HCG11

Summary

HCG11 (HLA complex group 11, HGNC:17707) is a long non-coding RNA gene on chromosome 6p22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17707
Approved symbol	HCG11
Name	HLA complex group 11
Location	6p22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	bK14H9.3, FLJ14049, FLJ30357
Ensembl gene	ENSG00000228223
Ensembl biotype	lncRNA
Entrez	493812
RNAcentral	URS000075DE27 — lncRNA, 5688 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000411553, ENST00000770668, ENST00000770669

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411553 — 1 exons

Exon	Start	End
ENSE00001649663	26521709	26527404

Expression profiles

Bgee: expression breadth ubiquitous, 202 present calls, max score 86.24.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 1.4005 / max 20.8486, expressed in 915 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66533	1.4005	915

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	86.24	gold quality
cortical plate	UBERON:0005343	81.52	gold quality
monocyte	CL:0000576	79.51	gold quality
leukocyte	CL:0000738	79.39	gold quality
ventricular zone	UBERON:0003053	78.95	gold quality
left ovary	UBERON:0002119	78.62	gold quality
right ovary	UBERON:0002118	78.02	gold quality
body of uterus	UBERON:0009853	77.96	gold quality
smooth muscle tissue	UBERON:0001135	77.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.55	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.55	gold quality
hindlimb stylopod muscle	UBERON:0004252	76.50	gold quality
lower esophagus	UBERON:0013473	76.50	gold quality
ganglionic eminence	UBERON:0004023	76.16	gold quality
left uterine tube	UBERON:0001303	76.09	gold quality
stromal cell of endometrium	CL:0002255	76.00	gold quality
descending thoracic aorta	UBERON:0002345	75.92	gold quality
right atrium auricular region	UBERON:0006631	75.72	gold quality
muscle of leg	UBERON:0001383	75.51	gold quality
endocervix	UBERON:0000458	75.30	gold quality
right coronary artery	UBERON:0001625	75.23	gold quality
mucosa of stomach	UBERON:0001199	75.01	gold quality
cardiac atrium	UBERON:0002081	74.95	gold quality
thoracic aorta	UBERON:0001515	74.83	gold quality
gastrocnemius	UBERON:0001388	74.82	gold quality
ascending aorta	UBERON:0001496	74.61	gold quality
aorta	UBERON:0000947	74.22	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.18	gold quality
popliteal artery	UBERON:0002250	74.11	gold quality
tibial artery	UBERON:0007610	74.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 23)

• the expression levels of HCG11 in prostate cancer tissues were significantly lower than those in non-tumor tissues, are reported. (PMID:27522256)
• HCG11 exerted its effect on Hepatocellular carcinoma (HCC)via interaction with IGF2BP1, leading to activation of MAPK signaling, which eventually promoted the progression of HCC. (PMID:28677801)
• LncRNA HCG11 suppresses the growth of glioma by cooperating with the miR-4425/MTA3 axis. (PMID:30706982)
• HCG11 was predominantly enriched in the cytoplasm of glioma cells and acted as a competing endogenous RNAs (ceRNAs) by sponging micro-496 to upregulate cytoplasmic polyadenylation element binding protein 3 (CPEB3). (PMID:31310044)
• LncRNA HCG11 accelerates the progression of hepatocellular carcinoma via miR-26a-5p/ATG12 axis. (PMID:31858580)
• LncRNA HCG11 suppresses laryngeal carcinoma cells progression via sponging miR-4469/APOM axis. (PMID:32271435)
• Long non-coding RNA HCG11 sponging miR-522-3p inhibits the tumorigenesis of non-small cell lung cancer by upregulating SOCS5. (PMID:32844573)
• LncRNA HCG11/miR-26b-5p/QKI5 feedback loop reversed high glucose-induced proliferation and angiogenesis inhibition of HUVECs. (PMID:33128346)
• Down-regulation of lncRNA HCG11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR-455-5p. (PMID:33151000)
• Knockdown of lncRNA HCG11 suppresses cell progression in ovarian cancer by modulating miR-144-3p/PBX3. (PMID:33215418)
• Long noncoding RNA HCG11 suppresses the malignant phenotype of nonsmall cell lung cancer cells by targeting a miR875/SATB2 axis. (PMID:34080031)
• lncRNA HCG11 suppresses human osteosarcoma growth through upregulating p27 Kip1. (PMID:34518440)
• LncRNA HCG11 promotes 5-FU resistance of colon cancer cells through reprogramming glucose metabolism by targeting the miR-144-3p-PDK4 axis. (PMID:34542064)
• LncRNA HCG11 mediated by METTL14 inhibits the growth of lung adenocarcinoma via IGF2BP2/LATS1. (PMID:34624573)
• Long non-coding RNA HCG11 enhances osteosarcoma phenotypes by sponging miR-1245b-5p that directly inhibits plakophilin 2. (PMID:34949159)
• LncRNA HCG11 represses ovarian cancer cell growth via AKT signaling pathway. (PMID:35016264)
• Long Non-Coding RNA HCG11 Inhibits Glioma Cells Proliferation and Migration through Decoying miR-590-3p and Up-Regulating CADM2. (PMID:35279660)
• Long-stranded non-coding RNA HCG11 regulates glioma cell proliferation, apoptosis and drug resistance via the sponge MicroRNA-144COX-2 axis. (PMID:35818213)
• LncRNA HCG11 Accelerates Atherosclerosis via Regulating the miR-224-3p/JAK1 Axis. (PMID:35931919)
• HCG11 inhibits salivary adenoid cystic carcinoma by upregulating EphA2 via binding to miR-1297. (PMID:36396591)
• lncRNA HCG11 suppresses cell proliferation in hormone receptor-positive breast cancer via SRSF1/beta-catenin. (PMID:36602530)
• Deregulated Long Non-Coding RNA HCG11 in Cerebral Atherosclerosis Serves as a Biomarker to Predict the Risk of Cerebrovascular Events. (PMID:38082538)
• LncRNA HCG11 enhances the chemosensitivity of non-small cell lung cancer cells to Gemcitabine via miR-17-5p/p21 axis. (PMID:38230690)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.