HAUS5

Summary

HAUS5 (HAUS augmin like complex subunit 5, HGNC:29130) is a protein-coding gene on chromosome 19q13.12, encoding HAUS augmin-like complex subunit 5 (O94927). Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. It is a common-essential gene (DepMap: required in 99.2% of cancer cell lines).

HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb ‘augmentare,’ meaning ’to increase.’ The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).

Source: NCBI Gene 23354 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 155 total
• Cancer dependency (DepMap): dependent in 99.2% of screened cell lines (common-essential)
• MANE Select transcript: NM_015302

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29130
Approved symbol	HAUS5
Name	HAUS augmin like complex subunit 5
Location	19q13.12
Locus type	gene with protein product
Status	Approved
Aliases	dgt5
Ensembl gene	ENSG00000249115
Ensembl biotype	protein_coding
OMIM	613432
Entrez	23354

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 9 protein_coding, 4 retained_intron, 3 nonsense_mediated_decay

ENST00000203166, ENST00000424522, ENST00000428854, ENST00000430749, ENST00000585968, ENST00000587439, ENST00000588570, ENST00000590994, ENST00000592291, ENST00000881486, ENST00000881487, ENST00000881488, ENST00000931152, ENST00000955865, ENST00000955866, ENST00000955867

RefSeq mRNA: 1 — MANE Select: NM_015302 NM_015302

CCDS: CCDS42550

Canonical transcript exons

ENST00000203166 — 19 exons

Exon	Start	End
ENSE00002956714	35612735	35612892
ENSE00003480323	35615042	35615147
ENSE00003513911	35622876	35625355
ENSE00003514706	35620012	35620123
ENSE00003529623	35617855	35617912
ENSE00003555583	35618402	35618465
ENSE00003560638	35617124	35617193
ENSE00003561618	35615227	35615386
ENSE00003565106	35618071	35618195
ENSE00003578528	35618887	35619049
ENSE00003605202	35617287	35617369
ENSE00003616822	35619613	35619758
ENSE00003638121	35618569	35618699
ENSE00003645461	35622601	35622733
ENSE00003658297	35620195	35620327
ENSE00003663448	35614035	35614059
ENSE00003663527	35619424	35619504
ENSE00003697581	35613868	35613900
ENSE00003699674	35613730	35613792

Expression profiles

Bgee: expression breadth ubiquitous, 271 present calls, max score 94.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.0427 / max 274.0797, expressed in 1680 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175354	10.0427	1680

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
type B pancreatic cell	CL:0000169	94.32	gold quality
olfactory bulb	UBERON:0002264	90.69	gold quality
secondary oocyte	CL:0000655	90.07	gold quality
vena cava	UBERON:0004087	89.60	silver quality
nasal cavity epithelium	UBERON:0005384	87.82	silver quality
left ovary	UBERON:0002119	87.20	gold quality
right testis	UBERON:0004534	87.19	gold quality
right ovary	UBERON:0002118	86.70	gold quality
left testis	UBERON:0004533	86.54	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.49	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	86.46	silver quality
right hemisphere of cerebellum	UBERON:0014890	86.23	gold quality
oocyte	CL:0000023	86.06	gold quality
pancreatic ductal cell	CL:0002079	86.03	gold quality
ventricular zone	UBERON:0003053	85.72	gold quality
inferior olivary complex	UBERON:0002127	85.52	gold quality
ovary	UBERON:0000992	85.44	gold quality
cerebellar hemisphere	UBERON:0002245	85.32	gold quality
cerebellar cortex	UBERON:0002129	85.16	gold quality
lower esophagus mucosa	UBERON:0035834	84.93	gold quality
right uterine tube	UBERON:0001302	84.80	gold quality
testis	UBERON:0000473	84.79	gold quality
ileal mucosa	UBERON:0000331	84.78	gold quality
body of uterus	UBERON:0009853	84.35	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	84.21	silver quality
cerebellum	UBERON:0002037	84.02	gold quality
ganglionic eminence	UBERON:0004023	83.90	gold quality
sural nerve	UBERON:0015488	83.77	gold quality
ectocervix	UBERON:0012249	83.57	gold quality
tibialis anterior	UBERON:0001385	83.39	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.70
E-GEOD-75367	no	74.02

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

96 targeting HAUS5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-4671-3P	99.88	72.46	1045
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-373-3P	99.84	70.68	1668
HSA-MIR-520E-3P	99.84	70.55	1698
HSA-MIR-372-3P	99.83	70.58	1691
HSA-MIR-520A-3P	99.83	70.59	1687

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.2% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 2)

• Our results suggest that GSCs differentially rely on ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS complex activity to maintain the integrity of centrosome function and viability. (PMID:28596487)
• Comprehensive analysis of the correlation of the pan-cancer gene HAUS5 with prognosis and immune infiltration in liver cancer. (PMID:36765148)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Haus5	ENSMUSG00000078762
rattus_norvegicus	Haus5	ENSRNOG00000024266

Protein

Protein identifiers

HAUS augmin-like complex subunit 5 — O94927 (reviewed: O94927)

All UniProt accessions (4): O94927, K7EQ61, U3KQG4, U3KQJ5

UniProt curated annotations — full annotation on UniProt →

Function. Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Subunit / interactions. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Interacts with EML3 (phosphorylated at ‘Thr-881’).

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle.

Similarity. Belongs to the HAUS5 family.

Isoforms (2)

UniProt ID	Names	Canonical?
O94927-1	1	yes
O94927-2	2

RefSeq proteins (1): NP_056117* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR026215	HAUS5_metazoa	Family
IPR029131	HAUS5	Family

Pfam: PF14817

UniProt features (12 total): coiled-coil region 3, sequence variant 2, modified residue 2, splice variant 2, chain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7SQK	ELECTRON MICROSCOPY	8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O94927-F1	77.18	0.16

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 1, 71

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259	Loss of Nlp from mitotic centrosomes
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912	Anchoring of the basal body to the plasma membrane
R-HSA-8854518	AURKA Activation by TPX2

MSigDB gene sets: 184 (showing top): MORF_RAGE, GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, MORF_FLT1, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, GOBP_MICROTUBULE_NUCLEATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, GOCC_MICROTUBULE_ORGANIZING_CENTER, SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A5, GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION, MORF_FANCG, GOCC_CENTROSOME, GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, GOBP_ORGANELLE_ASSEMBLY, SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP

GO Biological Process (4): centrosome cycle (GO:0007098), regulation of microtubule nucleation (GO:0010968), spindle assembly (GO:0051225), cell division (GO:0051301)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (8): centrosome (GO:0005813), cytosol (GO:0005829), HAUS complex (GO:0070652), mitotic spindle microtubule (GO:1990498), cytoplasm (GO:0005737), spindle (GO:0005819), cytoskeleton (GO:0005856), microtubule (GO:0005874)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
G2/M Transition	2
Centrosome maturation	2
Loss of proteins required for interphase microtubule organization from the centrosome	1
Mitotic Prometaphase	1
Assembly of the 9+0 primary cilium	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
microtubule cytoskeleton	2
intracellular membraneless organelle	2
cell cycle process	1
microtubule organizing center organization	1
microtubule nucleation	1
regulation of microtubule polymerization	1
spindle organization	1
chromosome segregation	1
membraneless organelle assembly	1
cellular process	1
binding	1
centriole	1
microtubule organizing center	1
cytoplasm	1
microtubule associated complex	1
spindle microtubule	1
mitotic spindle	1
intracellular anatomical structure	1
polymeric cytoskeletal fiber	1

Protein interactions and networks

STRING

904 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HAUS5	HAUS6	Q7Z4H7	956
HAUS5	HAUS3	Q68CZ6	854
HAUS5	HAUS7	Q99871	771
HAUS5	HAUS8	Q9BT25	743
HAUS5	NEDD1	Q8NHV4	739
HAUS5	HAUS2	Q9NVX0	685
HAUS5	NUMA1	Q14980	680
HAUS5	TUBG1	P23258	674
HAUS5	ZNF672	Q499Z4	617
HAUS5	HAUS4	Q9H6D7	606
HAUS5	HAUS1	Q96CS2	518
HAUS5	ZBTB35	P52739	504
HAUS5	CFAP263	Q9H0I3	458
HAUS5	RAB4B	P22750	437
HAUS5	POC5	Q8NA72	421

IntAct

163 interactions, top by confidence:

A	B	Type	Score
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
SNX6	SNX2	psi-mi:“MI:0914”(association)	0.800
IFT70B	IFT56	psi-mi:“MI:0914”(association)	0.790
HAUS1	HAUS5	psi-mi:“MI:0915”(physical association)	0.780
HAUS1	HAUS5	psi-mi:“MI:0914”(association)	0.780
RFXANK	RFXAP	psi-mi:“MI:0914”(association)	0.780
HAUS2	HAUS5	psi-mi:“MI:0914”(association)	0.730
HAUS6	HAUS5	psi-mi:“MI:0915”(physical association)	0.710
HAUS6	HAUS5	psi-mi:“MI:0914”(association)	0.710
LRIF1	SMCHD1	psi-mi:“MI:0914”(association)	0.680
HAUS4	HAUS5	psi-mi:“MI:0914”(association)	0.640
Haus4	HAUS5	psi-mi:“MI:0914”(association)	0.560
Haus4	HAUS5	psi-mi:“MI:0915”(physical association)	0.560
HAUS3	HAUS5	psi-mi:“MI:0914”(association)	0.530
TIGD5	P4HA2	psi-mi:“MI:0914”(association)	0.530
HSPB8	VWA8	psi-mi:“MI:0914”(association)	0.530
PRKAG3	PFDN6	psi-mi:“MI:0914”(association)	0.530
SYCE3	RER1	psi-mi:“MI:0914”(association)	0.530
TNFSF8	LGALS8	psi-mi:“MI:0914”(association)	0.530
ILK	ILVBL	psi-mi:“MI:0914”(association)	0.530
KIAA0753	OFD1	psi-mi:“MI:2364”(proximity)	0.480
HSPA8	ARHGEF10	psi-mi:“MI:2364”(proximity)	0.480
CEP162	CCP110	psi-mi:“MI:2364”(proximity)	0.420
GSK3B	SEC16A	psi-mi:“MI:2364”(proximity)	0.420
Haus2	HAUS5	psi-mi:“MI:0915”(physical association)	0.400
Plk1		psi-mi:“MI:0915”(physical association)	0.400
Haus6	HAUS5	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (204): HAUS5 (Affinity Capture-MS), HAUS5 (Affinity Capture-MS), HAUS5 (Affinity Capture-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS), HAUS5 (Proximity Label-MS)

ESM2 similar proteins: A1A5D9, A6NGB0, A9QT41, B8JK76, F6XLV1, O94927, P0C7N4, P58660, Q0KK56, Q0VG85, Q1RMI8, Q29RS0, Q2KJ21, Q2NL23, Q2TAC2, Q3LUD3, Q3V0F0, Q4QRL3, Q571B6, Q5D525, Q5ND29, Q5RD60, Q5XHZ2, Q66HR5, Q6NSJ2, Q6PHN1, Q6QZQ4, Q86UK5, Q8BFT2, Q8BP01, Q8CB62, Q8CGU1, Q8CHW5, Q8CJ40, Q8HZ57, Q8HZ58, Q8HZ59, Q8HZ60, Q8K1G2, Q8K2I2

Diamond homologs: O94927, Q9D786

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
HAUS5	“form complex”	“HAUS complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 204 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Loss of Nlp from mitotic centrosomes	17	24.1×	3e-17
Loss of proteins required for interphase microtubule organization from the centrosome	17	24.1×	3e-17
AURKA Activation by TPX2	17	23.1×	5e-17
Recruitment of mitotic centrosome proteins and complexes	17	20.6×	3e-16
Regulation of PLK1 Activity at G2/M Transition	17	19.3×	9e-16
Anchoring of the basal body to the plasma membrane	19	19.2×	3e-17
Recruitment of NuMA to mitotic centrosomes	17	17.7×	3e-15
Cilium Assembly	7	6.8×	4e-03

GO biological processes:

GO term	Partners	Fold	FDR
spindle assembly	9	23.2×	4e-08
centriole replication	5	21.3×	7e-04
centrosome cycle	10	19.6×	3e-08
cell division	15	4.0×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

155 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	120
Likely benign	13
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2814 predictions. Top by Δscore:

Variant	Effect	Δscore
19:35613863:TGTAG:T	acceptor_loss	1.0000
19:35613865:TAG:T	acceptor_loss	1.0000
19:35615039:CAGGT:C	acceptor_loss	1.0000
19:35615040:A:AG	acceptor_gain	1.0000
19:35615041:G:GG	acceptor_gain	1.0000
19:35615041:GGTCC:G	acceptor_gain	1.0000
19:35615144:CAGGG:C	donor_loss	1.0000
19:35615145:AGGGT:A	donor_loss	1.0000
19:35615146:GG:G	donor_gain	1.0000
19:35615147:G:GT	donor_gain	1.0000
19:35615147:GGTGA:G	donor_loss	1.0000
19:35615148:G:GG	donor_gain	1.0000
19:35615148:GTG:G	donor_loss	1.0000
19:35615149:T:A	donor_loss	1.0000
19:35615224:C:G	acceptor_gain	1.0000
19:35615225:A:AG	acceptor_gain	1.0000
19:35615225:A:G	acceptor_loss	1.0000
19:35615226:G:GA	acceptor_gain	1.0000
19:35615226:GA:G	acceptor_gain	1.0000
19:35615226:GAC:G	acceptor_gain	1.0000
19:35615226:GACA:G	acceptor_gain	1.0000
19:35615226:GACAC:G	acceptor_gain	1.0000
19:35615376:G:GT	donor_gain	1.0000
19:35615384:GAG:G	donor_gain	1.0000
19:35615385:AGG:A	donor_loss	1.0000
19:35615386:GGTG:G	donor_loss	1.0000
19:35615387:GTG:G	donor_loss	1.0000
19:35615399:G:T	donor_gain	1.0000
19:35617286:GC:G	acceptor_gain	1.0000
19:35617370:G:GG	donor_gain	1.0000

AlphaMissense

4024 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:35617895:T:A	W227R	0.981
19:35617895:T:C	W227R	0.981
19:35613758:T:A	W43R	0.954
19:35613758:T:C	W43R	0.954
19:35622940:T:A	W617R	0.947
19:35622940:T:C	W617R	0.947
19:35612833:G:C	W13C	0.943
19:35612833:G:T	W13C	0.943
19:35619027:T:C	I386T	0.942
19:35617323:T:C	F198L	0.936
19:35617325:C:A	F198L	0.936
19:35617325:C:G	F198L	0.936
19:35613760:G:C	W43C	0.934
19:35613760:G:T	W43C	0.934
19:35622952:T:A	W621R	0.931
19:35622952:T:C	W621R	0.931
19:35617897:G:C	W227C	0.930
19:35617897:G:T	W227C	0.930
19:35622732:T:A	W595R	0.929
19:35622732:T:C	W595R	0.929
19:35622879:G:C	W596C	0.915
19:35622879:G:T	W596C	0.915
19:35622954:G:C	W621C	0.915
19:35622954:G:T	W621C	0.915
19:35619455:T:C	I404T	0.908
19:35619477:G:C	K411N	0.908
19:35619477:G:T	K411N	0.908
19:35618575:T:A	W298R	0.905
19:35618575:T:C	W298R	0.905
19:35622942:G:C	W617C	0.904

dbSNP variants (sampled 300 via entrez): RS1000060718 (19:35616478 C>T), RS1000080171 (19:35610820 C>G), RS1000195038 (19:35610954 G>A), RS1000822204 (19:35613065 G>C), RS1001376111 (19:35613459 C>A), RS1001410562 (19:35616056 C>A,T), RS1001824411 (19:35611920 C>G), RS1001846921 (19:35618261 G>A), RS1001996802 (19:35624109 T>G), RS1002049247 (19:35623840 G>A,T), RS1002300687 (19:35617946 C>T), RS1002369534 (19:35611761 A>T), RS1002900592 (19:35616667 G>A), RS1003057583 (19:35622528 T>C), RS1003622689 (19:35620024 G>A,T)

Disease associations

OMIM: gene MIM:613432 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases reaction, increases expression, affects expression, affects binding	3
bisphenol A	affects cotreatment, increases methylation, affects expression, increases abundance	2
ginger extract	affects cotreatment, affects expression, increases abundance	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
butyraldehyde	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
chromium hexavalent ion	decreases expression, increases abundance	1
jinfukang	increases expression	1
NSC 689534	affects binding, decreases expression	1
(+)-JQ1 compound	decreases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Benzo(a)pyrene	decreases methylation	1
Calcitriol	decreases expression, affects cotreatment	1
Cisplatin	increases expression	1
Copper	affects binding, decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Diethylhexyl Phthalate	decreases expression	1
Doxorubicin	decreases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Oils, Volatile	affects cotreatment, affects expression, increases abundance	1
Smoke	decreases expression	1
Testosterone	affects cotreatment, decreases expression	1
Tetrachlorodibenzodioxin	affects expression	1
Urethane	decreases expression	1
Valproic Acid	decreases expression	1
Aflatoxin B1	increases methylation	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.