HCG22

Summary

HCG22 (HLA complex group 22, HGNC:27780) is a long non-coding RNA gene on chromosome 6p21.33.

Predicted to be located in extracellular region.

Source: NCBI Gene 285834 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27780
Approved symbol	HCG22
Name	HLA complex group 22
Location	6p21.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ37114, PBMUCL2
Ensembl gene	ENSG00000228789
Ensembl biotype	lncRNA
OMIM	613918
Entrez	285834
RNAcentral	URS0002A34C10 — lncRNA, 2055 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 30 lncRNA

ENST00000426185, ENST00000562344, ENST00000565192, ENST00000566475, ENST00000570223, ENST00000805383, ENST00000805384, ENST00000805385, ENST00000805386, ENST00000805387, ENST00000805388, ENST00000805389, ENST00000805390, ENST00000805391, ENST00000805392, ENST00000805393, ENST00000805394, ENST00000805395, ENST00000805396, ENST00000805397, ENST00000805398, ENST00000805399, ENST00000805400, ENST00000805401, ENST00000805402, ENST00000805403, ENST00000805404, ENST00000805405, ENST00000805406, ENST00000805407

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426185 — 3 exons

Exon	Start	End
ENSE00004197603	31054159	31054516
ENSE00004197613	31055710	31056910
ENSE00004197628	31059408	31059894

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 96.69.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2545 / max 43.0608, expressed in 97 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66856	0.1421	61
66857	0.0756	19
66855	0.0369	17

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	96.69	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.21	silver quality
esophagus mucosa	UBERON:0002469	82.47	gold quality
vagina	UBERON:0000996	81.44	gold quality
ventricular zone	UBERON:0003053	74.62	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.53	gold quality
ganglionic eminence	UBERON:0004023	66.25	gold quality
esophagus	UBERON:0001043	64.93	gold quality
substantia nigra	UBERON:0002038	61.53	gold quality
ectocervix	UBERON:0012249	59.37	gold quality
lymph node	UBERON:0000029	59.32	gold quality
tonsil	UBERON:0002372	57.46	gold quality
hypothalamus	UBERON:0001898	56.97	gold quality
Ammon’s horn	UBERON:0001954	56.90	gold quality
temporal lobe	UBERON:0001871	53.31	gold quality
uterine cervix	UBERON:0000002	53.10	gold quality
amygdala	UBERON:0001876	52.96	gold quality
thyroid gland	UBERON:0002046	52.46	gold quality
subcutaneous adipose tissue	UBERON:0002190	52.24	gold quality
left lobe of thyroid gland	UBERON:0001120	52.23	gold quality
right atrium auricular region	UBERON:0006631	52.05	gold quality
cortical plate	UBERON:0005343	52.01	gold quality
minor salivary gland	UBERON:0001830	51.64	gold quality
smooth muscle tissue	UBERON:0001135	51.54	gold quality
right lobe of thyroid gland	UBERON:0001119	51.46	gold quality
saliva-secreting gland	UBERON:0001044	51.45	gold quality
heart left ventricle	UBERON:0002084	51.32	gold quality
putamen	UBERON:0001874	50.92	gold quality
nucleus accumbens	UBERON:0001882	50.78	gold quality
caudate nucleus	UBERON:0001873	50.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Study cloned 2 novel mucin-like genes designated panbronchiolitis related mucin-like 1 and 2 (PBMUCL1 and PBMUCL2) in the candidate region, which form a mucin-like gene cluster together with two adjacent genes. (PMID:20981447)
• HCG22 expression is significantly upregulated in human masticatory mucosa during wound healing (PMID:28005267)
• Comprehensive bioinformatics analysis identifies lncRNA HCG22 as a migration inhibitor in esophageal squamous cell carcinoma. (PMID:31236983)
• Assessment of multiple pathways involved in the inhibitory effect of HCG22 on oral squamous cell carcinoma progression. (PMID:33649984)
• Expression and mechanism of long non-coding RNA HCG22 in oral squamous cell carcinoma. (PMID:34859625)
• lncRNA HCG22 regulated cell growth and metastasis of papillary thyroid cancer via negatively modulating miR-425-5p. (PMID:38497386)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.