HAUS1

Summary

HAUS1 (HAUS augmin like complex subunit 1, HGNC:25174) is a protein-coding gene on chromosome 18q21.1, encoding HAUS augmin-like complex subunit 1 (Q96CS2). Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. It is a common-essential gene (DepMap: required in 99.8% of cancer cell lines).

HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb ‘augmentare,’ meaning ’to increase.’ The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).

Source: NCBI Gene 115106 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 60 total
• Cancer dependency (DepMap): dependent in 99.8% of screened cell lines (common-essential)
• MANE Select transcript: NM_138443

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25174
Approved symbol	HAUS1
Name	HAUS augmin like complex subunit 1
Location	18q21.1
Locus type	gene with protein product
Status	Approved
Aliases	HEI-C, HsT1461, FLJ40084
Ensembl gene	ENSG00000152240
Ensembl biotype	protein_coding
OMIM	608775
Entrez	115106

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 17 protein_coding, 5 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000282058, ENST00000585425, ENST00000585518, ENST00000586060, ENST00000588704, ENST00000589554, ENST00000591098, ENST00000591715, ENST00000592206, ENST00000592471, ENST00000593165, ENST00000595199, ENST00000857067, ENST00000857068, ENST00000857069, ENST00000857070, ENST00000857071, ENST00000857072, ENST00000857073, ENST00000921196, ENST00000921197, ENST00000921198, ENST00000921199, ENST00000921200, ENST00000921201, ENST00000921202

RefSeq mRNA: 1 — MANE Select: NM_138443 NM_138443

CCDS: CCDS11928

Canonical transcript exons

ENST00000282058 — 9 exons

Exon	Start	End
ENSE00002860585	46104385	46104441
ENSE00002934719	46128075	46128333
ENSE00003470771	46119926	46120060
ENSE00003481667	46124822	46124893
ENSE00003520362	46123299	46123364
ENSE00003523057	46118181	46118316
ENSE00003617507	46125744	46125791
ENSE00003666165	46105194	46105368
ENSE00003667290	46122467	46122590

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 96.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.2998 / max 3051.3775, expressed in 1799 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
170144	27.1130	1799
170143	0.1868	65

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	96.32	gold quality
ventricular zone	UBERON:0003053	94.96	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.37	gold quality
cortical plate	UBERON:0005343	92.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.98	gold quality
monocyte	CL:0000576	91.88	gold quality
leukocyte	CL:0000738	91.66	gold quality
stromal cell of endometrium	CL:0002255	90.36	gold quality
rectum	UBERON:0001052	90.21	gold quality
calcaneal tendon	UBERON:0003701	89.90	gold quality
left ovary	UBERON:0002119	89.54	gold quality
smooth muscle tissue	UBERON:0001135	89.50	gold quality
right ovary	UBERON:0002118	89.11	gold quality
bone marrow	UBERON:0002371	88.88	gold quality
ovary	UBERON:0000992	88.73	gold quality
gall bladder	UBERON:0002110	88.55	gold quality
lymph node	UBERON:0000029	88.51	gold quality
granulocyte	CL:0000094	88.42	gold quality
vermiform appendix	UBERON:0001154	88.41	gold quality
trabecular bone tissue	UBERON:0002483	88.20	gold quality
islet of Langerhans	UBERON:0000006	87.97	gold quality
mucosa of stomach	UBERON:0001199	87.96	gold quality
body of uterus	UBERON:0009853	87.72	gold quality
descending thoracic aorta	UBERON:0002345	87.60	gold quality
ectocervix	UBERON:0012249	87.47	gold quality
corpus epididymis	UBERON:0004359	87.40	gold quality
tibial artery	UBERON:0007610	87.13	gold quality
popliteal artery	UBERON:0002250	87.11	gold quality
endocervix	UBERON:0000458	87.03	gold quality
metanephros	UBERON:0000081	86.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

16 targeting HAUS1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-3133	99.81	70.92	3506
HSA-MIR-4517	99.76	69.19	1867
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-548B-3P	99.38	67.26	1000
HSA-MIR-3125	99.14	68.49	2269
HSA-MIR-3916	98.99	68.04	2155
HSA-MIR-6859-5P	98.99	68.07	2049
HSA-MIR-1265	98.36	66.46	598
HSA-MIR-4511	98.32	67.97	1500
HSA-MIR-4778-5P	97.96	68.06	1634
HSA-MIR-3664-5P	96.74	66.56	770
HSA-MIR-3162-5P	95.67	67.53	794

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.8% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 2)

• These results place human enhancer of invasion-cluster as a novel regulator of spindle function and integrity during the metaphase-anaphase transition. (PMID:15082789)
• Single-cell and bulk RNA-sequencing reveals mitosis-involved gene HAUS1 is a promising indicator for predicting prognosis and immune responses in prostate adenocarcinoma (PRAD). (PMID:38818762)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	haus1	ENSDARG00000058968
mus_musculus	Haus1	ENSMUSG00000041840
rattus_norvegicus	Haus1	ENSRNOG00000017067

Protein

Protein identifiers

HAUS augmin-like complex subunit 1 — Q96CS2 (reviewed: Q96CS2)

Alternative names: Coiled-coil domain-containing protein 5, Enhancer of invasion-cluster

All UniProt accessions (7): Q96CS2, K7EJA9, K7EK72, K7EKH4, K7EM54, K7EQT8, K7ES67

UniProt curated annotations — full annotation on UniProt →

Function. Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Subunit / interactions. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect. Interacts with EML3 (phosphorylated at ‘Thr-881’).

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle. Spindle pole.

Tissue specificity. Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver and heart. Weakly expressed in lung, brain and placenta.

Miscellaneous. HAUS1-depleted cells retain functional cell cycle checkpoints, but the depletion decreases the G2/M cell cycle compartment and induces apoptosis. The protein level remains constant through the cell cycle.

Similarity. Belongs to the HAUS1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96CS2-1	1	yes
Q96CS2-2	2

RefSeq proteins (1): NP_612452* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026243	HAUS1	Family

Pfam: PF25762

UniProt features (5 total): coiled-coil region 3, chain 1, splice variant 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7SQK	ELECTRON MICROSCOPY	8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96CS2-F1	88.63	0.60

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259	Loss of Nlp from mitotic centrosomes
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912	Anchoring of the basal body to the plasma membrane
R-HSA-8854518	AURKA Activation by TPX2

MSigDB gene sets: 161 (showing top): GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_UP, RRAGTTGT_UNKNOWN, GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MICROTUBULE_NUCLEATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOCC_MICROTUBULE_ORGANIZING_CENTER, MUELLER_PLURINET, GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION, GOCC_CENTROSOME, GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, GOBP_ORGANELLE_ASSEMBLY

GO Biological Process (4): centrosome cycle (GO:0007098), regulation of microtubule nucleation (GO:0010968), spindle assembly (GO:0051225), cell division (GO:0051301)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (9): spindle pole (GO:0000922), centrosome (GO:0005813), cytosol (GO:0005829), HAUS complex (GO:0070652), mitotic spindle microtubule (GO:1990498), cytoplasm (GO:0005737), spindle (GO:0005819), cytoskeleton (GO:0005856), microtubule (GO:0005874)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
G2/M Transition	2
Centrosome maturation	2
Loss of proteins required for interphase microtubule organization from the centrosome	1
Mitotic Prometaphase	1
Assembly of the 9+0 primary cilium	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
microtubule cytoskeleton	2
intracellular membraneless organelle	2
cell cycle process	1
microtubule organizing center organization	1
microtubule nucleation	1
regulation of microtubule polymerization	1
spindle organization	1
chromosome segregation	1
membraneless organelle assembly	1
cellular process	1
binding	1
spindle	1
centriole	1
microtubule organizing center	1
cytoplasm	1
microtubule associated complex	1
spindle microtubule	1
mitotic spindle	1
intracellular anatomical structure	1
polymeric cytoskeletal fiber	1

Protein interactions and networks

STRING

1306 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HAUS1	HAUS6	Q7Z4H7	939
HAUS1	HAUS7	Q99871	810
HAUS1	HAUS2	Q9NVX0	793
HAUS1	HAUS4	Q9H6D7	788
HAUS1	TUBG1	P23258	782
HAUS1	HAUS8	Q9BT25	781
HAUS1	NUMA1	Q14980	714
HAUS1	HAUS3	Q68CZ6	667
HAUS1	NEDD1	Q8NHV4	638
HAUS1	TUBGCP4	Q9UGJ1	629
HAUS1	CEP85	Q6P2H3	528
HAUS1	HAUS5	O94927	518
HAUS1	A6NLF2	A6NLF2	436
HAUS1	ANAPC1	Q9H1A4	429
HAUS1	OR5H1	A6NKK0	419

IntAct

398 interactions, top by confidence:

A	B	Type	Score
DMD	HAUS1	psi-mi:“MI:0915”(physical association)	0.800
HAUS1	DMD	psi-mi:“MI:0915”(physical association)	0.800
HAUS1	WASHC3	psi-mi:“MI:0915”(physical association)	0.790
WASHC3	HAUS1	psi-mi:“MI:0915”(physical association)	0.790
HAUS1	KRT38	psi-mi:“MI:0915”(physical association)	0.740
HAUS1	CCHCR1	psi-mi:“MI:0915”(physical association)	0.720
HAUS1	TSG101	psi-mi:“MI:0915”(physical association)	0.720
TSG101	HAUS1	psi-mi:“MI:0915”(physical association)	0.720
HAUS1	IFT20	psi-mi:“MI:0915”(physical association)	0.670
SYCE3	HAUS1	psi-mi:“MI:0915”(physical association)	0.670
HAUS1	C3orf62	psi-mi:“MI:0915”(physical association)	0.670
HAUS1	LURAP1	psi-mi:“MI:0915”(physical association)	0.670
HAUS1	ODAD1	psi-mi:“MI:0915”(physical association)	0.670
IFT20	HAUS1	psi-mi:“MI:0915”(physical association)	0.670
C3orf62	HAUS1	psi-mi:“MI:0915”(physical association)	0.670
LURAP1	HAUS1	psi-mi:“MI:0915”(physical association)	0.670
ODAD1	HAUS1	psi-mi:“MI:0915”(physical association)	0.670

BioGRID (258): HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid), HAUS1 (Two-hybrid)

ESM2 similar proteins: A8E4X8, H2LP95, O15259, O15360, O35347, O73770, O75182, O75800, O88480, P68943, P86182, Q14129, Q155Q3, Q17Q97, Q1JPG0, Q2TBK4, Q2TBN4, Q32KQ7, Q4KLN4, Q4R5A4, Q571B6, Q5M9F0, Q5RAX7, Q5RC14, Q5RKN3, Q6AXZ5, Q6NVC9, Q6ZS81, Q7L4E1, Q7SYB5, Q7TNH6, Q8BHR8, Q8C2K1, Q8C3S2, Q8N4C6, Q8N9B5, Q8R322, Q8TF30, Q8WYP5, Q920D3

Diamond homologs: Q2TBK4, Q8BHX1, Q96CS2, Q9R0A8, F4IK01

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
HAUS1	“form complex”	“HAUS complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 71 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Loss of Nlp from mitotic centrosomes	7	27.8×	3e-07
Loss of proteins required for interphase microtubule organization from the centrosome	7	27.8×	3e-07
AURKA Activation by TPX2	7	26.6×	3e-07
Recruitment of mitotic centrosome proteins and complexes	7	23.8×	5e-07
Anchoring of the basal body to the plasma membrane	8	22.6×	3e-07
Regulation of PLK1 Activity at G2/M Transition	7	22.2×	6e-07
Recruitment of NuMA to mitotic centrosomes	7	20.4×	1e-06
Formation of the cornified envelope	6	13.2×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
centrosome cycle	7	38.7×	2e-07
morphogenesis of an epithelium	5	28.2×	1e-04
intermediate filament organization	5	19.7×	3e-04
epithelial cell differentiation	5	14.4×	9e-04
cilium assembly	8	9.7×	1e-04
cell division	10	7.6×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1757 predictions. Top by Δscore:

Variant	Effect	Δscore
18:46118313:C:G	donor_gain	1.0000
18:46120061:G:GG	donor_gain	1.0000
18:46122463:AAAG:A	acceptor_gain	1.0000
18:46122463:AAAGG:A	acceptor_gain	1.0000
18:46122466:GGGAT:G	acceptor_gain	1.0000
18:46123361:AGAGG:A	donor_loss	1.0000
18:46123362:GAG:G	donor_gain	1.0000
18:46123363:AGGT:A	donor_loss	1.0000
18:46123364:GGTG:G	donor_loss	1.0000
18:46123365:G:T	donor_loss	1.0000
18:46123366:T:A	donor_loss	1.0000
18:46124889:TGCCG:T	donor_loss	1.0000
18:46124890:GCCG:G	donor_gain	1.0000
18:46124891:CCG:C	donor_loss	1.0000
18:46124892:CG:C	donor_loss	1.0000
18:46124894:G:GA	donor_loss	1.0000
18:46124895:T:A	donor_loss	1.0000
18:46125730:A:AG	acceptor_gain	1.0000
18:46125731:T:G	acceptor_gain	1.0000
18:46125740:A:AG	acceptor_gain	1.0000
18:46125741:A:G	acceptor_gain	1.0000
18:46125742:A:AG	acceptor_gain	1.0000
18:46125743:G:GT	acceptor_gain	1.0000
18:46125743:GA:G	acceptor_gain	1.0000
18:46125743:GAA:G	acceptor_gain	1.0000
18:46125743:GAAT:G	acceptor_gain	1.0000
18:46125743:GAATC:G	acceptor_gain	1.0000
18:46125787:AACTA:A	donor_gain	1.0000
18:46125788:ACTA:A	donor_gain	1.0000
18:46125789:CTA:C	donor_gain	1.0000

AlphaMissense

1820 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:46125777:G:C	A258P	0.988
18:46125757:C:A	A251D	0.969
18:46124886:T:C	L244S	0.957
18:46125784:G:C	R260P	0.956
18:46125790:T:C	L262P	0.950
18:46105203:T:A	W14R	0.947
18:46105203:T:C	W14R	0.947
18:46105207:T:C	L15S	0.945
18:46105273:T:C	L37S	0.942
18:46122554:G:C	K188N	0.937
18:46122554:G:T	K188N	0.937
18:46122540:T:C	F184L	0.933
18:46122542:T:A	F184L	0.933
18:46122542:T:G	F184L	0.933
18:46105282:T:C	L40P	0.930
18:46118315:A:C	S114R	0.920
18:46119926:T:A	S114R	0.920
18:46119926:T:G	S114R	0.920
18:46128094:T:C	L269P	0.919
18:46125756:G:C	A251P	0.913
18:46105368:G:C	A69P	0.909
18:46105347:G:C	A62P	0.905
18:46118279:G:C	A102P	0.896
18:46105205:G:C	W14C	0.892
18:46105205:G:T	W14C	0.892
18:46123338:C:G	H214D	0.892
18:46122544:T:C	L185P	0.891
18:46120054:T:C	L157P	0.890
18:46123340:T:A	H214Q	0.881
18:46123340:T:G	H214Q	0.881

dbSNP variants (sampled 300 via entrez): RS1000051050 (18:46126217 G>T), RS1000139005 (18:46103938 T>G), RS1000190457 (18:46104318 G>A), RS1000196648 (18:46120370 G>T), RS1000228978 (18:46120546 C>A,T), RS1000287287 (18:46113930 C>T), RS1000301322 (18:46110597 C>T), RS1000383097 (18:46106843 C>T), RS1000478099 (18:46117148 A>G,T), RS1000658918 (18:46113585 C>T), RS1000941250 (18:46121831 ATTAT>A), RS1001020636 (18:46124720 T>C), RS1001278583 (18:46103876 T>C), RS1001453433 (18:46125077 T>C), RS1001561293 (18:46128396 A>G)

Disease associations

OMIM: gene MIM:608775 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): male infertility (MONDO:0005372)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D007248	Infertility, Male	C12.100.500.430; C12.100.750.700; C12.200.294.430

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	increases oxidation, decreases expression, affects cotreatment, increases abundance	2
Cyclosporine	decreases expression	2
GSK-J4	decreases expression	1
dicrotophos	decreases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	affects expression	1
sodium arsenite	decreases expression	1
manganese chloride	increases abundance, increases expression	1
potassium chromate(VI)	decreases expression, affects cotreatment	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
beta-methylcholine	affects expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
azoxystrobin	increases expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	decreases expression	1
trans-10,cis-12-conjugated linoleic acid	decreases expression	1
picoxystrobin	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Acetaminophen	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Benzo(a)pyrene	increases expression	1
Cisplatin	increases expression	1
Coumestrol	affects cotreatment, increases expression	1
Dimethyl Sulfoxide	increases expression	1
Manganese	increases abundance, increases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	increases abundance, affects cotreatment, increases oxidation	1

Clinical trials (associated diseases)

125 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02202382	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Male Infertility
NCT02204826	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
NCT03802864	PHASE4	COMPLETED	Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine
NCT06100432	PHASE4	ACTIVE_NOT_RECRUITING	Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Males
NCT07523022	PHASE4	ENROLLING_BY_INVITATION	Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
NCT00975117	PHASE3	COMPLETED	Spermotrend in the Treatment of Male Infertility
NCT01407432	PHASE3	COMPLETED	Impact of Folates in the Care of the Male Infertility
NCT01895816	PHASE3	COMPLETED	Herbal Tonic Fertile Supplement(ZO2C5)
NCT02605070	PHASE3	TERMINATED	Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
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NCT00756561	Not specified	COMPLETED	HOP-2A - Intratesticular Hormone Levels
NCT00961558	Not specified	TERMINATED	Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy
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NCT01178463	Not specified	UNKNOWN	Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia