HAUS8

Summary

HAUS8 (HAUS augmin like complex subunit 8, HGNC:30532) is a protein-coding gene on chromosome 19p13.11, encoding HAUS augmin-like complex subunit 8 (Q9BT25). Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. It is a selective cancer dependency (DepMap: 79.7% of cell lines).

HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb ‘augmentare,’ meaning ’to increase.’ The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).

Source: NCBI Gene 93323 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 87 total
• Cancer dependency (DepMap): dependent in 79.7% of screened cell lines
• MANE Select transcript: NM_033417

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30532
Approved symbol	HAUS8
Name	HAUS augmin like complex subunit 8
Location	19p13.11
Locus type	gene with protein product
Status	Approved
Aliases	MGC20533, NY-SAR-48
Ensembl gene	ENSG00000131351
Ensembl biotype	protein_coding
OMIM	613434
Entrez	93323

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 5 protein_coding, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000253669, ENST00000448593, ENST00000593360, ENST00000595958, ENST00000597479, ENST00000597917, ENST00000598517, ENST00000601564, ENST00000936148, ENST00000936149

RefSeq mRNA: 2 — MANE Select: NM_033417 NM_001011699, NM_033417

CCDS: CCDS32948, CCDS46009

Canonical transcript exons

ENST00000253669 — 11 exons

Exon	Start	End
ENSE00000899834	17073274	17073335
ENSE00001333001	17075394	17075452
ENSE00003204461	17049729	17050176
ENSE00003493580	17059557	17059651
ENSE00003495265	17052825	17052966
ENSE00003511247	17058811	17058876
ENSE00003593841	17069031	17069086
ENSE00003600780	17062698	17062779
ENSE00003647633	17059997	17060092
ENSE00003687808	17055861	17056002
ENSE00003687910	17058549	17058707

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 90.81.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.4235 / max 88.6392, expressed in 1284 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179833	3.3461	1274
179832	0.0774	39

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.87	gold quality
granulocyte	CL:0000094	87.66	gold quality
mucosa of transverse colon	UBERON:0004991	84.28	gold quality
right testis	UBERON:0004534	83.64	gold quality
left testis	UBERON:0004533	83.35	gold quality
ventricular zone	UBERON:0003053	83.19	gold quality
testis	UBERON:0000473	82.42	gold quality
ganglionic eminence	UBERON:0004023	81.85	gold quality
spleen	UBERON:0002106	80.42	gold quality
secondary oocyte	CL:0000655	80.02	gold quality
lymph node	UBERON:0000029	79.80	gold quality
vermiform appendix	UBERON:0001154	79.67	gold quality
lower esophagus mucosa	UBERON:0035834	79.47	gold quality
leukocyte	CL:0000738	78.98	gold quality
transverse colon	UBERON:0001157	78.88	gold quality
right lobe of liver	UBERON:0001114	78.73	gold quality
monocyte	CL:0000576	78.53	gold quality
bone marrow cell	CL:0002092	78.10	gold quality
small intestine Peyer’s patch	UBERON:0003454	77.95	gold quality
apex of heart	UBERON:0002098	77.85	gold quality
stromal cell of endometrium	CL:0002255	77.55	gold quality
left adrenal gland	UBERON:0001234	77.07	gold quality
popliteal artery	UBERON:0002250	76.88	gold quality
tibial artery	UBERON:0007610	76.88	gold quality
descending thoracic aorta	UBERON:0002345	76.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	76.85	gold quality
left adrenal gland cortex	UBERON:0035825	76.85	gold quality
right adrenal gland	UBERON:0001233	76.64	gold quality
right adrenal gland cortex	UBERON:0035827	76.63	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.04
E-MTAB-4850	no	167.27

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

28 targeting HAUS8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-106A-5P	99.90	73.94	2683
HSA-MIR-17-5P	99.89	73.83	2665
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-106B-5P	99.88	74.72	2795
HSA-MIR-20A-5P	99.88	74.76	2769
HSA-MIR-20B-5P	99.88	74.01	2621
HSA-MIR-519D-3P	99.88	73.97	2607
HSA-MIR-526B-3P	99.88	74.06	2587
HSA-MIR-93-5P	99.88	73.98	2606
HSA-MIR-373-3P	99.84	70.68	1668
HSA-MIR-520E-3P	99.84	70.55	1698
HSA-MIR-372-3P	99.83	70.58	1691
HSA-MIR-520A-3P	99.83	70.59	1687
HSA-MIR-520B-3P	99.83	70.56	1699
HSA-MIR-520C-3P	99.83	70.56	1699
HSA-MIR-520D-3P	99.83	70.78	1676
HSA-MIR-3609	99.52	69.89	2587
HSA-MIR-548AH-5P	99.52	69.73	2626
HSA-MIR-142-5P	99.48	70.92	2416
HSA-MIR-5590-3P	99.48	70.91	2429
HSA-MIR-3140-5P	99.39	69.04	1136
HSA-MIR-4796-3P	99.08	68.38	1681
HSA-MIR-299-5P	98.56	71.14	1140

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 79.7% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 5)

• Hice1 is a novel microtubule-associated protein important for maintaining spindle integrity and chromosomal stability, in part by virtue of its ability to bind, bundle, and stabilize microtubules. (PMID:18362163)
• Results suggest that Hec1, through cooperation with Hice1, contributes to centrosome-directed microtubule growth to facilitate establishing a proper mitotic spindle. (PMID:19776357)
• Aurora-A modulates the microtubule binding activity of Hice1 in a spatiotemporal manner for proper bipolar spindle assembly. (PMID:21705324)
• Hice1 and hDgt6 are core components of distinct augmin sub-complexes. (PMID:25173975)
• these results demonstrated that HAUS8 may function as a positive regulator of RLRVISA dependent antiviral signaling by targeting the VISA complex, providing a novel regulatory mechanism of antiviral responses (PMID:29916539)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	haus8	ENSDARG00000109646
mus_musculus	Haus8	ENSMUSG00000035439
rattus_norvegicus	Haus8	ENSRNOG00000052038

Protein

Protein identifiers

HAUS augmin-like complex subunit 8 — Q9BT25 (reviewed: Q9BT25)

Alternative names: HEC1/NDC80-interacting centrosome-associated protein 1, Sarcoma antigen NY-SAR-48

All UniProt accessions (3): Q9BT25, M0R1H1, M0R3B3

UniProt curated annotations — full annotation on UniProt →

Function. Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.

Subunit / interactions. Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. Associates with microtubules. The interaction with microtubules is strong during mitosis, while it is weak or absent during interphase. It is unclear whether this interaction is direct or indirect. Interacts with EML3 (phosphorylated at ‘Thr-881’) and TUBG1.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Spindle. Spindle pole.

Similarity. Belongs to the HAUS8 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9BT25-1	1	yes
Q9BT25-2	2
Q9BT25-3	3

RefSeq proteins (2): NP_001011699, NP_219485* (*=MANE)

Domains & families (InterPro)

UniProt features (20 total): sequence conflict 7, region of interest 3, splice variant 2, compositionally biased region 2, modified residue 2, initiator methionine 1, chain 1, sequence variant 1, coiled-coil region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7SQK	ELECTRON MICROSCOPY	8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BT25-F1	69.89	0.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 105

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259	Loss of Nlp from mitotic centrosomes
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912	Anchoring of the basal body to the plasma membrane
R-HSA-8854518	AURKA Activation by TPX2

MSigDB gene sets: 204 (showing top): GOBP_REGULATION_OF_PROTEIN_POLYMERIZATION, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, GOBP_MICROTUBULE_NUCLEATION, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION, GOCC_CENTROSOME, GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, GOBP_ORGANELLE_ASSEMBLY, FISCHER_DREAM_TARGETS, GOBP_SPINDLE_ASSEMBLY, GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION, GOBP_REGULATION_OF_CYTOSKELETON_ORGANIZATION, GOBP_MICROTUBULE_POLYMERIZATION, GOCC_SPINDLE

GO Biological Process (4): centrosome cycle (GO:0007098), regulation of microtubule nucleation (GO:0010968), spindle assembly (GO:0051225), cell division (GO:0051301)

GO Molecular Function (2): microtubule binding (GO:0008017), protein binding (GO:0005515)

GO Cellular Component (10): spindle pole (GO:0000922), cytoplasm (GO:0005737), centrosome (GO:0005813), cytosol (GO:0005829), nuclear microtubule (GO:0005880), HAUS complex (GO:0070652), mitotic spindle microtubule (GO:1990498), spindle (GO:0005819), cytoskeleton (GO:0005856), microtubule (GO:0005874)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
G2/M Transition	2
Centrosome maturation	2
Loss of proteins required for interphase microtubule organization from the centrosome	1
Mitotic Prometaphase	1
Assembly of the 9+0 primary cilium	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
microtubule cytoskeleton	2
intracellular membraneless organelle	2
cell cycle process	1
microtubule organizing center organization	1
microtubule nucleation	1
regulation of microtubule polymerization	1
spindle organization	1
chromosome segregation	1
membraneless organelle assembly	1
cellular process	1
tubulin binding	1
binding	1
spindle	1
intracellular anatomical structure	1
centriole	1
microtubule organizing center	1
cytoplasm	1
nucleus	1
microtubule	1
microtubule associated complex	1
spindle microtubule	1
mitotic spindle	1
polymeric cytoskeletal fiber	1

Protein interactions and networks

STRING

930 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HAUS8	HAUS6	Q7Z4H7	977
HAUS8	HAUS3	Q68CZ6	824
HAUS8	HAUS1	Q96CS2	781
HAUS8	NDC80	O14777	770
HAUS8	HAUS7	Q99871	758
HAUS8	TUBG1	P23258	754
HAUS8	HAUS5	O94927	743
HAUS8	HAUS4	Q9H6D7	703
HAUS8	NUMA1	Q14980	703
HAUS8	HAUS2	Q9NVX0	678
HAUS8	NEDD1	Q8NHV4	669
HAUS8	GPR137C	Q8N3F9	522
HAUS8	ULK4	Q96C45	517
HAUS8	FBXO47	Q5MNV8	456
HAUS8	SYCE2	Q6PIF2	453

IntAct

200 interactions, top by confidence:

A	B	Type	Score
CEP97	CCP110	psi-mi:“MI:2364”(proximity)	0.950
MED4	MED19	psi-mi:“MI:2364”(proximity)	0.900
CEP290	CCP110	psi-mi:“MI:2364”(proximity)	0.890
HAUS2	HAUS6	psi-mi:“MI:0915”(physical association)	0.880
HAUS6	HAUS8	psi-mi:“MI:0915”(physical association)	0.850
HAUS6	HAUS8	psi-mi:“MI:0407”(direct interaction)	0.850
HAUS8	HAUS6	psi-mi:“MI:0407”(direct interaction)	0.850
HAUS1	HAUS6	psi-mi:“MI:0915”(physical association)	0.810
HAUS1	HAUS5	psi-mi:“MI:0915”(physical association)	0.780
HAUS1	HAUS5	psi-mi:“MI:0914”(association)	0.780
HAUS2	HAUS5	psi-mi:“MI:0914”(association)	0.730
HAUS6	HAUS5	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
CEP170	KIF2A	psi-mi:“MI:2364”(proximity)	0.650
HAUS4	HAUS5	psi-mi:“MI:0914”(association)	0.640
Haus4	HAUS5	psi-mi:“MI:0914”(association)	0.560

BioGRID (175): HAUS8 (Affinity Capture-MS), HAUS8 (Affinity Capture-MS), HAUS8 (Affinity Capture-MS), HAUS8 (Affinity Capture-MS), HAUS8 (Two-hybrid), HAUS8 (Proximity Label-MS), HAUS8 (Proximity Label-MS), HAUS8 (Proximity Label-MS), HAUS8 (Proximity Label-MS), HAUS8 (Proximity Label-MS), HAUS8 (Proximity Label-MS), HAUS8 (Proximity Label-MS), HAUS8 (Proximity Label-MS), HAUS8 (Proximity Label-MS), HAUS8 (Proximity Label-MS)

ESM2 similar proteins: A0A059XKS9, A0A125YS36, A0A125YYR0, A0A7J6K144, A0A7J6K7I9, A0A7J6K7Y0, A4HK17, A4I7K1, B5APK2, B9Q0C2, E9PSU6, F2YGR7, F4IVL6, F6N7K6, O04064, O48767, P0CH66, P23915, P24686, Q2PAY2, Q2PAY3, Q384Y0, Q387Y5, Q388F1, Q40504, Q40505, Q4CTY5, Q4D7L5, Q4DHA1, Q4Q5P8, Q57XK8, Q57XV5, Q580X6, Q5R4R7, Q6B9Y8, Q6GV23, Q75CM4, Q80TL4, Q84VW5, Q8L5Y5

Diamond homologs: Q0IHJ3, Q99L00, Q9BT25, Q5BK57

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
HAUS8	“form complex”	“HAUS complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 165 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Anchoring of the basal body to the plasma membrane	27	29.1×	2e-30
Loss of Nlp from mitotic centrosomes	19	28.7×	4e-21
Loss of proteins required for interphase microtubule organization from the centrosome	19	28.7×	4e-21
AURKA Activation by TPX2	19	27.6×	8e-21
Recruitment of mitotic centrosome proteins and complexes	20	25.9×	4e-21
Regulation of PLK1 Activity at G2/M Transition	19	23.0×	2e-19
Recruitment of NuMA to mitotic centrosomes	20	22.2×	5e-20
Centrosome maturation	6	14.5×	2e-04

GO biological processes:

GO term	Partners	Fold	FDR
centriole replication	9	45.5×	1e-10
centrosome cycle	10	23.2×	3e-09
spindle assembly	7	21.4×	4e-06
non-motile cilium assembly	10	20.0×	1e-08
motile cilium assembly	5	20.0×	4e-04
cilium assembly	18	9.1×	3e-10
intracellular protein localization	10	7.2×	1e-04
cell division	18	5.7×	4e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	62
Likely benign	4
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2007 predictions. Top by Δscore:

Variant	Effect	Δscore
19:17052820:GGTAC:G	donor_loss	1.0000
19:17052823:ACCTT:A	donor_loss	1.0000
19:17052836:AAGGT:A	donor_gain	1.0000
19:17052858:T:TA	donor_gain	1.0000
19:17052964:CGT:C	acceptor_gain	1.0000
19:17055859:ACCT:A	donor_loss	1.0000
19:17055860:C:CT	donor_loss	1.0000
19:17055915:G:A	donor_gain	1.0000
19:17055999:CGAT:C	acceptor_gain	1.0000
19:17056000:GAT:G	acceptor_gain	1.0000
19:17056002:TCT:T	acceptor_loss	1.0000
19:17056003:C:CC	acceptor_gain	1.0000
19:17056003:C:T	acceptor_loss	1.0000
19:17058540:A:AC	donor_gain	1.0000
19:17058541:C:CC	donor_gain	1.0000
19:17058541:CAA:C	donor_gain	1.0000
19:17058581:T:TA	donor_gain	1.0000
19:17058878:T:C	acceptor_gain	1.0000
19:17059652:C:CC	acceptor_gain	1.0000
19:17073269:CTTA:C	donor_loss	1.0000
19:17073270:TTAC:T	donor_loss	1.0000
19:17073271:TA:T	donor_loss	1.0000
19:17073332:CTTC:C	acceptor_gain	1.0000
19:17073333:TTC:T	acceptor_gain	1.0000
19:17073334:TC:T	acceptor_gain	1.0000
19:17073334:TCC:T	acceptor_loss	1.0000
19:17073335:CC:C	acceptor_gain	1.0000
19:17073336:C:CC	acceptor_gain	1.0000
19:17073336:C:G	acceptor_loss	1.0000
19:17073337:T:A	acceptor_loss	1.0000

AlphaMissense

2661 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:17069063:A:C	Y39D	0.985
19:17069063:A:G	Y39H	0.983
19:17055933:C:G	A239P	0.982
19:17058674:C:G	A174P	0.982
19:17055908:A:G	L247P	0.979
19:17055929:A:G	L240P	0.978
19:17058846:A:G	S151P	0.978
19:17069062:T:G	Y39S	0.977
19:17050130:C:G	A326P	0.976
19:17050153:A:G	L318P	0.976
19:17058830:A:G	L156P	0.976
19:17052831:A:G	L308P	0.975
19:17055938:G:T	A237D	0.974
19:17055951:A:C	Y233D	0.973
19:17050127:C:G	A327P	0.972
19:17055939:C:G	A237P	0.972
19:17058836:A:G	L154P	0.972
19:17060057:A:G	S89P	0.972
19:17058821:A:G	L159P	0.971
19:17069059:A:G	L40P	0.967
19:17069063:A:T	Y39N	0.967
19:17069062:T:C	Y39C	0.966
19:17050137:G:C	S323R	0.965
19:17050137:G:T	S323R	0.965
19:17050139:T:G	S323R	0.965
19:17055926:T:A	D241V	0.964
19:17058824:A:G	L158P	0.963
19:17060002:A:T	I107N	0.963
19:17060053:G:T	T90K	0.962
19:17069066:G:C	R38G	0.962

dbSNP variants (sampled 300 via entrez): RS1000007759 (19:17069713 C>T), RS1000015982 (19:17070362 C>T), RS1000077348 (19:17073265 A>G), RS1000233578 (19:17061991 A>G), RS1000244382 (19:17067577 G>C), RS1000406227 (19:17077513 C>T), RS1000579932 (19:17066270 A>T), RS1000747911 (19:17076325 G>A), RS1000804311 (19:17051444 G>A,C,T), RS1000835335 (19:17051784 T>C), RS1000970963 (19:17071183 T>G), RS1000996019 (19:17057365 T>A), RS1001059744 (19:17050963 G>A), RS1001117057 (19:17062659 C>A,T), RS1001144794 (19:17062879 T>C)

Disease associations

OMIM: gene MIM:613434 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST003814_3	Selective IgA deficiency	2.000000e-07
GCST004863_38	Mosquito bite size	5.000000e-06
GCST90002391_108	Mean corpuscular hemoglobin concentration	8.000000e-09
GCST90020025_1420	Waist-to-hip ratio adjusted for BMI	4.000000e-10
GCST90020027_132	Waist-hip index	4.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0008378	mosquito bite reaction size measurement
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, increases abundance, decreases expression, affects cotreatment	2
Resveratrol	increases expression, affects cotreatment	2
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	decreases phosphorylation	1
ginger extract	affects expression, increases abundance, affects cotreatment	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	increases expression	1
perfluorooctanoic acid	decreases expression	1
zinc chromate	decreases expression, increases abundance	1
benzo(e)pyrene	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
CGP 52608	affects binding, increases reaction	1
jinfukang	increases expression	1
Temozolomide	increases expression	1
Sunitinib	decreases expression	1
Leflunomide	decreases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	increases phosphorylation	1
Calcitriol	decreases expression, affects cotreatment	1
Coumestrol	affects cotreatment, increases expression	1
Dimethyl Sulfoxide	increases expression	1
Ivermectin	decreases expression	1
Lead	affects expression	1
Methapyrilene	increases methylation	1
Methyl Methanesulfonate	increases expression	1
Mustard Gas	decreases expression	1
Oils, Volatile	affects cotreatment, affects expression, increases abundance	1
Oxygen	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.