HCG14

Summary

HCG14 (HLA complex group 14, HGNC:18323) is a long non-coding RNA gene on chromosome 6p22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18323
Approved symbol	HCG14
Name	HLA complex group 14
Location	6p22.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	dJ111M5.4
Ensembl gene	ENSG00000224157
Ensembl biotype	lncRNA
Entrez	414760
RNAcentral	URS000075B70A — lncRNA, 411 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000444986

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000444986 — 2 exons

Exon	Start	End
ENSE00001660898	28897111	28897322
ENSE00004041298	28896428	28896730

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 88.17.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4218 / max 26.3698, expressed in 200 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66643	0.4218	200

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.17	gold quality
right uterine tube	UBERON:0001302	82.34	gold quality
ventricular zone	UBERON:0003053	74.10	gold quality
colonic epithelium	UBERON:0000397	73.70	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.42	gold quality
bone marrow cell	CL:0002092	70.64	silver quality
hindlimb stylopod muscle	UBERON:0004252	67.00	gold quality
fallopian tube	UBERON:0003889	65.83	gold quality
sural nerve	UBERON:0015488	65.02	gold quality
granulocyte	CL:0000094	64.78	gold quality
bone marrow	UBERON:0002371	64.75	gold quality
islet of Langerhans	UBERON:0000006	64.08	gold quality
duodenum	UBERON:0002114	63.79	gold quality
calcaneal tendon	UBERON:0003701	63.53	gold quality
adrenal tissue	UBERON:0018303	62.98	gold quality
skeletal muscle tissue	UBERON:0001134	62.50	gold quality
blood	UBERON:0000178	62.04	gold quality
monocyte	CL:0000576	61.21	gold quality
muscle tissue	UBERON:0002385	60.55	gold quality
liver	UBERON:0002107	59.98	gold quality
gall bladder	UBERON:0002110	59.86	gold quality
endometrium	UBERON:0001295	59.82	gold quality
lymph node	UBERON:0000029	59.45	gold quality
prefrontal cortex	UBERON:0000451	59.13	gold quality
smooth muscle tissue	UBERON:0001135	58.40	gold quality
right lobe of liver	UBERON:0001114	58.01	gold quality
stromal cell of endometrium	CL:0002255	57.96	gold quality
pancreas	UBERON:0001264	57.81	gold quality
adult mammalian kidney	UBERON:0000082	57.51	gold quality
kidney	UBERON:0002113	57.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.84

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• We have identified a novel additional celiac disease risk variant in the lncRNA HCG14. This lncRNA seems to regulate the expression of NOD1 in an allele-specific manner. (PMID:29601440)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.