HDAC2-AS2

Summary

HDAC2-AS2 (HDAC2 and HS3ST5 antisense RNA 2, HGNC:43590) is a long non-coding RNA gene on chromosome 6q21-q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43590
Approved symbol	HDAC2-AS2
Name	HDAC2 and HS3ST5 antisense RNA 2
Location	6q21-q22.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	ENST00000421891
Ensembl gene	ENSG00000228624
Ensembl biotype	lncRNA
Entrez	101927768
RNAcentral	URS00007E3953 — lncRNA, 2007 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 50 — 50 lncRNA

ENST00000421891, ENST00000431399, ENST00000436876, ENST00000449620, ENST00000451415, ENST00000517965, ENST00000518470, ENST00000519104, ENST00000519270, ENST00000519629, ENST00000520034, ENST00000520554, ENST00000520891, ENST00000521888, ENST00000522697, ENST00000522844, ENST00000523087, ENST00000606947, ENST00000691803, ENST00000765656, ENST00000765657, ENST00000765658, ENST00000765659, ENST00000765660, ENST00000765661, ENST00000765662, ENST00000765663, ENST00000765664, ENST00000765665, ENST00000826280, ENST00000826281, ENST00000826282, ENST00000826283, ENST00000826284, ENST00000826285, ENST00000826286, ENST00000826287, ENST00000826288, ENST00000826289, ENST00000826290, ENST00000826291, ENST00000826292, ENST00000826293, ENST00000826294, ENST00000826295, ENST00000826296, ENST00000826297, ENST00000826298, ENST00000826299, ENST00000826300

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421891 — 3 exons

Exon	Start	End
ENSE00001693002	113999537	113999798
ENSE00002109802	113995600	113996060
ENSE00002115705	113995144	113995251

Expression profiles

Bgee: expression breadth ubiquitous, 161 present calls, max score 89.20.

FANTOM5 (CAGE): breadth broad, TPM avg 2.1980 / max 54.2742, expressed in 739 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
69385	1.2858	360
69384	0.4011	223
69386	0.2032	113
69382	0.1810	93
69381	0.0740	25
69383	0.0529	20

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.29	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	83.60	gold quality
sural nerve	UBERON:0015488	82.53	gold quality
spinal cord	UBERON:0002240	80.88	gold quality
cortical plate	UBERON:0005343	79.71	gold quality
corpus callosum	UBERON:0002336	79.47	gold quality
left testis	UBERON:0004533	79.20	gold quality
right testis	UBERON:0004534	78.86	gold quality
putamen	UBERON:0001874	77.59	gold quality
ganglionic eminence	UBERON:0004023	76.88	gold quality
testis	UBERON:0000473	76.52	gold quality
amygdala	UBERON:0001876	75.48	gold quality
caudate nucleus	UBERON:0001873	75.41	gold quality
nucleus accumbens	UBERON:0001882	73.96	gold quality
monocyte	CL:0000576	73.67	gold quality
leukocyte	CL:0000738	73.37	gold quality
adrenal tissue	UBERON:0018303	72.81	gold quality
bone marrow cell	CL:0002092	72.67	silver quality
Brodmann (1909) area 9	UBERON:0013540	72.65	gold quality
hypothalamus	UBERON:0001898	72.59	gold quality
substantia nigra	UBERON:0002038	72.50	gold quality
prefrontal cortex	UBERON:0000451	71.77	gold quality
right frontal lobe	UBERON:0002810	71.23	gold quality
anterior cingulate cortex	UBERON:0009835	71.06	gold quality
ventricular zone	UBERON:0003053	70.83	gold quality
midbrain	UBERON:0001891	70.39	gold quality
granulocyte	CL:0000094	68.37	gold quality
stromal cell of endometrium	CL:0002255	67.64	gold quality
colonic epithelium	UBERON:0000397	67.46	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.