HCG27

Summary

HCG27 (HLA complex group 27, HGNC:27366) is a long non-coding RNA gene on chromosome 6p21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27366
Approved symbol	HCG27
Name	HLA complex group 27
Location	6p21.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	bPG299F13.9, bCX101P6.9, bQB115I13.2, FLJ40123
Ensembl gene	ENSG00000206344
Ensembl biotype	lncRNA
Entrez	253018
RNAcentral	URS000075C87D — lncRNA, 1742 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000383331, ENST00000414008, ENST00000415276, ENST00000424675, ENST00000638546, ENST00000692501, ENST00000755328, ENST00000755329, ENST00000755330, ENST00000755331, ENST00000755332, ENST00000755333

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000383331 — 2 exons

Exon	Start	End
ENSE00001669493	31197760	31197882
ENSE00001899881	31202372	31203968

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 95.24.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0171 / max 109.5046, expressed in 261 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66869	1.0171	261

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	95.24	gold quality
spleen	UBERON:0002106	88.38	gold quality
cerebellar hemisphere	UBERON:0002245	83.46	gold quality
vermiform appendix	UBERON:0001154	83.37	gold quality
cerebellar cortex	UBERON:0002129	83.35	gold quality
cerebellum	UBERON:0002037	83.22	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.16	gold quality
right lung	UBERON:0002167	82.88	gold quality
monocyte	CL:0000576	81.80	gold quality
leukocyte	CL:0000738	81.47	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.13	gold quality
lymph node	UBERON:0000029	81.08	gold quality
apex of heart	UBERON:0002098	80.70	gold quality
bone marrow cell	CL:0002092	80.32	gold quality
granulocyte	CL:0000094	79.30	gold quality
right uterine tube	UBERON:0001302	79.17	gold quality
small intestine Peyer’s patch	UBERON:0003454	78.32	gold quality
bone marrow	UBERON:0002371	78.18	gold quality
small intestine	UBERON:0002108	77.76	gold quality
rectum	UBERON:0001052	77.69	gold quality
upper lobe of left lung	UBERON:0008952	77.57	gold quality
mucosa of transverse colon	UBERON:0004991	77.31	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.30	gold quality
descending thoracic aorta	UBERON:0002345	76.11	gold quality
pituitary gland	UBERON:0000007	76.02	gold quality
duodenum	UBERON:0002114	75.82	gold quality
transverse colon	UBERON:0001157	75.09	gold quality
adenohypophysis	UBERON:0002196	75.00	gold quality
ascending aorta	UBERON:0001496	74.80	gold quality
thoracic aorta	UBERON:0001515	74.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA HCG27 Promotes Glucose Uptake Ability of HUVECs by MiR-378a-3p/MAPK1 Pathway. (PMID:37405607)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.