H2BC17

Summary

H2BC17 (H2B clustered histone 17, HGNC:4758) is a protein-coding gene on chromosome 6p22.1, encoding Histone H2B type 1-O (P23527). Core component of nucleosome.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

Source: NCBI Gene 8348 — RefSeq curated summary.

At a glance

• GWAS associations: 18
• Clinical variants (ClinVar): 13 total
• MANE Select transcript: NM_003527

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:4758
Approved symbol	H2BC17
Name	H2B clustered histone 17
Location	6p22.1
Locus type	gene with protein product
Status	Approved
Aliases	H2B/n, H2B.2
Ensembl gene	ENSG00000274641
Ensembl biotype	protein_coding
OMIM	602808
Entrez	8348

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000616182

RefSeq mRNA: 1 — MANE Select: NM_003527 NM_003527

CCDS: CCDS4640

Canonical transcript exons

ENST00000616182 — 1 exons

Exon	Start	End
ENSE00003717748	27893425	27893891

Expression profiles

Bgee: expression breadth ubiquitous, 137 present calls, max score 95.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 317.5954 / max 9939.5629, expressed in 1703 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66602	316.3650	1702
66603	1.2303	377

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	95.61	gold quality
adrenal tissue	UBERON:0018303	89.20	gold quality
monocyte	CL:0000576	80.99	gold quality
leukocyte	CL:0000738	79.82	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.65	gold quality
granulocyte	CL:0000094	70.76	gold quality
colonic epithelium	UBERON:0000397	67.28	gold quality
calcaneal tendon	UBERON:0003701	64.83	gold quality
ventricular zone	UBERON:0003053	64.14	gold quality
blood	UBERON:0000178	62.67	gold quality
bone marrow	UBERON:0002371	59.51	gold quality
tonsil	UBERON:0002372	56.65	gold quality
tendon	UBERON:0000043	55.94	gold quality
mucosa of transverse colon	UBERON:0004991	54.30	gold quality
right lung	UBERON:0002167	51.76	gold quality
spleen	UBERON:0002106	50.88	gold quality
rectum	UBERON:0001052	50.86	gold quality
lower esophagus mucosa	UBERON:0035834	49.32	gold quality
blood vessel layer	UBERON:0004797	49.29	gold quality
choroid plexus epithelium	UBERON:0003911	48.89	gold quality
corpus callosum	UBERON:0002336	47.78	silver quality
periodontal ligament	UBERON:0008266	47.14	gold quality
renal glomerulus	UBERON:0000074	46.86	gold quality
metanephric glomerulus	UBERON:0004736	46.77	gold quality
nephron tubule	UBERON:0001231	46.71	gold quality
ganglionic eminence	UBERON:0004023	46.33	gold quality
lymph node	UBERON:0000029	46.14	gold quality
lung	UBERON:0002048	45.99	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	45.35	gold quality
upper leg skin	UBERON:0004262	45.33	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (21): H2BW2 (ENSG00000101812), H2BW1 (ENSG00000123569), H2BC11 (ENSG00000124635), H2BC1 (ENSG00000146047), H2BC5 (ENSG00000158373), H2BC4 (ENSG00000180596), H2BC21 (ENSG00000184678), H2BC13 (ENSG00000185130), H2BC26 (ENSG00000196890), H2BC12 (ENSG00000197903), H2BC18 (ENSG00000203814), H2BC15 (ENSG00000233822), H2BC12L (ENSG00000234289), H2BC14 (ENSG00000273703), H2BC8 (ENSG00000273802), H2BC6 (ENSG00000274290), H2BC9 (ENSG00000275713), H2BC3 (ENSG00000276410), H2BC7 (ENSG00000277224), H2BC10 (ENSG00000278588), H2BK1 (ENSG00000285480)

Protein

Protein identifiers

Histone H2B type 1-O — P23527 (reviewed: P23527)

Alternative names: H2B-clustered histone 17, Histone H2B.2, Histone H2B.n

All UniProt accessions (1): P23527

UniProt curated annotations — full annotation on UniProt →

Function. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit / interactions. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Subcellular location. Nucleus. Chromosome.

Post-translational modifications. Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 ‘Lys-4’ (H3K4me) and ‘Lys-79’ (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ‘Lys-4’ and ‘Lys-79’ methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons. Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription. Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes. ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage. H2BS6ADPr promotes recruitment of CHD1L. Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.

Miscellaneous. The mouse orthologous protein does not seem to exist.

Similarity. Belongs to the histone H2B family.

RefSeq proteins (1): NP_003518* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000558	Histone_H2B	Family
IPR007125	H2A/H2B/H3	Domain
IPR009072	Histone-fold	Homologous_superfamily
IPR055333	HISTONE_H2B_site	Conserved_site

Pfam: PF00125

UniProt features (106 total): modified residue 90, helix 4, cross-link 4, strand 2, initiator methionine 1, chain 1, region of interest 1, compositionally biased region 1, glycosylation site 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7WLP	X-RAY DIFFRACTION	2.29

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P23527-F1	88.04	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (94): 6, 6, 6, 7, 12, 12, 12, 12, 12, 12, 13, 13, 13, 15, 16, 16, 16, 16, 17, 17 …

Glycosylation sites (1): 113

Function

Pathways and Gene Ontology

Reactome pathways

58 pathways

ID	Pathway
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine
R-HSA-110329	Cleavage of the damaged pyrimidine
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine
R-HSA-110331	Cleavage of the damaged purine
R-HSA-1221632	Meiotic synapsis
R-HSA-171306	Packaging Of Telomere Ends
R-HSA-1912408	Pre-NOTCH Transcription and Translation
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex
R-HSA-212300	PRC2 methylates histones and DNA
R-HSA-2299718	Condensation of Prophase Chromosomes
R-HSA-2559580	Oxidative Stress Induced Senescence
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence
R-HSA-3214815	HDACs deacetylate histones
R-HSA-3214847	HATs acetylate histones
R-HSA-427359	SIRT1 negatively regulates rRNA expression
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-427413	NoRC negatively regulates rRNA expression
R-HSA-5250924	B-WICH complex positively regulates rRNA expression
R-HSA-5334118	DNA methylation
R-HSA-5578749	Transcriptional regulation by small RNAs
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5689880	Ub-specific processing proteases
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)
R-HSA-5693607	Processing of DNA double-strand break ends
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68616	Assembly of the ORC complex at the origin of replication
R-HSA-69473	G2/M DNA damage checkpoint

MSigDB gene sets: 177 (showing top): REACTOME_MEIOTIC_RECOMBINATION, REACTOME_DNA_REPLICATION, REACTOME_SIGNALING_BY_NOTCH, GOBP_ANTIMICROBIAL_HUMORAL_RESPONSE, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_MEIOTIC_SYNAPSIS, REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT, GOBP_ORGAN_OR_TISSUE_SPECIFIC_IMMUNE_RESPONSE, REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_INNATE_IMMUNE_RESPONSE_IN_MUCOSA, GOBP_HUMORAL_IMMUNE_RESPONSE, FISCHER_DREAM_TARGETS, GOBP_PROTEIN_DNA_COMPLEX_ORGANIZATION, REACTOME_DNA_REPAIR

GO Biological Process (1): nucleosome assembly (GO:0006334)

GO Molecular Function (4): DNA binding (GO:0003677), structural constituent of chromatin (GO:0030527), protein heterodimerization activity (GO:0046982), protein binding (GO:0005515)

GO Cellular Component (5): nucleosome (GO:0000786), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829), chromosome (GO:0005694)

Reactome top-level categories

Rollup of top-12 pathways:

Category	Pathways
Cellular Senescence	3
Depyrimidination	2
Depurination	2
Epigenetic regulation of gene expression	2
Chromatin modifying enzymes	2
Negative epigenetic regulation of rRNA expression	2
Positive epigenetic regulation of rRNA expression	2
Meiosis	1
Telomere Maintenance	1
Pre-NOTCH Expression and Processing	1
TCF dependent signaling in response to WNT	1
Mitotic Prophase	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
chromatin	2
cellular anatomical structure	2
chromatin organization	1
nucleosome organization	1
protein-DNA complex assembly	1
nucleic acid binding	1
structural molecule activity	1
protein dimerization activity	1
binding	1
protein-DNA complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

2376 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
H2BC17	H3C1	P02295	882
H2BC17	PLG	P00747	867
H2BC17	RNF20	Q5VTR2	843
H2BC17	H3C14	Q71DI3	814
H2BC17	H3-5	Q6NXT2	814
H2BC17	H3-4	Q16695	814
H2BC17	H3-3A	P06351	813
H2BC17	H3-7	Q5TEC6	812
H2BC17	RNF40	O75150	777
H2BC17	H2AC19	P20670	761
H2BC17	H2AC20	Q16777	760
H2BC17	H4C16	P02304	746
H2BC17	H4C7	Q99525	746
H2BC17	DET1	Q7L5Y6	729
H2BC17	USP22	Q9UPT9	727

IntAct

44 interactions, top by confidence:

A	B	Type	Score
H2AZ1	ZNHIT1	psi-mi:“MI:0914”(association)	0.770
H2AX	PPM1G	psi-mi:“MI:0914”(association)	0.730
XPC	CETN3	psi-mi:“MI:0914”(association)	0.730
H2BC17	PCDHB12	psi-mi:“MI:0915”(physical association)	0.560
ING4	KAT7	psi-mi:“MI:0914”(association)	0.530
EPB41L5	SETD1A	psi-mi:“MI:0914”(association)	0.530
H2AC20	PPM1G	psi-mi:“MI:0914”(association)	0.530
PRPF38A	H2BC17	psi-mi:“MI:0914”(association)	0.510
ARRB1		psi-mi:“MI:0914”(association)	0.350
ARRB2		psi-mi:“MI:0914”(association)	0.350
Prdm16	ESYT2	psi-mi:“MI:0914”(association)	0.350
EPB41L5	AP3B1	psi-mi:“MI:0914”(association)	0.350
RPS6KA3	BAG2	psi-mi:“MI:0914”(association)	0.350
Aire	NOP56	psi-mi:“MI:0914”(association)	0.350
P		psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
H1-7		psi-mi:“MI:0914”(association)	0.350
HNRNPCL1	KPNA3	psi-mi:“MI:0914”(association)	0.350
ZNF346	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
PRKRA	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
ANP32E	KPNA5	psi-mi:“MI:0914”(association)	0.350
H2AJ	WDR46	psi-mi:“MI:0914”(association)	0.350
CACUL1	H2BC17	psi-mi:“MI:0914”(association)	0.350

BioGRID (369): HIST1H2BO (Affinity Capture-RNA), HIST1H2BO (Affinity Capture-RNA), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), PRPF38A (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS), HIST1H2BO (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8Y619, O97484, P02284, P02285, P02286, P02287, P02288, P04255, P04913, P07794, P07795, P0C1H4, P16888, P16889, P16890, P19374, P21897, P23527, P27326, P30757, P33778, P35067, P35068, P35069, P48557, P57053, P62807, P62808, P70696, P83863, Q00715, Q00729, Q16778, Q27894, Q32L48, Q5QNW6, Q5R893, Q5RCP8, Q64475, Q64478

Diamond homologs: A0A2R8Y619, A2WKT1, A2WKT4, A2WWU2, A2XF66, A2YWI3, A3AGM4, O22582, O60814, O65819, P02281, P02283, P02284, P02285, P02286, P02287, P02288, P02289, P02290, P04255, P06145, P06899, P06900, P07794, P07795, P0C1H3, P0C1H4, P0C1H5, P10853, P10854, P14001, P16888, P16889, P16890, P17271, P19374, P21897, P23527, P27326, P27807

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
SLBP	“up-regulates quantity by expression”	H2BC17	“translation regulation”
“MSL acetyltransferase”	“down-regulates activity”	H2BC17	monoubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 49 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
heterochromatin formation	5	33.6×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

13 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	12
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

38 predictions. Top by Δscore:

Variant	Effect	Δscore
6:27893596:TGCTG:T	donor_gain	0.7200
6:27893573:T:G	donor_gain	0.6800
6:27893637:GCCA:G	donor_gain	0.6700
6:27893597:GCTGA:G	donor_gain	0.6400
6:27893604:C:T	donor_gain	0.6100
6:27893569:A:T	donor_gain	0.5800
6:27893818:TCACC:T	donor_gain	0.5400
6:27893538:G:GT	donor_gain	0.5300
6:27893592:A:AC	acceptor_gain	0.4900
6:27893840:G:GG	donor_gain	0.4900
6:27893598:C:CG	donor_gain	0.4800
6:27893839:A:AG	donor_gain	0.4200
6:27893619:ACC:A	acceptor_gain	0.4100
6:27893543:C:T	donor_gain	0.4000
6:27893591:CA:C	acceptor_gain	0.3900
6:27893690:C:T	donor_gain	0.3900
6:27893825:G:GG	donor_gain	0.3800
6:27893589:TACA:T	acceptor_gain	0.3600
6:27893590:ACAA:A	acceptor_gain	0.3600
6:27893824:A:AG	donor_gain	0.3600
6:27893827:ACACC:A	donor_gain	0.3600
6:27893843:A:AG	donor_gain	0.3300
6:27893593:A:G	acceptor_gain	0.3000
6:27893676:G:GC	acceptor_gain	0.2900
6:27893546:G:GT	donor_gain	0.2800
6:27893585:C:CA	acceptor_gain	0.2700
6:27893599:T:G	donor_gain	0.2700
6:27893621:C:A	acceptor_gain	0.2600
6:27893742:G:T	donor_gain	0.2600
6:27893634:A:AC	acceptor_gain	0.2500

AlphaMissense

813 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:27893599:T:C	L46P	1.000
6:27893605:A:C	Q48P	1.000
6:27893668:A:T	D69V	1.000
6:27893686:C:A	A75D	1.000
6:27893694:G:C	A78P	1.000
6:27893695:C:A	A78D	1.000
6:27893704:T:C	L81P	1.000
6:27893740:G:C	R93T	1.000
6:27893740:G:T	R93M	1.000
6:27893741:G:C	R93S	1.000
6:27893741:G:T	R93S	1.000
6:27893742:G:A	E94K	1.000
6:27893750:G:C	Q96H	1.000
6:27893750:G:T	Q96H	1.000
6:27893754:G:C	A98P	1.000
6:27893755:C:A	A98D	1.000
6:27893760:C:A	R100S	1.000
6:27893764:T:A	L101Q	1.000
6:27893764:T:C	L101P	1.000
6:27893775:G:A	G105R	1.000
6:27893775:G:C	G105R	1.000
6:27893775:G:T	G105W	1.000
6:27893776:G:A	G105E	1.000
6:27893776:G:T	G105V	1.000
6:27893778:G:A	E106K	1.000
6:27893782:T:A	L107Q	1.000
6:27893782:T:C	L107P	1.000
6:27893785:C:A	A108D	1.000
6:27893789:G:C	K109N	1.000
6:27893789:G:T	K109N	1.000

dbSNP variants (sampled 300 via entrez): RS1000031105 (6:27892110 C>T), RS1000538626 (6:27892660 G>A,C), RS1000653439 (6:27892473 AC>A), RS1001722973 (6:27891963 G>A), RS1001775135 (6:27892177 C>G), RS1001825482 (6:27893057 C>A,G,T), RS1003892930 (6:27894202 G>A,C), RS1006508969 (6:27891599 C>A,G), RS1007560035 (6:27892495 T>C), RS1008011219 (6:27893207 G>A,T), RS1008089069 (6:27892245 G>T), RS1009911597 (6:27893098 G>C,T), RS1010462329 (6:27892423 CT>C), RS1011592663 (6:27894288 G>A), RS1012639702 (6:27891700 C>A)

Disease associations

OMIM: gene MIM:602808 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

18 associations (top):

Study	Trait	p-value
GCST004521_112	Autism spectrum disorder or schizophrenia	3.000000e-26
GCST004521_115	Autism spectrum disorder or schizophrenia	3.000000e-16
GCST004521_116	Autism spectrum disorder or schizophrenia	3.000000e-16
GCST004521_166	Autism spectrum disorder or schizophrenia	4.000000e-24
GCST004521_22	Autism spectrum disorder or schizophrenia	2.000000e-11
GCST004521_23	Autism spectrum disorder or schizophrenia	2.000000e-11
GCST004521_6	Autism spectrum disorder or schizophrenia	2.000000e-15
GCST004521_73	Autism spectrum disorder or schizophrenia	8.000000e-11
GCST004748_90	Lung cancer	2.000000e-10
GCST008921_6	Asthma and major depressive disorder	1.000000e-09
GCST010142_16	Fish- and plant-related diet	2.000000e-10
GCST010142_19	Fish- and plant-related diet	4.000000e-10
GCST010142_34	Fish- and plant-related diet	7.000000e-09
GCST010142_35	Fish- and plant-related diet	8.000000e-09
GCST010142_42	Fish- and plant-related diet	1.000000e-08
GCST010142_7	Fish- and plant-related diet	3.000000e-12
GCST010702_75	Subcortical volume (MOSTest)	3.000000e-11
GCST010703_272	Brain morphology (MOSTest)	7.000000e-16

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression	2
Dimethyl Sulfoxide	decreases expression, affects expression	2
Doxorubicin	decreases expression	2
Particulate Matter	increases abundance, increases expression, decreases expression	2
decabromobiphenyl ether	affects expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	affects cotreatment, decreases expression, increases abundance, increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
ferrous chloride	increases expression	1
coumarin	decreases phosphorylation	1
S-(1,2-dichlorovinyl)cysteine	increases expression, affects cotreatment	1
licochalcone B	increases expression	1
jinfukang	increases expression	1
incobotulinumtoxinA	decreases expression	1
(+)-JQ1 compound	increases expression	1
Resveratrol	decreases expression, affects cotreatment	1
Sunitinib	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance, increases expression	1
Berberine	decreases expression	1
Caffeine	affects phosphorylation	1
Calcitriol	decreases expression, affects cotreatment	1
Enzyme Inhibitors	increases O-linked glycosylation, decreases activity	1
Estradiol	affects expression	1
Lipopolysaccharides	affects cotreatment, increases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
N-Nitrosopyrrolidine	decreases expression	1
Oxygen	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.