HAS2-AS1

Summary

HAS2-AS1 (HAS2 antisense RNA 1, HGNC:34340) is a long non-coding RNA gene on chromosome 8q24.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34340
Approved symbol	HAS2-AS1
Name	HAS2 antisense RNA 1
Location	8q24.13
Locus type	RNA, long non-coding
Status	Approved
Aliases	HASNT, NCRNA00077
Ensembl gene	ENSG00000248690
Ensembl biotype	lncRNA
OMIM	614353
Entrez	594842
RNAcentral	URS000075CDC2 — lncRNA, 2300 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 32 lncRNA

ENST00000458107, ENST00000514180, ENST00000518865, ENST00000520043, ENST00000522197, ENST00000523550, ENST00000647560, ENST00000648171, ENST00000653591, ENST00000656261, ENST00000656304, ENST00000656543, ENST00000662694, ENST00000663147, ENST00000664717, ENST00000665664, ENST00000668492, ENST00000669984, ENST00000671409, ENST00000728130, ENST00000728132, ENST00000728133, ENST00000728134, ENST00000728135, ENST00000728136, ENST00000728137, ENST00000728138, ENST00000770507, ENST00000770508, ENST00000770509, ENST00000770510, ENST00000770511

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000458107 — 3 exons

Exon	Start	End
ENSE00002101737	121707544	121707631
ENSE00002115151	121679126	121679257
ENSE00002136769	121679899	121680017

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 85.13.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0670 / max 4.5301, expressed in 28 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
90434	0.0670	28

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.49	gold quality
left testis	UBERON:0004533	78.06	gold quality
testis	UBERON:0000473	77.99	gold quality
right testis	UBERON:0004534	76.82	gold quality
colonic epithelium	UBERON:0000397	73.37	gold quality
stromal cell of endometrium	CL:0002255	71.35	gold quality
rectum	UBERON:0001052	69.94	gold quality
tibial nerve	UBERON:0001323	66.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.72	gold quality
sural nerve	UBERON:0015488	66.66	silver quality
ventricular zone	UBERON:0003053	65.85	gold quality
hypothalamus	UBERON:0001898	65.45	gold quality
calcaneal tendon	UBERON:0003701	65.11	gold quality
omental fat pad	UBERON:0010414	63.92	gold quality
substantia nigra	UBERON:0002038	63.65	gold quality
adipose tissue	UBERON:0001013	63.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.34	gold quality
muscle tissue	UBERON:0002385	63.04	gold quality
right atrium auricular region	UBERON:0006631	62.56	gold quality
smooth muscle tissue	UBERON:0001135	62.48	gold quality
ganglionic eminence	UBERON:0004023	62.40	gold quality
prefrontal cortex	UBERON:0000451	61.49	gold quality
thoracic mammary gland	UBERON:0005200	61.38	gold quality
left coronary artery	UBERON:0001626	61.35	gold quality
apex of heart	UBERON:0002098	61.31	gold quality
mucosa of transverse colon	UBERON:0004991	60.89	gold quality
skeletal muscle tissue	UBERON:0001134	60.12	gold quality
gall bladder	UBERON:0002110	60.11	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	60.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• HAS2 transcription can be finely regulated not only by recruiting transcription factors to the promoter as previously described but also by modulating chromatin accessibility by epigenetic modifications (PMID:25183006)
• Results suggest that hypoxia would induce an overexpression of HAS2-AS1 in an HIF-1alpha dependent manner. The increase of HAS2-AS1 plays important roles mediating the hypoxia-regulated EMT and invasiveness of oral squamous cell carcinoma. (PMID:28485478)
• Results provide evidence that Has2-AS has a key role in TGFbeta- and HAS2-induced breast cancer epithelial-mesenchymal transition, migration and acquisition of stemness. Its expression is inversely correlated with survival of patients with invasive breast carcinomas. (PMID:30194979)
• Hyaluronan synthase 2 (HAS2) antisense RNA 1 (HAS2-AS1) shows low expression in immature cumulus cells (CCs) and a significant increase expression in mature CCs. Functional studies reveal that inhibition of HAS2-AS1 by siRNA causes decreased expression of HAS2. Inhibition of HAS2-AS1 by siRNA results in decreased migration of granulosa cells. (PMID:30819231)
• Long noncoding RNA HAS2-AS1 promotes tumor progression in glioblastoma via functioning as a competing endogenous RNA. (PMID:31385362)
• Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-kappaB and expression of the long-noncoding RNA HAS2-AS1. (PMID:31932306)
• The natural antisense transcript HAS2-AS1 regulates breast cancer cells aggressiveness independently from hyaluronan metabolism. (PMID:35395387)
• The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-beta Signaling and Upregulating HAS2. (PMID:35938797)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.