HAGLROS

Summary

HAGLROS (HAGLR opposite strand lncRNA, HGNC:50646) is a long non-coding RNA gene on chromosome 2q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50646
Approved symbol	HAGLROS
Name	HAGLR opposite strand lncRNA
Location	2q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226363
Ensembl biotype	lncRNA
Entrez	102800310
RNAcentral	URS000075CA0B — lncRNA, 699 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000426615

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426615 — 2 exons

Exon	Start	End
ENSE00004269602	176178425	176179018
ENSE00004269603	176177717	176178253

Expression profiles

Bgee: expression breadth ubiquitous, 139 present calls, max score 81.84.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3299 / max 81.5011, expressed in 421 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
23873	1.2385	415
23872	0.0914	49

Top tissues by expression

228 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.84	gold quality
mucosa of transverse colon	UBERON:0004991	70.39	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.13	gold quality
spinal cord	UBERON:0002240	68.45	gold quality
right uterine tube	UBERON:0001302	66.83	gold quality
right testis	UBERON:0004534	65.31	gold quality
stromal cell of endometrium	CL:0002255	63.89	gold quality
cortex of kidney	UBERON:0001225	63.67	gold quality
adult mammalian kidney	UBERON:0000082	63.01	gold quality
left testis	UBERON:0004533	62.85	gold quality
metanephros cortex	UBERON:0010533	62.72	gold quality
testis	UBERON:0000473	62.59	gold quality
corpus epididymis	UBERON:0004359	62.54	silver quality
germinal epithelium of ovary	UBERON:0001304	61.77	gold quality
transverse colon	UBERON:0001157	61.38	gold quality
ganglionic eminence	UBERON:0004023	60.72	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.32	gold quality
caput epididymis	UBERON:0004358	60.06	silver quality
cauda epididymis	UBERON:0004360	59.71	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.25	gold quality
kidney	UBERON:0002113	59.21	gold quality
small intestine	UBERON:0002108	58.22	gold quality
right ovary	UBERON:0002118	57.79	gold quality
ovary	UBERON:0000992	57.66	gold quality
tendon of biceps brachii	UBERON:0008188	57.48	gold quality
left ovary	UBERON:0002119	57.21	gold quality
prefrontal cortex	UBERON:0000451	56.58	gold quality
metanephros	UBERON:0000081	56.09	gold quality
mucosa of stomach	UBERON:0001199	55.93	gold quality
intestine	UBERON:0000160	55.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• the GC-associated lncRNA HAGLROS is an oncogenic lncRNA that promotes tumorigenesis and progression through mTOR pathway-mediated autophagy suppression by serving as a ceRNA for miR-100-5p and as a cytoplasmic scaffold to bind mTORC1. (PMID:29329543)
• downregulation of HAGLROS may alleviate lipopolysaccharide-induced inflammatory injury in WI-38cells via modulating miR-100/NF-kappaB axis. (PMID:29673591)
• LncRNA HAGLROS accelerates the progression of lung carcinoma via sponging microRNA-152. (PMID:31378893)
• Long non-coding RNA HAGLROS regulates lipid metabolism reprogramming in intrahepatic cholangiocarcinoma via the mTOR signaling pathway. (PMID:32446859)
• HAGLROS promotes cell proliferation and angiogenesis and inhibits apoptosis by activating multiple signaling pathways in LSCC cells. (PMID:34634160)
• Long non-coding RNA HAGLROS promotes the development of diffuse large B-cell lymphoma via suppressing miR-100. (PMID:34888946)
• Knockdown of lncRNA HAGLROS inhibits metastasis and promotes apoptosis in nephroblastoma cells by inhibition of autophagy. (PMID:35358010)
• Upregulation and the clinical significance of KCNQ1OT1 and HAGLROS lncRNAs in papillary thyroid cancer: An observational study. (PMID:37478216)
• LncRNA HAGLROS contribute to papillary thyroid cancer progression by modulating miR-206/HMGA2 expression. (PMID:38112616)
• LncRNA HAGLROS promotes breast cancer evolution through miR-135b-3p/COL10A1 axis and exosome-mediated macrophage M2 polarization. (PMID:39198393)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.