H3-7

Summary

H3-7 (H3.7 histone (putative), HGNC:32060) is a protein-coding gene on chromosome 1q21.1, encoding Histone H3-7 (Q5TEC6). Core component of nucleosome.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a member of the H3 family, but is found outside of the histone cluster. There is evidence that it is transcribed and has an intact CDS, but residue changes in the protein suggest that it may be on its way to becoming a psuedogene.

Source: NCBI Gene 440686 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 2 total
• MANE Select transcript: NM_001372105

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32060
Approved symbol	H3-7
Name	H3.7 histone (putative)
Location	1q21.1
Locus type	gene with protein product
Status	Approved
Aliases	p06, H3.7
Ensembl gene	ENSG00000273213
Ensembl biotype	protein_coding
Entrez	440686

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 nonsense_mediated_decay

ENST00000392948, ENST00000609879, ENST00000650532

RefSeq mRNA: 2 — MANE Select: NM_001372105 NM_001355409, NM_001372105

CCDS: CCDS30842

Canonical transcript exons

ENST00000392948 — 1 exons

Exon	Start	End
ENSE00001513688	143905510	143905977

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 86.56.

Top tissues by expression

234 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ovary	UBERON:0002119	86.56	gold quality
right adrenal gland	UBERON:0001233	85.30	gold quality
right ovary	UBERON:0002118	85.16	gold quality
right adrenal gland cortex	UBERON:0035827	84.60	gold quality
left adrenal gland	UBERON:0001234	84.58	gold quality
left adrenal gland cortex	UBERON:0035825	84.40	gold quality
adrenal tissue	UBERON:0018303	83.15	gold quality
adrenal cortex	UBERON:0001235	82.70	gold quality
body of stomach	UBERON:0001161	82.67	gold quality
adrenal gland	UBERON:0002369	82.67	gold quality
ovary	UBERON:0000992	82.04	gold quality
cerebellar hemisphere	UBERON:0002245	81.24	gold quality
cerebellar cortex	UBERON:0002129	81.17	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.74	gold quality
lower esophagus mucosa	UBERON:0035834	80.38	gold quality
stomach	UBERON:0000945	79.70	gold quality
cerebellum	UBERON:0002037	79.52	gold quality
buccal mucosa cell	CL:0002336	76.49	gold quality
monocyte	CL:0000576	76.14	gold quality
spleen	UBERON:0002106	76.12	gold quality
ventricular zone	UBERON:0003053	75.43	gold quality
leukocyte	CL:0000738	75.29	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.68	gold quality
stromal cell of endometrium	CL:0002255	74.19	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.04	silver quality
medial globus pallidus	UBERON:0002477	73.98	gold quality
smooth muscle tissue	UBERON:0001135	73.86	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	72.97	gold quality
right lobe of thyroid gland	UBERON:0001119	72.86	gold quality
spinal cord	UBERON:0002240	72.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.87

Regulation

Is transcription factor: no

Cross-species orthologs

23 orthologs

Organism	Symbol	Gene ID
danio_rerio	zgc:173552	ENSDARG00000051737
danio_rerio	si:ch1073-153i20.2	ENSDARG00000105345
danio_rerio	zgc:173552	ENSDARG00000110909
danio_rerio	si:ch211-113a14.27	ENSDARG00000111396
danio_rerio	si:ch211-113a14.20	ENSDARG00000112131
danio_rerio	zgc:173552	ENSDARG00000112175
danio_rerio	si:ch211-113a14.23	ENSDARG00000114334
drosophila_melanogaster	His3:CG33812	FBGN0053812
caenorhabditis_elegans		WBGENE00001876
caenorhabditis_elegans		WBGENE00001880
caenorhabditis_elegans		WBGENE00001883
caenorhabditis_elegans		WBGENE00001887
caenorhabditis_elegans		WBGENE00001891
caenorhabditis_elegans		WBGENE00001899
caenorhabditis_elegans		WBGENE00001901
caenorhabditis_elegans		WBGENE00001906
caenorhabditis_elegans		WBGENE00001914
caenorhabditis_elegans		WBGENE00001916
caenorhabditis_elegans		WBGENE00001919
caenorhabditis_elegans		WBGENE00001923
caenorhabditis_elegans		WBGENE00001929
caenorhabditis_elegans		WBGENE00001933
caenorhabditis_elegans		WBGENE00001937

Paralogs (20): CENPA (ENSG00000115163), H3-3B (ENSG00000132475), H3-3A (ENSG00000163041), H3-4 (ENSG00000168148), H3C13 (ENSG00000183598), H3-5 (ENSG00000188375), H3C12 (ENSG00000197153), H3C4 (ENSG00000197409), H3C14 (ENSG00000203811), H3C15 (ENSG00000203852), H3Y2 (ENSG00000268799), H3Y1 (ENSG00000269466), H3C8 (ENSG00000273983), H3C6 (ENSG00000274750), H3C11 (ENSG00000275379), H3C1 (ENSG00000275714), H3C7 (ENSG00000277775), H3C10 (ENSG00000278828), H3C2 (ENSG00000286522), H3C3 (ENSG00000287080)

Protein

Protein identifiers

Histone H3-7 — Q5TEC6 (reviewed: Q5TEC6)

All UniProt accessions (2): A0A590UJL8, Q5TEC6

UniProt curated annotations — full annotation on UniProt →

Function. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Subunit / interactions. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. During nucleosome assembly the chaperone ASF1A interacts with the histone H3-H4 heterodimer.

Subcellular location. Nucleus. Chromosome.

Post-translational modifications. Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Citrullination at Arg-9 (H3R8ci) and/or Arg-18 (H3R17ci) by PADI4 impairs methylation and represses transcription. Asymmetric dimethylation at Arg-18 (H3R17me2a) by CARM1 is linked to gene activation. Symmetric dimethylation at Arg-9 (H3R8me2s) by PRMT5 is linked to gene repression. Asymmetric dimethylation at Arg-3 (H3R2me2a) by PRMT6 is linked to gene repression and is mutually exclusive with H3 Lys-5 methylation (H3K4me2 and H3K4me3). H3R2me2a is present at the 3’ of genes regardless of their transcription state and is enriched on inactive promoters, while it is absent on active promoters. Methylation at Lys-5 (H3K4me), Lys-37 (H3K36me) and Lys-80 (H3K79me) are linked to gene activation. Methylation at Lys-5 (H3K4me) facilitates subsequent acetylation of H3 and H4. Methylation at Lys-80 (H3K79me) is associated with DNA double-strand break (DSB) responses and is a specific target for TP53BP1. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are linked to gene repression. Methylation at Lys-10 (H3K9me) is a specific target for HP1 proteins (CBX1, CBX3 and CBX5) and prevents subsequent phosphorylation at Ser-11 (H3S10ph) and acetylation of H3 and H4. Methylation at Lys-5 (H3K4me) and Lys-80 (H3K79me) require preliminary monoubiquitination of H2B at ‘Lys-120’. Methylation at Lys-10 (H3K9me) and Lys-28 (H3K27me) are enriched in inactive X chromosome chromatin. Monomethylation at Lys-57 (H3K56me1) by EHMT2/G9A in G1 phase promotes interaction with PCNA and is required for DNA replication. Phosphorylated at Thr-4 (H3T3ph) by HASPIN during prophase and dephosphorylated during anaphase. Phosphorylation at Ser-11 (H3S10ph) by AURKB is crucial for chromosome condensation and cell-cycle progression during mitosis and meiosis. In addition phosphorylation at Ser-11 (H3S10ph) by RPS6KA4 and RPS6KA5 is important during interphase because it enables the transcription of genes following external stimulation, like mitogens, stress, growth factors or UV irradiation and result in the activation of genes, such as c-fos and c-jun. Phosphorylation at Ser-11 (H3S10ph), which is linked to gene activation, prevents methylation at Lys-10 (H3K9me) but facilitates acetylation of H3 and H4. Phosphorylation at Ser-11 (H3S10ph) by AURKB mediates the dissociation of HP1 proteins (CBX1, CBX3 and CBX5) from heterochromatin. Phosphorylation at Ser-11 (H3S10ph) is also an essential regulatory mechanism for neoplastic cell transformation. Phosphorylated at Ser-29 (H3S28ph) by MAP3K20 isoform 1, RPS6KA5 or AURKB during mitosis or upon ultraviolet B irradiation. Phosphorylation at Thr-7 (H3T6ph) by PRKCB is a specific tag for epigenetic transcriptional activation that prevents demethylation of Lys-5 (H3K4me) by LSD1/KDM1A. At centromeres, specifically phosphorylated at Thr-12 (H3T11ph) from prophase to early anaphase, by DAPK3 and PKN1. Phosphorylation at Thr-12 (H3T11ph) by PKN1 or isoform M2 of PKM (PKM2) is a specific tag for epigenetic transcriptional activation that promotes demethylation of Lys-10 (H3K9me) by KDM4C/JMJD2C. Phosphorylation at Tyr-42 (H3Y41ph) by JAK2 promotes exclusion of CBX5 (HP1 alpha) from chromatin. Ubiquitinated. Lysine deamination at Lys-5 (H3K4all) to form allysine is mediated by LOXL2. Allysine formation by LOXL2 only takes place on H3K4me3 and results in gene repression. Butyrylation of histones marks active promoters and competes with histone acetylation. It is present during late spermatogenesis. Succinylation at Lys-80 (H3K79succ) by KAT2A takes place with a maximum frequency around the transcription start sites of genes. It gives a specific tag for epigenetic transcription activation. Desuccinylation at Lys-123 (H3K122succ) by SIRT7 in response to DNA damage promotes chromatin condensation and double-strand breaks (DSBs) repair. Serine ADP-ribosylation constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Serine ADP-ribosylation at Ser-11 (H3S10ADPr) is mutually exclusive with phosphorylation at Ser-11 (H3S10ph) and impairs acetylation at Lys-10 (H3K9ac).

Similarity. Belongs to the histone H3 family.

RefSeq proteins (2): NP_001342338, NP_001359034* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000164	Histone_H3/CENP-A	Family
IPR007125	H2A/H2B/H3	Domain
IPR009072	Histone-fold	Homologous_superfamily

Pfam: PF00125

UniProt features (116 total): modified residue 110, cross-link 3, initiator methionine 1, chain 1, region of interest 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
5MR8	X-RAY DIFFRACTION	1.74
4H75	X-RAY DIFFRACTION	2.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5TEC6-F1	86.42	0.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (113): 5, 80, 81, 87, 108, 116, 116, 123, 123, 123, 123, 5, 123, 123, 123, 15, 19, 24, 5, 5 …

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 47 (showing top): GOBP_CHROMOSOME_ORGANIZATION, GOBP_CHROMOSOME_LOCALIZATION, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, GOBP_ORGANELLE_FISSION, GOBP_MITOTIC_NUCLEAR_DIVISION, GOBP_ORGANELLE_ASSEMBLY, GOBP_MITOTIC_CELL_CYCLE, GOBP_CHROMATIN_REMODELING, GOBP_HETEROCHROMATIN_ORGANIZATION, GOBP_ORGANELLE_LOCALIZATION, GOBP_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION, GOBP_KINETOCHORE_ORGANIZATION, GOBP_NUCLEAR_CHROMOSOME_SEGREGATION, GOBP_METAPHASE_CHROMOSOME_ALIGNMENT, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN

GO Biological Process (0):

GO Molecular Function (3): DNA binding (GO:0003677), structural constituent of chromatin (GO:0030527), protein heterodimerization activity (GO:0046982)

GO Cellular Component (4): nucleosome (GO:0000786), nucleus (GO:0005634), nucleoplasm (GO:0005654), chromosome (GO:0005694)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
chromatin	2
nucleic acid binding	1
structural molecule activity	1
protein dimerization activity	1
protein-DNA complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

8476 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
H3-7	H2AC20	Q16777	998
H3-7	H2BC21	Q16778	998
H3-7	H2AC19	P20670	998
H3-7	H4C16	P02304	997
H3-7	WDR5	P61964	997
H3-7	H4C7	Q99525	997
H3-7	CBX5	P45973	995
H3-7	DNMT3L	Q9UJW3	994
H3-7	CBX3	Q13185	991
H3-7	BRD4	O60885	989
H3-7	DNMT3A	Q9Y6K1	987
H3-7	RAG2	P55895	977
H3-7	DNMT1	P26358	973
H3-7	CBX1	P23197	973
H3-7	HDAC1	Q13547	966

IntAct

110 interactions, top by confidence:

A	B	Type	Score
HSPA8	GAK	psi-mi:“MI:0914”(association)	0.760
H2AX	PPM1G	psi-mi:“MI:0914”(association)	0.730
ANXA9	PPL	psi-mi:“MI:0914”(association)	0.660
AIPL1	PDE5A	psi-mi:“MI:0914”(association)	0.640
H2BC1	PPM1G	psi-mi:“MI:0914”(association)	0.640
MACROD1	PARP1	psi-mi:“MI:0914”(association)	0.620
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
HSD3B2	NARS1	psi-mi:“MI:0914”(association)	0.530
LACC1	DUSP14	psi-mi:“MI:0914”(association)	0.530
HERC3	H3-7	psi-mi:“MI:0914”(association)	0.530
H2AC20	PPM1G	psi-mi:“MI:0914”(association)	0.530
C1orf174	AHCYL1	psi-mi:“MI:0914”(association)	0.530
RRP7A	ATP4A	psi-mi:“MI:0914”(association)	0.530
ZNF428	PIP4K2A	psi-mi:“MI:0914”(association)	0.530
NASP	H4C16	psi-mi:“MI:0914”(association)	0.530
TOMM20	TPP1	psi-mi:“MI:0914”(association)	0.480
CENPQ	CENPX	psi-mi:“MI:0914”(association)	0.350
CCNYL1	A2ML1	psi-mi:“MI:0914”(association)	0.350
CDK15	A2ML1	psi-mi:“MI:0914”(association)	0.350
CDX1	ZNF724	psi-mi:“MI:0914”(association)	0.350
RRP7A	MAPT	psi-mi:“MI:0914”(association)	0.350
CENPA	OIP5	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A2XHJ3, C6Y4D0, G2TRL2, O60076, O97484, P06353, P06902, P15512, P16890, P22843, P41353, P59169, P68431, P68432, P68433, P69071, P69074, P69076, P69078, P69149, P69150, P69244, P69245, P80553, Q0JCT1, Q16695, Q22RG7, Q27489, Q27490, Q2Z2F4, Q3C2E5, Q3E835, Q55BN9, Q55BP0, Q5MYA4, Q5TEC6, Q64400, Q6LBF0, Q6LED0, Q6NXT2

Diamond homologs: A2XHJ3, A2Y533, A5DWE2, A5PK61, C0HL66, C0HL67, P02299, P02301, P02302, P06352, P08437, P08898, P08903, P09988, P22843, P50564, P59169, P59226, P68427, P68428, P68429, P68430, P68431, P68432, P68433, P69071, P69072, P69073, P69074, P69075, P69076, P69077, P69078, P69079, P69244, P69245, P69246, P69248, P80553, P84227

SIGNOR signaling

12 interactions.

A	Effect	B	Mechanism
SLBP	“up-regulates quantity by expression”	H3-2	“translation regulation”
BAZ2B	“down-regulates activity”	H3-2	binding
KAT2A	“down-regulates activity”	H3-2	acetylation
KAT2B	“down-regulates activity”	H3-2	acetylation
“SAGA complex”	“down-regulates activity”	H3-2	acetylation
KDM3A	“up-regulates activity”	H3-2	demethylation
SIRT7	“up-regulates activity”	H3-2	deacetylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 139 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Nucleosome assembly	5	27.7×	4e-05
Deposition of new CENPA-containing nucleosomes at the centromere	10	18.4×	7e-08
SIRT1 negatively regulates rRNA expression	9	17.8×	4e-07
FXIIa activates plasma kallikrein-kinin system	8	16.1×	5e-06
Packaging Of Telomere Ends	6	15.3×	6e-05
RNA Polymerase I Promoter Opening	7	15.0×	4e-05
Chromosome Maintenance	6	14.8×	7e-05
DNA methylation	7	14.5×	4e-05

GO biological processes:

GO term	Partners	Fold	FDR
heterochromatin formation	9	18.2×	1e-06
nucleosome assembly	9	10.0×	1e-04
double-strand break repair	6	9.7×	6e-03
chromatin organization	9	7.1×	2e-03
DNA damage response	11	4.7×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

89 predictions. Top by Δscore:

Variant	Effect	Δscore
1:143905798:T:TA	donor_gain	0.7600
1:143905730:AAACT:A	donor_gain	0.7500
1:143905912:T:TA	donor_gain	0.7400
1:143905858:TC:T	donor_gain	0.6200
1:143905855:TCTTC:T	donor_gain	0.5900
1:143905753:CCAG:C	donor_gain	0.5800
1:143905567:C:CA	donor_gain	0.5200
1:143905558:AGG:A	donor_gain	0.4600
1:143905752:A:AC	donor_gain	0.4600
1:143905753:C:CC	donor_gain	0.4600
1:143905583:G:T	donor_gain	0.4500
1:143905683:T:TA	donor_gain	0.4500
1:143905925:G:A	donor_gain	0.4500
1:143905752:ACCAG:A	donor_gain	0.4400
1:143905753:CCAGC:C	donor_gain	0.4400
1:143905748:GCGT:G	donor_loss	0.4300
1:143905749:CGTA:C	donor_loss	0.4300
1:143905750:GT:G	donor_loss	0.4300
1:143905751:T:TG	donor_loss	0.4300
1:143905752:A:AA	donor_loss	0.4300
1:143905753:C:CG	donor_loss	0.4300
1:143905775:G:A	donor_gain	0.4300
1:143905558:AGGC:A	donor_gain	0.4100
1:143905568:C:A	donor_gain	0.4000
1:143905596:T:TA	donor_gain	0.4000
1:143905717:G:GA	acceptor_gain	0.4000
1:143905754:C:G	donor_loss	0.3900
1:143905772:C:A	acceptor_gain	0.3900
1:143905816:C:CA	donor_gain	0.3900
1:143905940:G:A	donor_gain	0.3900

AlphaMissense

862 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:143905712:G:C	F85L	0.910
1:143905712:G:T	F85L	0.910
1:143905714:A:G	F85L	0.910
1:143905763:G:C	F68L	0.909
1:143905763:G:T	F68L	0.909
1:143905765:A:G	F68L	0.909
1:143905952:C:A	K5N	0.861
1:143905952:C:G	K5N	0.861
1:143905799:C:A	Q56H	0.830
1:143905799:C:G	Q56H	0.830
1:143905812:A:G	I52T	0.828
1:143905910:C:A	K19N	0.801
1:143905910:C:G	K19N	0.801
1:143905856:C:A	K37N	0.768
1:143905856:C:G	K37N	0.768
1:143905730:A:C	F79L	0.758
1:143905730:A:T	F79L	0.758
1:143905732:A:G	F79L	0.758
1:143905809:C:G	R53P	0.758
1:143905758:C:G	R70P	0.754
1:143905749:C:G	R73P	0.738
1:143905652:G:C	F105L	0.733
1:143905652:G:T	F105L	0.733
1:143905654:A:G	F105L	0.733
1:143905806:C:G	R54P	0.733
1:143905818:C:G	R50P	0.729
1:143905937:C:A	K10N	0.728
1:143905937:C:G	K10N	0.728
1:143905824:G:T	A48D	0.727
1:143905895:T:A	K24N	0.718

dbSNP variants (sampled 300 via entrez): RS1156929433 (1:143903097 C>T), RS1157042980 (1:143903836 C>T), RS1157280492 (1:143902329 GA>G,GAA), RS1157324457 (1:143903149 G>A,T), RS1157807124 (1:143903415 C>T), RS1157997993 (1:143904687 C>A,T), RS1158140485 (1:143906799 C>T), RS1158163975 (1:143901953 T>G), RS1158265921 (1:143907715 G>A,C), RS1158281554 (1:143902843 C>CCA), RS1158473865 (1:143905365 G>A,C,T), RS1158570697 (1:143903325 C>A,G,T), RS1159402450 (1:143904659 AC>A), RS1159408857 (1:143907600 C>T), RS1159698047 (1:143906688 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
deoxynivalenol	increases expression	1
ferrous chloride	increases expression	1
Atrazine	increases expression	1
Doxorubicin	affects response to substance	1
Fluorouracil	decreases expression	1
Furaldehyde	affects cotreatment, affects localization, increases expression	1
Ivermectin	increases expression	1
Oxygen	decreases expression	1
Sodium Chloride	increases expression, affects cotreatment, affects localization	1
Thiram	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.