HCG25

Summary

HCG25 (HLA complex group 25, HGNC:20196) is a long non-coding RNA gene on chromosome 6p21.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20196
Approved symbol	HCG25
Name	HLA complex group 25
Location	6p21.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	dJ1033B10.16
Ensembl gene	ENSG00000232940
Ensembl biotype	lncRNA
Entrez	414765
RNAcentral	URS000075D944 — lncRNA, 703 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000422366, ENST00000427196, ENST00000442228, ENST00000450514, ENST00000658980, ENST00000662241, ENST00000666260, ENST00000669650, ENST00000701749, ENST00000755651, ENST00000755652, ENST00000755653, ENST00000755654, ENST00000755655, ENST00000755656, ENST00000755657, ENST00000755658, ENST00000755659, ENST00000755660, ENST00000755661, ENST00000755662, ENST00000755663

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000422366 — 4 exons

Exon	Start	End
ENSE00001593986	33249584	33249655
ENSE00001699568	33251513	33251939
ENSE00001722541	33249790	33249889
ENSE00001774483	33250609	33250711

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 95.56.

FANTOM5 (CAGE): breadth broad, TPM avg 1.5558 / max 25.0836, expressed in 896 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
67261	1.5558	896

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	95.56	gold quality
mucosa of transverse colon	UBERON:0004991	93.84	gold quality
primary visual cortex	UBERON:0002436	93.43	gold quality
apex of heart	UBERON:0002098	92.97	gold quality
adenohypophysis	UBERON:0002196	92.45	gold quality
putamen	UBERON:0001874	92.20	gold quality
substantia nigra	UBERON:0002038	92.05	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	92.04	gold quality
amygdala	UBERON:0001876	91.95	gold quality
pituitary gland	UBERON:0000007	91.90	gold quality
Ammon’s horn	UBERON:0001954	91.88	gold quality
temporal lobe	UBERON:0001871	91.57	gold quality
right hemisphere of cerebellum	UBERON:0014890	91.46	gold quality
right lobe of liver	UBERON:0001114	91.29	gold quality
right frontal lobe	UBERON:0002810	91.26	gold quality
cerebellar cortex	UBERON:0002129	91.05	gold quality
cerebellar hemisphere	UBERON:0002245	91.01	gold quality
right lobe of thyroid gland	UBERON:0001119	90.94	gold quality
caudate nucleus	UBERON:0001873	90.85	gold quality
cortex of kidney	UBERON:0001225	90.78	gold quality
nucleus accumbens	UBERON:0001882	90.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.74	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	90.71	gold quality
cerebellum	UBERON:0002037	90.68	gold quality
spleen	UBERON:0002106	90.63	gold quality
metanephros cortex	UBERON:0010533	90.59	gold quality
anterior cingulate cortex	UBERON:0009835	90.37	gold quality
hypothalamus	UBERON:0001898	90.28	gold quality
left lobe of thyroid gland	UBERON:0001120	90.21	gold quality
granulocyte	CL:0000094	90.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.90

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.