HAR1B

Summary

HAR1B (highly accelerated region 1B, HGNC:33118) is a long non-coding RNA gene on chromosome 20q13.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33118
Approved symbol	HAR1B
Name	highly accelerated region 1B
Location	20q13.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	HAR1R, NCRNA00065, LINC00065
Ensembl gene	ENSG00000231133
Ensembl biotype	lncRNA
OMIM	610557
Entrez	768097
RNAcentral	URS000015EEC8 — lncRNA, 896 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000447910, ENST00000608031, ENST00000651266, ENST00000651299, ENST00000651861, ENST00000657642, ENST00000658410, ENST00000665105, ENST00000790850, ENST00000790851

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000447910 — 2 exons

Exon	Start	End
ENSE00001619660	63102115	63102319
ENSE00001697713	63095493	63096183

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 75.35.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4963 / max 26.1055, expressed in 226 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188321	0.3789	199
188319	0.0748	38
188318	0.0254	6
188320	0.0172	8

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.35	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	72.71	silver quality
nucleus accumbens	UBERON:0001882	72.53	gold quality
right frontal lobe	UBERON:0002810	72.53	gold quality
superior frontal gyrus	UBERON:0002661	72.44	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.31	gold quality
primary visual cortex	UBERON:0002436	72.21	gold quality
frontal cortex	UBERON:0001870	71.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.59	gold quality
prefrontal cortex	UBERON:0000451	71.07	gold quality
cerebral cortex	UBERON:0000956	71.04	gold quality
anterior cingulate cortex	UBERON:0009835	70.78	gold quality
putamen	UBERON:0001874	70.63	gold quality
caudate nucleus	UBERON:0001873	69.61	gold quality
left testis	UBERON:0004533	68.66	gold quality
brain	UBERON:0000955	68.56	gold quality
testis	UBERON:0000473	68.41	gold quality
Ammon’s horn	UBERON:0001954	67.50	gold quality
right testis	UBERON:0004534	66.16	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.79	gold quality
pituitary gland	UBERON:0000007	65.62	gold quality
hypothalamus	UBERON:0001898	65.54	gold quality
temporal lobe	UBERON:0001871	64.70	gold quality
cerebellum	UBERON:0002037	64.67	gold quality
amygdala	UBERON:0001876	64.63	gold quality
cerebellar cortex	UBERON:0002129	64.63	gold quality
ganglionic eminence	UBERON:0004023	64.55	gold quality
cerebellar hemisphere	UBERON:0002245	64.53	gold quality
adenohypophysis	UBERON:0002196	63.58	gold quality
substantia nigra	UBERON:0002038	62.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Expression profiling of cancer-related long non-coding RNAs revealed upregulation and biomarker potential of HAR1B and JPX in colorectal cancer. (PMID:35526243)
• The expression profile of HAR1A and HAR1B in the peripheral blood cells of multiple sclerosis patients. (PMID:36583781)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.