 C>G), RS1010183329 (6:27836689 G>T), RS1011520991 (6:27839279 C>G), RS1012294977 (6:27838499 G>A), RS1012336593 (6:27837420 T>G)

Disease associations

OMIM: gene MIM:602801 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

22 associations (top):

Study	Trait	p-value
GCST004521_112	Autism spectrum disorder or schizophrenia	3.000000e-26
GCST004521_115	Autism spectrum disorder or schizophrenia	3.000000e-16
GCST004521_116	Autism spectrum disorder or schizophrenia	3.000000e-16
GCST004521_166	Autism spectrum disorder or schizophrenia	4.000000e-24
GCST004521_22	Autism spectrum disorder or schizophrenia	2.000000e-11
GCST004521_23	Autism spectrum disorder or schizophrenia	2.000000e-11
GCST004521_6	Autism spectrum disorder or schizophrenia	2.000000e-15
GCST004521_73	Autism spectrum disorder or schizophrenia	8.000000e-11
GCST005316_412	Intelligence (MTAG)	6.000000e-13
GCST006269_1220	General cognitive ability	4.000000e-08
GCST008921_6	Asthma and major depressive disorder	1.000000e-09
GCST010002_50	Refractive error	4.000000e-34
GCST010142_16	Fish- and plant-related diet	2.000000e-10
GCST010142_19	Fish- and plant-related diet	4.000000e-10
GCST010142_34	Fish- and plant-related diet	7.000000e-09
GCST010142_35	Fish- and plant-related diet	8.000000e-09
GCST010142_42	Fish- and plant-related diet	1.000000e-08
GCST010142_7	Fish- and plant-related diet	3.000000e-12
GCST010702_75	Subcortical volume (MOSTest)	3.000000e-11
GCST010703_272	Brain morphology (MOSTest)	7.000000e-16
GCST012228_153	Waist-hip index	2.000000e-08
GCST012230_276	Waist-to-hip ratio adjusted for BMI	2.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004337	intelligence
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression, increases expression	2
Copper Sulfate	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
bisphenol A	decreases expression	1
decabromobiphenyl ether	affects expression	1
perfluorooctanoic acid	decreases expression	1
deguelin	increases expression	1
K 7174	increases expression	1
fenpyroximate	increases expression	1
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	increases expression	1
pyrimidifen	increases expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, decreases expression	1
incobotulinumtoxinA	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	decreases expression	1
Antimycin A	increases expression	1
Berberine	decreases expression	1
Cisplatin	affects cotreatment, decreases expression	1
N-Nitrosopyrrolidine	decreases expression	1
Paraquat	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Silicon Dioxide	increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Aflatoxin B1	decreases methylation	1
Sodium Selenite	decreases expression	1
Genistein	increases reaction, increases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.