HCG15

Summary

HCG15 (HLA complex group 15, HGNC:18361) is a long non-coding RNA gene on chromosome 6p21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18361
Approved symbol	HCG15
Name	HLA complex group 15
Location	6p21
Locus type	RNA, long non-coding
Status	Approved
Aliases	dJ25J6.6, dJ25J6.7
Ensembl gene	ENSG00000227214
Ensembl biotype	lncRNA
Entrez	414761
RNAcentral	URS0000ABD815 — lncRNA, 707 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000438190, ENST00000716159, ENST00000716160, ENST00000759769, ENST00000759770, ENST00000759771, ENST00000759772, ENST00000759773, ENST00000759774, ENST00000759775, ENST00000759776, ENST00000759777, ENST00000759778, ENST00000759779, ENST00000759780, ENST00000759781, ENST00000759782

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000438190 — 3 exons

Exon	Start	End
ENSE00001782473	28986313	28986506
ENSE00004028997	28986677	28987484
ENSE00004029004	28986203	28986232

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 65.80.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4425 / max 27.0525, expressed in 247 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66647	0.4425	247

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	65.80	gold quality
sural nerve	UBERON:0015488	65.12	silver quality
ganglionic eminence	UBERON:0004023	63.52	gold quality
cortical plate	UBERON:0005343	62.63	gold quality
endometrium	UBERON:0001295	60.08	gold quality
mucosa of stomach	UBERON:0001199	57.85	gold quality
right lobe of thyroid gland	UBERON:0001119	57.56	gold quality
left lobe of thyroid gland	UBERON:0001120	57.30	gold quality
thyroid gland	UBERON:0002046	57.14	gold quality
left ovary	UBERON:0002119	57.11	gold quality
smooth muscle tissue	UBERON:0001135	57.05	gold quality
ovary	UBERON:0000992	56.78	gold quality
fallopian tube	UBERON:0003889	55.49	gold quality
right uterine tube	UBERON:0001302	55.47	gold quality
gall bladder	UBERON:0002110	54.81	gold quality
popliteal artery	UBERON:0002250	54.81	gold quality
tibial artery	UBERON:0007610	54.74	gold quality
duodenum	UBERON:0002114	54.40	gold quality
body of uterus	UBERON:0009853	54.19	gold quality
rectum	UBERON:0001052	54.06	gold quality
prostate gland	UBERON:0002367	53.99	gold quality
myometrium	UBERON:0001296	53.88	gold quality
ectocervix	UBERON:0012249	53.57	gold quality
right ovary	UBERON:0002118	53.50	gold quality
left coronary artery	UBERON:0001626	52.74	gold quality
descending thoracic aorta	UBERON:0002345	52.73	gold quality
bone marrow	UBERON:0002371	52.66	silver quality
endocervix	UBERON:0000458	52.57	gold quality
prefrontal cortex	UBERON:0000451	52.45	gold quality
thoracic mammary gland	UBERON:0005200	52.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription. (PMID:35427894)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.