HAUS4

Summary

HAUS4 (HAUS augmin like complex subunit 4, HGNC:20163) is a protein-coding gene on chromosome 14q11.2, encoding HAUS augmin-like complex subunit 4 (Q9H6D7). Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. It is a common-essential gene (DepMap: required in 98.6% of cancer cell lines).

This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Source: NCBI Gene 54930 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 49 total
• Cancer dependency (DepMap): dependent in 98.6% of screened cell lines (common-essential)
• MANE Select transcript: NM_001166269

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20163
Approved symbol	HAUS4
Name	HAUS augmin like complex subunit 4
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20424
Ensembl gene	ENSG00000092036
Ensembl biotype	protein_coding
OMIM	613431
Entrez	54930

Gene structure

Transcript identifiers

Ensembl transcripts: 45 — 37 protein_coding, 5 protein_coding_CDS_not_defined, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000206474, ENST00000342454, ENST00000347758, ENST00000490506, ENST00000541587, ENST00000553420, ENST00000553794, ENST00000553859, ENST00000554063, ENST00000554349, ENST00000554373, ENST00000554406, ENST00000554446, ENST00000554516, ENST00000554651, ENST00000555040, ENST00000555367, ENST00000555986, ENST00000556421, ENST00000556915, ENST00000557591, ENST00000891766, ENST00000891767, ENST00000891768, ENST00000891769, ENST00000891770, ENST00000891771, ENST00000891772, ENST00000891773, ENST00000891774, ENST00000932954, ENST00000932955, ENST00000932956, ENST00000932957, ENST00000932958, ENST00000932959, ENST00000932960, ENST00000958328, ENST00000958329, ENST00000958330, ENST00000958331, ENST00000958332, ENST00000958333, ENST00000958334, ENST00000958335

RefSeq mRNA: 3 — MANE Select: NM_001166269 NM_001166269, NM_001166270, NM_017815

CCDS: CCDS53886, CCDS9580

Canonical transcript exons

ENST00000541587 — 10 exons

Exon	Start	End
ENSE00001922973	22946228	22946708
ENSE00002204859	22956916	22957090
ENSE00003466291	22947171	22947239
ENSE00003510008	22952541	22952683
ENSE00003512311	22947868	22948013
ENSE00003568136	22952328	22952459
ENSE00003586967	22951555	22951689
ENSE00003591775	22955100	22955176
ENSE00003785134	22950314	22950410
ENSE00003790839	22947601	22947731

Expression profiles

Bgee: expression breadth ubiquitous, 139 present calls, max score 96.27.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 24.9554 / max 286.5213, expressed in 1815 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142270	13.5622	1790
142273	6.6238	1658
142271	2.6000	1324
142272	2.1694	1129

Top tissues by expression

142 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	96.27	gold quality
left ovary	UBERON:0002119	95.46	gold quality
ovary	UBERON:0000992	95.18	gold quality
body of pancreas	UBERON:0001150	95.06	gold quality
right ovary	UBERON:0002118	94.79	gold quality
ventricular zone	UBERON:0003053	94.32	gold quality
leukocyte	CL:0000738	94.03	gold quality
monocyte	CL:0000576	94.02	gold quality
spleen	UBERON:0002106	93.71	gold quality
skin of abdomen	UBERON:0001416	93.69	gold quality
granulocyte	CL:0000094	93.64	gold quality
lymph node	UBERON:0000029	93.60	gold quality
endocervix	UBERON:0000458	93.49	gold quality
zone of skin	UBERON:0000014	93.37	gold quality
minor salivary gland	UBERON:0001830	93.20	gold quality
skin of leg	UBERON:0001511	93.18	gold quality
saliva-secreting gland	UBERON:0001044	93.15	gold quality
descending thoracic aorta	UBERON:0002345	93.14	gold quality
body of uterus	UBERON:0009853	92.98	gold quality
tibial nerve	UBERON:0001323	92.90	gold quality
right lung	UBERON:0002167	92.90	gold quality
vagina	UBERON:0000996	92.89	gold quality
pancreas	UBERON:0001264	92.76	gold quality
right uterine tube	UBERON:0001302	92.76	gold quality
vermiform appendix	UBERON:0001154	92.65	gold quality
myometrium	UBERON:0001296	92.55	gold quality
ectocervix	UBERON:0012249	92.53	gold quality
uterine cervix	UBERON:0000002	92.45	gold quality
thoracic mammary gland	UBERON:0005200	92.45	gold quality
transverse colon	UBERON:0001157	92.42	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.15
E-MTAB-7303	no	288.96
E-CURD-11	no	102.20

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting HAUS4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-6165	99.44	67.12	1389
HSA-MIR-1276	99.36	68.18	1642
HSA-MIR-4311	99.31	70.47	3041
HSA-MIR-892C-5P	99.16	70.56	2116
HSA-MIR-6780B-3P	99.13	67.18	622
HSA-MIR-5008-5P	98.42	65.87	1019
HSA-MIR-4768-3P	98.16	66.02	2330
HSA-MIR-506-5P	98.02	67.41	1065
HSA-MIR-33B-3P	97.92	67.39	529
HSA-MIR-519E-3P	97.92	68.25	508
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-6730-3P	97.03	67.54	889
HSA-MIR-31-3P	95.17	69.82	575
HSA-MIR-4301	95.00	65.22	554

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 98.6% of screened cell lines, common-essential.

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	haus4	ENSDARG00000016594
mus_musculus	Haus4	ENSMUSG00000022177
rattus_norvegicus	Haus4	ENSRNOG00000039284

Protein

Protein identifiers

HAUS augmin-like complex subunit 4 — Q9H6D7 (reviewed: Q9H6D7)

All UniProt accessions (8): Q9H6D7, G3V2I5, G3V4X7, G3V541, G3V5A5, G3V5Z2, H0YIZ6, H0YJ09

UniProt curated annotations — full annotation on UniProt →

Function. Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Subunit / interactions. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Interacts with EML3 (phosphorylated at ‘Thr-881’).

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle.

Similarity. Belongs to the HAUS4 family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9H6D7-1	1	yes
Q9H6D7-2	2
Q9H6D7-3	3
Q9H6D7-4	4

RefSeq proteins (3): NP_001159741, NP_001159742, NP_060285 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026214	HAUS4_met	Family
IPR029327	HAUS4	Family

Pfam: PF14735

UniProt features (5 total): splice variant 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7SQK	ELECTRON MICROSCOPY	8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H6D7-F1	82.17	0.37

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259	Loss of Nlp from mitotic centrosomes
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912	Anchoring of the basal body to the plasma membrane
R-HSA-8854518	AURKA Activation by TPX2

MSigDB gene sets: 197 (showing top): GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, GOBP_MICROTUBULE_NUCLEATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GGGTGGRR_PAX4_03, GOCC_MICROTUBULE_ORGANIZING_CENTER, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION, SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4, GOCC_CENTROSOME, GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, GOBP_ORGANELLE_ASSEMBLY, AFP1_Q6, FISCHER_DREAM_TARGETS, GOBP_SPINDLE_ASSEMBLY

GO Biological Process (4): centrosome cycle (GO:0007098), regulation of microtubule nucleation (GO:0010968), spindle assembly (GO:0051225), cell division (GO:0051301)

GO Molecular Function (2): microtubule minus-end binding (GO:0051011), protein binding (GO:0005515)

GO Cellular Component (8): centrosome (GO:0005813), cytosol (GO:0005829), HAUS complex (GO:0070652), mitotic spindle microtubule (GO:1990498), cytoplasm (GO:0005737), spindle (GO:0005819), cytoskeleton (GO:0005856), microtubule (GO:0005874)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
G2/M Transition	2
Centrosome maturation	2
Loss of proteins required for interphase microtubule organization from the centrosome	1
Mitotic Prometaphase	1
Assembly of the 9+0 primary cilium	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
microtubule cytoskeleton	2
intracellular membraneless organelle	2
cell cycle process	1
microtubule organizing center organization	1
microtubule nucleation	1
regulation of microtubule polymerization	1
spindle organization	1
chromosome segregation	1
membraneless organelle assembly	1
cellular process	1
microtubule binding	1
binding	1
centriole	1
microtubule organizing center	1
cytoplasm	1
microtubule associated complex	1
spindle microtubule	1
mitotic spindle	1
intracellular anatomical structure	1
polymeric cytoskeletal fiber	1

Protein interactions and networks

STRING

670 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HAUS4	HAUS6	Q7Z4H7	902
HAUS4	HAUS3	Q68CZ6	827
HAUS4	HAUS1	Q96CS2	788
HAUS4	HAUS7	Q99871	711
HAUS4	HAUS8	Q9BT25	703
HAUS4	TUBG1	P23258	694
HAUS4	NUMA1	Q14980	693
HAUS4	HAUS2	Q9NVX0	689
HAUS4	HAUS5	O94927	606
HAUS4	C9orf40	Q8IXQ3	506
HAUS4	TTC39C	Q8N584	502
HAUS4	GTF3C4	Q9UKN8	464
HAUS4	LYSMD4	Q5XG99	409
HAUS4	C14orf93	Q9H972	402
HAUS4	CDCA4	Q9BXL8	390

IntAct

106 interactions, top by confidence:

A	B	Type	Score
HAUS4	HAUS1	psi-mi:“MI:0407”(direct interaction)	0.910
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
CEP290	CCP110	psi-mi:“MI:2364”(proximity)	0.890
DMD	DTNB	psi-mi:“MI:0914”(association)	0.890
HAUS1	HAUS6	psi-mi:“MI:0915”(physical association)	0.810
HAUS1	HAUS5	psi-mi:“MI:0915”(physical association)	0.780
COPRS	PRMT5	psi-mi:“MI:0914”(association)	0.770
TADA3	TADA2A	psi-mi:“MI:0914”(association)	0.740
HAUS6	HAUS5	psi-mi:“MI:0914”(association)	0.710
HAUS6	HAUS4	psi-mi:“MI:0915”(physical association)	0.710
EFHC1	BRAP	psi-mi:“MI:0914”(association)	0.660
HAUS4	HAUS5	psi-mi:“MI:0914”(association)	0.640
CCDC120	AIP	psi-mi:“MI:0914”(association)	0.640
PIK3R2	IRS4	psi-mi:“MI:0914”(association)	0.640
Haus4	HAUS5	psi-mi:“MI:0915”(physical association)	0.560
BMAL2	CLOCK	psi-mi:“MI:0914”(association)	0.550
HAUS3	HAUS5	psi-mi:“MI:0914”(association)	0.530
CCDC59	GAPDHS	psi-mi:“MI:0914”(association)	0.530
ZNF223	CENPB	psi-mi:“MI:0914”(association)	0.530
DMD	UTRN	psi-mi:“MI:0914”(association)	0.530
COG3	TBCC	psi-mi:“MI:0914”(association)	0.530
SYCE3	RER1	psi-mi:“MI:0914”(association)	0.530

BioGRID (154): HAUS4 (Affinity Capture-RNA), HAUS4 (Affinity Capture-RNA), HAUS4 (Affinity Capture-MS), HAUS4 (Affinity Capture-MS), HAUS4 (Affinity Capture-MS), HAUS4 (Affinity Capture-MS), HAUS4 (Affinity Capture-MS), HAUS4 (Affinity Capture-MS), GGA3 (Co-fractionation), HAUS4 (Synthetic Growth Defect), HAUS4 (Proximity Label-MS), HAUS4 (Affinity Capture-MS), HAUS4 (Affinity Capture-MS), HAUS4 (Proximity Label-MS), HAUS4 (Proximity Label-MS)

ESM2 similar proteins: A2AKG8, A5A777, A6H754, A7YDW0, A7YY97, A8DZJ1, B5X5N3, F6S215, O00443, O08576, O08662, O60268, P35608, P97357, Q15573, Q17QK1, Q2NL11, Q3B7U2, Q4V847, Q4V8Z3, Q561Q8, Q561X3, Q571H0, Q59EK9, Q5M8Y7, Q5R565, Q5RA87, Q5RAY1, Q5VW36, Q5WNI9, Q5XG48, Q5XIC3, Q61194, Q63603, Q6TNU3, Q751Y8, Q75QN2, Q7L3B6, Q80V86, Q80Y56

Diamond homologs: Q8BFT2, Q9H6D7

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
HAUS4	“form complex”	“HAUS complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 134 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Loss of Nlp from mitotic centrosomes	17	28.4×	2e-18
Loss of proteins required for interphase microtubule organization from the centrosome	17	28.4×	2e-18
AURKA Activation by TPX2	17	27.2×	3e-18
Recruitment of mitotic centrosome proteins and complexes	17	24.3×	1e-17
Regulation of PLK1 Activity at G2/M Transition	17	22.7×	4e-17
Anchoring of the basal body to the plasma membrane	19	22.6×	2e-18
Recruitment of NuMA to mitotic centrosomes	18	22.1×	9e-18

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of cilium assembly	5	31.9×	7e-05
centriole replication	5	30.5×	7e-05
spindle assembly	8	29.6×	6e-08
centrosome cycle	10	28.1×	7e-10
non-motile cilium assembly	6	14.5×	3e-04
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	5	14.0×	2e-03
cilium assembly	11	6.8×	8e-05
cell division	15	5.8×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1514 predictions. Top by Δscore:

Variant	Effect	Δscore
14:22947166:CTCAC:C	donor_loss	1.0000
14:22947167:TCAC:T	donor_loss	1.0000
14:22947167:TCACC:T	donor_loss	1.0000
14:22947168:CACCT:C	donor_loss	1.0000
14:22947169:A:AT	donor_loss	1.0000
14:22947170:C:CG	donor_loss	1.0000
14:22947170:CC:C	donor_loss	1.0000
14:22947597:TCA:T	donor_loss	1.0000
14:22947598:CA:C	donor_loss	1.0000
14:22947600:CCT:C	donor_gain	1.0000
14:22947605:G:C	donor_gain	1.0000
14:22947629:TG:T	donor_gain	1.0000
14:22947634:T:TA	donor_gain	1.0000
14:22947732:CTGAG:C	acceptor_loss	1.0000
14:22947733:T:G	acceptor_loss	1.0000
14:22947739:C:CT	acceptor_gain	1.0000
14:22947739:C:T	acceptor_gain	1.0000
14:22947739:CAAGA:C	acceptor_gain	1.0000
14:22947740:A:T	acceptor_gain	1.0000
14:22947743:A:AC	acceptor_gain	1.0000
14:22947743:A:C	acceptor_gain	1.0000
14:22947854:ATGC:A	donor_gain	1.0000
14:22947857:C:CA	donor_gain	1.0000
14:22950418:C:CT	acceptor_gain	1.0000
14:22950418:CA:C	acceptor_gain	1.0000
14:22950425:G:GC	acceptor_gain	1.0000
14:22952700:C:CT	acceptor_gain	1.0000
14:22952702:CAGG:C	acceptor_gain	1.0000
14:22952705:G:GC	acceptor_gain	1.0000
14:22952708:C:CT	acceptor_gain	1.0000

AlphaMissense

2378 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:22946615:A:C	F334L	0.976
14:22946615:A:T	F334L	0.976
14:22946617:A:G	F334L	0.976
14:22947604:A:G	L279P	0.960
14:22950361:A:G	L172P	0.959
14:22947228:A:G	L284P	0.953
14:22947697:A:G	L248P	0.944
14:22947637:A:G	L268P	0.942
14:22952426:A:G	W78R	0.941
14:22952426:A:T	W78R	0.941
14:22947719:A:G	C241R	0.937
14:22951687:A:C	F111L	0.937
14:22951687:A:T	F111L	0.937
14:22951689:A:G	F111L	0.937
14:22947627:C:A	K271N	0.935
14:22947627:C:G	K271N	0.935
14:22951676:A:G	L115P	0.928
14:22946595:T:G	Y341S	0.926
14:22947184:G:C	H299D	0.923
14:22951664:A:G	L119P	0.921
14:22952568:G:C	S57R	0.920
14:22952568:G:T	S57R	0.920
14:22952570:T:G	S57R	0.920
14:22947706:A:G	L245P	0.919
14:22946586:A:G	L344P	0.918
14:22946616:A:G	F334S	0.916
14:22947620:C:G	A274P	0.913
14:22946596:A:C	Y341D	0.911
14:22947606:C:A	K278N	0.911
14:22947606:C:G	K278N	0.911

dbSNP variants (sampled 300 via entrez): RS1000066543 (14:22948275 T>A,G), RS1000231326 (14:22958978 T>A,C), RS1000901034 (14:22954685 C>T), RS1001041001 (14:22958732 T>G), RS1001113098 (14:22959009 C>T), RS1001627474 (14:22954063 T>C), RS1001935039 (14:22955456 T>C), RS1001994859 (14:22953898 A>G), RS1002060697 (14:22948521 C>G), RS1002134361 (14:22948680 C>A), RS1002377045 (14:22948382 C>T), RS1002406141 (14:22955292 A>T), RS1002526239 (14:22949997 G>A), RS1002683004 (14:22956688 C>A,G,T), RS1002752997 (14:22949816 TAA>T)

Disease associations

OMIM: gene MIM:613431 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST006135_13	Cortical amyloid beta load	6.000000e-06
GCST006135_3	Cortical amyloid beta load	5.000000e-06
GCST006135_4	Cortical amyloid beta load	4.000000e-07
GCST006135_6	Cortical amyloid beta load	4.000000e-06
GCST007430_55	Peak expiratory flow	5.000000e-06
GCST007431_20	Lung function (FEV1/FVC)	8.000000e-15

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007707	cerebral amyloid deposition measurement
EFO:0009718	peak expiratory flow
EFO:0004713	FEV/FVC ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	4
bisphenol A	affects expression, increases methylation, affects cotreatment, increases expression	3
Estradiol	affects cotreatment, increases expression, decreases expression	3
Cyclosporine	increases expression, decreases expression	3
perfluorooctane sulfonic acid	increases expression	2
Benzo(a)pyrene	decreases expression, increases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Testosterone	affects cotreatment, decreases expression	2
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	decreases expression, increases activity, affects binding	1
beta-lapachone	increases expression	1
sodium arsenite	decreases expression	1
potassium chromate(VI)	decreases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
perfluorohexanesulfonic acid	increases expression	1
abrine	decreases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	increases expression, decreases reaction	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	affects cotreatment, increases expression	1
Norethindrone Acetate	affects cotreatment, increases expression	1
Acetaminophen	decreases expression	1
Atrazine	increases expression	1
Vehicle Emissions	decreases reaction, increases expression	1
Caffeine	increases phosphorylation	1
Calcitriol	decreases expression, affects cotreatment	1
Cisplatin	affects cotreatment, increases expression	1
Coumestrol	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.