HDAC4-AS1

Summary

HDAC4-AS1 (HDAC4 antisense RNA 1, HGNC:54064) is a long non-coding RNA gene on chromosome 2q37.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54064
Approved symbol	HDAC4-AS1
Name	HDAC4 antisense RNA 1
Location	2q37.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000222020
Ensembl biotype	lncRNA
Entrez	101928111
RNAcentral	URS00007DB98B — lncRNA, 384 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000409526, ENST00000413029, ENST00000428471, ENST00000670479, ENST00000688456, ENST00000690671, ENST00000691044, ENST00000750736, ENST00000750737, ENST00000750738, ENST00000750739, ENST00000750740

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000409526 — 2 exons

Exon	Start	End
ENSE00004095330	239401183	239401536
ENSE00004095347	239402075	239402400

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 94.14.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3296 / max 35.1846, expressed in 692 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
26379	0.7295	381
26380	0.6001	317

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	94.14	gold quality
right testis	UBERON:0004534	93.68	gold quality
testis	UBERON:0000473	89.77	gold quality
pancreatic ductal cell	CL:0002079	88.57	silver quality
sperm	CL:0000019	88.25	silver quality
right uterine tube	UBERON:0001302	80.79	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.25	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.04	gold quality
sural nerve	UBERON:0015488	76.90	gold quality
right adrenal gland	UBERON:0001233	76.78	gold quality
adenohypophysis	UBERON:0002196	75.55	gold quality
left adrenal gland	UBERON:0001234	75.11	gold quality
left adrenal gland cortex	UBERON:0035825	75.11	gold quality
spinal cord	UBERON:0002240	75.03	gold quality
right adrenal gland cortex	UBERON:0035827	74.91	gold quality
pituitary gland	UBERON:0000007	73.80	gold quality
mucosa of transverse colon	UBERON:0004991	73.67	gold quality
omental fat pad	UBERON:0010414	73.41	gold quality
peritoneum	UBERON:0002358	73.33	gold quality
right lobe of liver	UBERON:0001114	73.30	gold quality
adipose tissue of abdominal region	UBERON:0007808	73.00	gold quality
adrenal cortex	UBERON:0001235	72.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.90	gold quality
lower esophagus	UBERON:0013473	72.84	gold quality
spleen	UBERON:0002106	72.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.50	gold quality
amygdala	UBERON:0001876	72.43	gold quality
right lobe of thyroid gland	UBERON:0001119	72.39	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.36	gold quality
endothelial cell	CL:0000115	72.35	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.92

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA histone deacetylase 4 antisense RNA 1 (HDAC4-AS1) inhibits HDAC4 expression in human ARPE-19 cells with hypoxic stress. (PMID:34057022)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.