HAR1A

Summary

HAR1A (highly accelerated region 1A, HGNC:33117) is a long non-coding RNA gene on chromosome 20q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33117
Approved symbol	HAR1A
Name	highly accelerated region 1A
Location	20q13.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	HAR1F, NCRNA00064, LINC00064
Ensembl gene	ENSG00000225978
Ensembl biotype	lncRNA
OMIM	610556
Entrez	768096
RNAcentral	URS0000CCE0EA — lncRNA, 2812 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000433161, ENST00000806886, ENST00000806887

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433161 — 2 exons

Exon	Start	End
ENSE00004200364	63102205	63103254
ENSE00004200366	63103555	63104421

Expression profiles

Bgee: expression breadth ubiquitous, 166 present calls, max score 83.92.

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.92	gold quality
right frontal lobe	UBERON:0002810	79.27	gold quality
Brodmann (1909) area 9	UBERON:0013540	79.14	gold quality
anterior cingulate cortex	UBERON:0009835	78.53	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	78.51	gold quality
nucleus accumbens	UBERON:0001882	77.74	gold quality
primary visual cortex	UBERON:0002436	76.07	gold quality
neocortex	UBERON:0001950	76.04	gold quality
frontal cortex	UBERON:0001870	75.67	gold quality
prefrontal cortex	UBERON:0000451	75.51	gold quality
cerebral cortex	UBERON:0000956	75.25	gold quality
putamen	UBERON:0001874	74.90	gold quality
caudate nucleus	UBERON:0001873	74.71	gold quality
hypothalamus	UBERON:0001898	74.60	gold quality
amygdala	UBERON:0001876	74.49	gold quality
occipital lobe	UBERON:0002021	74.14	gold quality
forebrain	UBERON:0001890	74.05	gold quality
Brodmann (1909) area 23	UBERON:0013554	73.85	gold quality
brain	UBERON:0000955	73.35	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.92	gold quality
superior frontal gyrus	UBERON:0002661	72.68	gold quality
Brodmann (1909) area 46	UBERON:0006483	72.47	gold quality
Ammon’s horn	UBERON:0001954	72.29	gold quality
middle temporal gyrus	UBERON:0002771	72.14	gold quality
cerebellar hemisphere	UBERON:0002245	71.91	gold quality
cerebellar cortex	UBERON:0002129	71.90	gold quality
temporal lobe	UBERON:0001871	71.74	gold quality
cerebellum	UBERON:0002037	71.63	gold quality
postcentral gyrus	UBERON:0002581	71.38	gold quality
parietal lobe	UBERON:0001872	71.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• In the first study between HAR1A gene and schizophrenia no significant association was found. (PMID:18054202)
• Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis. (PMID:34097087)
• The expression profile of HAR1A and HAR1B in the peripheral blood cells of multiple sclerosis patients. (PMID:36583781)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.