HCG18

Summary

HCG18 (HLA complex group 18, HGNC:31337) is a long non-coding RNA gene on chromosome 6p22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31337
Approved symbol	HCG18
Name	HLA complex group 18
Location	6p22.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ31598, FLJ25550, Em:AB014087.1
Ensembl gene	ENSG00000231074
Ensembl biotype	lncRNA
Entrez	414777
RNAcentral	URS000075CE1F — lncRNA, 6820 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 111 — 111 lncRNA

ENST00000412685, ENST00000413358, ENST00000426882, ENST00000438412, ENST00000444126, ENST00000449544, ENST00000453558, ENST00000454129, ENST00000454269, ENST00000455957, ENST00000602290, ENST00000602319, ENST00000602498, ENST00000602516, ENST00000602550, ENST00000602591, ENST00000602698, ENST00000602861, ENST00000653301, ENST00000653541, ENST00000654915, ENST00000654996, ENST00000656629, ENST00000657247, ENST00000657595, ENST00000658695, ENST00000659132, ENST00000659563, ENST00000659836, ENST00000660593, ENST00000664861, ENST00000665953, ENST00000666294, ENST00000668243, ENST00000668974, ENST00000669374, ENST00000670071, ENST00000670397, ENST00000686575, ENST00000687430, ENST00000687471, ENST00000687815, ENST00000691282, ENST00000702209, ENST00000844410, ENST00000844411, ENST00000844412, ENST00000844413, ENST00000844414, ENST00000844415, ENST00000844416, ENST00000844417, ENST00000844418, ENST00000844419, ENST00000844420, ENST00000844421, ENST00000844422, ENST00000844423, ENST00000844424, ENST00000844425, ENST00000844426, ENST00000844427, ENST00000844428, ENST00000844429, ENST00000844430, ENST00000844431, ENST00000844432, ENST00000844433, ENST00000844434, ENST00000844435, ENST00000844436, ENST00000844437, ENST00000844438, ENST00000844439, ENST00000844440, ENST00000844441, ENST00000844442, ENST00000844443, ENST00000844444, ENST00000844445, ENST00000844446, ENST00000844447, ENST00000844448, ENST00000844449, ENST00000844450, ENST00000844451, ENST00000844452, ENST00000844453, ENST00000844454, ENST00000844455, ENST00000844456, ENST00000844457, ENST00000844458, ENST00000844459, ENST00000844460, ENST00000844461, ENST00000844462, ENST00000844463, ENST00000844464, ENST00000844465, ENST00000844466, ENST00000844467, ENST00000844468, ENST00000844469, ENST00000844470, ENST00000844471, ENST00000844472, ENST00000844473, ENST00000844474, ENST00000844475, ENST00000844476

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412685 — 3 exons

Exon	Start	End
ENSE00001767107	30296132	30296237
ENSE00003229579	30291246	30292599
ENSE00004271162	30326354	30326886

Expression profiles

Bgee: expression breadth ubiquitous, 265 present calls, max score 98.60.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.8219 / max 162.8225, expressed in 1799 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
72523	6.6773	1676
72519	3.8398	1475
72518	1.7387	1028
72521	1.1005	758
72525	0.9378	582
72522	0.5783	289
72517	0.3932	120
72524	0.3226	122
72520	0.2338	83

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	98.60	gold quality
colonic epithelium	UBERON:0000397	93.76	gold quality
lateral globus pallidus	UBERON:0002476	90.26	gold quality
lateral nuclear group of thalamus	UBERON:0002736	90.15	gold quality
lower esophagus mucosa	UBERON:0035834	89.81	gold quality
cortical plate	UBERON:0005343	89.44	gold quality
substantia nigra pars compacta	UBERON:0001965	88.72	gold quality
adenohypophysis	UBERON:0002196	88.71	gold quality
sural nerve	UBERON:0015488	88.37	gold quality
granulocyte	CL:0000094	88.25	gold quality
pituitary gland	UBERON:0000007	87.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.71	gold quality
tonsil	UBERON:0002372	87.34	gold quality
subthalamic nucleus	UBERON:0001906	87.17	gold quality
substantia nigra pars reticulata	UBERON:0001966	87.11	gold quality
postcentral gyrus	UBERON:0002581	86.77	gold quality
parietal lobe	UBERON:0001872	86.34	gold quality
superior vestibular nucleus	UBERON:0007227	86.12	gold quality
calcaneal tendon	UBERON:0003701	86.04	gold quality
superficial temporal artery	UBERON:0001614	85.98	gold quality
ganglionic eminence	UBERON:0004023	85.90	gold quality
adrenal tissue	UBERON:0018303	85.87	gold quality
entorhinal cortex	UBERON:0002728	85.76	gold quality
inferior vagus X ganglion	UBERON:0005363	85.27	gold quality
pons	UBERON:0000988	85.21	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.13	gold quality
left ovary	UBERON:0002119	84.87	gold quality
lower lobe of lung	UBERON:0008949	84.80	gold quality
right lobe of thyroid gland	UBERON:0001119	84.63	gold quality
right ovary	UBERON:0002118	84.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• Low HCG18 expression is associated with proliferation and migration of bladder cancer. (PMID:30426533)
• LncRNA HCG18 contributes to nasopharyngeal carcinoma development by modulating miR-140/CCND1 and Hedgehog signaling pathway. (PMID:31841193)
• LncRNA HCG18 contributes to the progression of hepatocellular carcinoma via miR-214-3p/CENPM axis. (PMID:32663252)
• Long noncoding RNA HCG18 up-regulates the expression of WIPF1 and YAP/TAZ by inhibiting miR-141-3p in gastric cancer. (PMID:32725768)
• Long noncoding RNA HCG18 inhibits the differentiation of human bone marrow-derived mesenchymal stem cells in osteoporosis by targeting miR-30a-5p/NOTCH1 axis. (PMID:33176682)
• Identification of HCG18 and MCM3AP-AS1 That Associate With Bone Metastasis, Poor Prognosis and Increased Abundance of M2 Macrophage Infiltration in Prostate Cancer. (PMID:33596783)
• LncRNA-HCG18 regulates the viability, apoptosis, migration, invasion and epithelial-mesenchymal transition of papillary thyroid cancer cells via regulating the miR-106a-5p/PPP2R2A axis. (PMID:33798913)
• Knockdown of HCG18 Inhibits Cell Viability, Migration and Invasion in Pediatric Osteosarcoma by Targeting miR-188-5p/FOXC1 Axis. (PMID:34041718)
• LncRNA HCG18 suppresses CD8(+) T cells to confer resistance to cetuximab in colorectal cancer via miR-20b-5p/PD-L1 axis. (PMID:34523356)
• Long non-coding RNA HLA complex group 18 promotes gastric cancer progression by targeting microRNA-370-3p expression. (PMID:34618022)
• lncRNA HLA Complex Group 18 (HCG18) Facilitated Cell Proliferation, Invasion, and Migration of Prostate Cancer Through Modulating miR-370-3p/DDX3X Axis. (PMID:34708395)
• Long noncoding RNA HCG18 facilitates the progression of laryngeal and hypopharyngeal squamous cell carcinoma by upregulating FGFR1 via miR133b. (PMID:34878161)
• LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b. (PMID:34983361)
• LncRNA HCG18 promotes osteosarcoma growth by enhanced aerobic glycolysis via the miR-365a-3p/PGK1 axis. (PMID:34991445)
• Long non-coding RNA HCG18 promotes gastric cancer progression by regulating miRNA-146a-5p/tumor necrosis factor receptor-associated factor 6 axis. (PMID:35240920)
• Long non-coding RNA human leucocyte antigen complex group-18 HCG18 (HCG18) promoted cell proliferation and migration in head and neck squamous cell carcinoma through cyclin D1-WNT pathway. (PMID:35389764)
• The role of long non-coding RNA HCG18 in cancer. (PMID:36346572)
• LncRNA HCG18 Promotes Osteosarcoma Cells Proliferation, Migration, and Invasion in by Regulating miR-34a/RUNX2 Pathway. (PMID:36401685)
• Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma. (PMID:36786348)
• Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424-5p/SOX9 axis through PI3K/AKT pathway. (PMID:36854894)
• Molecular mechanisms of HCG18 in the sorafenib resistance of hepatocellular carcinoma. (PMID:37823256)
• The role of lncRNA HCG18 in human diseases. (PMID:38425124)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.