HCFC2

Summary

HCFC2 (host cell factor C2, HGNC:24972) is a protein-coding gene on chromosome 12q23.3, encoding Host cell factor 2 (Q9Y5Z7).

This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described.

Source: NCBI Gene 29915 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 68 total
• MANE Select transcript: NM_013320

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24972
Approved symbol	HCFC2
Name	host cell factor C2
Location	12q23.3
Locus type	gene with protein product
Status	Approved
Aliases	HCF-2
Ensembl gene	ENSG00000111727
Ensembl biotype	protein_coding
OMIM	607926
Entrez	29915

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 2 retained_intron, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000229330, ENST00000544223, ENST00000547194, ENST00000550335, ENST00000550444, ENST00000552343, ENST00000894561, ENST00000894562, ENST00000894563

RefSeq mRNA: 1 — MANE Select: NM_013320 NM_013320

CCDS: CCDS9097

Canonical transcript exons

ENST00000229330 — 15 exons

Exon	Start	End
ENSE00001104674	104102959	104106524
ENSE00001104675	104080746	104080830
ENSE00001104678	104087986	104088038
ENSE00001104682	104086847	104087014
ENSE00001104685	104079445	104079653
ENSE00001104687	104082713	104082901
ENSE00001104691	104067947	104068107
ENSE00001513397	104064531	104064723
ENSE00003463160	104101968	104102153
ENSE00003471401	104066167	104066315
ENSE00003527177	104095360	104095563
ENSE00003546291	104098343	104098480
ENSE00003551467	104082500	104082606
ENSE00003641940	104093386	104093563
ENSE00003645368	104096360	104096433

Expression profiles

Bgee: expression breadth ubiquitous, 264 present calls, max score 92.65.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.3295 / max 75.8534, expressed in 1411 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
127724	3.3295	1411

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	92.65	gold quality
sperm	CL:0000019	92.10	gold quality
left testis	UBERON:0004533	91.42	gold quality
right testis	UBERON:0004534	90.71	gold quality
testis	UBERON:0000473	90.64	gold quality
germinal epithelium of ovary	UBERON:0001304	90.25	gold quality
male germ cell	CL:0000015	89.60	gold quality
cauda epididymis	UBERON:0004360	88.79	gold quality
tendon	UBERON:0000043	88.28	gold quality
mucosa of stomach	UBERON:0001199	87.76	gold quality
muscle layer of sigmoid colon	UBERON:0035805	87.56	gold quality
gastrocnemius	UBERON:0001388	87.14	gold quality
biceps brachii	UBERON:0001507	87.13	gold quality
adrenal tissue	UBERON:0018303	86.99	gold quality
islet of Langerhans	UBERON:0000006	86.67	gold quality
muscle of leg	UBERON:0001383	86.40	gold quality
tibial artery	UBERON:0007610	86.34	gold quality
popliteal artery	UBERON:0002250	86.33	gold quality
oocyte	CL:0000023	86.22	gold quality
lower esophagus muscularis layer	UBERON:0035833	86.07	gold quality
lower esophagus	UBERON:0013473	86.05	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	86.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	85.97	gold quality
colonic epithelium	UBERON:0000397	85.46	gold quality
Brodmann (1909) area 23	UBERON:0013554	85.44	gold quality
cortical plate	UBERON:0005343	85.41	gold quality
parietal pleura	UBERON:0002400	85.29	gold quality
aorta	UBERON:0000947	85.01	gold quality
visceral pleura	UBERON:0002401	84.95	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	84.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.70

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

207 targeting HCFC2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-9-5P	100.00	72.28	2361
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-5696	99.98	72.36	4487

Literature-anchored findings (GeneRIF, showing 1)

• HCF-2 is broadly present in human and mouse cells, and possesses activities distinct from HCF-1 (PMID:31049581)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Hcfc2	ENSMUSG00000020246
rattus_norvegicus	Hcfc2	ENSRNOG00000053510
drosophila_melanogaster	Hcf	FBGN0039904
caenorhabditis_elegans		WBGENE00001827

Paralogs (10): FBXO42 (ENSG00000037637), LZTR1 (ENSG00000099949), KLHDC4 (ENSG00000104731), KLHDC3 (ENSG00000124702), KLHDC10 (ENSG00000128607), RABEPK (ENSG00000136933), KLHDC9 (ENSG00000162755), KLHDC2 (ENSG00000165516), HCFC1 (ENSG00000172534), KLHDC1 (ENSG00000197776)

Protein

Protein identifiers

Host cell factor 2 — Q9Y5Z7 (reviewed: Q9Y5Z7)

Alternative names: C2 factor

All UniProt accessions (2): Q9Y5Z7, F8VU09

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2. Interacts with TASOR.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y5Z7-1	1	yes
Q9Y5Z7-2	2

RefSeq proteins (1): NP_037452* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003961	FN3_dom	Domain
IPR011043	Gal_Oxase/kelch_b-propeller	Homologous_superfamily
IPR013783	Ig-like_fold	Homologous_superfamily
IPR015915	Kelch-typ_b-propeller	Homologous_superfamily
IPR036116	FN3_sf	Homologous_superfamily
IPR043536	HCF1/2	Family
IPR059124	Kelch_HCF	Domain

Pfam: PF13854

UniProt features (15 total): repeat 4, domain 3, splice variant 2, sequence variant 2, chain 1, cross-link 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y5Z7-F1	73.78	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 553

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes

MSigDB gene sets: 189 (showing top): GSE45365_NK_CELL_VS_CD8A_DC_MCMV_INFECTION_DN, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, CAGCTG_AP4_Q5, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, TGIF_01, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_DEFENSE_RESPONSE_TO_VIRUS, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS, GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_INTRACELLULAR_RECEPTOR_SIGNALING_PATHWAY, GOBP_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS, GOBP_CYTOPLASMIC_PATTERN_RECOGNITION_RECEPTOR_SIGNALING_PATHWAY

GO Biological Process (9): negative regulation of transcription by RNA polymerase II (GO:0000122), chromatin remodeling (GO:0006338), regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357), viral process (GO:0016032), regulation of toll-like receptor 3 signaling pathway (GO:0034139), antiviral innate immune response (GO:0140374), immune response involved in response to exogenous dsRNA (GO:1902615), positive regulation of DNA-templated transcription (GO:0045893)

GO Molecular Function (3): transcription coactivator activity (GO:0003713), transcription coregulator activity (GO:0003712), protein binding (GO:0005515)

GO Cellular Component (9): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytosol (GO:0005829), plasma membrane (GO:0005886), histone methyltransferase complex (GO:0035097), MLL1/2 complex (GO:0044665), Set1C/COMPASS complex (GO:0048188), MLL1 complex (GO:0071339)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Epigenetic regulation by WDR5-containing histone modifying complexes	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
transcription by RNA polymerase II	2
DNA-templated transcription	2
regulation of DNA-templated transcription	2
histone methyltransferase complex	2
regulation of transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
chromatin organization	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
biological_process	1
toll-like receptor 3 signaling pathway	1
regulation of cytoplasmic pattern recognition receptor signaling pathway	1
innate immune response	1
defense response to virus	1
immune response	1
response to exogenous dsRNA	1
positive regulation of RNA biosynthetic process	1
transcription coregulator activity	1
positive regulation of DNA-templated transcription	1
transcription regulator activity	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
cytoplasm	1
membrane	1
cell periphery	1
nucleoplasm	1
methyltransferase complex	1
nuclear protein-containing complex	1
MLL1/2 complex	1

Protein interactions and networks

STRING

774 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HCFC2	CREBZF	Q9NS37	971
HCFC2	CREB3	O43889	868
HCFC2	POU2F1	P14859	836
HCFC2	CREB3L4	Q8TEY5	832
HCFC2	POU2F2	P09086	764
HCFC2	WDR5	P61964	560
HCFC2	RBBP5	Q15291	556
HCFC2	IRF2	P14316	506
HCFC2	TET1	Q8NFU7	469
HCFC2	NPC1	O15118	451
HCFC2	TMPRSS2	O15393	448
HCFC2	PPARGC1A	Q9UBK2	441
HCFC2	TET2	Q6N021	439
HCFC2	CTSB	P07858	433
HCFC2	RNF2	Q99496	433

IntAct

64 interactions, top by confidence:

A	B	Type	Score
WDR5	KMT2D	psi-mi:“MI:0914”(association)	0.910
ASH2L	KMT2D	psi-mi:“MI:0914”(association)	0.890
RBBP5	KMT2D	psi-mi:“MI:0914”(association)	0.840
RAMAC	RNMT	psi-mi:“MI:0914”(association)	0.810
NFE2L3	MAFG	psi-mi:“MI:0914”(association)	0.780
BAP1	OGT	psi-mi:“MI:0914”(association)	0.730
WDR5	MEN1	psi-mi:“MI:0914”(association)	0.710
HCFC2	NUDCD3	psi-mi:“MI:0915”(physical association)	0.670
CSNK2B	RPS6KA4	psi-mi:“MI:0914”(association)	0.640
PPP2R2B	MYO9A	psi-mi:“MI:0914”(association)	0.640
KMT2A	MEN1	psi-mi:“MI:0914”(association)	0.640
HCFC2	SETD1A	psi-mi:“MI:0914”(association)	0.530
THAP2	OGT	psi-mi:“MI:0914”(association)	0.530
IRF2	CTSS	psi-mi:“MI:0914”(association)	0.530
CREB3	MYO9A	psi-mi:“MI:0914”(association)	0.530
GLMN	MGST3	psi-mi:“MI:0914”(association)	0.530
ZNF597	HCFC1	psi-mi:“MI:0914”(association)	0.530
BAP1	HAT1	psi-mi:“MI:0914”(association)	0.530
PPP2R2B	DDX3X	psi-mi:“MI:0914”(association)	0.460
FOXO3	HCFC2	psi-mi:“MI:0915”(physical association)	0.400
HCFC2	SIRT1	psi-mi:“MI:0915”(physical association)	0.400
HCFC2	MEN1	psi-mi:“MI:0915”(physical association)	0.400
NUDC	HCFC2	psi-mi:“MI:0915”(physical association)	0.400
Set	ZKSCAN1	psi-mi:“MI:0914”(association)	0.350
IRF2	VWA8	psi-mi:“MI:0914”(association)	0.350

BioGRID (158): HCFC2 (Affinity Capture-MS), HCFC2 (Affinity Capture-MS), HCFC2 (Affinity Capture-MS), HCFC2 (Affinity Capture-MS), HCFC2 (Affinity Capture-MS), KMT2B (Affinity Capture-MS), KMT2A (Affinity Capture-MS), CXXC1 (Affinity Capture-MS), SETD1A (Affinity Capture-MS), DIDO1 (Affinity Capture-MS), BOD1L1 (Affinity Capture-MS), ASH2L (Affinity Capture-MS), CCT2 (Affinity Capture-MS), HCFC2 (Affinity Capture-MS), CCT6B (Affinity Capture-MS)

ESM2 similar proteins: A1Z7A6, A8Y3R9, B0WAU8, B3NKK1, B4IMC3, B4IT27, B4NSS9, G5EC23, G5EEW9, G5EFD2, H2KZW3, O43150, O45487, O61460, O73630, P24583, P36582, Q09441, Q09589, Q10149, Q12469, Q13972, Q19857, Q20500, Q45FX5, Q4P3S3, Q5ACW8, Q5DX34, Q5RDX4, Q5RKG2, Q6BU95, Q6DTM3, Q6NRL1, Q754R5, Q7PLI7, Q7S9B6, Q7SIG6, Q8BXK8, Q8K3E5, Q8TBZ3

Diamond homologs: A8JAM0, D3ZN95, P38853, P51610, P51611, Q2R2W1, Q39610, Q4V516, Q5E9A7, Q5RKG2, Q61191, Q6PDJ6, Q7M3S9, Q86L99, Q8N7A1, Q8RWD9, Q9D968, Q9MA55, Q9V4C8, Q9Y5Z7, G5EC23, Q10AZ7, Q4V8F4, Q53EP0, Q5RDA9, Q6AYI2, Q6NWW9, Q6P3S6, Q8H4D4, Q8VEM9, Q93XW5, Q9BQ90, A1XLE2, G1FNI6, O04316, O04318, O49326, Q5EA50, Q5ZJ37, Q6AXB2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 78 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of WDR5-containing histone-modifying complexes	12	58.0×	2e-16
Deactivation of the beta-catenin transactivating complex	6	25.4×	7e-06
Epigenetic regulation by WDR5-containing histone modifying complexes	8	22.4×	3e-07
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes	6	21.5×	2e-05
Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)	7	18.6×	7e-06
PKMTs methylate histone lysines	6	17.6×	4e-05
Formation of the beta-catenin:TCF transactivating complex	8	17.5×	1e-06
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	7	15.3×	2e-05

GO biological processes:

GO term	Partners	Fold	FDR
transcription initiation-coupled chromatin remodeling	5	26.6×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

68 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2238 predictions. Top by Δscore:

Variant	Effect	Δscore
12:104064722:GG:G	donor_gain	1.0000
12:104064723:GG:G	donor_gain	1.0000
12:104064723:GGT:G	donor_loss	1.0000
12:104064724:GTAG:G	donor_loss	1.0000
12:104064725:T:G	donor_loss	1.0000
12:104066157:T:TA	acceptor_gain	1.0000
12:104066158:G:A	acceptor_gain	1.0000
12:104066161:A:AG	acceptor_gain	1.0000
12:104066162:A:G	acceptor_gain	1.0000
12:104066316:G:GG	donor_gain	1.0000
12:104067942:TTTA:T	acceptor_loss	1.0000
12:104067945:A:AG	acceptor_gain	1.0000
12:104067946:G:A	acceptor_loss	1.0000
12:104067946:G:GG	acceptor_gain	1.0000
12:104067946:GGCAA:G	acceptor_gain	1.0000
12:104068104:CCAGG:C	donor_loss	1.0000
12:104068105:CAGGT:C	donor_loss	1.0000
12:104068106:AGGTA:A	donor_loss	1.0000
12:104068108:G:T	donor_loss	1.0000
12:104068109:T:A	donor_loss	1.0000
12:104080744:A:AG	acceptor_gain	1.0000
12:104080745:G:GG	acceptor_gain	1.0000
12:104080831:G:GG	donor_gain	1.0000
12:104082711:A:AG	acceptor_gain	1.0000
12:104082712:G:GA	acceptor_gain	1.0000
12:104082712:GA:G	acceptor_gain	1.0000
12:104082712:GAT:G	acceptor_gain	1.0000
12:104082712:GATA:G	acceptor_gain	1.0000
12:104082712:GATAC:G	acceptor_gain	1.0000
12:104082902:GTAG:G	donor_gain	1.0000

AlphaMissense

5159 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:104064619:C:A	P20H	1.000
12:104064630:C:G	H24D	1.000
12:104064631:A:G	H24R	1.000
12:104064632:C:A	H24Q	1.000
12:104064632:C:G	H24Q	1.000
12:104064633:G:A	G25R	1.000
12:104064633:G:C	G25R	1.000
12:104064634:G:A	G25E	1.000
12:104064634:G:T	G25V	1.000
12:104064661:T:C	L34P	1.000
12:104064675:G:A	G39R	1.000
12:104064675:G:C	G39R	1.000
12:104064676:G:A	G39E	1.000
12:104064676:G:T	G39V	1.000
12:104064678:G:A	G40R	1.000
12:104064678:G:C	G40R	1.000
12:104064678:G:T	G40W	1.000
12:104064679:G:A	G40E	1.000
12:104064679:G:T	G40V	1.000
12:104064681:G:A	G41R	1.000
12:104064681:G:C	G41R	1.000
12:104064682:G:A	G41E	1.000
12:104064686:T:A	N42K	1.000
12:104064686:T:G	N42K	1.000
12:104064690:G:C	G44R	1.000
12:104064712:T:A	V51D	1.000
12:104064714:T:G	Y52D	1.000
12:104066178:T:A	W59R	1.000
12:104066178:T:C	W59R	1.000
12:104066180:G:C	W59C	1.000

dbSNP variants (sampled 300 via entrez): RS1000125776 (12:104082066 TAA>T), RS1000143897 (12:104076761 G>A,C,T), RS1000206894 (12:104065731 G>A), RS1000538136 (12:104080275 C>A), RS1000575728 (12:104066073 T>C,G), RS1000635585 (12:104071305 C>A), RS1000643527 (12:104101252 C>T), RS1000669227 (12:104093932 C>G), RS1000715069 (12:104101633 A>T), RS1000837904 (12:104092193 T>A,G), RS1000851925 (12:104078000 G>A), RS1000905194 (12:104072596 G>A), RS1000948881 (12:104086054 G>C), RS1000980267 (12:104086483 C>A,G), RS1001118234 (12:104093676 A>C,G,T)

Disease associations

OMIM: gene MIM:607926 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010320_5	PR interval	3.000000e-11
GCST010321_76	PR interval	2.000000e-12

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004462	PR interval

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, decreases expression	3
Acetaminophen	decreases expression, increases expression	2
Cadmium Chloride	increases abundance, increases expression	2
bisphenol F	affects cotreatment, increases expression	1
TAK-243	decreases sumoylation	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
bisphenol A	affects cotreatment, increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	decreases expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	increases reaction, affects binding	1
monomethylarsonous acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	decreases expression, affects cotreatment	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Cadmium	increases abundance, increases expression	1
Cisplatin	affects cotreatment, decreases expression	1
Dexamethasone	increases expression, affects cotreatment	1
Diazinon	increases methylation	1
Doxorubicin	decreases expression	1
Endosulfan	increases expression	1
Ethyl Methanesulfonate	increases expression	1
Indomethacin	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.