HAPLN1

Summary

HAPLN1 (hyaluronan and proteoglycan link protein 1, HGNC:2380) is a protein-coding gene on chromosome 5q14.3, encoding Hyaluronan and proteoglycan link protein 1 (P10915). Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

Predicted to enable hyaluronic acid binding activity. Predicted to be an extracellular matrix structural constituent conferring compression resistance. Predicted to be involved in central nervous system development and skeletal system development. Located in collagen-containing extracellular matrix.

Source: NCBI Gene 1404 — RefSeq curated summary.

At a glance

• GWAS associations: 14
• Clinical variants (ClinVar): 55 total
• MANE Select transcript: NM_001884

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:2380
Approved symbol	HAPLN1
Name	hyaluronan and proteoglycan link protein 1
Location	5q14.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000145681
Ensembl biotype	protein_coding
OMIM	115435
Entrez	1404

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 protein_coding

ENST00000274341, ENST00000503117, ENST00000504713, ENST00000508307, ENST00000510978, ENST00000514416, ENST00000515590, ENST00000875523, ENST00000936313, ENST00000936314

RefSeq mRNA: 1 — MANE Select: NM_001884 NM_001884

CCDS: CCDS4061

Canonical transcript exons

ENST00000274341 — 5 exons

Exon	Start	End
ENSE00000971593	83652453	83652824
ENSE00001005118	83673424	83673549
ENSE00001120540	83637805	83641785
ENSE00001163611	83720789	83720855
ENSE00003789770	83644363	83644665

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 99.95.

FANTOM5 (CAGE): breadth broad, TPM avg 16.6134 / max 824.1748, expressed in 600 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
62365	10.4147	525
62368	3.6895	394
62369	1.1077	253
62366	0.7471	166
62367	0.5379	191
62362	0.0625	21
62364	0.0444	21
62363	0.0095	5

Top tissues by expression

271 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	99.95	gold quality
cartilage tissue	UBERON:0002418	99.74	gold quality
placenta	UBERON:0001987	89.61	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.39	gold quality
endothelial cell	CL:0000115	88.28	gold quality
colonic epithelium	UBERON:0000397	87.74	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.35	gold quality
buccal mucosa cell	CL:0002336	84.46	gold quality
mucosa of sigmoid colon	UBERON:0004993	82.78	gold quality
jejunal mucosa	UBERON:0000399	81.55	gold quality
rectum	UBERON:0001052	80.94	gold quality
trachea	UBERON:0003126	80.51	gold quality
right coronary artery	UBERON:0001625	78.58	gold quality
colonic mucosa	UBERON:0000317	78.29	gold quality
calcaneal tendon	UBERON:0003701	76.53	gold quality
ascending aorta	UBERON:0001496	75.86	gold quality
thoracic aorta	UBERON:0001515	75.40	gold quality
embryo	UBERON:0000922	73.32	gold quality
mucosa of transverse colon	UBERON:0004991	72.98	gold quality
duodenum	UBERON:0002114	72.82	gold quality
mucosa of paranasal sinus	UBERON:0005030	72.49	gold quality
prefrontal cortex	UBERON:0000451	71.87	gold quality
left coronary artery	UBERON:0001626	71.70	gold quality
periodontal ligament	UBERON:0008266	71.51	silver quality
coronary artery	UBERON:0001621	71.40	gold quality
jejunum	UBERON:0002115	71.14	gold quality
tendon	UBERON:0000043	70.92	gold quality
trabecular bone tissue	UBERON:0002483	70.54	gold quality
descending thoracic aorta	UBERON:0002345	70.03	gold quality
ventricular zone	UBERON:0003053	69.29	gold quality

Single-cell (SCXA)

Detected in 12 experiment(s), a significant marker in 11.

Experiment	Marker?	Max mean expression
E-HCAD-23	yes	2113.70
E-MTAB-6701	yes	1824.95
E-HCAD-24	yes	1764.27
E-MTAB-9388	yes	1677.57
E-MTAB-7008	yes	921.35
E-MTAB-10018	yes	654.89
E-HCAD-11	yes	605.12
E-MTAB-3929	yes	289.58
E-CURD-46	yes	21.67
E-CURD-112	yes	7.95
E-ANND-3	yes	5.34
E-MTAB-8271	no	2223.59

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): RUNX1, RUNX2, SOX9

miRNA regulators (miRDB)

259 targeting HAPLN1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-9-5P	100.00	72.28	2361
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882

Literature-anchored findings (GeneRIF, showing 18)

• link protein may function as a stabilizer of the interaction between aggrecan and hyaluronan in cartilage and between versican and hyaluronan in many tissues (PMID:14724283)
• SOX9 is a key regulator of CRTL1 (PMID:15456769)
• cLP and versican did not bind directly to each other in solution yet formed ternary complexes with hyaluronan (PMID:15590670)
• Overexpression of HAPLN1 and its SP-IgV domain increases tumorigenic properties of mesothelioma. Thus, targeting the SP-IgV domain may be one of the therapeutic approaches in cancer treatment. (PMID:19351750)
• An in vitro model of perineuronal nets has been developed demonstrating that cartilage link protein (along with hyaluronan synthase) are necessary for their formation. (PMID:20584105)
• Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women. (PMID:20953637)
• HAPLN1 is overexpressed in metastatic melanoma and is secreted exclusively by the tumor cells (PMID:22159717)
• CSGalNAcT-1 and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis. (PMID:23748413)
• HAPLN1 reflects a signaling network leading to stemness, mesenchymal commitment and hepatocellular carcinoma progression (PMID:27191501)
• HAPLN1 is produced in bone marrow stromal cells from multiple myeloma patients and can activate bortezomib-resistant NF-kappaB. (PMID:29279332)
• A novel role of HAPLN1 loss was reported in the aging lymphatic ECM in mediating lymphatic endothelial permeability, thus permitting melanoma cells to escape from the lymphatic system to distant metastatic sites. (PMID:30279172)
• A Role for HAPLN1 During Phenotypic Modulation of Human Lung Fibroblasts In Vitro. (PMID:33064036)
• A Hyaluronan and Proteoglycan Link Protein 1 Matrikine: Role of Matrix Metalloproteinase 2 in Multiple Myeloma NF-kappaB Activation and Drug Resistance. (PMID:35604822)
• HAPLN1 Affects Cell Viability and Promotes the Pro-Inflammatory Phenotype of Fibroblast-Like Synoviocytes. (PMID:35720292)
• Hyaluronan and Proteoglycan Link Protein 1 Activates the BMP4/Smad1/5/8 Signaling Pathway to Promote Osteogenic Differentiation: an Implication in Fracture Healing. (PMID:36737556)
• HAPLN1 matrikine: a bone marrow homing factor linked to poor outcomes in patients with MM. (PMID:37647592)
• Probing binding and occlusion of substrate in the human creatine transporter-1 by computation and mutagenesis. (PMID:38032325)
• Analysis of ANO6, HAPLN1, and EDIL3 Polymorphisms in Patients with Ankylosing Spondylitis in a Chinese Han Population: A Case-Control Study. (PMID:39358671)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	hapln1b	ENSDARG00000068516
		ENSDARG00000102395
mus_musculus	Hapln1	ENSMUSG00000021613
rattus_norvegicus	Hapln1	ENSRNOG00000032002

Paralogs (7): VCAN (ENSG00000038427), NCAN (ENSG00000130287), BCAN (ENSG00000132692), HAPLN2 (ENSG00000132702), HAPLN3 (ENSG00000140511), ACAN (ENSG00000157766), HAPLN4 (ENSG00000187664)

Protein

Protein identifiers

Hyaluronan and proteoglycan link protein 1 — P10915 (reviewed: P10915)

Alternative names: Cartilage-linking protein 1, Proteoglycan link protein

All UniProt accessions (7): D6RAK7, D6RBS1, D6RBX9, D6RC59, D6RFI7, D6RG04, P10915

UniProt curated annotations — full annotation on UniProt →

Function. Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

Subcellular location. Secreted. Extracellular space. Extracellular matrix.

Tissue specificity. Widely expressed. Weakly expressed in the brain.

Similarity. Belongs to the HAPLN family.

RefSeq proteins (1): NP_001875* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000538	Link_dom	Domain
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR013106	Ig_V-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR016186	C-type_lectin-like/link_sf	Homologous_superfamily
IPR016187	CTDL_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR050691	Hyaluronan_bind_Proteoglycan	Family

Pfam: PF00193, PF07686

UniProt features (15 total): disulfide bond 5, domain 3, sequence variant 2, glycosylation site 2, propeptide 1, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P10915-F1	89.64	0.81

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (5): 279–349, 304–325, 61–139, 181–252, 205–226

Glycosylation sites (2): 21, 56

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-3000178	ECM proteoglycans

MSigDB gene sets: 254 (showing top): HNF3ALPHA_Q6, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, TATTATA_MIR374, MEF2_02, GGGTGGRR_PAX4_03, NAISHIRO_CTNNB1_TARGETS_WITH_LEF1_MOTIF, SENESE_HDAC1_AND_HDAC2_TARGETS_DN, TCF4_Q5, MODULE_205, GOMF_EXTRACELLULAR_MATRIX_STRUCTURAL_CONSTITUENT, WTGAAAT_UNKNOWN, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, TGACATY_UNKNOWN, IRF_Q6, GOMF_GLYCOSAMINOGLYCAN_BINDING

GO Biological Process (3): skeletal system development (GO:0001501), cell adhesion (GO:0007155), central nervous system development (GO:0007417)

GO Molecular Function (2): hyaluronic acid binding (GO:0005540), extracellular matrix structural constituent conferring compression resistance (GO:0030021)

GO Cellular Component (5): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), extracellular matrix (GO:0031012), synapse (GO:0045202), perineuronal net (GO:0072534)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Extracellular matrix organization	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
system development	2
cellular process	1
nervous system development	1
carboxylic acid binding	1
extracellular matrix structural constituent	1
cellular anatomical structure	1
external encapsulating structure	1
cell junction	1
perisynaptic extracellular matrix	1

Protein interactions and networks

STRING

1462 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HAPLN1	ACAN	P16112	925
HAPLN1	COL9A1	P20849	818
HAPLN1	COL11A1	P12107	774
HAPLN1	COL9A2	Q14055	765
HAPLN1	SLC6A8	P48029	726
HAPLN1	COL2A1	P02458	717
HAPLN1	COMP	P49747	703
HAPLN1	COL11A2	P13942	680
HAPLN1	EDIL3	O43854	644
HAPLN1	HAS3	O00219	611
HAPLN1	MATN3	O15232	590
HAPLN1	LUM	P51884	581
HAPLN1	PRELP	P51888	580
HAPLN1	GATM	P50440	573
HAPLN1	IHH	Q14623	564

IntAct

14 interactions, top by confidence:

A	B	Type	Score
ADGRA2	HAPLN1	psi-mi:“MI:0915”(physical association)	0.400
HAPLN1	CNTN4	psi-mi:“MI:0915”(physical association)	0.400
HAPLN1	MPIG6B	psi-mi:“MI:0915”(physical association)	0.400
IGDCC4	HAPLN1	psi-mi:“MI:0915”(physical association)	0.400
IL1RL1	HAPLN1	psi-mi:“MI:0915”(physical association)	0.400
MICA	HAPLN1	psi-mi:“MI:0915”(physical association)	0.400
HAPLN1	PRTG	psi-mi:“MI:0915”(physical association)	0.400
AGER	HAPLN1	psi-mi:“MI:0915”(physical association)	0.400
HAPLN1	TNFRSF11B	psi-mi:“MI:0915”(physical association)	0.400
TREML2	HAPLN1	psi-mi:“MI:0915”(physical association)	0.400
MAPT	NCAN	psi-mi:“MI:0914”(association)	0.350
PRNP	WDR91	psi-mi:“MI:0914”(association)	0.350
AFG2B	MMP24OS	psi-mi:“MI:0914”(association)	0.350

BioGRID (5): HAPLN1 (Reconstituted Complex), HAPLN1 (Affinity Capture-MS), HAPLN1 (Affinity Capture-MS), HAPLN1 (Affinity Capture-MS), APP (Reconstituted Complex)

ESM2 similar proteins: A1A4K5, A2ARA8, A7XY94, A8MWY0, O08859, O15041, O42237, O54890, O70309, P03994, P05106, P07354, P10859, P10915, P15396, P18084, P21860, P22413, P26009, P35436, P53708, P55252, P70207, P70275, P80747, P98066, Q00959, Q00960, Q01097, Q07441, Q13224, Q13822, Q28381, Q3UZV7, Q5R1P3, Q5RB22, Q61526, Q64610, Q6BEA0, Q6P9A2

Diamond homologs: A0A182C2Z2, C6KFA3, F1RWC3, O08628, O08859, O14594, O14786, O35276, O35375, O43897, O57382, O57460, O60462, O60494, O70244, P03994, P07354, P07897, P07898, P10859, P10915, P13497, P13608, P13611, P14745, P16112, P25723, P28824, P42674, P55066, P55067, P55252, P79795, P97333, P98063, P98065, P98066, P98068, P98069, P98070

SIGNOR signaling

7 interactions.

A	Effect	B	Mechanism
MMP2	“down-regulates quantity by destabilization”	HAPLN1	cleavage
MMP9	“down-regulates quantity by destabilization”	HAPLN1	cleavage
MMP7	“down-regulates quantity by destabilization”	HAPLN1	cleavage
MMP3	“down-regulates quantity by destabilization”	HAPLN1	cleavage
MMP10	“down-regulates quantity by destabilization”	HAPLN1	cleavage

Disease & clinical

Clinical variants and AI predictions

ClinVar

55 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	49
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1257 predictions. Top by Δscore:

Variant	Effect	Δscore
5:83641782:CGGC:C	acceptor_gain	1.0000
5:83641784:GCC:G	acceptor_loss	1.0000
5:83641786:C:CC	acceptor_gain	1.0000
5:83641786:CT:C	acceptor_loss	1.0000
5:83641787:T:A	acceptor_loss	1.0000
5:83644426:AGTT:A	donor_gain	1.0000
5:83644429:T:TA	donor_gain	1.0000
5:83644556:CAG:C	donor_gain	1.0000
5:83644663:CAC:C	acceptor_gain	1.0000
5:83644671:C:T	acceptor_gain	1.0000
5:83652449:ATACC:A	donor_loss	1.0000
5:83652450:TA:T	donor_loss	1.0000
5:83652451:A:AC	donor_gain	1.0000
5:83652451:A:T	donor_loss	1.0000
5:83652452:C:CC	donor_gain	1.0000
5:83652653:T:TA	donor_gain	1.0000
5:83652654:C:A	donor_gain	1.0000
5:83652820:TTCTG:T	acceptor_gain	1.0000
5:83652822:CTG:C	acceptor_gain	1.0000
5:83652825:C:CC	acceptor_gain	1.0000
5:83652831:T:C	acceptor_gain	1.0000
5:83652831:T:TC	acceptor_gain	1.0000
5:83673418:CCTTA:C	donor_loss	1.0000
5:83673419:CTTA:C	donor_loss	1.0000
5:83673420:TTA:T	donor_loss	1.0000
5:83673421:TAC:T	donor_loss	1.0000
5:83673422:A:T	donor_loss	1.0000
5:83673423:C:CT	donor_loss	1.0000
5:83673548:CA:C	acceptor_gain	1.0000
5:83673562:C:CT	acceptor_gain	1.0000

AlphaMissense

2312 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:83652684:A:G	W81R	1.000
5:83652684:A:T	W81R	1.000
5:83641514:G:C	C349W	0.999
5:83641515:C:T	C349Y	0.999
5:83641637:C:A	W308C	0.999
5:83641637:C:G	W308C	0.999
5:83641639:A:G	W308R	0.999
5:83641639:A:T	W308R	0.999
5:83641724:A:C	C279W	0.999
5:83641725:C:T	C279Y	0.999
5:83644382:A:C	C252W	0.999
5:83644595:A:C	C181W	0.999
5:83652509:C:G	C139S	0.999
5:83652510:A:G	C139R	0.999
5:83652510:A:T	C139S	0.999
5:83652682:C:A	W81C	0.999
5:83652682:C:G	W81C	0.999
5:83641515:C:A	C349F	0.998
5:83641515:C:G	C349S	0.998
5:83641516:A:G	C349R	0.998
5:83641516:A:T	C349S	0.998
5:83641587:C:G	C325S	0.998
5:83641588:A:T	C325S	0.998
5:83641650:C:G	C304S	0.998
5:83641650:C:T	C304Y	0.998
5:83641651:A:T	C304S	0.998
5:83641725:C:A	C279F	0.998
5:83641725:C:G	C279S	0.998
5:83641726:A:G	C279R	0.998
5:83641726:A:T	C279S	0.998

dbSNP variants (sampled 300 via entrez): RS1000048946 (5:83721143 A>T), RS1000105715 (5:83698402 A>C), RS1000118097 (5:83678053 A>G), RS1000125556 (5:83708968 A>G), RS1000195464 (5:83718538 T>C), RS1000281063 (5:83695715 T>A,C), RS1000286601 (5:83643015 T>C), RS1000364272 (5:83711279 A>G), RS1000411356 (5:83717566 T>C), RS1000443830 (5:83689850 T>A), RS1000456192 (5:83679370 A>G), RS1000544023 (5:83680378 C>T), RS1000558216 (5:83674395 A>G), RS1000560827 (5:83708119 G>A), RS1000600685 (5:83685537 A>C,T)

Disease associations

OMIM: gene MIM:115435 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

14 associations (top):

Study	Trait	p-value
GCST000095_3	Prostate cancer	3.000000e-06
GCST001345_1	Ankylosing spondylitis	9.000000e-10
GCST001525_14	Visceral fat	2.000000e-06
GCST002875_12	Diisocyanate-induced asthma	9.000000e-06
GCST006063_1	White matter integrity (fractional anisotropy)	5.000000e-10
GCST006064_1	White matter integrity (mean diffusivity)	6.000000e-13
GCST006585_2705	Blood protein levels	1.000000e-06
GCST008151_11	Waist circumference	6.000000e-06
GCST008160_56	Waist circumference	6.000000e-06
GCST008832_23	Gastroesophageal reflux disease	2.000000e-08
GCST009391_332	Metabolite levels	9.000000e-06
GCST009391_358	Metabolite levels	5.000000e-06
GCST009391_852	Metabolite levels	8.000000e-06
GCST009921_12	Carotid intima media thickness (mean)	9.000000e-10

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0006995	response to diisocyanate
EFO:0004641	white matter integrity
EFO:0010432	triacylglycerol 56:5 measurement
EFO:0010434	triacylglycerol 56:7 measurement
EFO:0010398	sphingomyelin 24:1 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, decreases expression, decreases methylation	8
methylmercuric chloride	decreases expression, increases expression	3
trichostatin A	affects cotreatment, increases expression	3
mercuric bromide	increases expression, affects cotreatment	2
belinostat	increases expression, affects cotreatment	2
Vorinostat	affects cotreatment, increases expression	2
Panobinostat	affects cotreatment, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Progesterone	decreases expression, increases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, increases expression	2
deoxynivalenol	decreases expression	1
sodium arsenite	decreases expression	1
triadimefon	decreases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	increases methylation	1
NSC 689534	affects binding, decreases expression	1
(+)-JQ1 compound	decreases expression	1
Sunitinib	decreases expression	1
Benzo(a)pyrene	increases methylation, affects methylation	1
Copper	affects binding, decreases expression	1
Cytarabine	decreases expression	1
Diethylhexyl Phthalate	decreases expression, increases expression	1
Estradiol	affects expression	1
Silicon Dioxide	affects expression	1
T-2 Toxin	decreases expression	1
Tamoxifen	affects expression	1
Tretinoin	increases expression	1
Triclosan	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.